CN102872145B - Houttuynoid C在抗人体真菌药物中的应用 - Google Patents
Houttuynoid C在抗人体真菌药物中的应用 Download PDFInfo
- Publication number
- CN102872145B CN102872145B CN 201210419627 CN201210419627A CN102872145B CN 102872145 B CN102872145 B CN 102872145B CN 201210419627 CN201210419627 CN 201210419627 CN 201210419627 A CN201210419627 A CN 201210419627A CN 102872145 B CN102872145 B CN 102872145B
- Authority
- CN
- China
- Prior art keywords
- houttuynoid
- human
- application
- human body
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- FCUIRBQXJWMGLZ-YLUJEXTNSA-N 2-(3-decanoyl-7-hydroxy-1-benzofuran-4-yl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical compound C=12C(C(=O)CCCCCCCCC)=COC2=C(O)C=CC=1C=1OC2=CC(O)=CC(O)=C2C(=O)C=1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O FCUIRBQXJWMGLZ-YLUJEXTNSA-N 0.000 title claims abstract description 52
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 229940079593 drug Drugs 0.000 title abstract 4
- 230000002538 fungal effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 241000233866 Fungi Species 0.000 claims abstract description 12
- 241000282414 Homo sapiens Species 0.000 claims abstract description 10
- 241001480048 Trichophyton tonsurans Species 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims description 11
- 241000893980 Microsporum canis Species 0.000 claims description 3
- 241000223238 Trichophyton Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000005764 inhibitory process Effects 0.000 abstract description 2
- 241001480037 Microsporum Species 0.000 abstract 1
- 241000223229 Trichophyton rubrum Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- 208000009889 Herpes Simplex Diseases 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 4
- 230000003602 anti-herpes Effects 0.000 description 4
- 240000000691 Houttuynia cordata Species 0.000 description 3
- 235000013719 Houttuynia cordata Nutrition 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 229930190556 houttuynoid Natural products 0.000 description 3
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229960004125 ketoconazole Drugs 0.000 description 2
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- 229930183010 Amphotericin Natural products 0.000 description 1
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229960004821 amikacin Drugs 0.000 description 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
- 229940009444 amphotericin Drugs 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 238000004362 fungal culture Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210419627 CN102872145B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid C在抗人体真菌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210419627 CN102872145B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid C在抗人体真菌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102872145A CN102872145A (zh) | 2013-01-16 |
CN102872145B true CN102872145B (zh) | 2013-08-28 |
Family
ID=47473816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201210419627 Expired - Fee Related CN102872145B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid C在抗人体真菌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102872145B (zh) |
-
2012
- 2012-10-27 CN CN 201210419627 patent/CN102872145B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN102872145A (zh) | 2013-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103479608B (zh) | Scopariusins在制备抗人体真菌药物中的应用 | |
CN102872145B (zh) | Houttuynoid C在抗人体真菌药物中的应用 | |
CN102872133B (zh) | Houttuynoid E在抗人体真菌药物中的应用 | |
CN102861083B (zh) | Houttuynoid B在抗人体真菌药物中的应用 | |
CN102872090B (zh) | Houttuynoid B在制备抗细菌药物中的应用 | |
CN102861087B (zh) | Houttuynoid D在抗人体真菌药物中的应用 | |
CN102872105B (zh) | Houttuynoid C在抗细菌药物中的应用 | |
CN102872059B (zh) | Gypensapogenin B在制备抗人体真菌药物中的应用 | |
CN102872007A (zh) | Eryngiolide A在抗人体真菌药物中的应用 | |
CN102861076B (zh) | Houttuynoid A在制备抗细菌药物中的应用 | |
CN103393696B (zh) | Chukrasone A在制备抗人体真菌药物中的应用 | |
CN103463029B (zh) | Lycojaponicumin B在制备抗人体真菌药物中的应用 | |
CN103462989A (zh) | Sarcaboside B在抗人体真菌药物中的应用 | |
CN103446115A (zh) | Sarcaboside A在抗人体真菌药物中的应用 | |
CN102895250A (zh) | Houttuynoid A在抗人体真菌药物中的应用 | |
CN103372004B (zh) | Chukrasone B在制备抗人体真菌药物中的应用 | |
CN103446135B (zh) | Lycojaponicumin A在制备抗人体真菌药物中的应用 | |
CN102988345A (zh) | Aphanamixoid A在制备抗人体真菌药物中的应用 | |
CN103479636B (zh) | Lycojaponicumin C在制备抗人体真菌药物中的应用 | |
CN103301142A (zh) | Polyflavanostilbene A在制备抗人体真菌药物中的应用 | |
CN103393692B (zh) | 化合物在制备抗人体真菌药物中的应用 | |
CN102861027B (zh) | Gypensapogenin A在抗人体真菌药物中的应用 | |
CN102872146A (zh) | Houttuynoid D在抗细菌药物中的应用 | |
CN103027907A (zh) | Aphanamixoid A在制备抗细菌药物中的应用 | |
CN102895251A (zh) | Houttuynoid E在抗细菌药物中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU XIN NEOLITHIC BASALT FIBER CO., LTD. Free format text: FORMER OWNER: WU JUNHUA Effective date: 20131209 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 210009 NANJING, JIANGSU PROVINCE TO: 213351 CHANGZHOU, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20131209 Address after: 213351 Jiangsu city of Changzhou province Liyang Liyang Town of Wuhu Shanghai Road No. 168 Patentee after: Jiangsu Neolith Basalt Fiber Co., Ltd. Address before: 210009 No. 22, Hankou Road, Gulou District, Jiangsu, Nanjing Patentee before: Wu Junhua |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130828 Termination date: 20151027 |
|
EXPY | Termination of patent right or utility model |