CN102805675A - Biological manufacturing and constructing method of customized artificial larynx - Google Patents
Biological manufacturing and constructing method of customized artificial larynx Download PDFInfo
- Publication number
- CN102805675A CN102805675A CN2012102861434A CN201210286143A CN102805675A CN 102805675 A CN102805675 A CN 102805675A CN 2012102861434 A CN2012102861434 A CN 2012102861434A CN 201210286143 A CN201210286143 A CN 201210286143A CN 102805675 A CN102805675 A CN 102805675A
- Authority
- CN
- China
- Prior art keywords
- laryngeal
- cartilages
- laryngeal cartilages
- layer
- constructing method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000867 larynx Anatomy 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000004519 manufacturing process Methods 0.000 title abstract description 8
- 210000002263 laryngeal cartilage Anatomy 0.000 claims abstract description 75
- 238000013178 mathematical model Methods 0.000 claims abstract description 13
- 210000000845 cartilage Anatomy 0.000 claims abstract description 9
- 239000000560 biocompatible material Substances 0.000 claims abstract description 7
- 210000003041 ligament Anatomy 0.000 claims abstract description 6
- 229920001577 copolymer Polymers 0.000 claims description 4
- 230000032798 delamination Effects 0.000 claims description 4
- 210000003205 muscle Anatomy 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 3
- 238000010276 construction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 description 8
- 230000006378 damage Effects 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 210000003800 pharynx Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 238000007493 shaping process Methods 0.000 description 4
- 210000003437 trachea Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000003685 cricoid cartilage Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 201000005264 laryngeal carcinoma Diseases 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 210000000534 thyroid cartilage Anatomy 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 206010002953 Aphonia Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 206010013887 Dysarthria Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010065787 Tracheal fistula Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 210000002409 epiglottis Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 206010023841 laryngeal neoplasm Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 208000026473 slurred speech Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Landscapes
- Prostheses (AREA)
Abstract
The invention relates to a biological manufacturing and constructing method of customized artificial larynx. The biological manufacturing and constructing method comprises the following steps of firstly taking image data as layer images of laryngeal cartilages; and adopting Mimics reconstruction software to obtain three-dimensional mathematical models of the laryngeal cartilages and reconstructing all ligaments for connecting all the cartilages together; secondly, layering the three-dimensional mathematical models by utilizing layer software to obtain two-dimensional images of all layers and compiling a numerical control code for the two-dimensional image on each layer; then selecting biocompatible material, inputting the numerical control codes into a rapid former for layered stacking or layered cutting to obtain a laryngeal cartilage bracket for holes communicated with one another; and finally, eliminating residual parts to obtain a final laryngeal cartilage bracket. As the complete laryngeal cartilage bracket can be manufactured by the biological manufacturing and constructing method, a doctor needs not to assemble all the laryngeal cartilages before operation. In addition, through the biological manufacturing and constructing method, all parts of the laryngeal cartilages can be modeled to manufacture the corresponding bracket.
Description
Technical field
The invention belongs to larynx injury repairing, plastic surgery and quick shaping field, be specifically related to a kind of preparation technology of integrally-implanted type laryngeal cartilages biomimetic scaffolds.
Background technology
Patient's an urgent demand of losing larynx because of congenital disease, laryngeal neoplasm surgical operation and injuries of larynx for a long time recovers the larynx function.And annual nearly 136000 routine patients are diagnosed as laryngeal carcinoma, and late period, patients with laryngeal carcinoma tended to carry out laryngectomy in therapeutic process.In laryngectomy, whole larynx comprises that thyroid cartilage and cricoid cartilage all can be excised, and postoperative patient has brought great mental pressure and inconvenience in life with complete aphonia to the patient.The reparation means have following several kinds at present:
Surgical method is repaired: mainly contain two kinds of methods here:
(1) esophageal voice
This is the means of at present most popular recovery larynx function.(the staple food pipe pierces through) or postoperative (inferior esophagus pierces through) between laryngectomy form an aperture between trachea and esophagus.With in the check valve load hole, make air to get into esophagus then from trachea.When the patient loquiturs, tracheostoma is locked the jail, and air has just got into esophagus from trachea.But this mode need manually cover pore when sounding, and needs periodic maintenance and replacing.
