CN102871651A - Near infrared lymphatic detector - Google Patents
Near infrared lymphatic detector Download PDFInfo
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- CN102871651A CN102871651A CN201210413763XA CN201210413763A CN102871651A CN 102871651 A CN102871651 A CN 102871651A CN 201210413763X A CN201210413763X A CN 201210413763XA CN 201210413763 A CN201210413763 A CN 201210413763A CN 102871651 A CN102871651 A CN 102871651A
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Abstract
The invention relates to a near infrared lymphatic detector which belongs to the field of medical technology of lymphatic detection, and the detector solves the problem that an existing lymphatic detection device cannot position the lesion lymph node positions of a patient or determine the lesion lymph node forms. An image acquisition part is used for acquiring an fluorescence image of human tissue; the fluorescence image appears after a near infrared laser emission part radiates to the human tissue; the laser control signal input end of the near infrared laser emission part is connected with the laser control signal output end of an image acquisition controller; the sampling control signal output end of the image acquisition controller is connected with the sampling control signal input end of the image acquisition part; the image signal output end of the image acquisition part is connected with the image signal input end of the image acquisition controller; the image signal output end of the image acquisition controller is connected with the image signal input end of a computer; and the computer is used for processing an acquired image signal, and obtaining a lymphatic abnormality image. The near infrared lymphatic detector is applicable to near infrared lymphatic detection.
Description
Technical field
The present invention relates to a kind of near-infrared lymph detector, belong to lymph and detect field of medical technology.
Background technology
Lymph tumor can be touched at health the lymph node of enlargement in early days, and is superficial because of it, therefore often ignored by the people, but this is the early symptom of lymphatic cancer in fact.Lymphadenectasis can occur at cervical region in nearly 60% lymphatic cancer in early days, and by the single enlargement in when beginning, slowly increases number, and volume also can increase simultaneously.
Because lymph tumor can betide the whole body lymphoid tissue, on following chin, lower jaw, front cervical region, the clavicle, by oxter, groin, vertical diaphragm chamber or the abdominal artery, sometimes betide internal organs, subcutaneous nodule, tonsil and mouth, nose, pharyngeal, stomach, small intestinal or large intestine, bone marrow etc.Generally speaking, the early symptom of lymph tumor is without characteristic symptom, and main manifestations is lymphadenectasis, and with symptoms such as repeatedly heating, skin pruritus, cough, uncomfortable in chest, abdominal distention, stomachache, therefore very easily mistaken diagnosis and mistake are examined.Existing medical treatment detection device is difficult to lymphadenopathy is made in early days, diagnosed accurately, and it can not accurately be determined the outer pathological changes of knot and accurately determine pathological changes lymph node position and form.
Summary of the invention
The present invention is in order to solve the pathological changes lymph node position that existing lymph checkout gear can not position patient and to determine the problem of its form, a kind of near-infrared lymph detector being provided.
Near-infrared lymph detector of the present invention, it comprises image acquisition section, it also comprises near-infrared laser emission part, image capture controller and computer,
Image acquisition section is used for gathering the fluoroscopic image of tissue, and this fluoroscopic image is that the near-infrared laser emission part shines the fluoroscopic image that presents after the tissue,
The laser control signal input of near-infrared laser emission part connects the laser control signal outfan of image capture controller, the sampling control signal outfan of image capture controller connects the sampling control signal input of image acquisition section, the image signal output end of image acquisition section connects the picture signal input of image capture controller, and the image signal output end of image capture controller connects the picture signal input of computer;
Computer is used for processing gathering the picture signal that obtains, and obtains the lymph abnormal image.
