CN102786429A - Synthesis method of tolfenamic acid - Google Patents
Synthesis method of tolfenamic acid Download PDFInfo
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- CN102786429A CN102786429A CN201210291976XA CN201210291976A CN102786429A CN 102786429 A CN102786429 A CN 102786429A CN 201210291976X A CN201210291976X A CN 201210291976XA CN 201210291976 A CN201210291976 A CN 201210291976A CN 102786429 A CN102786429 A CN 102786429A
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Abstract
The invention provides a synthesis method of tolfenamic acid, and belongs to the field of medicament synthesis. According to the technical scheme, the synthesis method comprises the following steps of: adding o-chlorobenzoic acid and alkali metal hydroxide into methyl isobutyl ketone; heating and raising temperature for reaction; adding 3-chloro-2-methylaniline, an acid-binding agent and a catalyst into mixture; heating to react; performing extraction, acidification and filtration to obtain a tolfenamic acid rough product; and recrystalizing the rough product to obtain the tolfenamic acid refined product. The method has the advantages of easiness in operation, easiness in implementation of industrial production, high yield, low cost, safety and environmental friendliness.
Description
Technical field
The invention belongs to the synthetic field of medicine, specifically, relate to a kind of compound method of tolfenamic acid.
Background technology
The English Tolfenamic Acid by name of tolfenamic acid, chemical name is 2-[(3-chloro-2-aminomethyl phenyl) amino] phenylformic acid, its structural formula is following:
Tolfenamic acid is a kind of widely used nonsteroidal anti-inflammatory drugs by the research and development of Denmark GEA Pharmaceutical Co., Ltd..The eastern water chestnut pharmaceutical industries of Japan in May nineteen eighty-three goes on the market as treatment arthritis and migraine people medication with the trade(brand)name of Clotam; At present the main manufacturer in market be a French and Canadian Vetoquinol company abroad; Product is tablet and injection, and commodity are called TOLFEDINE.Tolfenamic acid was listed a company by Vetoquinol in 1994 and is used for veterinary clinic, was mainly used in anti-inflammatory, analgesic, the analgesia therapy of dog, cat etc., and is also relevant to recently the intravital research report of ox.
The synthesis technique of having reported at present is following:
With 0-chloro-benzoic acid and N, the dinethylformamide Hybrid Heating adds a certain amount of 3-chloro-2-aminotoluene then, after continuing to heat up; Add salt of wormwood, back flow reaction for some time, reacted back solvent evaporated N; Resistates is used water dissolution, regulates PH to alkalescence, and acidifying obtains the very low bullion of purity; Use 45% ethyl alcohol recrystallization then, use the Diluted Alcohol recrystallization again, prepare subsequently its sodium salt then acidifying obtain pure article.Yield is very low, is about 38%.
This route has adopted comparatively cheap reagent 0-chloro-benzoic acid and 3-chloro-2-aminotoluene as starting raw material, but adopted DMF as solvent, and boiling point is than higher and toxicity is bigger; And need the high boiling DMF solvent of evaporate to dryness after having reacted; Operational difficulty, and take the method for solvent evaporated, impurity is not separated with product; Cause the subsequent product treating process loaded down with trivial details, product yield is low.
Summary of the invention
The objective of the invention is for deficiency, a kind of compound method of new tolfenamic acid is provided to existing synthesis technique.It is little that this method has solvent toxicity, simple to operate and be easy to realize characteristics such as yield height.
For solving the problems of the technologies described above, the present invention adopts following technical scheme to be achieved:
A kind of compound method of tolfenamic acid may further comprise the steps:
1. 0-chloro-benzoic acid and alkali metal hydroxide are joined in the MIBK, heat temperature raising reacts;
2. subsequently, upwards go on foot and add 3-chloro-2-aminotoluene, acid binding agent and catalyzer in the reaction mixture of gained, the heat temperature raising reaction; Subsequently, cooling adds entry then and extracts; Separatory, water are used the hcl acidifying crystallization, filter; Filter cake is the tolfenamic acid bullion, and the bullion recrystallization obtains the tolfenamic acid refined prod.
