CN102805891A - Spray bottle for small-capacity spray device - Google Patents
Spray bottle for small-capacity spray device Download PDFInfo
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- CN102805891A CN102805891A CN2011101438630A CN201110143863A CN102805891A CN 102805891 A CN102805891 A CN 102805891A CN 2011101438630 A CN2011101438630 A CN 2011101438630A CN 201110143863 A CN201110143863 A CN 201110143863A CN 102805891 A CN102805891 A CN 102805891A
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Abstract
The invention provides a novel spray bottle for a small-capacity spray device, and the small-capacity spray device comprising the spray bottle. The spray bottle and the small-capacity spray device are applicable to small-capacity sprays, such as nasal sprays, oral sprays and external sprays, preferably the nasal sprays. The spray bottle comprises a casing and an inner container. The size and a connection of the casing are the same as those of a spray bottle for common sprays. The inner container is smaller than 5ml in volume. Liquid medicine is stored in the inner container. The requirements of small-capacity sprays can be met. The liquid medicine is fully utilized. Waste and out-of-control dosages are avoided. The small-capacity spray device can be directly provided with domestic massively-produced spraying devices (sprayers), customizing is not needed, a filling production line of common aerosols can be directly used for production, repurchase of new small-capacity filling production lines is not needed, production management is greatly facilitated, equipment requirements are lowered, and cost is reduced.
Description
Technical field
The present invention relates to a kind of novel low capacity spray device and use spray bottle, be specifically related to a kind of employing have volume be not more than 5ml in cholic spray bottle, and the low capacity spray device that adopts this spray bottle.
Background technology:
Spray (spray), for not containing propellant, with content by the pressure of manual pump aerosol formulations with form ejection such as vaporific.Be divided into single dose and multiple dose spray by method for using; Be categorized as solution-type, emulsion-type and suspension type by disperse system.
The spray device comprises the container (being commonly called as spray bottle) and the sprayer unit (being commonly called as fog-spray nozzle) of splendid attire medicinal liquid, and the two can connect through screw thread, bayonet socket or other modes.Wherein, the suction pipe of fog-spray nozzle is inserted into the bottom of container, and purpose is to guarantee that the medicinal liquid in the spray bottle can be utilized as much as possible.The spray of conventional capacity, because of its required medicine liquid volume is bigger, therefore used conventional spray bottle volume is also bigger; The general 5-500ml of volume, and the less spray of those consumptions for example need the spray (like single dose or dose double spray) of dosed administration; And some need limit the multiple dose spray that sprays the medicine number of times every day, because single hydrojet volume less (generally at 50-200 μ l), the volume total amount of the medicinal liquid that needs is also less; Be generally less than 5ml, for example 1ml or 2ml are commonly referred to the low capacity spray; Its equipment therefor is called low capacity spray device.
For the low capacity spray, generally adopt following two kinds of methods to realize at present:
Method one: adopt special low capacity spray bottle and supporting special-purpose fog-spray nozzle.Be about to liquid medicine filling in the low capacity glass container; Be generally single dose or dose double (representative value is 100 μ l or 200 μ l), add the plug sealing, place in the special-purpose fog-spray nozzle (profile is shown in accompanying drawing 1); As bullets loading; Push fog-spray nozzle during spraying, after the syringe needle in the fog-spray nozzle punctured plug, the liquid in the glass container was transported in the fog-spray nozzle via syringe needle and sprays.The spraying dosage of this type of device is accurate, is used for the low capacity spray of external listing more, but following defective is arranged:
1, low capacity spray bottle and supporting special-purpose fog-spray nozzle all are custom-mades, and required precision is high, and the cost of device own is higher.
2, owing to external diameter all very little (less than 1cm) in the low capacity spray bottle, higher to the required precision of equipment when causing pharmaceutical factory's large-scale industrial production spray, production line needs high-precision transporter and filling apparatus, costs an arm and a leg;
3, a whole set of sprayer unit is disposable; Each device can only spray 1-2 time, uses up promptly and abandons, and in one day, needs the repeatedly medicine of medication like this; Must need multiple arrangement; Cause very big waste, (Ketorolac Tromethamine, commodity are called SPRIX for example to be used to alleviate the ketorolac tromethamine nasal spray of postoperative pain
TM), its usage and dosage clinically is each two sprays, one is no more than 8 and sprays; A kind of dose double preparation (100 μ l/ time, 200 μ l loading amounts) that went on the market the earliest, each device can only spray twice; Needed 4 devices at most, and caused very big waste, and cause too much financial burden in one day to the patient.
4,2010 editions regulations of Chinese Pharmacopoeia, every spray discharge rate of spray all should be and indicate 80%～120% of discharge rate.The low capacity spray of single dose or dose double, because there is dead volume in spray bottle, medicinal liquid can't be drawn fully; Must be according to 120%～130% volume liquid drug of theoretical amount; Could guarantee the regulation spray once or twice the time discharge rate reach above-mentioned standard-required, more because of residual medicinal liquid, waste bigger; The further like this cost that increased, and cause too much financial burden to the patient.
Above-mentioned defective finally causes the low capacity spray expensive produced, and waste is serious, and causes too much financial burden to the patient.
Method two: adopt conventional fog-spray nozzle and conventional spray bottle, the medicinal liquid of fill less volume.Some low capacity sprays adopts 5ml or the conventional spray bottle of 10ml, fill 1～2ml liquid only, and Novartis's salmon calcitonin nasal spray in Chinese (trade name: Mi Gai breath) of producing for example, medicinal liquid has only 2ml.This type of device can utilize conventional fog-spray nozzle, conventional spray bottle and the filling apparatus production line of existing widely used common spray device, and cost is relatively low, but following shortcoming is arranged:
1) because conventional spray bottle volume is bigger, the medicinal liquid of smaller size smaller (have only usually 1～2ml) exist only in spray bottle the bottom, liquid level is lower; Can not submergence pipette certain depth, the slight inclination in spray process promptly might make the liquid level can not the submergence pipette with rocking, and causes imbibition incomplete; Cause spouting liquid to reduce; Dosage is on the low side (seeing accompanying drawing 2), can not guarantee that the patient obtains stable and enough dosages, and influence is to treatment of diseases.
