CN102835960A - Portable intelligent glucometer supporting measured data to be real-timely sent through mobile short messages - Google Patents
Portable intelligent glucometer supporting measured data to be real-timely sent through mobile short messages Download PDFInfo
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Abstract
The invention discloses a portable intelligent glucometer supporting measured data to be real-timely sent through mobile short messages and belongs to the technical field of electronic medical measuring apparatus with communication functions. On the promise of conforming to national regulations, on the basis of ensuring the characteristics of portable glucometer series which are researched and developed independently and the characteristics include convenient portability, concise utilization, accurate measurement and algorithm, embedded-type measured data communication sending functions of various short message cards such as global system for mobile communication (GSM) are perfected in emphasized mode. On the basis of innovation, a software platform of a medical Internet of Things, based on servers and intelligent mobile terminals, is constructed. Particularly, based on data of measured blood glucose in batch, background server software of each user is developed to realize services such as data comparison, curve analysis and long-distance diagnosis through a mobile phone or personal computer (PC) foreground inquiry software.
Description
Technical field
Medical treatment gauge → the possess electron medical treatment gauge of communication function.
Background technology
According to investigations, the present diabetics of China has exceeded 9,240 ten thousand people, accounts for 1/4th of whole world sum, and the impetus that increases fast makes us worrying very much, and diabetes become and have a strong impact on one of sanitarian subject matter of China.And in the monitoring field of blood glucose, China only has 1.5% diabetics that oneself portable blood sugar monitor is arranged, and the diabetics of American-European countries more than 90% all has the portable blood sugar monitor of oneself.China's blood glucose meter produce market is mainly captured by foreign brand names such as U.S. Johnson & Johnson, German Luo Shi at present; Domestic brand is only occupied the market share less than about 10%, and all there are matching problem in varying degrees in the blood glucose meter of most of domestic brands and corresponding supporting reagent paper plug-in unit.And at present on the market domestic portable blood glucose meter function is simple, does not possess the measurement data that sends to doctor and relatives to the mode of measurement data through SMS in real time and communicates by letter and managerial function.
The appearance and the popularization of the portable medical electronics product of China, the rise, consumer that comes from domestic medicine nursing is to the increase of self and household's health concerns degree and the individual consumer demand to health care and simple diagnostic products.On the one hand; China's aged tendency of population aggravation; For diabetics, the ill risk of 60-74 year diabetes is 70 times of 20-34 year male, the increasing the weight of of this factor; Accelerated the trend of blood glucose meter networking, children, doctor constantly strengthen the monitoring demand that the gerontal patient measures access times and test data.On the other hand, along with the development of mobile communication technology and technology of Internet of things, business functions such as intelligent measuring, tracking, monitoring and management have been guaranteed to realize electronic medical equipments such as portable glucose meter are carried out.
The instrument of the accurate blood glucose measurement of hospital's employing at present is the blood glucose biochemical instruments; Method is to obtain blood plasma through the back that phlebotomizes with the centrifuge separating blood; Blood plasma through with the glucose oxidase enzyme reaction after produce hydrogen peroxide, through measuring what of hydrogen peroxide, thereby draw blood sugar content.The advantage of biochemical instruments is to measure very accurately, and shortcoming is that Measuring Time is slow, just can obtain measurement result in common second day; Blood using amount is many, wants 3000～5000 microlitres usually; Complicated operation could be operated by the people of professional training only; Machine costs an arm and a leg, and has only part hospitals that outfit is just arranged.
The pocket portable rapid blood sugar appearance of the seventies in last century invention can be bled with one and measured blood glucose numerical value, patient's blood glucose of can testing oneself, and draw the blood glucose value result fast, thereby be considered to a milestone on the treating diabetes history.Because the rapid blood sugar appearance can be by patient from advantages such as line operates; So diabetes association not only is recommended as patient's household and carries the usefulness of testing oneself; And can be used as the usefulness of inpatient's bedside inspection, especially more suitable in places such as emergency room, operating room, small hospitals of community.At present, pharmaceuticals industry require to be promoted the quick portable blood glucose meter blood glucose of testing oneself, and the venous plasma measured value of using biochemical instruments as diagnosis, proofread and correct the method for portable blood glucose meter, subsidiary mensuration in the time of also can carrying out the scientific research comparison and do other biochemical analysis.
