CN102871775A - Foldable suspension-type artificial ligament - Google Patents

Foldable suspension-type artificial ligament Download PDF

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Publication number
CN102871775A
CN102871775A CN2012104177675A CN201210417767A CN102871775A CN 102871775 A CN102871775 A CN 102871775A CN 2012104177675 A CN2012104177675 A CN 2012104177675A CN 201210417767 A CN201210417767 A CN 201210417767A CN 102871775 A CN102871775 A CN 102871775A
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Prior art keywords
knit unit
section
free
artificial ligament
fiber
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CN2012104177675A
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CN102871775B (en
Inventor
陈世益
蒋佳
杨建军
李宏
李毓卓
董宇
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Shanghai Ligetai Biotechnology Co ltd
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Huashan Hospital of Fudan University
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Abstract

The invention provides a foldable suspension-type artificial ligament, comprising a first traction line part (11), a first tibia tunnel weaving part (21), a first joint inner free fiber part (31), a thighbone tunnel weaving part (4), a second joint inner free fiber part (32), a second tibia tunnel weaving part (22) and a second traction line part (12). The beneficial effects of the invention are as follows: when artificial ligament is used for rebuilding human anterior cruciate ligament, the fixation of the artificial ligament is enhanced and the contact area of the artificial ligament and the bone tunnels is increased. Thus, the union of the artificial ligament and bone tunnels is promoted. In addition, the artificial ligament is simple in structure and convenient for use.