2) because the volume of medicinal liquid own is less, yet conventional spray bottle volume is bigger, and dead volume is big; Inner wall surface area is also big in addition, and for the big slightly medicinal liquid of viscosity, spray bottle inwall adsorbance is bigger, and these all cause the medicinal liquid utilization rate low, and are residual many, and waste is big, and the administration number of times that possibly cause discharge rate to reach standard-required is lower than the sign number of times.Therefore often need could guarantee the enough amounts of medicinal liquid ejection by 400%～500% volume fill of theoretical amount, effectively the hydrojet number of times reaches the sign number of times.
3) though can solve effective hydrojet number of times defect of insufficient through the fill amount that strengthens medicinal liquid; Yet can cause unnecessary waste; Increase production cost; The more important thing is the spray for some dose limitation and number of times, for example hormone drugs, spiritual quasi drugs or anesthesia quasi drugs have also then that dosage is out of control, the danger of over administration and drug dependence.
In sum, for medicine and doser, guaranteeing that the most basic requirement is cheapness and safety under the effective prerequisite, yet above-mentioned two kinds of methods all can not the perfect requirement that solves the low capacity spray, can not satisfy patient's demand.
The spray filling production lines that adopt in present domestic pharmaceutical factory; Generally be according to the common spray design more than the 5ml; Above spray bottle and the fog-spray nozzle of 5ml a large amount of and that filling production lines is supporting also arranged on the market; Wherein modal is spray bottle and the fog-spray nozzle of capacity 10ml and the line that forms a complete production network, because the market share is high, shipment amount is big, technology maturation, thereby inexpensive.
When producing the low capacity spray; If employing method one, because low capacity spray bottle and supporting special-purpose fog-spray nozzle all are the custom-made processings, and required precision is high; But the present domestic producer that does not still have mass industrialized production; Can only be customized specially or the external complete sprayer unit of producing of high price import, cost an arm and a leg, cost is very high.In addition; Even purchased special customized or give a long price for the complete sprayer unit of import; Domestic existing spray filling production lines also can't be supporting with it, need buy new production line again, because supporting low capacity filling production lines needs higher transporter of precision and filling apparatus; Can only cost an arm and a leg from external import at present; And this production line can only be specifically designed to produces the low capacity spray, and production that can't the compatible conventional spray has further increased the production cost of manufacturer, and these factors finally cause causing too much financial burden to the patient.Adopt method two; Though the cost of spray device and apparatus for production line is lower; Yet not only liquid waste is bigger, and has potential safety hazard, can not guarantee that not only the patient obtains stable but also enough dosages; Influence is to treatment of diseases, but also has the danger of over administration and drug dependence.The problems referred to above perplex those skilled in the art for a long time always, never find cheapness and the solution of safety.
In sum, how to prepare cheapness and the low capacity spray of safety, reduce the production cost of low capacity spray, guarantee its safety simultaneously, thereby satisfy the growing urgent needs of patient, be one and be badly in need of solving and the long-term problem that is not resolved.
Summary of the invention:
The object of the invention: overcome the defective that prior art exists, reduce the production cost of low capacity spray, guarantee its safety simultaneously.Therefore, the invention provides the used spray bottle of a kind of low capacity spray device, in addition, the present invention also provides a kind of low capacity spray device that adopts above-mentioned novel spray bottle.
For realizing the foregoing invention purpose, basic design of the present invention is spray bottle to be made comprise inside and outside two parts, and inner bag (2) is promptly arranged in shell (1); Shell (1) is all identical with profile, interface, the size of the spray bottle of prior art, thereby reaches the compatibility with existing fog-spray nozzle and filling production lines, need not to customize fog-spray nozzle and newly purchases production line; And inner bag (2) has smaller volume, is used for the less medicinal liquid of splendid attire volume, guarantees that dosage is accurate, residual little, safe, stops overdose and drug dependence.Above-mentioned spray bottle not only can combine to form low capacity spray device with the low capacity fog-spray nozzle of specialized designs processing; Especially can above-mentioned spray bottle be combined with existing commercially available fog-spray nozzle, thereby obtain simultaneously satisfying the used device of low capacity spray of cheap and safety requirements.Design philosophy of the present invention not only combines the advantage of two kinds of methods in the prior art, has avoided the shortcoming of the two simultaneously, and large-scale industrialization implements when producing and is easy to.
As the technical scheme that realizes the present invention's design; The spray bottle that is used for low capacity spray device of the present invention; Comprise shell and inner bag two parts, inner bag (2) is arranged in shell (1), the two is at the mouth cylindrical part bit combination of spray bottle or link together; Thereby constitute the spray bottle of an integral body, one-shot forming during preferred for preparation.Accompanying drawing 3,4,5,6,7,8 can be used for understanding structure of the present invention; But shell of the present invention with in cholic concrete structure and combination or connected mode be not limited to these; Any employing design philosophy of the present invention and can reach foregoing invention purpose concrete structure and combination or connected mode all is the part of technical scheme of the present invention.
The spray bottle that is used for low capacity spray device of the present invention; Its shell preferably has identical profile and the size of spray bottle with existing common spray device; Especially the interface section that is connected with sprayer unit (being commonly called as fog-spray nozzle); Identical with the spray bottle interface of commercially available existing common spray device; Can or roll connecting device commonly used such as mouthful aluminum cover through screw thread, bayonet socket and be connected with fog-spray nozzle in the existing common spray device, thereby the assurance container is airtight, medicinal liquid can not evaporate or leak.As most preferably; The spray bottle that is used for low capacity spray device of the present invention; Its shell preferably has identical profile and the size of spray bottle with the existing common spray device of commercially available 10ml; And have identical interface, can combine with fog-spray nozzle with the common spray device of existing commercially available 10ml, thereby obtain simultaneously satisfying the used device of low capacity spray of cheap and safety requirements.