The computer-internal module comprises pre-amplifying module, synchronizing separator circuit, image acquisition storage control module, image buffer storage module, image pretreatment module, frame memory, image processing module and image display,
The image signal output end of image capture controller connects the picture signal input of pre-amplifying module, the image amplifying signal outfan of pre-amplifying module connects the picture signal input of image acquisition storage control module, the image processing control signals outfan of image acquisition storage control module connects the image processing control signals input of image processing module, image acquisition storage control module connection data bus, image processing module connection data bus;
The synchronous signal output end of pre-amplifying module connects the synchronous signal input end of synchronizing separator circuit, the synchronous signal output end connection layout of synchronizing separator circuit is as the synchronous signal input end of cache module, the image buffer storage signal input output end of image buffer storage module connects the image buffer storage signal I/O of image acquisition storage control module, the image signal output end connection layout of image buffer storage module is as the picture signal input of pretreatment module, the image signal output end of image pretreatment module connects the picture signal input of frame memory, frame memory connection data bus
Image display connection data bus.
Computer is processed detecting the fluoroscopic image that obtains, and the process that obtains the lymph abnormal image is:
Step 1: the unusual number of times m=0 of prediction picture, images acquired frequency n=0, m is less than or equal to 3 natural number, and n is less than or equal to 10 natural number;
Step 2: the fluoroscopic image that obtains carries out the figure image intensifying and edge sharpening is processed to detecting;
Step 3: carry out the conversion and the lymph image that merges after obtaining to process of image;
Step 4: the lymph image after will processing compares with the database images that prestores, preset the tissue image of normal partes corporis humani position among this data base who prestores, judge whether the lymph image after processing is identical with the corresponding database images that prestores, if, make n=n+1, execution in step five; Otherwise, execution in step six:
Step 5: whether judge n+1 greater than 10, if image acquisition finishes; Otherwise, return step 2;
Step 6: judge that the lymph image after this processing is the lymph abnormal image, then output lymph abnormal image makes n=n+1, m=m+1, and then execution in step seven;
Step 7: whether judge n greater than 10, perhaps whether m greater than 3, if, execution in step eight; Otherwise, return step 2;
Step 8: image acquisition finishes.
Advantage of the present invention is: detector of the present invention, be applied to detect the lymphoid pathological changes of patient, the detected image that it provides, help the foundation that provides assistance in diagnosis, pathological changes is found by early diagnosis, and can accurately determine pathological changes lymph node position and form, precisely the guided operation doctor excises the pathological changes lymph node.
Detector of the present invention has been filled up the blank that near-infrared field lymph detects, and is conducive to early warning, the early diagnosis of lymphadenopathy.Organizational structure and metamorphosis before occuring in lymphadenopathy, cellular metabolism meeting abnormal, the near infrared detection that the present invention adopts has been utilized near infrared strong penetrance, it does not have to judge potential hidden danger by image information in the obvious disease situation the patient, can earlier pinpoint the problems.
Detector of the present invention have online detection, convenient and swift, to human body without advantages such as destructivenesses, it is compared with the indagation method such as structure image and can shift to an earlier date half a year and even more early find to try to gain time precious to one pathological changes for early discovery and the control of disease.
Description of drawings
Fig. 1 is structured flowchart of the present invention;
Fig. 2 is the computer-internal module frame chart;
Fig. 3 is that computer is processed detecting the fluoroscopic image that obtains, and obtains the flow chart of lymph abnormal image.
The specific embodiment
The specific embodiment one: below in conjunction with Fig. 1 and Fig. 2 present embodiment is described, the described near-infrared lymph of present embodiment detector, it comprises image acquisition section 1, it also comprises near-infrared laser emission part 2, image capture controller 3 and computer 4,
The laser control signal input of near-infrared laser emission part 2 connects the laser control signal outfan of image capture controller 3, the sampling control signal outfan of image capture controller 3 connects the sampling control signal input of image acquisition section 1, the image signal output end of image acquisition section 1 connects the picture signal input of image capture controller 3, and the image signal output end of image capture controller 3 connects the picture signal input of computer 4;
In the present embodiment, near-infrared laser emission part 2 can adopt laser instrument, and image acquisition section 1 can adopt high-resolution camera, all needs to carry out the accurate debugging of specialty before the use, and computer 4 is by data acquisition chip and image processing software processing image information.