Description

Folding suspension artificial ligament
Technical field
The present invention relates to the artificial ligament of implant into body, the artificial ligament that especially is connected with button plate particularly, relates to folding suspension artificial ligament and preparation method thereof.
Background technology
At present, clinical practice more and comparatively ripe artificial ligament in the whole world is the LARS artificial ligament of France, and this ligament is take high tenacity polyethylene terephthalate (PET) as raw material.Began to be applied to clinical in 1994, successfully used at home first in 2004, authenticate by European CE authentication and Chinese SFDA.The LARS artificial ligament is to be reeled to close up by polymer fiber net self to form, and is divided into both sides osseous tunnel section, middle joint fiber section and two ends draught line section.During LARS artificial ligament implantable bone tunnel, in femur and tibial tunnel, adopt respectively one piece of metallic screw extruding fixing.But, this fixed form has not only reduced the contact area of ligament and osseous tunnel, and because screw causes the ligament inner space to be reduced to the extruding of ligament, affects autologous tissue and grow into, osseous tunnel inner bolt at a specified future date occurs loosening easily, finally causes the failure of artificial ligament.
Summary of the invention
Be unfavorable for the defective that ligament and the healing of bone road and fixed form are not good for LARS artificial ligament in the prior art, the purpose of this invention is to provide a kind of folding suspension artificial ligament and preparation method thereof.Can connect button plate according to artificial ligament provided by the invention increases fixing firm degree, and more can increase the contact area of artificial ligament and osseous tunnel, thereby promotes the healing of ligament and osseous tunnel.
According to an aspect of the present invention, a kind of folding suspension artificial ligament is provided, comprises the interior free-fiber section of the first draught line section, the first tibial tunnel knit unit, the first intraarticular free-fiber section, femur tunnel knit unit, second joint, the second tibial tunnel knit unit and the second draught line section that connect successively.
Preferably, its mid point about described femur tunnel knit unit is centrosymmetric.
Preferably, described femur tunnel knit unit is bent into the U font in the place of putting therein.
Preferably, described femur tunnel knit unit is bent into axisymmetricly U font in the place of putting therein.
Preferably, it is about the axis of symmetry of described femur tunnel knit unit axisymmetricly.
Preferably, on long axis direction, the length of described the first tibial tunnel knit unit and the second tibial tunnel knit unit is 30mm, and the length of free-fiber section is 30mm in described the first intraarticular free-fiber section and the second joint, and the length of described femur tunnel knit unit is 50mm.
Preferably, also comprise band button steel plate, wherein, described band button steel plate is connected with the midpoint of described femur tunnel knit unit.
According to a further aspect of the present invention, also provide a kind of preparation method of folding suspension artificial ligament, comprise the steps:
Steps A: with a pet fiber net, along its long axis direction, be made as successively the first draw fibers section, the first knit unit, the first free-fiber section, the second knit unit, the second free-fiber section, the 3rd knit unit and the second draught line section by one end to the other end;
Step B: this pet fiber net is carried out self being wound into cylinder along major axis, make described the first draw fibers section form described the first draught line section, make described the first knit unit form described the first tibial tunnel knit unit, make described the first free-fiber section form described the first intraarticular free-fiber section, make described the second knit unit form described femur tunnel knit unit, make described the second free-fiber section form free-fiber section in the described second joint, make described the 3rd knit unit form described the second tibial tunnel knit unit, make described the second draught line section form described the first draught line section.
Preferably, also comprise the steps:
Step C: described femur tunnel knit unit is bent into the U font in the place of putting therein.
According to a further aspect of the invention, also provide a kind of preparation method of folding suspension artificial ligament, it is characterized in that,
Steps A: prepare to throw the net the different pet fiber net of lattice density more, with each Zhang Suoshu pet fiber net, along its long axis direction, be made as successively the first draw fibers section 611, the first knit unit 621, the first free-fiber section 631, the second knit unit 64, the second free-fiber section 632, the 3rd knit unit 622 and the second draught line section 612 by one end to the other end;
Step B: the pet fiber net of mesh-density maximum is carried out self being wound into cylinder as core along major axis, remaining described pet fiber net carries out self being wound into cylinder to wrap layer by layer described core, wherein along major axis successively according to mesh-density is descending:
Make fibroreticulate described the first draw fibers section 611 of these phthalic acid glycol esters form described the first draught line section 11, described the first knit unit 621 forms described the first tibial tunnel knit unit 21, described the first free-fiber section 631 forms described the first intraarticular free-fiber section 31, described the second knit unit 64 forms described femur tunnel knit unit 4, described the second free-fiber section 632 forms free-fiber section 32 in the described second joint, described the 3rd knit unit 622 forms described the second tibial tunnel knit unit 22, and described the second draught line section 612 forms described the first draught line section 12;
Step C: described femur tunnel knit unit 4 is bent into the U font in the some place therein.