(2) tracheal sound
This method does not need external auxiliary property equipment.Patient's esophagus top is as air reservoir.When the patient wanted to speak, air was ejected out esophagus, thereby caused the vibration of esophagus pharynx section, thus patient's sound that just can be produced like this through the face adjustment of controlling them.Make and repair injury of larynx in this way, the probability that postoperative can reach good result is very little, and has heartburn sometimes and swallow phenomenon such as air abdominal distention, has abandoned this therapeutic modality owing to many-sided reason causes a lot of patients.
Artificial larynx: also mainly contain two kinds of methods:
(1) pneumatic type artificial larynx
The pneumatic type artificial larynx is made up of the cup that tightly is embedded on the tracheal fistula mouth; Pressure air passes on vibrating reed or the film through cup; This vibration gets into mouth through flexible pipe again; Become the understandable sound of speaking by the formed vibration of moving of enunciator's mouth then, tone changes with the tension force respiratory pressure on the film.The patient uses this artificial larynx multipotency comparatively fast to grasp, and cost of use is not high, but the sound that it produces is accompanied by tangible whistling, and needs periodic maintenance cavity pipe.Old patient is because deficiency of air uses a bit difficulty of this method pronunciation.Because numerous inconvenient factors, this kind method is not accepted by the patient.
(2) electron type artificial larynx
Artificial electronic larynx was born in the seventies in 20th century, and (being initially simple sounding amplifier (boxlike)) probably experienced 3 stages in development, and capsule formula sound producer is sounded, and by a plastic catheter sound is imported by the oral cavity, becomes language; Because use inconvenience, sounding is unintelligible, use micromotor bump sounding film afterwards instead, produce sound, because of hum is quite big, slurred speech is not accepted by doctor and patient gradually; The electric bell of application principle is also arranged, and the bump sounding film produces sound, but since heavy, do not welcome by the patient yet; Develop at last and utilize semi-conducting material to produce the vibratory impulse ripple, through power amplification, the bump sounding film, the sound that so produces is not only stable but also regular.Here mainly divide two kinds again: (1) mouth type artificial electronic larynx, attract attention during use, be placed in the mouth with hand-held outlet tube, mouthful pipe is often stopped up and needs often to clean by saliva, and language neither be very clear; (2) neck type artificial electronic larynx, sound do not have the variation of rising and falling merely, and the lost sound that does not import into has influenced the definition of language, and battery needs often to change, and must place cervical region by the handheld electronic larynx in the time of in a minute, is not suitable for cervical region acoustic gastrointestinal disease patient, and costs an arm and a leg.
The electromagnetic type artificial larynx also has report, but also costs an arm and a leg and weak points such as asophia is clear.
Summary of the invention
The manufacturing approach of implanted laryngeal cartilages support that the purpose of this invention is to provide the be with Movable joint of a kind of and patient coupling, its function of pronunciation is recovered by implantable patient throat.
The inventive method is specifically:
1) obtains CT, MRI image data synusia image as laryngeal cartilages.
2) the synusia image with the laryngeal cartilages of gained adopts the Mimics reconstruction software; Utilize the nuance of laryngeal cartilages and perienchyma's threshold value independent with laryngeal cartilages; Reconstruct more coarse laryngeal cartilages model, and then it is carried out obtaining after the smooth treatment three-dimensional mathematical model of the laryngeal cartilages of smoother.
3) has the characteristic of relative motion function according to laryngeal cartilages; The ligament that when making up laryngeal cartilages, will connect each cartilage also in the lump reconstruct in step 2) in the three-dimensional mathematical model of laryngeal cartilages in; Make up the little muscle of each laryngeal cartilages of connection then, make laryngeal cartilages possess certain activity characteristic.