The near-infrared laser emission part 2 that adopts in the present embodiment is semiconductor laser, semiconductor laser presents fluoroscopic image after shining tissue after expanding, utilize high-resolution camera can survey the very faint fluorescence signal of tissue.The power of semiconductor laser irradiation is less than 5.0 milliwatts, almost to not injury of human body.Image capture controller 3 control semiconductor lasers luminous, and the data acquisition of video camera and store computer into.Computer is finally processed by image, generates the clearly medical image of lymph, blood vessel.For diagnosing with operative treatment, the doctor provides scientific basis.
Tissue to be detected needs injection fluorescence molecule developing agent indocyanine-green ICG before detecting, this reagent is very safe biological reagent, clinically Secure Application more than 50 year, injected dose is less than the peak of clinical regulation.Injected dose only is 25 milligrams and gets final product.
Near-infrared laser emission part 2 adopts near infrared laser, and its wavelength is in the 650nm-900nm nanometer, and power is less than 5.0 milliwatts.
The specific embodiment two: present embodiment is described below in conjunction with Fig. 2, present embodiment is further specifying embodiment one, computer 4 internal modules comprise pre-amplifying module 4-1, synchronizing separator circuit 4-2, image acquisition storage control module 4-3, image buffer storage module 4-4, image pretreatment module 4-5, frame memory 4-6, image processing module 4-7 and image display 4-8
The image signal output end of image capture controller 3 connects the picture signal input of pre-amplifying module 4-1, the image amplifying signal outfan of pre-amplifying module 4-1 connects the picture signal input of image acquisition storage control module 4-3, the image processing control signals outfan of image acquisition storage control module 4-3 connects the image processing control signals input of image processing module 4-7, image acquisition storage control module 4-3 connection data bus, image processing module 4-7 connection data bus;
The synchronous signal output end of pre-amplifying module 4-1 connects the synchronous signal input end of synchronizing separator circuit 4-2, the synchronous signal output end connection layout of synchronizing separator circuit 4-2 is as the synchronous signal input end of cache module 4-4, the image buffer storage signal input output end of image buffer storage module 4-4 connects the image buffer storage signal I/O of image acquisition storage control module 4-3, the image signal output end connection layout of image buffer storage module 4-4 is as the picture signal input of pretreatment module 4-5, the image signal output end of image pretreatment module 4-5 connects the picture signal input of frame memory 4-6, frame memory 4-6 connection data bus
Image display 4-8 connection data bus.
In the present embodiment, the picture signal that computer sends the image acquisition section 1 that collects is carried out preposition amplification, is produced synchronizing signal through synchronizing separator circuit, deposits the image information that gathers in buffer memory, carries out pretreatment again.Process by image, deposit the view data of processing in frame memory VRAM.Image acquisition storage control module 4-3 controls, monitors and show output from the VRAM sense data and to whole gatherer process.
The specific embodiment three: present embodiment is described below in conjunction with Fig. 1 to Fig. 3, the described near-infrared lymph of present embodiment detector, at first treat human body tissue injection fluorescence molecule developing agent indocyanine-green, then adopting near-infrared laser emission part 2 to shine tissue to be detected makes it present fluorescence, adopt image acquisition section 1 to gather the fluoroscopic image of this tissue
The process that the fluoroscopic image that 4 pairs of detections of computer obtain is processed is:
Step 1: the unusual number of times m=0 of prediction picture, images acquired frequency n=0, m is less than or equal to 3 natural number, and n is less than or equal to 10 natural number;
Step 2: the fluoroscopic image that obtains carries out the figure image intensifying and edge sharpening is processed to detecting;
Step 3: carry out the conversion and the lymph image that merges after obtaining to process of image;
Step 4: the lymph image after will processing compares with the database images that prestores, preset the tissue image of normal partes corporis humani position among this data base who prestores, judge whether the lymph image after processing is identical with the corresponding database images that prestores, if, make n=n+1, execution in step five; Otherwise, execution in step six:
Step 5: whether judge n+1 greater than 10, if image acquisition finishes; Otherwise, return step 2;
Step 6: judge that the lymph image after this processing is the lymph abnormal image, then output lymph abnormal image makes n=n+1, m=m+1, and then execution in step seven;
Step 7: whether judge n greater than 10, perhaps whether m greater than 3, if, execution in step eight; Otherwise, return step 2;
Step 8: image acquisition finishes.