The beneficial effect of patent of the present invention is, can be when using artificial ligament to rebuild people's anterior cruciate ligament, and strengthen the fixing of artificial ligament and increase the contact area of artificial ligament and osseous tunnel, thus the healing in promotion artificial ligament and bone road, and simple in structure, easy to use.In the ACL reconstruction operations, select as required the band button plate of corresponding length to be connected with the femur tunnel section mid point of artificial ligament.When this artificial ligament implantable bone tunnel, femur tunnel end employing button plate is connected with artificial ligament to suspend in midair and fixes, because of to a greater degree contact area increase in femur and tibial tunnel section ligament and the osseous tunnel, and ligament inner space larger (without the screw extruding) can reach and strengthen fixing purpose.
Description of drawings
By reading the detailed description of non-limiting example being done with reference to the following drawings, it is more obvious that other features, objects and advantages of the present invention will become:
Fig. 1 illustrates the structural representation according to folding suspension artificial ligament of the present invention;
Fig. 2 illustrates the principle schematic according to the preparation method of folding suspension artificial ligament of the present invention.
The specific embodiment
Fig. 1 illustrates the structural representation according to folding suspension artificial ligament of the present invention.Particularly, according to folding suspension artificial ligament provided by the invention, comprise the interior free-fiber section 32 of the first draught line section 11, the first tibial tunnel knit unit 21, the first intraarticular free-fiber section 31, femur tunnel knit unit 4, second joint, the second tibial tunnel knit unit 22, the second draught line section 12 and the band button steel plate that connect successively.Described folding suspension artificial ligament is centrosymmetric about the mid point of described femur tunnel knit unit 4, and described band button steel plate is connected with the midpoint of described femur tunnel knit unit 4.
More specifically, described femur tunnel knit unit 4 therein some place is bent into the U font, preferably, described femur tunnel knit unit 4 therein some place is bent into axisymmetricly U font, preferably corresponding, described folding suspension artificial ligament about the axis of symmetry of described femur tunnel knit unit 4 axisymmetricly.
In a preference of present embodiment, on long axis direction, the length of described the first tibial tunnel knit unit 21 and the second tibial tunnel knit unit 22 is 30mm, the length of free-fiber section 32 is 30mm in described the first intraarticular free-fiber section 31 and the second joint, and the length of described femur tunnel knit unit 4 is 50mm.
The present invention also provides the preparation method of folding suspension artificial ligament.
In one embodiment of the invention, described preparation method comprises the steps:
Steps A: with a pet fiber net, along its long axis direction, be made as successively the first draw fibers section 611, the first knit unit 621, the first free-fiber section 631, the second knit unit 64, the second free-fiber section 632, the 3rd knit unit 622 and the second draught line section 612 by one end to the other end, as shown in Figure 2;
Step B: this pet fiber net is carried out self being wound into cylinder along major axis, make described the first draw fibers section 611 form described the first draught line section 11, make described the first knit unit 621 form described the first tibial tunnel knit unit 21, make described the first free-fiber section 631 form described the first intraarticular free-fiber section 31, make described the second knit unit 64 form described femur tunnel knit unit 4, make described the second free-fiber section 632 form free-fiber section 32 in the described second joint, make described the 3rd knit unit 622 form described the second tibial tunnel knit unit 22, make described the second draught line section 612 form described the first draught line section 12;
Step C: described femur tunnel knit unit 4 is bent into the U font in the some place therein.
In another embodiment of the present invention, described preparation method comprises the steps:
Steps A: prepare to throw the net the different pet fiber net of lattice density more, with each Zhang Suoshu pet fiber net, along its long axis direction, be made as successively the first draw fibers section 611, the first knit unit 621, the first free-fiber section 631, the second knit unit 64, the second free-fiber section 632, the 3rd knit unit 622 and the second draught line section 612 by one end to the other end;
Step B: the pet fiber net of mesh-density maximum is carried out self being wound into cylinder as core along major axis, remaining described pet fiber net carries out self being wound into cylinder to wrap layer by layer described core, wherein along major axis successively according to mesh-density is descending:
Make fibroreticulate described the first draw fibers section 611 of these phthalic acid glycol esters form described the first draught line section 11, described the first knit unit 621 forms described the first tibial tunnel knit unit 21, described the first free-fiber section 631 forms described the first intraarticular free-fiber section 31, described the second knit unit 64 forms described femur tunnel knit unit 4, described the second free-fiber section 632 forms free-fiber section 32 in the described second joint, described the 3rd knit unit 622 forms described the second tibial tunnel knit unit 22, and described the second draught line section 612 forms described the first draught line section 12;
Step C: described femur tunnel knit unit 4 is bent into the U font in the some place therein.
More than specific embodiments of the invention are described.It will be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or modification within the scope of the claims, and this does not affect flesh and blood of the present invention.