The spray bottle that is used for low capacity spray device of the present invention has an inner bag in above-mentioned enclosure, and medicinal liquid is stored in the inner bag, said in cholic shape can be any, as long as satisfy following condition:
1, is convenient to processing;
2, can make that the terminal inlet of medicinal liquid submergence suction pipe is enough dark,, can guarantee that also accurate the and medicinal liquid of hydrojet dosage can make full use of even small inclination takes place during administration.
As one of embodiment of the present invention, cholic shape can be selected from cylinder, circular cone, spheroid, spheroid, parabolic body in the said spray bottle, perhaps is selected from the combination of above-mentioned shape; The mode of said combination comprises the combination of shape of the same race, and the part of above-mentioned any shape and other any or the combination of the part of several kinds of shapes.From angle simple in structure, that mould is easy to make, cholicly in preferred be shaped as cylinder, circular cone or the two combination, said combination comprises the combination of cylinder or circular cone shape of the same race and the combination of cylinder and circular cone; For example, near the inner bag epimere of bottleneck near the bottle inner bag hypomere at the end, can adopt upper and lower two sections or adopt the three sections combinations in upper, middle and lower.Upper and lower two periods whens combination both can be the combinations of circular cone of combination or two sections different cone angle angles of the cylinder of two sections different-diameters, also can be epimere cylinder+hypomere circular cones, perhaps epimere circular cone+hypomere cylinder; When the three sections combinations in upper, middle and lower; Can adopt the combination of circular cone of combination or three sections different cone angle angles of the cylinder of three sections different-diameters; Perhaps there is one section to be another combination of shapes in three sections of the upper, middle and lower, for example epimere cylinder+stage casing circular cone+hypomere cylinder, epimere circular cone+stage casing cylinder+hypomere circular cone, epimere cylinder+stage casing cylinder+hypomere circular cone, epimere circular cone+stage casing circular cone+hypomere cylinder; When the circular cone in the combinations thereof is in epimere or stage casing,, do not comprise the cone tip part branch, therefore in fact refer to the frustum of a cone owing to only adopted the part of cone.Combination between other all shapes except that cylinder and the two combination of circular cone; Its mode and above-mentioned similar; Both can make up by two sections; Also can three sections or the multistage combination, for example be respectively the combination (seeing accompanying drawing 17) of cylinder+spheroid+circular cone and the combination (seeing accompanying drawing 18) of cylinder+eggplant shape from top to bottom.
Preferred as further, near the inner bag epimere of bottleneck near the bottle inner bag hypomere at the end, inner bag adopts shape wide at the top and narrow at the bottom.The bigger opening shape of diameter is adopted at inner bag epimere bottleneck position, and the external diameter at preferred inner bag epimere bottleneck position equals or be slightly smaller than the internal diameter of shell, and the inner bag hypomere then adopts the less shape of diameter, and preferred diameter bottom is a bit larger tham the suction pipe external diameter.For example, inner bag is shaped as taper shape wide at the top and narrow at the bottom (seeing accompanying drawing 4); When adopting cylinder, circular cone or the two combination; The inner bag epimere is selected the big slightly cylinder of diameter for use; And in cholic hypomere, adopt with epimere and connect the littler cylinder of diameter (referring to accompanying drawing 7) under the smaller cylinder of diameter group or one section circular cone (seeing accompanying drawing 5 and accompanying drawing 6 respectively) or one section circular cone mutually; Perhaps epimere is selected the bigger circular cone of angle of taper (platform) for use, and in cholic hypomere, adopt the less cylinder (referring to accompanying drawing 8) of diameter, perhaps adopt with epimere and compare the smaller circular cone of angle of taper, can also have a cylinder to come transition between two circular cones.The inner bag of above-mentioned shape has characteristics wide at the top and narrow at the bottom, and the bottle mouth position broad need not accurate location in the time of can guaranteeing fill, the same easy operation with the common spray bottle of fill; Simultaneously, narrower hypomere can guarantee: even spray is through after using, the residue medicine liquid volume hour, the height of medicinal liquid liquid level still can submergence suction pipe inlet enough deeply, thereby medicinal liquid can be fully used.
Adopt at inner bag on the basis of shape wide at the top and narrow at the bottom; The end portion of further preferred inner bag hypomere at the bottom of near bottle is hemisphere, semielliptical or other are between circular cone and interhemispheric shape (for example parabolic body); For example, include but not limited to be followed successively by from top to bottom the inner bag (seeing accompanying drawing 7) of circular cone+hemisphere, cylinder+circular cone+hemisphere, circular cone+circular cone+hemisphere, cylinder+cylinder+hemisphere, circular cone+cylinder+hemisphere, circular cone+circular cone+circular cone+hemisphere, cylinder+cylinder+cylinder+hemisphere, cylinder+cylinder+circular cone+hemisphere, cylinder+circular cone+circular cone+hemisphere, circular cone+circular cone+cylinder+hemisphere, cylinder+circular cone+cylinder+hemisphere.Circular cone described in the combinations thereof owing to only adopted the part of cone, does not comprise the cone tip part branch, therefore in fact refers to the frustum of a cone.Adopt the advantage of above-mentioned bottom shape to be, can reduce the dead volume under the suction pipe inlet, further improve the utilization rate of medicinal liquid.
