CN102861074A - Houttuynoid B在治疗膀胱癌药物中的应用 - Google Patents
Houttuynoid B在治疗膀胱癌药物中的应用 Download PDFInfo
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- CN102861074A CN102861074A CN2012104186246A CN201210418624A CN102861074A CN 102861074 A CN102861074 A CN 102861074A CN 2012104186246 A CN2012104186246 A CN 2012104186246A CN 201210418624 A CN201210418624 A CN 201210418624A CN 102861074 A CN102861074 A CN 102861074A
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- houttuynoid
- bladder cancer
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- 206010005003 Bladder cancer Diseases 0.000 title claims abstract description 25
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 title claims abstract description 23
- 201000005112 urinary bladder cancer Diseases 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 17
- OXBQNNYXKZSXES-RDHYKQKTSA-N 5,7-dihydroxy-2-(7-hydroxy-2-nonyl-1-benzofuran-4-yl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical compound C1=CC(O)=C2OC(CCCCCCCCC)=CC2=C1C=1OC2=CC(O)=CC(O)=C2C(=O)C=1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O OXBQNNYXKZSXES-RDHYKQKTSA-N 0.000 title abstract description 42
- 150000001875 compounds Chemical class 0.000 claims description 16
- 229930190556 houttuynoid Natural products 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 abstract description 14
- 230000012010 growth Effects 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 208000009889 Herpes Simplex Diseases 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 4
- 230000003602 anti-herpes Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 240000000691 Houttuynia cordata Species 0.000 description 3
- 235000013719 Houttuynia cordata Nutrition 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000001531 bladder carcinoma Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210418624.6A CN102861074B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid B在制备治疗膀胱癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210418624.6A CN102861074B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid B在制备治疗膀胱癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102861074A true CN102861074A (zh) | 2013-01-09 |
CN102861074B CN102861074B (zh) | 2014-04-16 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201210418624.6A Active CN102861074B (zh) | 2012-10-27 | 2012-10-27 | Houttuynoid B在制备治疗膀胱癌药物中的应用 |
Country Status (1)
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CN (1) | CN102861074B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1880328A (zh) * | 2006-04-30 | 2006-12-20 | 重庆大学 | 贯叶连翘中金丝桃苷和金丝桃素的制备方法 |
CN102697942A (zh) * | 2012-01-04 | 2012-10-03 | 陈玉堂 | 一种能杀死癌细胞治愈各种肿瘤癌症和白血病的药物 |
-
2012
- 2012-10-27 CN CN201210418624.6A patent/CN102861074B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1880328A (zh) * | 2006-04-30 | 2006-12-20 | 重庆大学 | 贯叶连翘中金丝桃苷和金丝桃素的制备方法 |
CN102697942A (zh) * | 2012-01-04 | 2012-10-03 | 陈玉堂 | 一种能杀死癌细胞治愈各种肿瘤癌症和白血病的药物 |
Non-Patent Citations (2)
Title |
---|
SHAO-DAN CHEN ET AL: "Houttuynoids A-E, anti-herpes simplex virus active flavonoids with novel skeletons from houttuynia cordata", 《ORGANIC LETTERS》 * |
李爽 等: "鱼腥草的有效成分、药理作用及临床应用的研究进展", 《沈阳药科大学学报》 * |
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Publication number | Publication date |
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CN102861074B (zh) | 2014-04-16 |
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Owner name: GU YONGLIANG Free format text: FORMER OWNER: NANJING UNIVERSITY Effective date: 20141226 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 210093 NANJING, JIANGSU PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20141226 Address after: 226400, No. 6, Southeast River, dug Town, Rudong County, Jiangsu Patentee after: Gu Yongliang Address before: 210093 Nanjing, Gulou District, Jiangsu, No. 22 Hankou Road Patentee before: Nanjing University |