4) utilize delamination software the three-dimensional mathematical model layering of gained to be obtained the X-Y scheme of each layer.
5) be each layer X-Y scheme establishment numerical control code.
6) select cell on laryngeal cartilages, grow and can adapt to the biocompatible materials of throat's environment, the numerical control code input fast forming machine of each layer X-Y scheme is carried out layer or layering is cut, the laryngeal cartilages support of the hole that obtains interpenetrating.
7) part unnecessary on the laryngeal cartilages support that obtains is rejected, obtained final laryngeal cartilages support.
Beneficial effect of the present invention is: the laryngeal cartilages support can be implanted in the full injury of larynx patient body, reaches the purpose of repairing the whole impaired larynx of patient, it can equally with the normal person be done swallow, action such as sounding.
Because each laryngeal cartilages of the present invention can be separated separately; The doctor can be according to patient's needs; Select each cartilage of laryngeal cartilages that the patient is treated, so also can help local injury of larynx patient to repair its damage location, it can equally with the normal person be done swallow, action such as sounding.
Description of drawings
Fig. 1 is a flow chart of the present invention;
Fig. 2 is front, side, the back side sectional drawing of the laryngeal cartilages that obtains after the modeling.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is further described.
As shown in Figure 1, the inventive method concrete steps are:
1) obtains CT, MRI image data synusia image as laryngeal cartilages.
2) the synusia image with the laryngeal cartilages of gained adopts the Mimics reconstruction software; Utilize the nuance of laryngeal cartilages and perienchyma's threshold value independent with laryngeal cartilages; Reconstruct more coarse laryngeal cartilages model, and then it is carried out obtaining after the smooth treatment three-dimensional mathematical model of the laryngeal cartilages of smoother.
3) have the characteristic of relative motion function according to laryngeal cartilages, the ligament that when making up laryngeal cartilages, will connect each cartilage also in the lump reconstruct in step 2) in the three-dimensional mathematical model of laryngeal cartilages in, make up the little muscle of each laryngeal cartilages of connection then; Make laryngeal cartilages possess certain activity characteristic, as shown in Figure 2, be front, side and the back side of laryngeal cartilages from left to right successively among Fig. 2; Label among the figure is represented: epiglottic cartilage 1, ligament 2, thyroid cartilage 3; Cricoid cartilage 4, tracheal cartilages 5.
4) utilize delamination software the three-dimensional mathematical model layering of gained to be obtained the X-Y scheme of each layer.
5) be each layer X-Y scheme establishment numerical control code.
6) select cell on laryngeal cartilages, grow and can adapt to the biocompatible materials of throat's environment, the numerical control code input fast forming machine of each layer X-Y scheme is carried out layer or layering is cut, the laryngeal cartilages support of the hole that obtains interpenetrating.
7) part unnecessary on the laryngeal cartilages support that obtains is rejected, obtained final laryngeal cartilages support.
Moulding material can be used biocompatible materials, like polyurethane (TPU), polylactic acid (PLA), polyglycolic acid (PGA) and the various copolymers between them, poly butyric ester with gather hydroxycaproic acid ester copolymer (PHBHH) etc.
But shaping laryngeal cartilages support can directly be implanted also and implant after the outer cultivation of donor again, can supply cultured cells can use bone marrow interstital stem cell, chondrocyte, fat stem cell, peripheral hematopoietic stem cells etc.
If used material is a biocompatible in the 6th step, then can turn over system with the laryngeal cartilages support that makes as model, obtain the laryngeal cartilages support of biocompatibility.
