CN102844243A

CN102844243A - Flexible pinch fitting for containers

Info

Publication number: CN102844243A
Application number: CN2011800160768A
Authority: CN
Inventors: D·王
Original assignee: Millipore Corp
Current assignee: EMD Millipore Corp
Priority date: 2010-03-26
Filing date: 2011-03-24
Publication date: 2012-12-26
Anticipated expiration: 2031-03-24
Also published as: KR20120118063A; KR101457447B1; CN104743222A; US20110235948A1; WO2011119837A3; JP2013523538A; CN102844243B; SG191647A1; WO2011119837A2; SG183534A1; EP2552798A2

Abstract

A device for reducing or eliminating the dead space in a fitting and tubing used on a disposable container by using a flexible elastic fitting that can accommodate a pinch valve or a clamp or the like closer to the flange portion of the fitting. The fitting is formed of a flange and a neck portion with a bore running through them. The neck may terminate in either a tubular section or a hose barb. The neck end section especially when in the form of a hose barb can be reinforced to provide a platform for attaching a tubing to it.

Description

The flexibility of container tightens accessory

The cross reference of related application

The application requires in the rights and interests of the 61/341st, No. 169 U.S. Provisional Application of submission on March 26th, 2010, and the full content of this application is incorporated into this by reference.

Technical field

The present invention relates to a kind of accessory that is used for container.More particularly, its relate to a kind of can be with very little or do not have a flexible fittings that dead volume sealing is tightened.

Background technology

The flexible cell of bag type is used in the current various industries and pharmacy and bio-pharmaceuticals industry that comprise food, beverage, medical treatment, chemistry.They provide than be used to handle with storage products and single-use in the middle of the more advantage of traditional rigid container of article; Thereby elimination need for cleaning; Allow the more manufacturing line of flexibility and changeability; This is because they can be connected to different parts as required, and unlike the stainless steel production line of traditional special use, and can such as utilize radiation (gamma or beta) or as the gas of epoxyethane (ETO) come to sterilize in advance.

Connection between the container typically utilizes rigidity plastics barb accessory as shown in Figure 12 to accomplish.Thereby these usually by such as poly-vinyl and polyacrylic plastic moulding and be designed to rigidity and inflexibility support following function.

Accessory 2 has the flange 4 of contiguous bag 12, straight basically neck part 6 and from flange barb part 8 farthest.Through hole 58 passes accessory 2 from the flange to the barb.Usually through sealing, sonic welded or the adhesive attachment opening 10 to bag 12, so that the opening 10 of bag 12 is communicated with hole 5 fluids of accessory 2, the hole 5 of accessory 2 is communicated with hole 16 fluids of pipeline 14 again accessory 2.Pipeline 14 cunnings are fitted on the barb 8 and rest at least a portion of neck 6, and are fixed to accessory 2 not slippage by mistake to guarantee it because such as intrasystem pressure through the device such as bandage 20 usually.

Bag 12 and accessory 2 usually through such as pinch valve 18 or clip (not shown) these can be manually or automatically controlled device other part of shutdown system optionally.

The use of this accessory has demonstrated the defective for dynamic process, the dynamic process of dead volume problem possibly occur such as mixing, bioreactor and other.As shown in Figure 1, be used for the valve 18 of shutdown system to be positioned on the flexible duct 14, apart from the certain position place before the barb 8.Therefore, fluid can be included in the hole 16 of hole 5 and the pipeline of the point at valve place of accessory 2.The problem of dead volume is noted that wherein the part of the volume of fluid before the valve of accessory 2 and pipeline 14 is hunted down.Confirm, for mix and be used in mix and the container of bioreactor in the holding back a little of material such as solid state powder stagnate.

Required is allows between accessory 2 and closing appliance 18 minimizing of this dead space and/or the equipment of elimination.

Summary of the invention

The present invention reduces or eliminates the dead space in valve preceding pipeline and accessory through using the flexible resilient accessory, and this flexible resilient accessory can hold more near the pinch valve of the flange portion of accessory or clip etc.

One aspect of the present invention provides a kind of accessory that is used for disposable plastic container; It has and can be sealed to the flange portion of the opening in the bag and from the opening outward extending neck part of flange portion with bag, and accessory is compressible by flexibility, the elastic force plastic material forms according to the close mode of liquid.Device such as pinch valve or clip can be used on the accessory, so that compression fitting comes airtight container.

An alternative embodiment of the invention provides the neck with tubulated ends part or hose barb.

It is a kind of by thermoplastic elastomer, such as the thermoset material or the accessory natural or that neoprene forms of polyurethane that additional embodiment provides.