The dosage of tissue injection fluorescence molecule developing agent indocyanine-green to be detected is 25 milligrams.
Claims (3)
1. near-infrared lymph detector, it comprises image acquisition section (1), it is characterized in that: it also comprises near-infrared laser emission part (2), image capture controller (3) and computer (4),
Image acquisition section (1) is used for gathering the fluoroscopic image of tissue, and this fluoroscopic image is that near-infrared laser emission part (2) shines the fluoroscopic image that presents after the tissue,
The laser control signal input of near-infrared laser emission part (2) connects the laser control signal outfan of image capture controller (3), the sampling control signal outfan of image capture controller (3) connects the sampling control signal input of image acquisition section (1), the image signal output end of image acquisition section (1) connects the picture signal input of image capture controller (3), and the image signal output end of image capture controller (3) connects the picture signal input of computer (4);
Computer (4) is used for processing gathering the picture signal that obtains, and obtains the lymph abnormal image.
2. near-infrared lymph detector according to claim 1, it is characterized in that: computer (4) internal module comprises pre-amplifying module (4-1), synchronizing separator circuit (4-2), image acquisition storage control module (4-3), image buffer storage module (4-4), image pretreatment module (4-5), frame memory (4-6), image processing module (4-7) and image display (4-8)
The image signal output end of image capture controller (3) connects the picture signal input of pre-amplifying module (4-1), the image amplifying signal outfan of pre-amplifying module (4-1) connects the picture signal input of image acquisition storage control module (4-3), the image processing control signals outfan of image acquisition storage control module (4-3) connects the image processing control signals input of image processing module (4-7), image acquisition storage control module (4-3) connection data bus, image processing module (4-7) connection data bus;
The synchronous signal output end of pre-amplifying module (4-1) connects the synchronous signal input end of synchronizing separator circuit (4-2), the synchronous signal output end connection layout of synchronizing separator circuit (4-2) is as the synchronous signal input end of cache module (4-4), the image buffer storage signal input output end of image buffer storage module (4-4) connects the image buffer storage signal I/O of image acquisition storage control module (4-3), the image signal output end connection layout of image buffer storage module (4-4) is as the picture signal input of pretreatment module (4-5), the image signal output end of image pretreatment module (4-5) connects the picture signal input of frame memory (4-6), frame memory (4-6) connection data bus
Image display (4-8) connection data bus.
3. near-infrared lymph detector according to claim 1 and 2 is characterized in that:
Computer (4) is processed detecting the fluoroscopic image that obtains, and the process that obtains the lymph abnormal image is:
Step 1: the unusual number of times m=0 of prediction picture, images acquired frequency n=0, m is less than or equal to 3 natural number, and n is less than or equal to 10 natural number;
Step 2: the fluoroscopic image that obtains carries out the figure image intensifying and edge sharpening is processed to detecting;
Step 3: carry out the conversion and the lymph image that merges after obtaining to process of image;
Step 4: the lymph image after will processing compares with the database images that prestores, preset the tissue image of normal partes corporis humani position among this data base who prestores, judge whether the lymph image after processing is identical with the corresponding database images that prestores, if, make n=n+1, execution in step five; Otherwise, execution in step six:
Step 5: whether judge n+1 greater than 10, if image acquisition finishes; Otherwise, return step 2;
Step 6: judge that the lymph image after this processing is the lymph abnormal image, then output lymph abnormal image makes n=n+1, m=m+1, and then execution in step seven;
Step 7: whether judge n greater than 10, perhaps whether m greater than 3, if, execution in step eight; Otherwise, return step 2;
Step 8: image acquisition finishes.
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Application publication date: 20130116 |