As further technical scheme of the present invention, the 1. used alkali metal hydroxide of above-mentioned synthesis step comprises one or more in sodium hydroxide, the Pottasium Hydroxide, preferred sodium hydroxide.
As further technical scheme of the present invention, the 2. employed acid binding agent of above-mentioned synthesis step comprises sodium acetate, potassium acetate; Sodium hydroxide, Pottasium Hydroxide, sodium hydrogencarbonate; Saleratus, yellow soda ash, sodium phosphate; Potassiumphosphate, one or more in the N-ethylmorpholine, a kind of or mixture in preferred sodium acetate or the sodium hydrogencarbonate.
As further technical scheme of the present invention, react used catalyzer and comprise cuprous bromide, cuprous chloride, copper powder, the mixture of one or more in the venus crystals.
As further technical scheme of the present invention, 0-chloro-benzoic acid and 3-chloro-2-aminotoluene mol ratio are 1:0.5-2, and preferred molar ratio is 1:0.9-1.1.
As further technical scheme of the present invention, 0-chloro-benzoic acid and acid binding agent mol ratio are 1:0.5-4, and preferred molar ratio is 1:0.8-1.5.
As further technical scheme of the present invention, above-mentioned synthesis step reacting by heating temperature 2. be 90 ℃ to reflux temperature.
As further technical scheme of the present invention, the used solvent of recrystallization be ethanol, ethanol/water mixed solvent, methyl alcohol one of them, preferred alcohol/water mixed solvent.
As further technical scheme of the present invention, synthesis step 1. heat temperature raising time of reacting at 0.5h-5h, synthesis step 2. time of heat temperature raising reaction at 3-12 hour.
Preferred tolfenamic acid synthetic technology scheme step is following:
1. 0-chloro-benzoic acid and sodium hydroxide are joined in the MIBK, heat temperature raising reacts;
2. upwards add 3-chloro-2-aminotoluene and sodium acetate and catalyzer in the reaction mixture of step reaction gained, reacting by heating for some time is after having reacted; Cooling; Add entry and extract, water is used the hcl acidifying crystallization, filters; Filter cake is the tolfenamic acid bullion, and bullion obtains the tolfenamic acid refined prod with the ethanol/water mixed solvent recrystallization; Wherein, the 2. middle reaction catalyst system therefor of step is selected cuprous bromide for use, cuprous chloride, copper powder, the mixture of one or more in the venus crystals.
The present invention makes reaction process change through having changed reaction solvent, and yield is improved; According to reaction characteristics, synthesize step by step in addition, also obtained good effect, in addition in aftertreatment because solvent, be able to adopt method of extraction processing reaction liquid, have advantages such as purification process is convenient.
Compared with prior art, advantage of the present invention and positively effect are: technical scheme provided by the invention has simple to operate, is easy to realize suitability for industrialized production, and yield is high, and cost is low, and advantages such as safety and environmental protection are particularly suitable for suitability for industrialized production.
Embodiment
Below in conjunction with embodiment the present invention is done further detailed explanation.
For technical scheme of the present invention is described better, the invention provides following specific embodiment and describe, but be not used in the restriction scope that the present invention protected.
Embodiment 1
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 40g sodium hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 90 g sodium acetates and 1g venus crystals and joins in the reaction mixture of step reaction gained, heating reflux reaction 3 h, cooling then; Add the extraction of 500mL water, separatory, water is acidified to PH=2 with concentrated hydrochloric acid; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 215g, yield 82%.
Embodiment 2
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 40g sodium hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 84 g sodium hydrogencarbonates and 1g copper powder and joins in the reaction mixture of step reaction gained, heating reflux reaction 4 h, cooling then; Add the extraction of 500mL water, separatory, water is acidified to PH=2 with concentrated hydrochloric acid; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 209g, yield 80%.