Claims (10)

1. folding suspension artificial ligament, it is characterized in that, comprise the interior free-fiber section (32) of the first draught line section (11), the first tibial tunnel knit unit (21), the first intraarticular free-fiber section (31), femur tunnel knit unit (4), second joint, the second tibial tunnel knit unit (22) and the second draught line section (12) that connect successively.
2. folding suspension artificial ligament according to claim 1 is characterized in that, its mid point about described femur tunnel knit unit (4) is centrosymmetric.
3. folding suspension artificial ligament according to claim 1 is characterized in that, described femur tunnel knit unit (4) therein some place is bent into the U font.
4. folding suspension artificial ligament according to claim 3 is characterized in that, described femur tunnel knit unit (4) therein some place is bent into axisymmetricly U font.
5. folding suspension artificial ligament according to claim 4 is characterized in that, it about the axis of symmetry of described femur tunnel knit unit (4) axisymmetricly.
6. folding suspension artificial ligament according to claim 1, it is characterized in that, on long axis direction, the length of described the first tibial tunnel knit unit (21) and the second tibial tunnel knit unit (22) is 30mm, the length of free-fiber section (32) is 30mm in described the first intraarticular free-fiber section (31) and the second joint, and the length of described femur tunnel knit unit (4) is 50mm.
7. folding suspension artificial ligament according to claim 1 is characterized in that, also comprises band button steel plate, and wherein, described band button steel plate is connected with the midpoint of described femur tunnel knit unit (4).
8. the preparation method of a folding suspension artificial ligament is characterized in that, comprises the steps:
Steps A: with a pet fiber net, along its long axis direction, be made as successively the first draw fibers section (611), the first knit unit (621), the first free-fiber section (631), the second knit unit (64), the second free-fiber section (632), the 3rd knit unit (622) and the second draught line section (612) by one end to the other end;
Step B: this pet fiber net is carried out self being wound into cylinder along major axis, make described the first draw fibers section (611) form described the first draught line section (11), make described the first knit unit (621) form described the first tibial tunnel knit unit (21), make described the first free-fiber section (631) form described the first intraarticular free-fiber section (31), make described the second knit unit (64) form described femur tunnel knit unit (4), make described the second free-fiber section (632) form free-fiber section (32) in the described second joint, make described the 3rd knit unit (622) form described the second tibial tunnel knit unit (22), make described the second draught line section (612) form described the first draught line section (12).
9. the preparation method of folding suspension artificial ligament according to claim 8 is characterized in that, also comprises the steps:
Step C: described femur tunnel knit unit (4) is bent into the U font in the some place therein.
10. the preparation method of a folding suspension artificial ligament is characterized in that, comprises the steps:
Steps A: prepare to throw the net the different pet fiber net of lattice density more, with each Zhang Suoshu pet fiber net, along its long axis direction, be made as successively the first draw fibers section (611), the first knit unit (621), the first free-fiber section (631), the second knit unit (64), the second free-fiber section (632), the 3rd knit unit (622) and the second draught line section (612) by one end to the other end;
Step B: the pet fiber net of mesh-density maximum is carried out self being wound into cylinder as core along major axis, remaining described pet fiber net carries out self being wound into cylinder to wrap layer by layer described core, wherein along major axis successively according to mesh-density is descending:
Make fibroreticulate described the first draw fibers section (611) of these phthalic acid glycol esters form described the first draught line section (11), described the first knit unit (621) forms described the first tibial tunnel knit unit (21), described the first free-fiber section (631) forms described the first intraarticular free-fiber section (31), described the second knit unit (64) forms described femur tunnel knit unit (4), described the second free-fiber section (632) forms free-fiber section (32) in the described second joint, described the 3rd knit unit (622) forms described the second tibial tunnel knit unit (22), and described the second draught line section (612) forms described the first draught line section (12);
Step C: described femur tunnel knit unit (4) is bent into the U font in the some place therein.
CN201210417767.5A 2012-10-15 2012-10-26 Foldable suspension-type artificial ligament and preparation method thereof Active CN102871775B (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103190964A (en) * 2013-04-07 2013-07-10 复旦大学附属华山医院 Easy-molded folding suspension type artificial ligament and preparation method thereof
CN103830020A (en) * 2014-03-07 2014-06-04 复旦大学附属华山医院 Hollow tubular banded foldable suspension type artificial ligament
CN105496605A (en) * 2015-12-04 2016-04-20 上海凯利泰医疗科技股份有限公司 Double-bundle artificial ligament and manufacturing method, implanting device and implanting method thereof
CN107106290A (en) * 2015-01-12 2017-08-29 苏黎世大学 For tendon and the device of ligament reconstructive
CN110037830A (en) * 2019-04-18 2019-07-23 东华大学 Bionical full molding three-phase structure artificial ligament of one kind and preparation method thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202875536U (en) * 2012-10-15 2013-04-17 复旦大学附属华山医院 Folding suspension type artificial ligament
CN107174377B (en) * 2017-06-19 2023-07-25 上海契斯特医疗科技公司 Tubular artificial ligament and processing method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800543A (en) * 1993-03-31 1998-09-01 Surgicraft Limited Artificial ligament
US20040199166A1 (en) * 2003-03-18 2004-10-07 Reinhold Schmieding ACL reconstruction technique using retrodrill
CN1777450A (en) * 2003-01-17 2006-05-24 拉思公司-科学研究与应用试验室 Biomimetic prosthetic ligament and production method thereof
US20080300683A1 (en) * 2007-03-20 2008-12-04 Altman Gregory H Prosthetic device and method of manufacturing the same
CN201542777U (en) * 2009-10-30 2010-08-11 复旦大学附属华山医院 Artificial ligament
WO2011012783A1 (en) * 2009-07-31 2011-02-03 Laboratoire D'application Et De Recherche Scientifique - Lars Prosthetic ligament for transverse fixation, and production method
CN202875536U (en) * 2012-10-15 2013-04-17 复旦大学附属华山医院 Folding suspension type artificial ligament