Below provide a specific embodiment:
1) for half injury of larynx patient, can carry out CT or its data of MRI extraction to patient's left side laryngeal cartilages or right-hand part laryngeal cartilages, in view of the left-right symmetric property of throat's tissue, can obtain full larynx data through mirror image with left side or right-hand part completion; For the serious sick patient who decreases, can take the healthy individuals close with patient's aspectual character carried out CT or MRI extraction data, obtain throat's data.
2) the laryngeal cartilages synusia image of gained is adopted reconstruction software such as Mimics, to laryngeal cartilages, connect ligament and the muscle modeling in the lump between each cartilage between each laryngeal cartilages, obtain complete laryngeal cartilages model.To this model mirror image, necessary finishing, obtain the three-dimensional mathematical model of laryngeal cartilages then.
3) required for subsequent hierarchy, the file conversion of the MCS form that three-dimensional mathematical model is obtained becomes the file of STL form.
4) will be input in the delamination software by the file of the STL form that the 3rd step obtained in the instance, along the short transverse layering, bed thickness is 0.1～0.3mm to three-dimensional digital model.
5) X-Y scheme that layering is obtained carries out scanning pattern and fill path planning, establishment numerical control code.
6) numerical control code is successively flowed in the rapidform machine.
7) rapidform machine instructs according to numerical control, on the profile of regulation with the fusing of selected biocompatible materials, stack shaping.Obtain the implantable laryngeal cartilages support that integral body, elasticity have Movable joint.
Except that the laryngeal cartilages support, the present invention can be used to make filling and repairing things such as credulous bone, the bridge of the nose equally.
Bio-medical material, through discrete, stack shaping, directly or turn over the system larynx and obtain bionical laryngeal cartilages support, this support can obtain the elasticity close with natural cartilage, can support the expansion of trachea and esophagus, resists their contraction; Has the hole that interpenetrates on this support, so that the reparation of its hetero-organization.The characteristic of support also is the overall structure of final products, and particularly it has Movable joint.Make the patient finally can be the same with the normal person.Because this method can be made a complete laryngeal cartilages support; So the doctor can assemble each laryngeal cartilages before operation; This method also can be carried out modeling to the each several part of laryngeal cartilages in addition; Thereby produce corresponding support, the doctor can select manufacturing to need the cartilage frame of part according to patient's demand.Realize the elasticity of final products through the elasticity of material.
Claims (2)
1. the biology of a customization artificial larynx is made construction method, it is characterized in that this method may further comprise the steps:
1) obtains CT, MRI image data synusia image as laryngeal cartilages;
2) the synusia image with the laryngeal cartilages of gained adopts the Mimics reconstruction software; Utilize the nuance of laryngeal cartilages and perienchyma's threshold value independent with laryngeal cartilages; Reconstruct more coarse laryngeal cartilages model, and then it is carried out obtaining after the smooth treatment three-dimensional mathematical model of the laryngeal cartilages of smoother;
3) has the characteristic of relative motion function according to laryngeal cartilages; The ligament that when making up laryngeal cartilages, will connect each cartilage also in the lump reconstruct in step 2) in the three-dimensional mathematical model of laryngeal cartilages in; Make up the little muscle of each laryngeal cartilages of connection then, make laryngeal cartilages possess certain activity characteristic;
4) utilize delamination software the three-dimensional mathematical model layering of gained to be obtained the X-Y scheme of each layer;
5) be each layer X-Y scheme establishment numerical control code;
6) select cell on laryngeal cartilages, grow and can adapt to the biocompatible materials of throat's environment, the numerical control code input fast forming machine of each layer X-Y scheme is carried out layer or layering is cut, the laryngeal cartilages support of the hole that obtains interpenetrating;
7) part unnecessary on the laryngeal cartilages support that obtains is rejected, obtained final laryngeal cartilages support.