An alternative embodiment of the invention provides a kind of flexible disposable container; It comprises that sealed plastic bag with at least one port, at least one accessory and neck part that can compression fitting are with from its device of bag sealing; At least one accessory partly forms by the flange portion that is sealed at least one opening in the bag according to the close mode of liquid and from the outward extending neck of opening of flange portion with bag, and at least one accessory is compressible by flexibility, the elastic force plastic material forms.

An alternative embodiment of the invention provides a kind of neck part that is the atubular extension spare form with hole of passing flange and neck part; And also comprise attaching parts; This attaching parts has first end of band hose barb, second end and the flat between two barb are divided of band hose barb; The flange portion neck part farthest that leaves of accessory makes first barb of adaptor union and the flat of adaptor union adhere to it according to the close mode of liquid, and makes pipeline be attached to second barb of adaptor union and the flat of adaptor union according to the close mode of liquid.

Additional embodiment of the present invention provides a kind of rigid insert from bag part place farthest at accessory.

An alternative embodiment of the invention provide a kind of accessory from the bag rigid insert at part place farthest, wherein rigid insert is processed by metal or plastics.

Further embodiment of the present invention provide a kind of accessory from the bag rigid insert at part place farthest, wherein plug-in unit is molded into that part ofly, or is attached to that part of (interior or outer) surface of accessory.

Further embodiment of the present invention provides a kind of device that is used for through bandage the end of neck being attached to pipeline.

Description of drawings

In the accompanying drawings:

Fig. 1 has illustrated the pipeline that being assembled to of being known in the prior art have pinch valve and the accessory of bag in cutaway view;

Fig. 2 has illustrated in cutaway view according to being assembled to of first embodiment of the invention has the pipeline of pinch valve and the accessory of bag;

Fig. 3 has illustrated in cutaway view according to being assembled to of second embodiment of the invention has the pipeline of pinch valve and the accessory of bag;

Fig. 4 has illustrated in cutaway view and has been assembled to according to the accessory of the pipeline with pinch valve in Fig. 3 in the closed position with bag;

Fig. 5 has illustrated the accessory that is assembled to pipeline with pinch valve and bag according to another embodiment of the present invention in cutaway view;

Fig. 6 has illustrated the accessory that is assembled to pipeline with pinch valve and bag according to another embodiment of the present invention in cutaway view;

Fig. 7 has illustrated in cutaway view according to being assembled to of further embodiment of this invention has the pipeline of pinch valve and the accessory of bag;

Fig. 8 shows the cutaway view of plug-in unit of the replacement of Fig. 6;

Fig. 9 shows the cutaway view of plug-in unit of the replacement of Fig. 7;

Figure 10 shows the cutaway view of the plug-in unit of replacement of the present invention;

Figure 11 shows the cutaway view of the plug-in unit of replacement of the present invention;

Figure 12 shows the cutaway view of the plug-in unit of replacement of the present invention.

The specific embodiment

Fig. 2 shows the first embodiment of the present invention.Encode with components identical when using same characteristic features in the accompanying drawings.Accessory 30 of the present invention is compressible by flexibility, the elastic force plastic material is processed.Preferably, accessory 30 is processed by the plastic material that can bond to bag 12 according to the mode identical with the conventional rigid plastic fittings of Fig. 1.For this embodiment and other all embodiment of the present invention, replacedly, accessory can be formed and through remaining to bag such as adhesives or like other device of the mechanical device of threaded portion and nut with liquid tight seal mode by other material.As shown in, pinch valve 18 is located on the neck 6 of accessory between bag 12 and the barb part 8.In this embodiment, accessory has the flange 4 that is sealed to bag 12.As shown in, accessory 30 has the in-to-in flange 4 at bag 12.If desired, it can likewise be attached to the outside face of bag 12.Neck 6 forms from bag 12 and flange 4 outward extending tubular portions.In this embodiment, hose coupling 7 is formed with two

barb

7A and 7B, and each hose coupling forms in the opposite end of adaptor union 7 and is formed with the flat 9 between

barb

7A and 7B simultaneously.The pipe or first end of hose coupling 7 be inserted into neck 6 from flange 4 end farthest, second flexible pipe 14 is attached to the other end of adaptor union 7 on barb 7B.The neck 6 that is used in accessory 30 such as the hose attachment device 20 of bandage is with flexible pipe or manage on 14 so that they are fixed together with the close mode of liquid.

Fig. 3 shows the second embodiment of the present invention.Accessory 30 of the present invention is compressible by flexibility, the elastic force plastic material is processed.Preferably, accessory 30 is processed by the plastic material that can bond to bag 12 according to the mode identical with the conventional rigid plastic fittings of Fig. 1.As shown in, pinch valve 18 is being positioned on the neck 6 of accessory between bag 12 and the barb part 8.