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800543A (en) * 1993-03-31 1998-09-01 Surgicraft Limited Artificial ligament
CN1777450A (en) * 2003-01-17 2006-05-24 拉思公司-科学研究与应用试验室 Biomimetic prosthetic ligament and production method thereof
US20040199166A1 (en) * 2003-03-18 2004-10-07 Reinhold Schmieding ACL reconstruction technique using retrodrill
US20080300683A1 (en) * 2007-03-20 2008-12-04 Altman Gregory H Prosthetic device and method of manufacturing the same
WO2011012783A1 (en) * 2009-07-31 2011-02-03 Laboratoire D'application Et De Recherche Scientifique - Lars Prosthetic ligament for transverse fixation, and production method
CN102625680A (en) * 2009-07-31 2012-08-01 拉思公司-科学研究与应用实验室 Prosthetic ligament for transverse fixation, and production method
CN201542777U (en) * 2009-10-30 2010-08-11 复旦大学附属华山医院 Artificial ligament
CN202875536U (en) * 2012-10-15 2013-04-17 复旦大学附属华山医院 Folding suspension type artificial ligament

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103190964A (en) * 2013-04-07 2013-07-10 复旦大学附属华山医院 Easy-molded folding suspension type artificial ligament and preparation method thereof
CN103830020A (en) * 2014-03-07 2014-06-04 复旦大学附属华山医院 Hollow tubular banded foldable suspension type artificial ligament
CN103830020B (en) * 2014-03-07 2017-05-17 复旦大学附属华山医院 Hollow tubular banded foldable suspension type artificial ligament
CN107106290A (en) * 2015-01-12 2017-08-29 苏黎世大学 For tendon and the device of ligament reconstructive
CN107106290B (en) * 2015-01-12 2019-12-17 苏黎世大学 Device for tendon and ligament reconstruction
US10959829B2 (en) 2015-01-12 2021-03-30 Universitat Zurich Device for tendon and ligament reconstruction
CN105496605A (en) * 2015-12-04 2016-04-20 上海凯利泰医疗科技股份有限公司 Double-bundle artificial ligament and manufacturing method, implanting device and implanting method thereof
CN110037830A (en) * 2019-04-18 2019-07-23 东华大学 Bionical full molding three-phase structure artificial ligament of one kind and preparation method thereof
CN110037830B (en) * 2019-04-18 2021-12-10 东华大学 Bionic full-molded three-phase structure artificial ligament and preparation method thereof

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