Embodiment 3
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 66g Pottasium Hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 156 g 3-chloro-2-aminotoluenes and 118 g potassium acetates and 1.5g cuprous bromide and joins in the reaction mixture of step reaction gained, heating reflux reaction 3 h, cooling then; Add the extraction of 500mL water, separatory, water is acidified to PH=2 with concentrated hydrochloric acid; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used recrystallizing methanol, obtain tolfenamic acid refined prod 191g, yield 73%.
Embodiment 4
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 40g sodium hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 170 g 3-chloro-2-aminotoluenes and 85 g yellow soda ash and 1.2g cuprous chloride and joins in the reaction mixture of step reaction gained, heating reflux reaction 3 h, cooling then; Add the extraction of 500mL water, separatory, water with 20% hcl acidifying to PH=2; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 204g, yield 78%.
Embodiment 5
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 40g sodium hydroxide joins in the 600mL MIBK, is heated to back flow reaction 1 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 164g sodium phosphate and 1.5g cuprous chloride and joins in the reaction mixture of step reaction gained, heating reflux reaction 5 h, cooling then; Add the extraction of 600mL water, separatory, water is acidified to PH=2 with concentrated hydrochloric acid; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used ethyl alcohol recrystallization, obtain tolfenamic acid refined prod 186g, yield 71%.
Embodiment 6
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 40g sodium hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 90 g sodium acetates and 1.5g venus crystals and joins in the reaction mixture of step reaction gained, is heated to 90 degree reaction 15h, cooling then; Add the extraction of 500mL water, separatory, water with 20% hcl acidifying to PH=2; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 207g, yield 79%.
Embodiment 7
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 66g Pottasium Hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 66 g Pottasium Hydroxide and 1g copper powder and joins in the reaction mixture of step reaction gained, is heated to 100 degree reaction 10h, cooling then; Add the extraction of 500mL water, separatory, water with 20% hcl acidifying to PH=2; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 194g, yield 74%.
Embodiment 8
Step 1. takes by weighing the 157g 0-chloro-benzoic acid and 66g Pottasium Hydroxide joins in the 600mL MIBK, is heated to back flow reaction 0.5 h.
Step 2. takes by weighing 142 g 3-chloro-2-aminotoluenes and 115g N-ethylmorpholine and 2g venus crystals and joins in the reaction mixture of step reaction gained, is heated to back flow reaction 4h, then cooling; Add the extraction of 600mL water, separatory, water with 20% hcl acidifying to PH=2.5; Continue to stir the 1h crystallization, filter, filter cake is the tolfenamic acid bullion; The tolfenamic acid bullion is used the ethanol/water mixed solvent recrystallization, obtain tolfenamic acid refined prod 202g, yield 77%.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (9)
1. the compound method of a tolfenamic acid is characterized in that may further comprise the steps:
1. 0-chloro-benzoic acid and alkali metal hydroxide are joined in the MIBK, heat temperature raising reacts;
2. subsequently, upwards go on foot and add 3-chloro-2-aminotoluene, acid binding agent and catalyzer in the reaction mixture of gained, the heat temperature raising reaction; Subsequently, cooling adds entry then and extracts; Separatory, water are used the hcl acidifying crystallization, filter; Filter cake is the tolfenamic acid bullion, and the bullion recrystallization obtains the tolfenamic acid refined prod.
2. compound method according to claim 1 is characterized in that: the 1. used alkali metal hydroxide of step comprises one or more in sodium hydroxide, the Pottasium Hydroxide.
3. compound method according to claim 1 is characterized in that: 2. step is reacted employed acid binding agent and is comprised in sodium acetate, potassium acetate, sodium hydroxide, Pottasium Hydroxide, sodium hydrogencarbonate, saleratus, yellow soda ash, sodium phosphate, potassiumphosphate, the N-ethylmorpholine one or more.