As shown in Figure 4, the pinch valve 18 of elastomeric material can trigger near the opening in bag 10 on the accessory 30, to reduce or eliminate the dead-volume that exists in the prior art.

Fitment material includes but not limited to any elastomeric material such as thermoplastic elastomer, thermoset material (such as poly-urethane rubber especially closed pore polyurathamc) and natural and neoprene.Preferably, they are thermoplastic elastomer such as TPOs and comprise polyolefinic elastomer alloy, directly are heat-bonded to bag material to allow accessory.A kind of such preferable material is thermoplastic elastomer

CL E85, is mixed with the styrene block copolymer from the polyethylene polymer system of lucky man of great strength (GLS) company.Another kind of material is RTP 2899X 106530A, from RTP company TPO.Another kind of material is

elastic body from the improvement elastic body system in city, Akron, Ohio.

Alternatively, suppose the suitable device that can be provided for adhering to, accessory can be processed by other elastomeric material.For example can use and bond to bag and accessory and make it bond to the two accessory is fixed on the intermediate materials of correct position.

Fig. 5 shows the second embodiment of the present invention.Rigid insert 32 is Overmolded or to insert accessory 30 molded, comprises plug-in unit 32 so that the downstream of the part of neck 6 are valve 18 and barb.This provides more traditional accessory for pipeline and has guaranteed that it is fixed to accessory and resists the regular event that possibly remove it.Rigid insert 32 can be by processing such as aluminium, copper or stainless metal, and perhaps it can be by processing such as the rigidity plastics of poly-vinyl or polypropylene etc.

Fig. 6 shows the third embodiment of the present invention.Rigid insert 34 is assembled to the outside and the in-to-in part of accessory 30, comprises plug-in unit 34 so that the downstream of the part of neck 6 are valve 18 and barb.This provides more traditional accessory for pipeline and has guaranteed that it is fixed to accessory and resists the regular event that possibly remove it.Preferably as shown in, plug-in unit 34 has below the barb that is assembled to accessory to help that it is remained on the part 35 of correct position.This plug-in unit 34 can be press fit in the accessory 30 and by friction force and keep.It can have one or more holding devices alternatively, such as barb shown in Figure 8 40 or towards accessory 30 from the ridge of flange 4 sloped-end farthest etc., to allow its patchhole 5 simultaneously in case insert and prevent it and remove.Additionally or alternatively, it can not be removed so that guarantee it through bonding to accessory such as hot stick or adhesives.Rigid insert 34 can be by processing such as aluminium, copper or stainless metal, and perhaps it can be by processing such as the rigidity plastics of poly-vinyl or polypropylene etc.

Fig. 7 shows another embodiment of the present invention.Rigid insert 36 fits in the hole 5 of accessory 30, comprises plug-in unit 36 so that the downstream of the part of neck 6 are valve 18 and barb.Alternatively as shown in, plug-in unit 36 has flange portion 38, flange portion 38 is resisted against the outside face of barb part that adjacent bores 5 leaves the some place of accessory 30, and is too dark and prevent to disturb valve 18 to prevent that its from inserting accessory 30.This plug-in unit 36 can be press fit in the accessory and by friction fit and keep.It can have one or more holding devices alternatively, such as barb shown in Figure 9 40 or towards accessory from the ridge of flange sloped-end farthest etc., to prevent its in case removing of inserting.Additionally or alternatively, it can not be removed to guarantee it through bonding to accessory such as hot stick or adhesives.Rigid insert 36 can be by processing such as aluminium, copper or stainless metal, and perhaps it can be by processing such as the rigidity plastics of poly-vinyl or polypropylene etc.

Fig. 8 and 9 shows and comprises such as the replacement plug-in unit 34 of the mechanical holder of

barb

40 and 36 closing in.

Figure 10 shows an alternative embodiment of the invention.Rigid insert 102 Overmolded or insert in the accessory 100 molded so that the part of neck 104 (downstream that valve is positioned at) comprises plug-in unit 102.As shown in neck 104 this part the design on be tubulose rather than like the barb accessory among the embodiment of Fig. 5.The rigid insert 102 that resembles its corresponding portion among above Fig. 6 can be by processing such as aluminium, copper or stainless metal, and perhaps it can be by processing such as the rigidity plastics of poly-vinyl or polypropylene etc.

Figure 11 and 12 shows the tubulated ends accessory with rigid insert 102 that is similar to Figure 10, and rigid insert 102 is inserted into or is placed on this part of neck 104 according to the mode of being instructed among the embodiment that is similar to Fig. 6-9.In Figure 12, plug-in unit 102 has barb end sections 106.