The measuring method of the portable glucose meter of each the big international merchant of medical apparatus and instruments factory product such as Johnson & Johnson, Luo Shi mainly is the glucose oxidase electrode measurement method at present.The fundamental measurement principle of the glucose oxidase electrode measurement method of portable rapid blood sugar appearance product is: the magnitude of current through glucose in the measurement blood and the glucose oxidase enzyme reaction in the reagent paper produce is measured blood glucose.Be specially: bleeding back 5-10 in second; In the blood in glucose and the reagent paper glucoseoxidase can produce reaction; In the process of reaction, generally get any time point (time point that each producer obtains differs) in 5 seconds to 10 seconds, the kinetic current that actual measurement is corresponding; Obtain this kinetic current through the portable glucose meter current sensor; And the voltage amplifier circuit of the embedded system through portable glucose meter obtains real-time amplified voltage value, and conversion obtains the measured value of blood glucose value with function algorithm through the analog digital conversion of embedded scm (8051, series monolithics such as ARM or DSP), and on portable glucose meter, realizes demonstration or voice suggestion fast.
Current mobile network communication is professional and the Internet of Things development communication technologies is swift and violent; What use at present mainly is that the second filial generation moves (2G technology) and the third generation (3G technology); These two kinds of mobile communication technologies can well be supported the real-time transmission and the reception of wireless data; The former is representative with GSM (Global System for Mobile Communication) and IS95-CDMA, and the latter is representative with WCDMA and CDMA2000, and these technology maturations are stable; Wide coverage; The communication service standard that telecom operators provide, and have advantages such as the measurement data transmission speed is fast, user's note transmission cost of use is low, can be widely used in fields such as long-distance intelligent control and data interactions.No matter be the note integrated circuit SIM of GSM/CDMA; Or the wide-band-message electronic cards of 3G information terminal; Can make things convenient in the economic hardware circuit that is embedded into relevant medical treatment electronic equipment, and set, realize that the quick real-time of short message is sent through concrete number.
Patent of the present invention " a kind of portable intelligent blood glucose meter of supporting that measurement data is sent through SMS in real time "; Under the prerequisite of standard GB/T 19634-2005 [test oneself and the use the blood glucose monitoring system general technical specifications] regulation that satisfies State General Administration for Quality Supervision's issue; Guaranteeing that the portable serial blood glucose meter of independent research has easy to carry, ease in use; On the basis of characteristics such as Measurement Algorithm is accurate; Focused on the embedded measurement data communication sending function of all kinds of note cards such as GSM perfect, the innovative point of this patent is mainly: 1) accomplish the real-time message sending function of the portable intelligent blood glucose meter measurement data that our company's research and development produce, in blood glucose meter, increase note such as GSM and send electronic module; With short message as data transmission manner; Each blood sugar test Value Data packing for obtaining sends to intended target (portable terminals of receiving terminals such as children, doctor), reaches the purpose that guarantees that the patient regularly uses blood glucose meter and data in real time to obtain.2) on the basis of above-mentioned innovation; Structure is based on the medical Internet of Things software platform of server and intelligent mobile terminal; The concrete blood glucose measurement data in batches that mainly are based on; Develop each user's background server software, realize carrying out data comparison, services such as tracing analysis and remote diagnosis through mobile phone or PC foreground queries software.