As one of preferred implementation of the present invention; Said spray bottle and in cholic shape and structure include but not limited to accompanying drawing 3,4,5,6,7, the shape shown in 8 and structure, promptly have cholic low capacity spray bottle in the cylinder, have cone inner bag low capacity spray bottle, have cholic low capacity spray bottle in cylinder+cylinder, have cholic low capacity spray bottle in cylinder+circular cone, have cholic low capacity spray bottle in cylinder+circular cone+cylinder+hemisphere, have in circular cone+cylinder shape and structure such as cholic low capacity spray bottle.Described circular cone owing to only adopted the part of cone, does not comprise the cone tip part branch, therefore in fact refers to the frustum of a cone.
Above-mentioned inner bag volume is not more than 5ml, preferably is not more than 3ml.
Above-mentioned have in the low capacity cholic spray bottle during fabrication, and material therefor can adopt the material that is used to prepare spray bottle in the prior art, for example glass, plastics or metal material.Preparation technology can adopt the conventional processing technique of glass processing, plastic processing or metallic article processing.
Cholic spray bottle during fabrication in the low capacity of the present invention; Material preferably adopts pharmaceutically acceptable plastic material; For example polyethylene, polypropylene or polrvinyl chloride and other pharmaceutical polymerses; Adopt plastic injection-moulded or the blow molding process preparation, further preferable preparation technique is shell and the injection mo(u)lding of inner bag one piece; Its advantage is that processing technique is simple more ripe with respect to adopting glass and metal, and cost is low, and the mouldability and the sealing of product are fine, and be low to process equipment and the requirement of personnel operation difficulty, and environmental pollution and power consumption are also still less.When shell and the injection mo(u)lding of inner bag one piece, can be empty between shell and the inner bag, promptly the inwall of shell and in do not have implant between the cholic outer wall, like accompanying drawing 3,4,5,6,7,8; Obviously, the inwall of shell and in also can be solid between the cholic outer wall, be about to shell inwall and in space between the cholic outer wall be injection molded into an integral body, shown in accompanying drawing 15.From the angle of economical with materials, preferably be empty between the two.
In the low capacity of the present invention cholic spray bottle during fabrication, above-mentioned shell and inner bag both can add the one-shot forming in man-hour like above-mentioned method, processed incorporate structure, also can prepare shell and inner bag respectively, and then the assembling or combine; Preferred shell and inner bag one-shot forming not only can be simplified manufacture process, enhance productivity, and coupling and sealing when assurance is connected with fog-spray nozzle more easily.
As one of embodiment of the present invention; Promptly prepare shell and inner bag and then assembling respectively or when combining; Make it into that as a whole spray bottle is given the pharmaceutical factory that produces spray and sealing when being convenient to be connected for ease of fixed housing and inner bag with fog-spray nozzle; Inner bag and shell can adopt and be suitable for the shape and the structure of assembling or being combined into one, and include but not limited to following structure:
1, in interior cholic finish portion an outstanding ring-type outer (6) is arranged; Ring-type outer upper surface is smooth smooth; The finish portion external diameter of the external diameter of ring-type outer and shell identical or approximate identical (for example can slightly more greatly); The inner bag external diameter of ring-type outer and inner bag junction is identical or approximate identical with the finish portion internal diameter of shell, the visible accompanying drawing 16 of structure.When inner bag inserts shell, enough closely contact at the mouth cylindrical part potential energy like this, outstanding ring-type outer can guarantee that inner bag is stuck in the bottle mouth position of shell; Inner bag ring-type outer upper surface is smooth smooth, in the time of can guaranteeing to be connected with fog-spray nozzle, closely contacts with sealing gasket in the fog-spray nozzle, thereby guarantees sealing.Further optional processing method through gluing or heat seal, in the finish portion of cholic finish portion and shell connect into an integral body.
2, be provided with external screw thread at interior cholic finish portion outer wall, and the inwall of the finish portion of shell is provided with the female thread that matches, rotates after can inner bag being inserted shell, thereby make the two screw thread back that coincide connect as one in finish portion; Cholic finish portion is concordant or higher slightly with the bottleneck position of shell in this moment, and when assurance was connected with fog-spray nozzle, inner bag closely contacted with the interior sealing gasket of fog-spray nozzle, thereby guarantees sealing.
For spray bottle manufacturer, the profile of cholic spray bottle and size in the low capacity of the present invention are identical with the spray bottle of the spray device of existing normal conventional capacity; Only increase the inner bag part, except the mould part slight change, still can continue to use material and the process equipment and the technology of original common spray device during the manufacturing; Need not special change; Thereby need not to increase excessive cost, to process equipment and the yet many requirements of no mistake in treatment of personnel operation level, technical difficulty does not increase yet; The manufacturer of therefore general ability production common aerosol device; Can produce spray bottle of the present invention, and after manufacturer's production in enormous quantities, cost and quality and common spray device and indistinction.
In addition, the present invention also provides a kind of low capacity spray device that has adopted above-mentioned novel spray bottle.
Low capacity spray device of the present invention; Comprise two parts of fog-spray nozzle (3) and spray bottle; Wherein, spray bottle adopts above-mentioned novel spray bottle, comprises shell (1), inner bag (2); Wherein the suction pipe (4) of fog-spray nozzle (3) is inserted into inner bag (2) bottom under medicinal liquid (5) liquid level, and for example accompanying drawing 9,10,11,12,13,14 promptly is the part instance.Said fog-spray nozzle not only can adopt the low capacity fog-spray nozzle of specialized designs processing, can also directly adopt existing commercially available fog-spray nozzle.Preferably will have commercially available fog-spray nozzle now and be connected, guarantee airtightly, can obtain low capacity spray device of the present invention with above-mentioned novel spray bottle.