The invention provides a kind of accessory, it allow to tighten more the accessory near the opening of bag, to reduce or eliminate any dead space.

Claims

1. accessory that is used for disposable plastic container; Comprise and to be sealed to the flange portion of the opening in the bag and from the opening outward extending neck part of flange portion with bag, and accessory is compressible by flexibility, the elastic force plastic material forms according to the close mode of liquid.

2. accessory according to claim 1 is characterized in that, neck is the atubular extension spare with hole of passing flange portion and neck part.

3. accessory according to claim 1 is characterized in that, neck is the atubular extension spare with hole of passing flange portion and neck part, terminating in the hose barb from flange portion point place farthest of neck.

4. accessory according to claim 1 is characterized in that, accessory by from thermoplastic elastomer, TPO, comprise the plastics of selecting the group that polyolefinic elastomer alloy, thermoset material and rubber forms and process.

5. accessory according to claim 1 is characterized in that, accessory is by from thermoplastic elastomer, TPO with comprise the plastics of selecting the group that polyolefinic elastomer alloy forms and process.

6. accessory according to claim 1; It is characterized in that; Accessory is processed by the plastics of from the group that thermoplastic elastomer and TPO are formed, selecting, and thermoplastic elastomer is selected from the group that the styrene block copolymer that is mixed with polyethylene polymer is formed.

7. accessory according to claim 1 is characterized in that accessory is processed by the plastics of selecting the group of forming from thermoset material.

8. accessory according to claim 1 is characterized in that accessory is processed by the thermosetting plastic of selecting the group of forming from polyurethane.

9. accessory according to claim 1 is characterized in that, accessory is processed by the plastics of from the group that India rubber and neoprene are formed, selecting.

10. flexible disposable container; Comprise sealed plastic bag with at least one port, at least one accessory and by neck part that can compression fitting with from bag with its sealing and make the minimized device of dead space; Said at least one accessory be formed with according to the close mode of liquid be sealed at least one opening in the bag flange portion, from flange portion and the bag the outward extending neck part of opening, said at least one accessory is compressible by flexibility, the elastic force plastic material forms.

11. container according to claim 10 is characterized in that, neck partly is the atubular extension spare with hole of passing flange portion and neck part.

12. container according to claim 10; It is characterized in that; Neck partly is to have the atubular extension spare that passes flange portion and neck part; And also comprise adaptor union; This adaptor union has first end of band hose barb, second end and the flat between two barb of band hose barb, and the flange portion neck part farthest that leaves of accessory makes first barb of adaptor union and the flat of adaptor union adhere to it according to the close mode of liquid, and makes pipeline be attached to second barb of adaptor union and the flat of adaptor union according to the close mode of liquid.

13. container according to claim 10 is characterized in that, neck partly is the atubular extension spare with hole of passing flange portion and neck part, and terminating in the hose barb from flange portion point place farthest at neck.

14. container according to claim 10 is characterized in that, accessory by from thermoplastic elastomer, TPO, comprise the plastics of selecting the group that polyolefinic elastomer alloy, thermoset material and rubber forms and process.

15. container according to claim 10 is characterized in that, accessory is by from thermoplastic elastomer, TPO with comprise the plastics of selecting the group that polyolefinic elastomer alloy forms and process.

16. container according to claim 10; It is characterized in that; Accessory is processed by the plastics of from the group that thermoplastic elastomer and TPO are formed, selecting, and thermoplastic elastomer is selected from the group that the styrene block copolymer that is mixed with polyethylene polymer is formed.

17. container according to claim 10 is characterized in that, accessory is processed by the plastics of selecting the group of forming from thermoset material.

18. container according to claim 10 is characterized in that, accessory is processed by the thermosetting plastic of selecting the group of forming from polyurethane.

19. container according to claim 10 is characterized in that, accessory is processed by the plastics of from the group that India rubber and neoprene are formed, selecting.

20. container according to claim 10; It is characterized in that; Neck partly is the atubular extension spare with hole of passing flange portion and neck part; And comprising that also adaptor union, this adaptor union have second end and the flat between two barb are divided of first end of band hose barb, band hose barb, the flange portion neck part farthest that leaves of accessory makes first barb of adaptor union and the flat of adaptor union adhere to it according to the close mode of liquid; And make pipeline be attached to the smooth part in plane of second barb and the adaptor union of adaptor union according to the close mode of liquid, and wherein accessory and pipeline are attached to adaptor union through bandage.

21. container according to claim 10 is characterized in that, said device is selected from the group of being made up of pinch valve and clip.