Check that relevant up-to-date announcements is technological, document and up-to-date blood glucose meter measure scientific and technological novelty assessment report; Documents 1 enzyme electrode method blood glucose meter is to adopt the curing technology of enzyme and the method for electro-detection to develop; Little current conversion that reaction produces on the electrode of measurement enzyme obtains blood glucose value; And not mentionedly how to improve concrete Measurement Algorithm, particularly how to improve blood glucose measurement precision and the function that realizes that note is sent in real time.Documents 2 has been mentioned the blood glucose meter measurement data has been sent to the thought on the mobile phone through bluetooth module; But should be mentioned that closely sends to the thought in the mobile phone of being with bluetooth module with the form of packet, and not mentioned directly the transmission also through way of short messages directly browsed.Documents 3 provides the system and method for diabetes management, can be used to analyze a large amount of measurement of blood sugar concentration relevant with the patient with identification and other physiological parameter patterns through the mode of data copy, does not have the function of real-time measurement and data analysis.Documents 4 provides a kind of system and method for new diabetes management, can be used to analyze a large amount of measurement of blood sugar concentration relevant with the patient with identification and other physiological parameter patterns.Documents 5 has been put forward a kind of hardware designs of portable glucose meter controller, comprises analog-digital converter, embedded scm, liquid crystal display, memorizer, timer manager, voltage monitor, level translator, manostat etc.Documents 6 has been discussed ultimate principle and the necessary condition of formation GSM network that GSM short message network data are sent.Documents 7,8 proposes to send to monitor supervision platform with after pollution sources information and the rural basic level information acquisition through GSM network and short message data, and platform is set up corresponding database through the different terminals code, is used for analyzing and checking.Documents 9 has proposed the hardware designs of GSM note tele-control system, comprises gsm module, control module, display module etc.
Be different from technological document and technical patent that above-mentioned contrast blood glucose meter and radio SMS send; Patent of the present invention " a kind of portable intelligent blood glucose meter of supporting that measurement data is sent through SMS in real time "; In the blood sugar test field; Innovate way of thinking and application that blood glucose value is measured and diagnosed, can accomplish the good fusion of different subject technologies.Exploitation and this support measurement data that produce to promote be through the portable intelligent blood glucose meter that the SMS breath sends in real time, has that blood glucose value is measured accurate, doctor and children obtain a series of hommization functionality advantages such as note data is timely, remote diagnosis is convenient.And the realization of this patent and popularization can be used as a part that makes up current domestic medical information Internet of Things and distance medical diagnosis net.
Documents
[1] the development Chinese journal of scientific instrument magazine of enzyme electrode method blood glucose meter is in 2003 24 phases of Yang Chun
[2] based on the master thesis Liu Jun of research Jilin University China of the blood glucose monitoring system of mobile phone 2005
[3] in diabetes management, be used for the patent of invention CN200810125865 of system and method Life Scanning Co., Ltd of pattern recognition
[4] be used for the patent of invention CN200810125872 of computer system Life Scanning Co., Ltd of diabetes management
[5] the patent of invention CN03116986.4 of portable glucose meter controller Shanghai Communications University
[6] inquire into Silicon Valley Pan about the network optimized approach of gsm wireless communication technology and build 2010 01 phases
[7] based on flourish 2010 05 phases of the polluter short message alarm system modern electronic technology Song Rong of GSM
[8] based on the information-based government affair platform patent of invention CN200720036659.8 of Nanjing Univ. of Posts and Telecommunications towards rural basic level of GSM network
[9] based on the patent of invention CN201020217097 of tele-control system Zhejiang Shuren University of GSM note.
Summary of the invention
The technical problem that 1, will solve (promptly former " goal of the invention ")
Concrete goal of the invention mainly contains following three parts:
1) in the application's patent; In blood glucose meter, increase SMS transmission electronic modules such as GSM;, measure the each blood sugar test value that obtains for blood glucose meter and carry out the data packing as data transmission manner with short message, design sends to the program of intended target (portable terminals of receiving terminals such as children, doctor); Set the corresponding mobile phone number, reach the assurance patient and regularly use blood glucose meter and intended target can obtain the purpose of real time blood sugar Value Data.
2) in the application's patent; Not only the target smart mobile phone can receive and check patient's blood glucose value note, can also be on this basis, through developing corresponding mobile phone upper layer software (applications); This software can carry out the diagnosis of data management and remote analysis to the multi-user's multi-group data that receives.
3) in the application's patent, the many patients blood glucose level data in certain zone can obtain and make up the remote server data storehouse by the way, on this basis, can set up this area blood glucose patient's medical Internet of Things basic data platform in the future.