4. compound method according to claim 1 is characterized in that: react used catalyzer and comprise cuprous bromide, cuprous chloride, copper powder, the mixture of one or more in the venus crystals.
5. compound method according to claim 1 is characterized in that: 0-chloro-benzoic acid and 3-chloro-2-aminotoluene mol ratio are 1:0.5-2, and 0-chloro-benzoic acid and acid binding agent mol ratio are 1:0.5-4.
6. compound method according to claim 5 is characterized in that: 0-chloro-benzoic acid and 3-chloro-2-aminotoluene mol ratio are 1:0.9-1.1, and 0-chloro-benzoic acid and acid binding agent mol ratio are 1:0.8-1.5.
7. compound method according to claim 1 is characterized in that: step reacting by heating temperature 2. be 90 ℃ to reflux temperature.
8. compound method according to claim 1 is characterized in that: the used solvent of recrystallization be ethanol, ethanol/water mixed solvent, methyl alcohol one of them.
9. compound method according to claim 1 is characterized in that: step 1. heat temperature raising time of reacting at 0.5h-5h, step 2. time of heat temperature raising reaction at 3-12 hour.
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| CN201210291976XA CN102786429A (en) | 2012-08-16 | 2012-08-16 | Synthesis method of tolfenamic acid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172530A (en) * | 2013-04-12 | 2013-06-26 | 沈阳三九药业有限公司 | Preparation method of tolfenamic acid |
| CN104557584A (en) * | 2013-10-23 | 2015-04-29 | 丹阳恒安化学科技研究所有限公司 | Method for synthesizing tolfenamic acid |
| CN107814733A (en) * | 2016-09-14 | 2018-03-20 | 天津科技大学 | A kind of Tolfenamic Acid novel crystal forms and preparation method thereof |
-
2012
- 2012-08-16 CN CN201210291976XA patent/CN102786429A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| YAGHOUB SARRAFI ET AL.: "Microwave-assisted chemoselective copper-catalyzed amination of o-chloro and o-bromobenzoic acids using aromatic amines under solvent free conditions", 《CHINESE CHEMICAL LETTERS》, vol. 20, 31 December 2009 (2009-12-31) * |
| 汪多仁: "《溶剂与专用化学品生产配方和合成工艺》", 30 June 2001, article "甲基异丁基酮", pages: 334-335 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172530A (en) * | 2013-04-12 | 2013-06-26 | 沈阳三九药业有限公司 | Preparation method of tolfenamic acid |
| CN103172530B (en) * | 2013-04-12 | 2015-04-01 | 沈阳三九药业有限公司 | Preparation method of tolfenamic acid |
| CN104557584A (en) * | 2013-10-23 | 2015-04-29 | 丹阳恒安化学科技研究所有限公司 | Method for synthesizing tolfenamic acid |
| CN104557584B (en) * | 2013-10-23 | 2016-08-17 | 丹阳恒安化学科技研究所有限公司 | A kind of synthetic method of Tolfenamic Acid |
| CN107814733A (en) * | 2016-09-14 | 2018-03-20 | 天津科技大学 | A kind of Tolfenamic Acid novel crystal forms and preparation method thereof |
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Address after: 266109 Qingdao Road, Chengyang District, Shandong, No. 700 the Great Wall Applicant after: Qingdao Agricultural University Applicant after: QINGDAO VLAND BIOLOGICAL CO., LTD. Applicant after: Heze Puen Pharmaceutical Co., Ltd. Address before: 266109 Qingdao Road, Chengyang District, Shandong, No. 700 the Great Wall Applicant before: Qingdao Agricultural University Applicant before: Qingdao KDN Pharmaceutical Co., Ltd. Applicant before: Heze Puen Pharmaceutical Co., Ltd. |
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Application publication date: 20121121 |