As one of preferred implementation of low capacity spray device of the present invention; Comprise two parts of fog-spray nozzle and spray bottle; Wherein, the spray bottle shell has identical profile and the size of spray bottle with the existing common spray device of commercially available 10ml, and has identical interface section (for example external screw thread or bayonet socket); The inner bag volume is not more than 5ml, preferably is not more than 3ml; Fog-spray nozzle adopts the fog-spray nozzle of the existing common spray device of commercially available 10ml.Because the market share of the common spray device of domestic 10ml is high; The manufacturer of corresponding fog-spray nozzle and spray bottle is numerous, shipment amount is very big; Thereby processing technique maturation, steady sources, low price, reliable in quality, pharmacy producer can obtain the cheap and good-quality source of goods; Simultaneously; The common spray production line of the supporting with it 10ml occupation rate of pharmacy producer at home is also quite high; Pharmacy producer can directly use the filling production lines of 10ml common aerosol to produce, and need not to buy new low capacity filling production lines again, is very easy to production management; Reduce equipment requirements, practice thrift cost.Even newly purchase the common spray production line of 10ml; Because Production Line producer is many, shipment amount is big, the manufacturing process maturation of production line, low price, stable and reliable operation, even so pharmacy producer newly purchase the common spray production line of 10ml; Cost can be not too many yet; Simultaneously can also utilize this production line to produce common spray, more flexible compared with the low capacity spray production line of special use, utilization rate of equipment and installations is higher; Further reduce equipment cost and management cost, thereby obtained satisfying simultaneously the used device of low capacity spray of cheap and safety requirements.
The shape and the structure of low capacity spray device of the present invention; Include but not limited to accompanying drawing 9,10,11,12,13, the shape shown in 14 and structure, promptly have cholic low capacity spray bottle in the cylinder, have cone inner bag low capacity spray bottle, have cholic low capacity spray bottle in cylinder+cylinder, have cholic low capacity spray bottle in cylinder+circular cone, have cholic low capacity spray bottle in cylinder+circular cone+cylinder+hemisphere, have the low capacity spray device of cholic low capacity spray bottle in circular cone+cylinder.
Low capacity spray device of the present invention can be used for preparing low capacity sprays such as nasal spray, mouth sprays, externally applied spray, is preferred for preparing nasal spray.
The present invention also provides the purposes of above-mentioned spray bottle in making low capacity spray device, and said low capacity spray device can be used for low capacity sprays such as nasal spray, mouth sprays, externally applied spray, is preferred for nasal spray.
The invention has the advantages that:
1, in the low capacity sprayer unit of the present invention, the spray bottle that is adopted has the inner bag of volume less than 5ml, preferably less than 3ml; Medicinal liquid is stored in the inner bag, can satisfy the requirement of low capacity spray, and effectively hydrojet number of times, spraying uniformity are all higher; The hydrojet residual rate is very low; Thereby can make full use of medicinal liquid, and avoid drug waste and abuse, strengthen drug safety.
2, the spray bottle profile in the low capacity sprayer unit of the present invention is identical with the used spray bottle of common spray device, and especially interface is identical, can directly use the domestic fog-spray nozzle that forms a complete production network in enormous quantities, need not custom-made, practices thrift cost greatly.
3, low capacity spray device profile of the present invention is identical with common spray device; Especially container joint is identical; Can directly use the filling production lines of common aerosol to produce, need not to buy new low capacity filling production lines again, be very easy to production management; Reduce equipment requirements, practice thrift cost.
4, adopt low capacity spray device of the present invention to produce the low capacity spray, can reduce the cost of pharmaceutical production manufacturer production low capacity spray greatly, thereby reduce market medicine valency, alleviate patient's financial burden greatly.
Design of the present invention is simple and effective, has solved a difficult problem that always perplexs those skilled in the art for a long time, has found cheap and the solution of safety.Adopt the present invention can prepare cheapness and the low capacity spray of safety; Reduce the production cost of low capacity spray, reduce the medicine valency, guarantee that ordinary people affords to use medicine; Guarantee its safety simultaneously; The assurance ordinary people can be used relieved medicine, thereby satisfies the growing urgent needs of patient, safeguards the stable and harmony of society.The present invention is through design cleverly; With very simple way; Thirst for for a long time solving and fail the technical barrier of succeeing all the time but solved a those skilled in the art,, have obvious improvement with respect to prior art; Not only abundant economic benefit and social benefit can be obtained, also great success can be obtained commercial.
Description of drawings
Fig. 1 single dose or dose double spray device outline drawing
The conventional 5ml spray of Fig. 2 device profile, wherein (1) is horizontal level figure, (2) are the 20 ° of angle locations drawing that tilt
Fig. 3 has cholic low capacity spray bottle in the cylinder
Fig. 4 has cone inner bag low capacity spray bottle
Fig. 5 has cholic low capacity spray bottle in cylinder+cylinder
Fig. 6 has cholic low capacity spray bottle in cylinder+cone
Fig. 7 has cholic low capacity spray bottle in cylinder+circular cone+cylinder+hemisphere
Fig. 8 has cholic low capacity spray bottle in circular cone+cylinder
Fig. 9 has the low capacity spray device of cholic low capacity spray bottle in the cylinder
Figure 10 has the low capacity spray device of cone inner bag low capacity spray bottle
Figure 11 has the low capacity spray device of cholic low capacity spray bottle in cylinder+cylinder
Figure 12 has the low capacity spray device of cholic low capacity spray bottle in cylinder+circular cone
Figure 13 has the low capacity spray device of cholic low capacity spray bottle in cylinder+circular cone+cylinder+hemisphere
Figure 14 has the low capacity spray device of cholic low capacity spray bottle in circular cone+cylinder
It between Figure 15 shell and the inner bag solid low capacity spray bottle
The low capacity spray bottle that adopts the ring-type outer to connect between Figure 16 shell and the inner bag
Figure 17 has cholic low capacity spray bottle in cylinder+spheroid+circular cone.