2. the biology of a kind of customization artificial larynx according to claim 1 is made construction method; It is characterized in that: described biocompatible materials is selected polyurethane for use; Polylactic acid, the various copolymers between polyglycolic acid and this three, poly butyric ester with gather the hydroxycaproic acid ester copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210286143.4A CN102805675B (en) | 2012-08-13 | 2012-08-13 | Biological manufacturing and constructing method of customized artificial larynx |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210286143.4A CN102805675B (en) | 2012-08-13 | 2012-08-13 | Biological manufacturing and constructing method of customized artificial larynx |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102805675A true CN102805675A (en) | 2012-12-05 |
| CN102805675B CN102805675B (en) | 2014-12-31 |
Family
ID=47229662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210286143.4A Expired - Fee Related CN102805675B (en) | 2012-08-13 | 2012-08-13 | Biological manufacturing and constructing method of customized artificial larynx |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102805675B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398320A (en) * | 2014-11-20 | 2015-03-11 | 杭州电子科技大学 | Method of assembling artificial laryngeal cartilage support in cell-controlled manner |
| CN105877875A (en) * | 2016-05-27 | 2016-08-24 | 华南理工大学 | Personalized thyroid cartilage prosthesis and production method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1404802A (en) * | 2002-11-15 | 2003-03-26 | 清华大学 | Method for preparing biological-material integrally-implanted type ear cartilage bionic carriage |
| CN1559359A (en) * | 2004-02-16 | 2005-01-05 | 程晓民 | Method for making artificial prosthesis |
| WO2005016114A2 (en) * | 2003-05-05 | 2005-02-24 | Massachusetts Eye & Ear Infirmary | Generation of living tissue constructs in vivo using a mold |
| US6993406B1 (en) * | 2003-04-24 | 2006-01-31 | Sandia Corporation | Method for making a bio-compatible scaffold |
| US20060136068A1 (en) * | 2004-12-13 | 2006-06-22 | Progentix B.V.I.O. | Tissue regeneration |
| CN102087676A (en) * | 2010-12-13 | 2011-06-08 | 上海大学 | Pore network model (PNM)-based bionic bone scaffold designing method |
| CN102415920A (en) * | 2011-07-27 | 2012-04-18 | 浙江工业大学 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
| CN102626347A (en) * | 2012-04-26 | 2012-08-08 | 上海优益基医疗器械有限公司 | Method for manufacturing oral implant positioning guiding template based on CBCT data |
-
2012
- 2012-08-13 CN CN201210286143.4A patent/CN102805675B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1404802A (en) * | 2002-11-15 | 2003-03-26 | 清华大学 | Method for preparing biological-material integrally-implanted type ear cartilage bionic carriage |
| US6993406B1 (en) * | 2003-04-24 | 2006-01-31 | Sandia Corporation | Method for making a bio-compatible scaffold |
| WO2005016114A2 (en) * | 2003-05-05 | 2005-02-24 | Massachusetts Eye & Ear Infirmary | Generation of living tissue constructs in vivo using a mold |
| CN1559359A (en) * | 2004-02-16 | 2005-01-05 | 程晓民 | Method for making artificial prosthesis |
| US20060136068A1 (en) * | 2004-12-13 | 2006-06-22 | Progentix B.V.I.O. | Tissue regeneration |
| CN102087676A (en) * | 2010-12-13 | 2011-06-08 | 上海大学 | Pore network model (PNM)-based bionic bone scaffold designing method |
| CN102415920A (en) * | 2011-07-27 | 2012-04-18 | 浙江工业大学 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
| CN102626347A (en) * | 2012-04-26 | 2012-08-08 | 上海优益基医疗器械有限公司 | Method for manufacturing oral implant positioning guiding template based on CBCT data |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398320A (en) * | 2014-11-20 | 2015-03-11 | 杭州电子科技大学 | Method of assembling artificial laryngeal cartilage support in cell-controlled manner |
| CN105877875A (en) * | 2016-05-27 | 2016-08-24 | 华南理工大学 | Personalized thyroid cartilage prosthesis and production method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102805675B (en) | 2014-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhong et al. | 3D printing for clinical application in otorhinolaryngology | |