For the disposal ability of small-sized medical instrument such as common blood glucose meter; Software functions such as the calculating of desk computer and management are powerful; Intelligent mobile terminal has more intellectuality; Lighting, the advantage that software management capability is more powerful can provide more powerful inquiry and managerial function to measurement data.The intelligent blood glucose meter that the support short message that the application's patent is set forth is sent can be carried out quantitative glucose assays to whole blood; Can be used for hospital and community medicine station; Patient's icon can be distinguished software functions such as each category feature of patient.The preservation and the analytic function that have data simultaneously, can category measurement with preserve blood glucose value; Can obtain on an empty stomach according to doctor's needs, the blood glucose numerical value after the lunch, after the dinner, before sleeping etc.Desk computer or smart mobile phone; After the blood glucose meter of present patent application obtained data through said short message breath mode; Can utilize the relevant software analysis of blood sugar curve that draws; Medical personnel can analyze blood glucose patient's the state of an illness, can instruct patient's the diet and the arrangement and the adjustment of medication in view of the above.This intelligent portable blood glucose meter scope of application is very wide, applicable to family, individual, small-sized medical institutions etc., optimized service can be provided for the diabetic population of entire society.
The research and development and the production of the application's patent " a kind of portable intelligent blood glucose meter of supporting that measurement data is sent through SMS in real time "; Under the prerequisite that the standard GB/T 19634-2005 [test oneself and use the blood glucose monitoring system general technical specifications] that satisfies the issue of Chinese people State Administration of Quality Supervision, Inspection and Quarantine stipulates; Realized that portable glucose meter rises to the leap that the remote analysis of the state of an illness of diabetes is handled from the monitoring of simple blood glucose, through human-computer interaction interface, realizes the real monitoring to the state of an illness; The patient is accurately understood the state of an illness; Taking treatment means that quantitative reference is provided targetedly, concerning diabetics, is in the life indispensable " helper ".
2, technical scheme (method invention)
Accompanying drawing 1 is always schemed for the art designs scheme of the application's patent, and among the figure, 1 is the CPU control module, 2 communication modules for communication functions such as note transmission such as band GSM, and 3 is the blood glucose measurement card module.Accompanying drawing 2 is blood glucose monitoring system circuit design completion figure.The art designs scheme that is adopted is concise and to the point in implementation procedure to be divided into two parts:
Part one) blood glucose meter sends to mobile phone with data with way of short messages through communication modules such as GSM, and realizes the corresponding software management:
In novel blood glucose meter, increased gsm module (also can increase the communication module that CDMA or 3G etc. support that note is sent), be accompanying drawing 3, and novel blood glucose meter has been carried out the change and the embedded program design of hardware circuit.
Corresponding main master control program flow chart is accompanying drawing 4, and this program can make this blood glucose meter after test is accomplished, automatically test data sent in the designated mobile phone.
The gsm module instruction is:
Signal testing: AT+CSQ+ < CR >
Data transmission modes: AT+CMGF=0+ < CR >
Data format: AT+CMGS=takes place " 13988888888 " < CR>Send Message by Text-Mode < Ctrl/Z >
// purpose phone number | end mark | content | send symbol |
The software copyright " based on the blood glucose meter data management system of smart mobile phone " that corresponding software control function has been authorized for our company in detail, soft outstanding application number 2011R11L125841.The EXE file of accompanying drawing 5 smart mobile phone blood glucose meter softwares and cell phone software master interface.Accompanying drawing 6 smart mobile phones and blood glucose meter realize the sketch map of GSM transfer of data and blood glucose measurement.Accompanying drawing 7 is this software copyright sketch map.
Part two) blood glucose meter sends to diabetics data platform with data with way of short messages through communication modules such as GSM, and realizes the corresponding software management:
The foundation of diabetics data platform is node with each different blood glucose meter, and through mobile network's networkings such as GSM management, accompanying drawing 8 is a system construction drawing.
Blood glucose meter can set whether send the data to data platform, send gsm module like need and will send to data platform to the data result of test, through platform to all patients manage, application such as monitoring and remote diagnosis.
The software copyright " blood glucose meter data exchange system V2.0 " that corresponding software control function has been authorized for our company in detail, soft outstanding application number 2011SR053424.Accompanying drawing 9 is diabetics data platform software master interface.Accompanying drawing 10 software copyright sketch maps.
3, beneficial effect
Portable intelligent blood glucose meter based on " a kind of portable intelligent blood glucose meter of supporting that measurement data is sent through SMS in real time " research and development of the application's patent and production; Under the prerequisite that the standard GB/T 19634-2005 [test oneself and use the blood glucose monitoring system general technical specifications] that satisfies the issue of Chinese people State Administration of Quality Supervision, Inspection and Quarantine stipulates; The improvement of novelty concrete blood glucose measurement mode and communication mode, and can be through the many-sided monitoring of accomplishing blood of devices such as blood glucose meter itself, desk computer or intelligent mobile terminal, show functions such as storage and analysis.Realized that portable glucose meter rises to the leap of the analysis of the accurate diabetes state of an illness from simple blood glucose measurement; Be in the diabetics life indispensable " helper "; And the result that will test in real time sends in the specified terminal; Real-time tracking and understanding have been reached, to patient and all good help of household to diabetics.Used electronic device is few, and cost is low, and volume is little, can make the size with common U, is easy to carry.The production and the popularization of the product of the application's patent correspondence are to be based on the growing health demand of the people thus; Be based on the new policy of medical reform; Be based on the new direction of the development in science and technology of intelligent portability, have tangible technological innovation property and product competition advantage.
Inventive method based on patent of the present invention; The accuracy and the stability indicator that obtain innovating the portable intelligent blood glucose meter after the improvement are superior to ISO of International Organization for Standardization and domestic industry standard index, and concrete beneficial effect can embody the improvement and the intelligent medical lifting of hommization of following medical measurement index parameter:
When blood glucose solubility is lower than 4.2mmol/L, the testing result error is in the scope of positive and negative 0.2mmol/L; When blood glucose solubility greater than 4.2mmol/L, the testing result error is in positive and negative 5% scope;
Medical measurement accuracy index is: the STDEV standard deviation is less than 0.1; Medical measurement degree of stability degree index is: CV (%) is less than 2%.
Further improving on the basis of user real time blood glucose value accuracy, guarantee that when the blood glucose interval of key was distinguished, hyperglycemia/euglycemia/hypoglycemic error differentiating rate was reduced to below 0.5% (5/1000ths).
The implementation of this patent and popularization, it is more convenient that the user is used, more humane.And can realize remote monitoring and diagnosis, make up the tele-medicine Internet of Things of community then the patient.
Accompanying drawing and subordinate list explanation
The art designs scheme of Fig. 1 the application patent is always schemed
Fig. 2 blood glucose monitoring system circuit design drawing
Fig. 3 gsm module outside drawing
Fig. 4 master control program flow chart
The software EXE file of Fig. 5 smart mobile phone blood glucose meter
The software master interface of Fig. 6 smart mobile phone blood glucose meter
Fig. 7 smart mobile phone and blood glucose meter realize the sketch map of GSM transfer of data and blood glucose measurement
Fig. 8 software copyright " based on the blood glucose meter measurement data management system V1.0 of smart mobile phone "
Fig. 9 data platform system construction drawing
The software master interface of Figure 10 desk computer
Figure 11 software copyright " blood glucose meter data exchange system V2.0 "
The specific embodiment
In the technical scheme and beneficial effect in the 4th part summary of the invention, specify.
Claims (2)
1. send electronic module through the GSM SMS;, blood glucose meter is measured the each blood sugar test value that obtains carry out the data packing as data transmission manner with short message, design sends to the program of intended target (portable terminals of receiving terminals such as children, doctor); Set the corresponding mobile phone number; Reach the assurance patient and regularly use blood glucose meter and intended target can obtain the purpose of real time blood sugar Value Data, reach real-time real monitoring, accurately understand the state of an illness the state of an illness through this invention mentality of designing.
2. on the basis of short message,,, carry out the diagnosis of data management and remote analysis, more powerful inquiry and managerial function to measurement data is provided the multi-user's multi-group data that receives through developing corresponding mobile phone upper layer software (applications) as transfer of data.
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| CN109330600A (en) * | 2013-03-14 | 2019-02-15 | M·祖贝尔·米尔扎 | Disease surveillance system (IDMS) Internet-based |
| US10311208B2 (en) | 2014-06-03 | 2019-06-04 | Smart Meter Corporation | System, apparatus and method for the wireless monitoring of medical test data |
| CN111246403A (en) * | 2018-11-28 | 2020-06-05 | 广州开信通讯系统有限公司 | Method and device for controlling short message sending through remote Telnet |
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Application publication date: 20121226 |