Figure 18 has cholic low capacity spray bottle in cylinder+eggplant shape
Reference numeral: 1: shell, 2: inner bag, 3: fog-spray nozzle, 4: suction pipe, 5: medicinal liquid, 6: the ring-type outer of inner bag bottleneck.
The specific embodiment
Following instantiation; Be illustrating of the specific embodiment of the invention; The low capacity sprayer unit of the present invention that cooperates the homemade common fog-spray nozzle of the proportional valve that adopts 100 μ l to form with spray bottle of the present invention is a specimen, and with commercially available single dose nasal spray device and the common nasal spray device of commercially available 10ml as reference.But protection scope of the present invention is not limited to following embodiment, and the technical scheme that any those skilled in the art design philosophy according to the present invention obtains includes but not limited to the embodiment that aforementioned summary of the invention is partly mentioned, and all falls into protection scope of the present invention.
Comparative example's 1 commercially available single dose low capacity nasal spray device
1, device situation
Commercially available single dose nasal spray device, fog-spray nozzle adopts the fog-spray nozzle of 100 μ l proportional valves, and manufacturer is: German Pfeiffer, spray bottle volume are 250 μ l, and profile is seen accompanying drawing 1.
2, spraying uniformity and hydrojet residual rate test
Test method: get the used nasal spray device of present embodiment, accurate claim surely, be initial installation weight, adds about 0.1ml water, installation weight decided in the precision title, for adding installation weight behind the water; Keep the sprayer unit level, push injection, clean also accurate title after having sprayed and decide installation weight, be installation weight after the hydrojet.Repeat aforesaid operations, measure altogether 10 times, add up or calculate following parameter:
Installation weight after installation weight-hydrojet behind spouting liquid=the add water
The effective number of times of hydrojet number of times=discharge rate in the 80-120mg scope
The relative standard deviation (RSD) * 100% of each time discharge rate of hydrojet uniformity=discharge rate in the 80-120mg scope
Installation weight-initial installation weight after residual quantity=hydrojet in the bottle
Add installation weight-initial installation weight behind the water yield=the add water
Hydrojet residual rate=(residual quantity/adding water yield in the bottle) * 100%
Result of the test such as following table:
Table 1 comparative example 1 result of the test
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Add the water yield (mg) | 100 | 102 | 100 | 102 | 100 | 101 | 98 | 99 | 100 | 101 |
| Spouting liquid (mg) | 78 | 80 | 83 | 79 | 77 | 81 | 76 | 76 | 85 | 77 |
| Residual quantity (mg) in the bottle | 20 | 20 | 16 | 20 | 21 | 17 | 21 | 20 | 13 | 22 |
Effective hydrojet number of times=4
Hydrojet uniformity: RSD=3.85%
Average hydrojet residual rate=19%
Above-mentioned result of the test shows that the hydrojet uniformity of commercially available single dose nasal spray device is better, if but come liquid drug according to the volume (present embodiment is 100 μ l) of theoretical amount; Its spouting liquid is on the low side; Cause effective hydrojet number of times on the low side, most of number of times can't reach effective discharge rate, and reason is that spray bottle exists dead volume; This part medicinal liquid can't be drawn by suction pipe, and the hydrojet residual rate is high.
3, for reaching effective discharge rate, will add the water yield and increase to about 0.12ml, repeat above-mentioned test with method, concrete result of the test such as following table:
Table 2 comparative example 1 increases the result of the test after the water yield
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Add the water yield (mg) | 121 | 119 | 123 | 119 | 120 | 121 | 119 | 124 | 120 | 121 |
| Spouting liquid (mg) | 102 | 97 | 104 | 99 | 100 | 102 | 97 | 106 | 99 | 102 |
| Residual quantity (mg) in the bottle | 18 | 20 | 17 | 18 | 18 | 17 | 20 | 16 | 19 | 17 |
Effective hydrojet number of times=10
Hydrojet uniformity: RSD=2.91%
Average hydrojet residual rate=15%
Above-mentioned result of the test shows; When low capacity spray device adopts single dose nasal spray device, because there is dead volume in spray bottle, if come liquid drug according to the volume of theoretical amount; Its spouting liquid can't reach effective discharge rate; And, then must increase the volume of liquid drug, thereby increased preparation cost in order to reach effective spouting liquid.
Comparative example's 2 commercially available common 10ml nasal spray devices
1, device situation
Commercially available common 10ml nasal spray device, manufacturer is: German Pfeiffer, structure is seen accompanying drawing 2.
Spray bottle volume 10ml, fog-spray nozzle adopt the homemade common fog-spray nozzle of the proportional valve of 100 μ l.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: get the used nasal spray device of present embodiment, accurate claim surely, be initial installation weight, add 1.0ml water, accurately claim to decide installation weight, for adding installation weight behind the water; Keep the sprayer unit level, push shower nozzle examination spray and make its activation 3 times, clean, accurately claim surely, continuous injection stops after discharge rate obviously reduces for several times again, all cleans after every spray once and accurate the title decided installation weight, calculates each discharge rate (mg):
Weight after n hydrojet of weight-Di after the n time discharge rate=the n-1 time hydrojet
The effective number of times of hydrojet number of times=discharge rate in the 80-120mg scope
The relative standard deviation (RSD) * 100% of each time discharge rate of hydrojet uniformity=discharge rate in the 80-120mg scope
Installation weight-initial installation weight after residual quantity in the bottle=last spray
Add installation weight-initial installation weight behind the water yield=the add water
Hydrojet residual rate=(residual quantity/adding water yield in the bottle) * 100%
Result of the test such as following table:
Table 3 comparative example 2 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | Residual quantity in the bottle |
| Spouting liquid (mg) | 108 | 115 | 78 | 32 | 15 | 0 | 636 |
Effective hydrojet number of times=2 times
Hydrojet uniformity: RSD=4.44%
Hydrojet residual rate=64%
Result of the test shows, when low capacity spray device adopts commercially available common 10ml nasal spray device, is under the situation of 1ml in the liquid loading amount, and effectively the hydrojet number of times is merely 2 times, and is promptly defective from beginning spouting liquid for the third time, differing greatly between every jetting liquid.And residual quantity is very big in the bottle, causes the hydrojet residual rate very high.From another point of view, use commercially available common 10ml nasal spray device to realize 2 effective hydrojets, necessary fill 1ml medicinal liquid, the fill amount is 500% of effective spouting liquid, wastes very serious.
Embodiments of the invention
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 3, and package unit is shown in accompanying drawing 9.The spray bottle shell is all identical with spray bottle shell shape, size and the interface of commercially available common 10ml nasal spray device of the comparative example 2.Inner bag is shaped as cylinder, and its diameter is 9mm, and the cylinder height is 39mm, adopts the preparation of integral plastics Shooting Technique, and the about 2.5ml of volume compares minimizing 75% with the common spray bottle of 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: get present embodiment nasal spray device according to the operation of comparative example's method, the adding water yield is 1.0ml,
Result of the test such as following table:
Table 4 embodiment 1 result of the test
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Residual quantity in the bottle |
| Spouting liquid (mg) | 107 | 105 | 103 | 98 | 102 | 110 | 106 | 75 | 106 |
Effective hydrojet number of times=7 times
Hydrojet uniformity: RSD=3.70%
Hydrojet residual rate=11%
Result of the test shows that the sprayer unit of embodiment 1 is under the situation of 1ml in the liquid loading amount, can carry out 7 effectively sprayings, and its uniformity is better, and the hydrojet residual rate is less, obviously is superior to comparative example's sprayer unit.
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 4, and package unit is shown in accompanying drawing 10.The spray bottle shell is identical with spray bottle shell shape, size and the interface of comparative example's commercially available common 10ml nasal spray device.The inner bag of spray bottle is shaped as circular cone, and the conical bottom diameter is 11mm, and height is 39mm, adopts the preparation of integral plastics Shooting Technique, the about 1.2ml of volume.Common spray bottle specific volume minimizing 88% mutually with 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: operation is with embodiment 1, and the adding water yield is 0.5ml.
Result of the test such as following table:
Table 5 embodiment 2 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | Residual quantity in the bottle |
| Spouting liquid (mg) | 105 | 109 | 103 | 79 | 26 |
Effective hydrojet number of times=3 times
Hydrojet uniformity: RSD=2.89%
Hydrojet residual rate=5%
Result of the test shows that the sprayer unit of embodiment 2 is merely in loading amount under the situation of 0.5ml, still can carry out 3 effectively sprayings, and its uniformity is better, and the hydrojet residual rate is less.
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 5, and package unit is shown in accompanying drawing 11.The spray bottle shell is identical with spray bottle shell shape, size and the interface of comparative example's commercially available common 10ml nasal spray device.The inner bag of spray bottle is shaped as cylinder+cylinder, and its diameter is respectively 9mm and 4mm, and cylinder high 33mm and 6mm respectively are for adopting the preparation of integral plastics Shooting Technique, the about 2.2ml of volume.Common spray bottle specific volume minimizing 78% mutually with 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: operation is with embodiment 1, and the adding water yield is 1.0ml.
Result of the test such as following table:
Table 6 embodiment 3 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Residual quantity in the bottle |
| Spouting liquid (mg) | 103 | 111 | 102 | 108 | 99 | 106 | 104 | 100 | 59 | 23 |
Effective hydrojet number of times=8 times
Hydrojet uniformity: RSD=3.89%
Hydrojet residual rate=2%
Result of the test shows, embodiment 3 devices are effective hydrojet 8 times under the situation of 1ml in loading amount, and uniformity is better, and the hydrojet residual rate is less.
Embodiment 4 inner bags are shaped as the low capacity spray device of cylinder+cone
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 6, and package unit is shown in accompanying drawing 12.The spray bottle shell is identical with spray bottle shell shape, size and the interface of comparative example's commercially available common 10ml nasal spray device.The inner bag of spray bottle is shaped as cylinder+cone, and its diameter is 9mm, and the height of cylinder and cone is 15mm and 24mm respectively, for adopting the preparation of integral plastics Shooting Technique, the about 1.5ml of volume.Common spray bottle specific volume minimizing 78% mutually with 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: operation is with embodiment 1, and the adding water yield is 1.0ml.
Result of the test such as following table:
Table 7 embodiment 4 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Residual quantity in the bottle |
| Spouting liquid (mg) | 106 | 110 | 105 | 112 | 97 | 104 | 102 | 101 | 68 | 18 |
Effective hydrojet number of times=8 times
Hydrojet uniformity: RSD=4.62%
Hydrojet residual rate=2%
Result of the test shows, embodiment 4 devices are effective hydrojet 8 times under the situation of 1ml in loading amount, and uniformity is better, and the hydrojet residual rate is less.
Embodiment 5 inner bags are shaped as cholic low capacity spray device in cylinder+circular cone+cylinder+hemisphere
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 7, and package unit is shown in accompanying drawing 13.The spray bottle shell is identical with spray bottle shell shape, size and the interface of comparative example's commercially available common 10ml nasal spray device.The inner bag of spray bottle is shaped as cylinder+circular cone+cylinder+semicircular body inner bag; The diameter of large cylinder and cone bottom surface is 9mm; The height of large cylinder and cone is 15mm and 10mm respectively, and small cylinder and hemispheroidal diameter are 4mm, and the height of small cylinder is 10mm; For adopting the preparation of integral plastics Shooting Technique, the about 1.4ml of volume.Common spray bottle specific volume minimizing 86% mutually with 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate
Test method: operation is with embodiment 1, and the adding water yield is 1.0ml.
Result of the test such as following table:
Table 8 embodiment 5 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Residual quantity in the bottle |
| Spouting liquid (mg) | 102 | 111 | 104 | 108 | 100 | 105 | 106 | 99 | 72 | 21 |
Effective hydrojet number of times=8 times
Hydrojet uniformity: RSD=3.86%
Hydrojet residual rate=2%
Result of the test shows, embodiment 5 devices are effective hydrojet 8 times under the situation of 1ml in loading amount, and uniformity is better, and the hydrojet residual rate is less.
Embodiment 6 inner bags are shaped as circular cone+cylindrical low capacity spray device
1, device situation
Fog-spray nozzle is identical with comparative example 2, and the spray bottle structure is shown in accompanying drawing 8, and package unit is shown in accompanying drawing 14.The spray bottle shell is identical with spray bottle shell shape, size and the interface of comparative example's commercially available common 10ml nasal spray device.The diameter that the inner bag of spray bottle is shaped as conical bottom is 11mm, highly is 28mm, and cylindrical diameter is 4mm, highly is 11mm, for adopting the preparation of integral plastics Shooting Technique, the about 1ml of volume.Common spray bottle specific volume minimizing 90% mutually with 10ml.
2, effectively hydrojet number of times, spraying uniformity and the test of hydrojet residual rate:
Test method: operation is with embodiment 1, and the adding water yield is 0.5ml.
Result of the test such as following table:
Table 9 embodiment 6 result of the tests
| The hydrojet number of |
1 | 2 | 3 | 4 | Residual quantity in the bottle |
| Spouting liquid (mg) | 108 | 109 | 103 | 60 | 28 |
Effective hydrojet number of times=3 times
Hydrojet uniformity: RSD=3.01%
Hydrojet residual rate=6%
Result of the test shows, embodiment 6 devices are effective hydrojet 3 times under the situation of 0.5ml in loading amount, and uniformity is better, and the hydrojet residual rate is less.
Comprehensive above-mentioned result of the test shows, adopts the novel low capacity sprayer unit of spray bottle of the present invention, on performance, compares with existing low capacity sprayer unit to have a clear superiority in.Compare with commercially available single dose nasal spray device, the two hydrojet uniformity is all fine, and hydrojet residual rate of the present invention is then lower.With comparing of the low capacity sprayer unit that adopts commercially available common 10ml nasal spray device, effectively hydrojet number of times and hydrojet residual rate are obviously more excellent.
Claims (12)
1. a spray bottle that is used for low capacity spray device is characterized in that inner bag (2) is arranged in shell (1), said in cholic volume be not more than 5ml.
2. spray bottle as claimed in claim 1, cholic volume is not more than 3ml in it is characterized in that.
3. spray bottle as claimed in claim 1; Cholic shape is selected from the combination that cylinder, circular cone, spheroid, spheroid, parabolic body perhaps are selected from above-mentioned shape in it is characterized in that; The mode of said combination comprises the combination of shape of the same race, and the part of above-mentioned any shape and other any or the combination of the part of several kinds of shapes.
4. spray bottle as claimed in claim 3 cholicly in it is characterized in that is shaped as cylinder, circular cone or the combination of the two, and said combination comprises the combination of cylinder or circular cone shape of the same race and the combination of cylinder and circular cone.
5. spray bottle as claimed in claim 3 is characterized in that inner bag adopts shape wide at the top and narrow at the bottom.
6. spray bottle as claimed in claim 5; It is characterized in that the bigger opening shape of inner bag epimere bottleneck position employing diameter; The external diameter at inner bag epimere bottleneck position equals or is slightly smaller than the internal diameter of shell, and the inner bag hypomere then adopts the less shape of diameter, and diameter bottom is a bit larger tham the suction pipe external diameter.
7. like claim 4,5 or 6 described spray bottles, it is characterized in that the inner bag end portion is hemisphere, semielliptical or other are between circular cone and interhemispheric shape.
8. spray bottle as claimed in claim 4, cholic shape is selected from the combination of cylinder, cone, cylinder+cylinder, the combination of cylinder+circular cone, the combination of cylinder+circular cone+cylinder+hemisphere or the combination of circular cone+cylinder in it is characterized in that.
9. a low capacity spray device comprises two parts of fog-spray nozzle and spray bottle, it is characterized in that spray bottle has adopted like the described spray bottle of the arbitrary claim of claim 1-8.
10. low capacity spray device as claimed in claim 9 is characterized in that fog-spray nozzle adopts the fog-spray nozzle of common spray device.
11. low capacity spray device as claimed in claim 10; The shell that it is characterized in that spray bottle has and identical profile, size and the interface section of spray bottle that has the common spray device of commercially available 10ml now, and fog-spray nozzle adopts the fog-spray nozzle of the existing common spray device of commercially available 10ml.
12. low capacity spray device as claimed in claim 9 is used to prepare the purposes of nasal spray, mouth sprays or externally applied spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101438630A CN102805891A (en) | 2011-05-31 | 2011-05-31 | Spray bottle for small-capacity spray device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101438630A CN102805891A (en) | 2011-05-31 | 2011-05-31 | Spray bottle for small-capacity spray device |
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|---|---|
| CN102805891A true CN102805891A (en) | 2012-12-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011101438630A Pending CN102805891A (en) | 2011-05-31 | 2011-05-31 | Spray bottle for small-capacity spray device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107042931A (en) * | 2017-05-26 | 2017-08-15 | 哈尔滨蜜雪儿化妆品有限公司 | A kind of replaceable capsule lotion pump |
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| CN2136668Y (en) * | 1992-09-30 | 1993-06-23 | 朱洪儒 | Multipurpose minisize plastic atomiser for therapy of rhinitis |
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| CN107042931A (en) * | 2017-05-26 | 2017-08-15 | 哈尔滨蜜雪儿化妆品有限公司 | A kind of replaceable capsule lotion pump |
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