| JP3927487B2 (en) | Manufacturing method of artificial bone model | |
| CN109172049A (en) | A kind of porous network structure orthopaedics based on the connection of laminated sheet bar repairs the designing and manufacturing method and implant of implant | |
| CN110613533A (en) | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant | |
| Ross et al. | Aesthetic reconstruction of microtia: a review of current techniques and new 3D printing approaches | |
| CN104473705A (en) | Head maxillofacial bone implant and method for quickly molding same | |
| CN106580520A (en) | Method for producing mandibular implant with PEKK supporting and fixing unit and tissue engineering growth unit and implant | |
| Jung et al. | Octahedron pore architecture to enhance flexibility of nasal implant-shaped scaffold for rhinoplasty | |
| Sharma | 3D-printed prosthetics roll off the presses | |
| Ballyns et al. | Image‐guided tissue engineering | |
| CN111986310B (en) | Design method of mandibular porous implant taking soft tissue attachment and bone growth into consideration and porous implant | |
| CN112107394A (en) | Implant for maxillofacial bone defect repair and preparation method thereof | |
| CN102805675B (en) | Biological manufacturing and constructing method of customized artificial larynx | |
| CN109172044B (en) | Degradable gradient pore mammary gland stent | |
| CN207384356U (en) | A kind of titanium alloy rib cage replacement prosthesis | |
| CN207286182U (en) | Repair titanium net-titanium plate complex of large-scale mandibular defect | |
| Chiesa et al. | Three-dimensional and four-dimensional printing in otolaryngology | |
| Wu et al. | Fabrication of repairing skull bone defects based on the rapid prototyping | |
| Foerster et al. | Current market for biomedical implants | |
| Brennan | Production of anatomical models from CT scan data | |
| WO2018122865A1 (en) | 3d printed artificial temporal bone and process of making the same | |
| Zopf et al. | Bioprinting in otolaryngology and airway reconstruction | |
| Zheng et al. | The research of laryngeal reconstruction with personalized artificial larynx using tissue engineering | |
| Jadhav et al. | A Review on Additive Manufacturing for Bio-Implants | |
| CN209574964U (en) | A kind of porous network structure orthopaedics reparation implant based on the connection of laminated sheet bar |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181108 Address after: 313000 industrial zone of Donglin Town, Wuxing District, Huzhou, Zhejiang Patentee after: ZHEJIANG YUANTE NEW MATERIAL CO.,LTD. Address before: 310018 2 street, Xiasha Higher Education Park, Hangzhou, Zhejiang Patentee before: HANGZHOU DIANZI University |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191211 Address after: 314000 No.166, Haiwang Road, Shendang Industrial Park, Haiyan County, Jiaxing City, Zhejiang Province Patentee after: Zhejiang Deyikang Photoelectric Co.,Ltd. Address before: 313000 Zhejiang Province, Huzhou city Wuxing District East Town Industrial Zone Patentee before: ZHEJIANG YUANTE NEW MATERIAL CO.,LTD. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20201202 Address after: 214000 2201 Wuxi chamber of Commerce building, financial 8th Street, economic development zone, Wuxi City, Jiangsu Province Patentee after: Jiangsu intelligent workshop Technology Research Institute Co.,Ltd. Address before: 314000 No.166, Haiwang Road, Shendang Industrial Park, Haiyan County, Jiaxing City, Zhejiang Province Patentee before: Zhejiang Deyikang Photoelectric Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210412 Address after: 226200 No.59, group 6, Wudong village, Donghai Town, Qidong City, Nantong City, Jiangsu Province Patentee after: Qidong Haimei Agricultural Technology Development Co.,Ltd. Address before: 214000 2201 Wuxi chamber of Commerce building, financial 8th Street, economic development zone, Wuxi City, Jiangsu Province Patentee before: Jiangsu intelligent workshop Technology Research Institute Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20210813 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |