CN102686110B

CN102686110B - Composition and method for controlling pests

Info

Publication number: CN102686110B
Application number: CN201080060685.9A
Authority: CN
Inventors: 仓桥真
Original assignee: Sumitomo Chemical Co Ltd
Current assignee: Sumitomo Chemical Co Ltd
Priority date: 2010-01-06
Filing date: 2010-12-22
Publication date: 2014-12-03
Anticipated expiration: 2030-12-22
Also published as: MY159766A; CN102686110A; AU2010340508B2; US20120264602A1; KR20120112519A; RU2012133442A; JP2011157347A; UA108090C2; AU2010340508A1; BR112012016565B1; KR101800907B1; JP5682300B2; TWI478667B; US9012361B2; ZA201204185B; RU2549761C2; TW201138630A; BR112012016565A2; WO2011083745A1; CA2782603A1

Abstract

The present invention provides: a composition for controlling pests comprising, as active ingredients, ethaboxam and avermectin; a method for controlling pests which comprises applying effective amounts of ethaboxam and avermectin to a pest, a plant or soil for growing plant; and so on.

Description

For composition and the method for disease and pest control

Technical field

The present invention relates to for the composition of disease and pest control (pest) and for the method for disease and pest control.

background technology

The known active component as Pest management agent be that the Guardian (ethaboxam) with Fungicidally active (is shown in; for example; U.S. Patent Publication No. 5514643) and the Avermectin (avermectin) with insecticidal activity (see; for example; " The Pesticide Manual-14 editions "; the Britain crop protection committee (BCPC) publishes, ISBN1901396142).

Summary of the invention

An object of the present invention is to provide have the excellent control effect for damage by disease and insect for the composition of disease and pest control and for the method for disease and pest control.

The invention provides for the composition of disease and pest control and for the method for disease and pest control, its use in conjunction by Guardian and Avermectin is brought into play the excellent control effect for damage by disease and insect.

Particularly, the invention provides:

[1] for the composition of disease and pest control, it comprises as the Guardian of active component and Avermectin;

[2] according to the composition [1] described, the scope that wherein weight ratio of Guardian and Avermectin is 1:0.01-1:50;

[3] seed treatment, it comprises as the Guardian of active component and Avermectin;

[4] with the Guardian of effective dose and the plant seed of Avermectin processing;

[5], for the method for disease and pest control, it comprises the Guardian of effective dose and Avermectin is applied to damage by disease and insect, plant or the soil for growing plant; And

[6] Guardian and Avermectin are for the use in conjunction of disease and pest control; Etc..

The excellent control effect for damage by disease and insect of composition performance of the present invention.

embodiment

Guardian for the composition for disease and pest control of the present invention is at the disclosed compound of U.S. Patent Publication No. 5514643.This compound can be obtained maybe and can be produced and be obtained by the method for describing in the disclosure thing by agent.

Avermectin for the composition for disease and pest control of the present invention is known compound; and for example at " The Pesticide Manual-14 editions "; the Britain crop protection committee (BCPC) publishes, and ISBN1901396142 is open in pp.3.This compound can be obtained maybe and can be produced and be obtained by known method by agent.

At the composition for disease and pest control of the present invention, the weight ratio of Guardian and Avermectin is generally the scope of 1:0.01-1:50, preferably 1:0.05-1:20.When as foliar spray mist, the weight ratio of Guardian and Avermectin is generally the scope of 1:0.01-1:10, preferably 1:0.05-1:5.When as seed treatment, the weight ratio of Guardian and Avermectin is generally the scope of 1:0.05-1:50, preferably 1:0.1-1:20.

Composition for disease and pest control of the present invention can be the simple mixtures of Guardian and Avermectin.Alternatively, for the composition of disease and pest control conventionally by by Guardian with Avermectin is mixed with inert carrier and add surfactant and other auxiliary agents to mixture on demand, thereby make mixture can be mixed with finish, emulsion, can flowable, prepared by wetting powder, a type wetting powder, pulvis, granule etc.The above-mentioned composition for disease and pest control can former state or is added other inert fractions and as seed treatment.

At the composition for disease and pest control of the present invention, the total amount of Guardian and Avermectin is generally 0.1-99% weight, preferably the scope of 0.2-90% weight.

The example of the solid carrier using in preparation comprises fine powder or particle, if mineral are as kaolin, attapulgite clay, bentonite, montmorillonite, acid white clay, pyrophyllite, talcum, diatomite and calcite; Natural organic is as corncob powder and walnut shell powder; Synthetic organic material is as urea; Salt is as calcium carbonate and ammonium sulfate; Synthetic inorganic material is as synthetic hydrated silica; With as liquid-carrier, aromatic hydrocarbon based as dimethylbenzene, alkylbenzene and methyl naphthalene; Alcohols is as 2-propyl alcohol, ethylene glycol, propane diols and ethylene glycol monoethyl ether; Ketone is as acetone, cyclohexanone and isophorone; Vegetable oil is as soybean oil and cottonseed oil; Oil aliphatic hydrocarbon, ester class, dimethyl sulfoxide (DMSO), acetonitrile and water.

The example of surfactant comprises: anion surfactant, as alkyl sulfate salt, alkylaryl sulfonates, dialkyl sulfosuccinates, polyoxyethylene alkylaryl ether phosphate ester salt, lignosulfonates and naphthalene sulphonate formaldehyde condensation polymer (lignosulfonate salts and naphthalene sulfonate formaldehyde polycondensates); With non-ionic surface active agent as polyoxyethylene alkylaryl ether, polyxyethylated polyoxypropylene block copolymers and sorbitan fatty acid ester; With cationic surfactant as alkyl trimethyl ammonium salt.

The example of other formulation auxiliary agents comprises water-soluble polymer, as polyvinyl alcohol and polyvinylpyrrolidone, polysaccharide is as gum Arabic, alginic acid and salt thereof, CMC (carboxymethyl cellulose), xanthans, inorganic material is as aluminium-magnesium silicate and alumina sol, preservative, colouring agent and stabilizing agent are as PAP (acid phosphatase isopropyl ester (acid phosphate isopropyl)) and BHT.

Composition for disease and pest control of the present invention can be avoided following damage by disease and insect (for example arthropods damage by disease and insect is as insect disease insect pest and mite class damage by disease and insect, nematode and phytopathogen) infringement by protective plant, and described damage by disease and insect causes damage as taken food or sucking to plant.It is had to the arthropods damage by disease and insect of effect of control to composition for disease and pest control of the present invention and the example of nematode comprises following:

Semiptera (Hemiptera): plant hopper (planthopper) is as small brown rice planthopper (Laodelphax striatellus), brown planthopper (Nilaparvata lugens) and white-backed planthopper (Sogatella furcifera); Leafhopper is as rice leafhopper (Nephotettix cincticeps) and black tail cicada at night (Nephotettix virescens); Aphid is as cotten aphid (Aphis gossypii), black peach aphid (Myzus persicae), cabbage aphid (Brevicoryne brassicae), potato aphid (Macrosiphum euphorbiae), eggplant is without net aphid (Aulacorthum solani), rhopalosiphum padi (Rhopalosiphum padi) and large citrus aphid (Toxoptera citricidus); Stinkbug is as green stinkbug (Nezara antennata), beans stinkbug (Riptortus clavetus), rice stinkbug (Leptocorisa chinensis), white star stinkbug (Eysarcoris parvus), tea wing stinkbug (Halyomorpha mista) and tarnished plant bug (Lygus lineolaris); Aleyrodid is as Trialeurodes vaporariorum Westwood (Trialeurodes vaporariorum), Bemisia tabaci (Bemisia tabaci) and Bemisia argentifolii (Bemisia argentifolii); Coccid is as California red scale (Aonidiella aurantii), san jose scale (Comstockaspis perniciosa), tangerine arrowhead scales (Unaspis citri), ceroplastes rubens (Ceroplastes rubens) and cottonycushion scale (Icerya purchasi); Lace bug (lace bug); And wood louse;

Lepidoptera (Lepidoptera): snout moth is as striped rice borer (Chilo suppressalis), paddy stem borer (Tryporyza incertulas), rice leaf roller (Cnaphalocrocis medinalis), the wild snout moth's larva of lap leaf (Notarcha derogata), Indian meal moth (Plodia interpunctella), Asiatic corn borer (Ostrinia furnacalis), European corn borer (Ostrinia nubilaris), Oeobia undalis (Hellula undalis) and annual bluegrass snout moth's larva (Pediasia teterrellus), noctuid is as prodenia litura (Spodoptera litura), beet armyworm (Spodoptera exigua), rice mythimna separata (Pseudaletia separata), tomato moth (Mamestra brassicae), black cutworm (Agrotis ipsilon), stain three-spotted plusia (Plusia nigrisigna), Thoricoplusia spp., Heliothis species, and Helicoverpa species, white butterfly is as imported cabbageworm (Pieris rapae), leaf roller is as brown band leaf roller species (Adoxophyes spp.), oriental fruit moth (Grapholita molesta), soybean pod borer (Leguminivora glycinivorella), azuki bean podworm (Matsumuraeses azukivora), apple olethreutid (Adoxophyes orana fasciata), tea olethreutid (Adoxophyes sp.), Homona magnanima (Homona magnanima), apple skin worm (Archips fuscocupreanus), and codling moth (Cydia pomonella), thin moth moth as thin in tea (Caloptilia theivora), and apple apple leaf miner (Phyllonorycter ringoneella), fruitworm moths is as peach fruit borer (Carposina niponensis), lyonetid (lyonetiid moths) is as lyonetid species, poison moth is as Euproctis species, and Euproctis spp., ermine moth is as diamond-back moth (Plutella xylostella), gelechiid is as pink bollworm (Pectinophora gossypiella), and potato tuberworm (Phthorimaea operculella), moths attracted by lamplight are as fall webworm (Hyphantria cunea), with rain moth as bag rain moth (Tinea translucens), and webbing clothes moth (Tineola bisselliella),

Thrips (Thysanoptera): thrips (Thripidae) is as Frankliniella occidentalis (Frankliniella occidentalis), melon thrips (Thrips parmi), yellow tea thrips (Scirtothrips dorsalis), onion thrips (Thrips tabaci), flower thrips (Frankliniella intonsa), and tobacco thrips (Frankliniella fusca);

Diptera (Diptera): housefly (Musca domestica), Culex pipiens pallens (Culex pipiens pallens), horsefly (Tabanus trigonus), onion fly (Hylemya antiqua), plant fly (Hylemya platura), Anopheles sinensis (Anopheles sinensis), Liriomyza is as paddy stem maggot (Agromyza oryzae), Hydrellia griseola (Hydrellia griseola), rice stem maggot (Chlorops oryzae) and Liriomyza trifolii (Liriomyza trifolii), melon trypetid (Dacus cucurbitae), and Mediterranean fruitfly (Ceratitis capitata),

Coleoptera (Coleoptera): potato ladybug (Epilachna vigintioctopunctata), aulacophora femoralis (Aulacophora femoralis), striped flea-beetle worm (Phyllotreta striolata), the chrysomelid worm of rice (Oulema oryzae), rice plant weevil (Echinocnemus squameus), rice water weevil (Lissorhoptrus oryzophilus), boll weevil (Anthonomus grandis), red bean bean weevil (Callosobruchus chinensis), hunt long beak and resemble (Sphenophorus venatus), Japanese beetle (Popillia japonica), green rutelian (Anomala cuprea), corn rootworm (Diabrotica spp.), Colorado beetle (Leptinotarsa decemlineata), kowtow the helmet (Agriotes spp.), lasioderma serricorne (Lasioderma serricorne), roundlet khapra beetle (Anthrenus verbasci), red flour beetle (Tribolium castaneum), powderpost beetles (Lyctus brunneus), longicorn beetle (Anoplophora malasiaca), and vertical pit cutting pin small moth (Tomicus piniperda),

Orthoptera (Orthoptera): Asiatic migratory locust (Locusta migratoria), African mole cricket (Gryllotalpa africana), oryza chinensis (Oxya yezoensis), and oryza chinensis (Oxya japonica);

Hymenoptera (hymenoptera): cabbage sawfly (Athalia rosae), leaf cutting ant (Acromyrmex spp.), and fiery ant (Solenopsis spp.);

Blattaria (Blattaria): Groton bug (Blattella germanica), Peroplaneta fluligginosa (Periplaneta fuliginosa), American cockroach (Periplaneta americana), brown blattaria (Periplaneta brunnea) and oriental cockroach (Blatta orientalis);

Acarina (Acarina): tetranychid is as Tetranychus urticae (Tetranychus urticae), citrus red mite (Panonychus citri), and Oligonychus spp.; Goitre mite is as citrus rust mite (Aculops pelekassi); Flat mite is as broad mite (Polyphagotarsonemus latus); False spider mite (false spider mites); Peacock mite (peacock mites); Flour mite is as tyrophagus putrescentiae (Tyrophagus putrescentiae); Dirt mite is as U.S. dirt mite (Dermatophagoides farinae), and dermatophagoides pteronyssinus (Dermatophagoides ptrenyssnus); With cheyletid mite as Cheyletus eruditus (Cheyletus eruditus), Malacca cheyletid mite (Cheyletus malaccensis) and Cheyletus moorei; And

Nematode: Aphelenchoides oryzae Yokoo (Aphelenchoides besseyi), strawberry bud nematode (Nothotylenchus acris), cotton root-knot nematode (Meloidogyne incognita), and cotton kidney shape nematode (Rotylenchulus reniformis).

The example that composition for disease and pest control of the present invention has to it plant disease of controlling effect comprises following:

Rice disease is as rice blast (rice blast pears spore (Magnaporthe grisea)), the long spore leaf spot (palace portion cochliobolus (Cochliobolus miyabeanus)) of wriggling, banded sclerotial blight (Rhizoctonia solani Kuhn (Rhizoctonia solani)) and bakanae disease (gibberella fujikuroi (Gibberella fujikuroi));

Wheat disease is as powdery mildew (standing grain powdery mildew (Erysiphe graminis)), head blight (F.graminearum schw (Fusarium graminearum), oat sickle spore (F. avenacerum), machete sickle spore (F. culmorum), avenge rotten microtorr bacterium (Microdochium nivale)), rust (bar shaped handle rest fungus (Puccinia striiformis), puccinia graminis (P. graminis), Puccinia recondita (P. recondita)), snow blight (Micronectriella nivale), snow blight (Typhula sp.), loose kernel smut (Ustilago tritici), bunt (Tilletia caries (Tilletia caries)), eye spot (wheat-based maize ear rot bacterium (Pseudocercosporella herpotrichoides)), moire disease (standing grain green-ball chamber bacterium (Mycosphaerella graminicola)), glume blight (Stagonospora nodorum) and maculopathy (wheat De Shi mould (Pyrenophora tritici-repentis)),

Barley disease is as powdery mildew (standing grain powdery mildew (Erysiphe graminis)), head blight (F.graminearum schw (Fusarium graminearum), oat sickle spore (F. avenacerum), machete sickle spore (F. culmorum), avenge rotten microtorr bacterium (Microdochium nivale)), rust (bar shaped handle rest fungus (Puccinia striiformis), puccinia graminis (P. graminis), barley handle rest fungus (P. hordei)), loose kernel smut (naked smut (Ustilago nuda)), clouding disease (rye beak spore (Rhynchosporium secalis)), net blotch (Pyrenophora teres), spot blight (standing grain revolves spore mould (Cochliobolus sativus)), leaf stripe (wheat class nuclear cavity bacteria (Pyrenophora graminea)) and rhizoctonia damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani)),

Corn disease is as smut (Ustilago maydis (Ustilago maydis)), brown spot (different cochliobolus (Cochliobolus heterostrophus)), copper spot (Chinese sorghum cercospora glue bacterium (Gloeocercospora sorghi)), southern type rust (Puccinia polysora (Puccinia polysora)), graywall (Gray Leaf Spot Pathogen (Cercospora zeae-maydis)) and rhizoctonia damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani)),

Citrus disease is as melanose (base shell bacterium between oranges and tangerines (Diaporthe citri)), shot hole (Elsinoe fawcetti), mould (Penicillium digitatum (Penicillium digitatum), Citrus mould (P. italicum)) and brown rot (black shank bacterium (Phytophthora parasitica), oranges and tangerines brown rot epidemic disease mould (Phytophthora citrophthora));

Apple disease is as blossom rot (apple chain sclerotinia sclerotiorum (Monilinia mali)), canker (apple black skin shell bacterium (Valsa ceratosperma)), powdery mildew (white cross hair list softgel shell (Podosphaera leucotricha)), interlinkage bag belongs to leaf spot (Alternaria alternata apple pathotype), shot hole (venturia inaequalis (Venturia inaequalis)), bitter rot (Colletotrichum acutatum), neck rot (Phytophtora cactorum), spot (Diplocarpon mali), ring rot (Botryosphaeria berengeriana) and violet root rot (Helicobasidium mompa),

Pears disease is as shot hole (Venturia nashicola, V. pirina), black spot (Pear black spot bacterium (Alternaria alternata Japanese pear pathotype)), rust (pear gymnosporangium (Gymnosporangium haraeanum)) and the mould fruit rot of epidemic disease (Phytophtora cactorum);

Peach disease is as brown rot (peach brown rot fungus (Monilinia fructicola)), shot hole (having a liking for fruit cladosporium (Cladosporium carpophilum)) and brown line disease (Phomopsis sp.);

Grape disease is as anthracnose (Elsinochrome (Elsinoe ampelina)), late blight (Glomerella cingulata), powdery mildew (Uncinula necator), rust (grape layer rest fungus (Phakopsora ampelopsidis)), black rot (Guignardia bidwellii) and downy mildew (the raw axle downy mildew of grape (Plasmopara viticola));

Japan's persimmon disease is as anthracnose (persimmon helicospore bacterium (Gloeosporium kaki)) and leaf spot (Cercospora kaki, Mycosphaerella nawae);

Cucurbit disease is as anthracnose (Colletotrichum lagenarium), powdery mildew (powdery mildew of cucumber bacterium (Sphaerotheca fuliginea)), climing rot (didymella bryoniae (Mycosphaerella melonis)), Fusariumsp wilt disease (Fusarium oxysporum (Fusarium oxysporum)), downy mildew (the false downy mildew of Cuba (Pseudoperonospora cubensis)), phytophthora rot (Phytophthora sp.) and damping off (pythium species (Pythium sp.)),

Tomato disease is as early blight (rope Lan Shi chain lattice spores (Alternaria solani)), leaf mold (cladosporium fulvum (Cladosporium fulvum)) and late blight (phytophthora infestans (Phytophthora infestans));

Eggplant disease is as brown spot (brown line Phomopsis (Phomopsis vexans)) and powdery mildew (Erysiphe cichoracearum);

Brassicaceous vegetable disease: interlinkage bag belongs to leaf spot (Alternaria japonica), Leucoplakia (overgrown with weeds bluish white pinta bacterium (Cercosporella brassicae)), club root (plasmodiophora brassicae (Plasmodiophora brassicae)) and downy mildew (parasitic downy mildew (Peronospora parasitica));

Shallot disease is as rust (green onion handle rest fungus (Puccinia allii)) and downy mildew (green onion downy mildew (Peronospora destructor));

Soybean disease is as purple spot (Kikuchi tail spore (Cercospora kikuchii)), scab circle spore belongs to shot hole (sphaceloma scad) (Elsinoe glycines), pod blight and cane blight (Diaporthe phaseolorum var. sojae), brown spot (Soybean Brown Spot line septoria musiva (Septoria glycines)), graywall (Cercospora sojina), rust (Phakopsora pachyrhizi), brown stem rot (soybean phytophthora (Phytophthora sojae)) and rhizoctonia damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani)),

Kidney bean disease is as anthracnose (Colletotrichum lindemthianum);

Peanut disease is as leaf spot (ball seat tail spore bacterium (Cercospora personata)), brown leaf spot (peanut tail spore bacterium (Cercospora arachidicola)) and southern blight (Sclerotium rolfsii (Sclerotium rolfsii));

Pea disease is as powdery mildew (pea powdery mildew (Erysiphe pisi)) and root rot (Fusarium solani f. sp. pisi);

Potato disease is as early blight (rope Lan Shi chain lattice spores (Alternaria solani)), late blight (phytophthora infestans (Phytophthora infestans)), pink rot (Phytophthora erythroseptica), powdery scab (Spongospora subterranean f. sp. subterranea) and tar spot (Rhizoctonia solani);

Strawberry disease is as powdery mildew (Powdery Mildew (Sphaerotheca humuli)) and anthracnose (Glomerella cingulata);

Tea tree disease is as net blister blight (Exobasidium reticulatum), white shot hole (Elsinoe leucospila), gray blight (Pestalotiopsis sp.) and anthracnose (Colletotrichum theae-sinensis);

Tobacco disease is as brown spot (long handle chain lattice spore (Alternaria longipes)), powdery mildew (two spore powdery mildews (Erysiphe cichoracearum)), anthracnose (Colletotrichum tabacum), downy mildew (peronospora tabacina (Peronospora tabacina)) and black shank (Phytophthora nicotianae);

Rape disease is as stalk break (sclerotinite (Sclerotinia sclerotiorum)) and rhizoctonia damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani));

Cotton disease is as rhizoctonia damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani));

Beet disease is as Cercospora leaf spot (beet tail spore (Cercospora beticola)), leaf blight (Rhizoctonia solani), root rot (Rhizoctonia solani) and Aphanomyces root rot (Aphanomyces cochlioides);

Rose disease is as black spot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa) and downy mildew (Peronospora sparsa);

Chrysanthemum and knotweed disease are as downy mildew (lettuce dish downy mildew (Bremia lactucae)), leaf blight (mother chrysanthemum septoria musiva (Septoria chrysanthemi-indici)) and white blister (Puccinia horiana (Puccinia horiana));

Each kind of groups disease is as the disease being caused by pythium species (Pythium spp.) (Pythium debarianum, standing grain raw rotten mould (Pythium graminicola), abnormal female corruption mould (Pythium irregulare), Pythium ultimum (Pythium ultimum)), gray mold (Botrytis cinerea), stalk break (Sclero.tinia sclerotiorum) or southern blight (Sclerotium rolfsii);

Japanese radish (Japanese radish) disease belongs to leaf spot (rape raw chain lattice spores (Alternaria brassicicola)) as interlinkage bag;

Lawn disease is as coin pinta (Sclerotinia homeocarpa) and brown spot and huge pinta (Rhizoctonia solani Kuhn (Rhizoctonia solani));

Banana disease is as leaf spot (banana secret note leaf spot fungi (Mycosphaerella fijiensis), the false tail spore of banana (Mycosphaerella musicola));

Sunflower disease is as downy mildew (sunflower reveals bacterium germ (Plasmopara halstedii));

Seed disease or the early stage disease of each plant growth, it is by aspergillus species (Aspergillus spp.), Penicillium species (Penicillium spp.), Fusarium species (Fusarium spp.), gibberella species (Gibberella spp.), trichoderma species (Tricoderma spp.), thielaviopsis sp species (Thielaviopsis spp.), Rhizopus species (Rhizopus spp.), Mucor species (Mucor spp.), corticium species (Corticium spp.), Phoma species (Phoma spp.), Rhizoctonia species (Rhizoctonia spp.) or Diplodia species (Diplodia spp.) cause, with

The viral disease of the each Plants being mediated by many Acarasiales species (Polymixa spp.) or oil can Pseudomonas species (Olpidium spp.).

In the situation that seed, bulb etc. are processed, the example of its expection high plant disease of controlling effect of the present invention is comprised:

Damping off and the root rot on wheat, barley, corn, rice, Chinese sorghum, soybean, cotton, rape, beet and the lawn being caused by pythium species (Pythium spp.) (Pythium debarianum, standing grain raw rotten mould (Pythium graminicola), abnormal female corruption mould (Pythium irregulare), Pythium ultimum (Pythium ultimum));

The silk mould root rot of capsule (Aphanomyces cochlioides) of beet;

The brown stem rot (Phytophthora sojae) of soybean;

The balck shank (Phytophthora nicotianae) of tobacco;

The downy mildew (Plasmopara halstedii) of sunflower; With

The late blight (Phytophthora infestans) of potato.

By by the Guardian of effective dose and Avermectin is applied to damage by disease and insect or damage by disease and insect is perched or the place of the plants and soil that may perch, can disease and pest control.

By the Guardian of effective dose and Avermectin are applied to plant or the soil for growing plant, can disease and pest control and can protective plant avoid the infringement of damage by disease and insect.Example as the plant of subject comprises the leaf of plant, the seed of plant, the bulb of plant.Bulb used herein refers to bulb, bulb, rhizome, stem tuber, piece root and root holder.

When being applied to damage by disease and insect, plant or during for the soil of growing plant, in the same period separate administration of Guardian and Avermectin, still, in order to use simplicity, they are used usually used as the composition for disease and pest control of the present invention.

The processing that the example of control method of the present invention comprises leaves of plants is used as foliar spray; The processing example in cultivation of plants soil is as soil treatment; The processing of seed is as seed disinfection and seed pelleting; And bulb is as the processing of seed stem tuber.

In control method of the present invention, the example of the processing of leaves of plants comprises the processing method that is applied to plant surface, as foliar spray mist and trunk (trunk) spraying.The example that directly absorbs the processing method of plant before transplanting comprises the method for soaking whole plant or root.Can by by applying solid carrier as mineral powder obtain preparation adhere to root.

The example of the agent, soil treatment method in control method of the present invention comprise be sprayed on soil, soil mixes with chemical liquid and is filled in soil (chemical liquid irrigation, soil injection and chemical liquid instil).The example of pending position comprises around implantation hole, ditch, implantation hole, around ditch, the part between whole surface, the soil and plant of milpa, the region between root, region, tap drain, soil for growth, seedling-raising box, seedling-cultivating tray and the seedbed of trunk below.The example of toeatment period comprise sow before, while sowing, sow after vegetative period immediately, before nursery stage, field planting, when field planting and after field planting.In above-mentioned soil treatment, active component can be applied to plant simultaneously, or the solid fertilizer that comprises active component can be applied to soil as cream fertilizer.Active component also can be sneaked in irrigation liquid, and the example comprise inject irrigating facility as irrigation pipeline, irrigation conduit and sprinkler (sprinkler), sneak into the flood irrigation liquid between ditch dug with a plow, and sneak into water culture medium.Alternatively, irrigation liquid and active component mix in advance, and for example for the irrigation method processing by suitable, comprise that the above-mentioned irrigation method of mentioning and additive method are as sprinkling irrigation and flood irrigation.

The example of processing the method for seed or bulb in control method of the present invention comprises the method for the treatment of the protected seed or the bulb that avoid damage by disease and insect by the compositions-treated for disease and pest control of the present invention, and its instantiation comprises spraying processing, wherein by the suspension atomization of the composition for disease and pest control of the present invention, and be sprayed on the surface of the seed or bulb surface; Smear processing, wherein by the wetting powder of the composition for disease and pest control of the present invention, emulsion or can flowable add a small amount of water or undiluted be applied to seed or bulb; Immersion treatment, is wherein soaked in seed solution a period of time of the composition for disease and pest control of the present invention; Film coating processing; With pill Cotton seeds.

While processing by Guardian and Avermectin when plant or for the soil of growing plant, for the treatment of Guardian and the amount of Avermectin can be according to changes such as the kind of pending floristics, damage by disease and insect to be controlled and occurrence frequency, dosage form, toeatment period, weather conditions, but every 10,000 m ²guardian and the total amount (the hereinafter referred to as amount of active component) of Avermectin be generally 1-5000g, and 2-500g preferably.

Emulsion, wetting powder and can the common dilute with water of flowable, and spray afterwards for the treatment of.In these cases, the total concentration of Guardian and Avermectin is conventionally in the scope of 0.0001-3% weight, preferably 0.0005-1% weight.Pulvis and granule conventionally do not dilute and for the treatment of.

In seed treatment, the amount of active component to be administered is generally the scope of 0.001-10g/kg seed, preferably 0.01-3g/kg seed.

Control method of the present invention can be used for agricultural land as field, rice field, meadow and orchard, or for non-agricultural land.

The present invention can be used for the damage by disease and insect in the agricultural land of controlling following for cultivating " plant " etc., and does not adversely affect plant etc.

The example of plant is as follows:

Crops are as corn, rice, wheat, barley, rye, oat, Chinese sorghum, cotton, soybean, peanut, buckwheat, beet, rape, sunflower, sugarcane and tobacco;

Vegetables, as Solanum vegetables comprise eggplant, tomato, pimento (pimento), green pepper and potato, cucurbitaceae vegetable comprises cucumber, pumpkin, custard squash, watermelon, muskmelon and pumpkin, brassicaceous vegetable comprises japanese radish, ternip, horseradish, root-mustard, Chinese cabbage, wild cabbage, leaf mustard, broccoli and cauliflower, aster section vegetables comprise burdock, garland chrysanthemum, arithoke and lettuce, liliaceous vegetable comprises shallot, onion, garlic and asparagus, umbrella flower section (ammiaceous) vegetables comprise carrot, parsley, celery and Indian Epimeredi Herb, goosefoot vegetable comprises spinach and Swiss chard, peppermint section vegetables comprise purple perilla, peppermint and sweet basil, strawberry, sweet potato, Japan Chinese yam and taro,

Flowers;

Ornamental foliage plant;

Turfgrass;

Fruit, as pomaceous fruits (pomaceous) fruit comprises apple, pears, Japanese pear, pawpaw is with Quinces Quince, stone fruit (stone fleshy fruits) comprises peach, plum, nectarine, apricot plum (Prunus mume), cherry, apricot and plum, citrus fruit comprises mandarin orange, orange, lemon, bitter orange and grapefruit, nut fruits comprises chestnut, walnut, fibert, almond, pistachio, cashew nut and macadamia nut, soft fruits comprises blueberry, the red certain kind of berries, blackberry, blueberry and raspberry, grape, persimmon, olive, plum (Japanese plum), banana, coffee, jujube and coconut, with

Tree beyond fruit tree, as tea tree, mulberry tree, decorative flower, and street tree comprises Chinese scholartree (ash), birch, dogwood, eucalyptus, ginkgo, cloves, maple, robur, willow, cercis, Chinese sweet gum, plane tree, beech tree (zelkova), Japanese arbor-vitaes (Japanese arborvitae), fir tree, Chinese hemlock spruce tree, thorn cypress, pine tree, dragon spruce and Japanese yew.

Control method of the present invention is especially used in the agricultural land of cultivated maize, rice, wheat, barley, Chinese sorghum, cotton, soybean, beet, rape, turfgrass or potato and controls disease.

Above-mentioned " plant " comprises following plant, it has been given for example isoxazole humulone (isoxaflutole) of HPPD inhibitor by classical breeding method or genetic engineering technology, for example imazethapyr of ALS inhibitor (imazethapyr) or thifensulfuronmethyl (thifensulfuron-methyl), epsp synthase inhibitor is as glyphosate (glyphosate), glutamine synthetase inhibitor is careless ammonium phosphine (glufosinate) for example, acetyl group CoA carboxylase inhibitor is as sethoxydim (sethoxydim), with for example Brominal of weed killer herbicide (bromoxynil), dicamba (dicamba), 2, the resistance of 4-D etc.

" plant " example of having given resistance by classical breeding method comprises has rape, wheat, sunflower and the rice of resistance to imidazolone type ALS inhibition weed killer herbicide as imazethapyr, it is commercialization, and name of product is Clearfield (registration mark).Similarly, exist by classical breeding method and given sulfonylureas ALS inhibition weed killer herbicide as the soybean of the resistance of thifensulfuronmethyl, it is commercialization, and name of product is STS soybean.Similarly, the example of having given the resistance to for example three ketoximes of acetyl group CoA carboxylase inhibitor or aryloxy group phenoxy propionic acid weed killer herbicide by classical breeding method comprises SR corn.The plant of having given the resistance to acetyl group CoA carboxylase inhibitor is described in Proceedings of the National Academy of Sciences of the United States of America (Proc. Natl. Acad. Sci. USA); vol. 87, pp. 7175-7179 (1990).The acetyl group CoA carboxylase of anti-acetyl group CoA carboxylase inhibitor makes a variation at Weed Science; vol. 53; pp. report in 728-746 (2005); and pass through in the gene introduced plant of this acetyl group CoA carboxylase variation by genetic engineering technology; or by giving in the variation introduced plant CoA carboxylase of resistance, can produce the plant of anti-acetyl group CoA carboxylase inhibitor.In addition; by will having introduced nucleic acid (being rendered as chimeraplasty (Chimeraplasty) technology) (the Gura T. 1999 of base replacement variation; Repairing the Genome ' s Spelling Mistakes; Science 285:316-318) be introduced into plant cell within; by pinpoint amino acid replacement mutation being introduced in the acetyl group CoA carboxylase gene or als gene of plant, can produce the plant of anti-acetyl group CoA carboxylase inhibitor or ALS inhibitor etc.

The example of having given the plant of resistance by genetic engineering technology comprises corn, soybean, cotton, rape, the beet with glyphosate resistance, they are commercialization, and name of product is RoundupReady (registration mark), AgrisureGT etc.Similarly, have corn, soybean, cotton and the rape of the anti-careless ammonium phosphine obtaining by genetic engineering technology, it is that commercialization, name of product are the classification of LibertyLink (registration mark).Equally, the commercialization of the cotton of the anti-Brominal obtaining by genetic engineering technology, name of product is BXN.

Aforementioned " plant " comprises the genetic engineering crop that uses this genetic engineering technology to produce, and it for example can synthesize known selectivity toxin in bacillus (genus Bacillus).

The example of the toxin of expressing in these genetic engineering crops comprises: derived from waxy Bacillus ( bacillus cereus) or Japanese beetle bacillus ( bacillus popilliae) insecticidal proteins; Derived from bacillus thuringiensis ( bacillus thuringiensis) delta-endotoxin, for example Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C; Insecticidal proteins is VIP1, VIP2, VIP3 or VIP3A for example; Derived from the insecticidal proteins of nematode; Produce the toxin from animal, for example scorpion toxin, spider toxin, melittin or insect-specific neurotoxin; Mycotoxin (mold fungi toxins); Phytolectin; Agglutinin; Protease inhibitors, for example trypsin inhibitor, serpin, potato tubers storage protein (patatin), cystatin or antipain; Ribosome inactivating protein (RIP), for example ricin (WA), corn RIP, abrin, Seeds of Luffa cylindrica albumen, Saponaria officinalis albumen or briodin; Steroid metabolism enzyme, for example 3-hydroxy steroid oxidase, decortication steroid class-UDP-glucosyltransferase or cholesterol oxidase; Moulting hormone inhibitor; HMG-COA reductase; Inhibitors of ion channels, for example sodium channel inhibitor or ockers; Juvenile hormone esterase; Diuretic hormone acceptor; Stilbene synthase; Bibenzyl synthase; Chitinase; And dextranase.

The toxin of expressing in this genetic engineering crop also comprises: delta-endotoxin proteins for example CrylAb, CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl, Cry9C, Cry34Ab or Cry35Ab and insecticidal proteins are as the hybrid toxins of VIP1, VIP2, VIP3 or VIP3A; Excalation toxin; With modified toxin.This hybrid toxins is used the new combination results of genetic engineering technology from the different structure territory of these albumen.As the toxin of excalation, comprise that the Cry1Ab of partial amino-acid series disappearance is always for known.Modified toxin is prepared by the one or more amino acid whose displacement of natural toxin.

This toxin is described in EP-A-O 374 753, WO 93/07278, WO 95/34656, EP-A-O 427 529, EP-A-451 878, WO 03/052073 etc. with the example of the genetic engineering plant that can synthesize this toxin.

Being included in toxin in this genetic engineering plant can give plant particularly to belonging to the resistance of insect disease insect pest of coleoptera, Semiptera, diptera, Lepidoptera and nematode.

The disease and insect resistance gene that it contains one or more desinsections and its genetic engineering plant of expressing one or more toxin are known, and some of these genetic engineering plants are commercially available.The example of these genetic engineering plants comprises YieldGard (registration mark) (expressing the corn variety of Cry1Ab toxin), YieldGard Rootworm (registration mark) (expressing the corn variety of Cry3Bb1 toxin), YieldGard Plus (registration mark) (expressing the corn variety of Cry1Ab and Cry3Bb1 toxin), Heculex I (registration mark) (expressing phosphine oxamate N-acetyltransferase (PAT) to give the corn variety of the resistance to Cry1Fa2 toxin and careless ammonium phosphine), NuCOTN33B (registration mark) (expressing the cotton variety of Cry1Ac toxin), Bollgard I (registration mark) (expressing the cotton variety of Cry1Ac toxin), Bollgard II (registration mark) (expressing the cotton variety of Cry1Ac and Cry2Ab toxin), VIPCOT (registration mark) (expressing the cotton variety of VIP toxin), NewLeaf (registration mark) (expressing the Potato Cultivars of Cry3A toxin), NatureGard (registration mark), Agrisure (registration mark) GT Advantage (GA21 resistance glyphosate characteristic), Agrisure (registration mark) CB Advantage (Bt1l corn borer (CB) characteristic), and Protecta (registration mark).

Aforementioned " plant " also comprises the crop that application genetic engineering technology is produced, and it possesses the ability that produces the antipathogen material with selectively acting.

Known PR albumen etc. is this antipathogen material (PRPs, EP-A-0 392 225).This antipathogen material and their genetic engineering crop of generation are described in EP-A-0 392 225, WO 95/33818, EP-A-0 353 191 etc.

The example of this antipathogen material of expressing in genetic engineering crop comprises: inhibitors of ion channels is as sodium channel inhibitor or ockers (the known KP1 being produced by virus, KP4 and KP6 toxin etc.); Stilbene synthase; Bibenzyl synthase; Chitinase; Dextranase; PR albumen; For example, with the antipathogen material by microorganisms, peptide antibiotic, there is the antibiotic of heterocycle, the rho factor (it be called plant disease resistance genes, and be described in WO 03/000906) relevant to disease resistance in plants.The genetic engineering plant of these antipathogen materials and these materials of generation is described in EP-A-0392225, WO 95/33818, EP-A-0 353191 etc.

Above-mentioned " plant " mentioned comprises by genetic engineering technology has given the plant that beneficial characteristics is improved characteristic or amino acid content enhancing characteristic as oil plant (oil stuff) composition.The example comprises VISTIVE (registration mark) low linolenic soybean, it has linolenic acid (linolenic) content reducing, or height-lysine (height-oil) corn (corn that lysine or oil content increase).Above-mentioned " plant " also comprises by genetic engineering technology and given the plant to environmental stress-tolerance, described environment-stress as drought stress, salt stress, heat stress, coldly coerce, pH coerces, light is coerced or coercing of being caused by heavy-metal contaminated soil.

Also comprise and pile up kind (stack varieties), wherein combine multiple beneficial characteristic as the weed killer herbicide feature of above-mentioned classics or herbicide tolerance genes, harmful insect-resistant gene, antipathogen material produce gene, oil plant composition improves characteristic or amino acid content strengthens characteristic and environmental stress-tolerance gene.

Embodiment

Although the present invention is described in more detail the example of formulations by below, seed treatment embodiment and test example, the present invention is not limited to the following example.In the following embodiments, unless illustrate in addition, part (part) represents weight portion.

Example of formulations 1

Fully mix 0.5 part of Guardian, 3 parts of Avermectin, 14 parts of polyoxyethylene styryl phenyl ethers, 6 parts of calcium dodecyl benzene sulfonates and 76.5 parts of dimethylbenzene, thus the emulsion of obtaining.

Example of formulations 2

Mixture (weight ratio 1:1) and 55 parts of water of two (2) parts of Guardians, 8 parts of Avermectin, 35 parts of white carbons and polyoxyethylene alkyl ether ammonium sulfate are mixed, and mixture carries out fine lapping according to wet lapping method, thereby obtain the preparation that can flow.

Example of formulations 3

By two (2) parts of Guardians, 10 parts of Avermectin, 1.5 part of three oleic acid Isosorbide Dinitrate and 31.5 parts of aqueous solution that comprise 2 parts of polyvinyl alcohol, and mixture carries out fine lapping according to wet lapping method.Afterwards, 45 parts of aqueous solution that comprise 0.05 part of xanthans and 0.1 part of aluminium-magnesium silicate are added in the mixture obtaining, and further add wherein 10 parts of propane diols.The mixture obtaining is passed through to stir fusion, thereby obtain the preparation that can flow.

Example of formulations 4

Five (5) parts of Guardians, 40 parts of Avermectin, 5 parts of propane diols (Nacalai Tesque production), 5 parts of SoprophorFLK (Rhodia Nikka production), 0.2 part of anti-form C emulsion (Dow Corning production), 0.3 part of proxel GXL (Arch Chemicals production) and 49.5 parts of ion exchange waters are mixed, thereby obtain this somaplasm (bulk slurry).150 parts of beades (diameter=1 millimeter) are added in this slurry of 100 parts, and in this slurry of simultaneous grinding by water quench 2 hours.After grinding, gains are filtered to remove bead, and obtain the preparation that can flow.

Example of formulations 5

Ten (10) parts of Guardians, 40 parts of Avermectin, 38.5 parts of NN kaolin (Takehara Chemical Industrial production), 10 parts of MorwetD425 and 1.5 parts of MorwerEFW (Akzo Nobel Corp. production) are mixed to get to AI premix.This premix is ground by airflow milling, thereby obtain powder formulation.

Example of formulations 6

Two (2) parts of Guardians, 3 parts of Avermectin, 1 part of synthetic hydrated silica, 2 parts of calcium lignosulfonates, 30 parts of bentonites and 62 parts of kaolin are fully ground and mixed, and the mixture obtaining is added water and fully mediate, then carry out granulation and dry, thereby obtain granular preparation.

Example of formulations 7

Ten five (15) parts of Guardians, 20 parts of Avermectin, 3 parts of calcium lignosulfonates, 2 parts of lauryl sodium sulfate and 60 parts of synthetic hydrated silicas are fully ground and mixed, thereby obtain wetting powder.

Example of formulations 8

One (1) part of Guardian, 5 parts of Avermectin, 84 parts of kaolin and 10 parts of talcums are fully ground and mixed, thereby obtain powder formulation.

Seed treatment embodiment 1

By rotation seed processing machine (seed medicine stirring device (seed dresser) for the emulsion of preparation in example of formulations 1, Hans-Ulrich Hege GmbH produces) be used for smearing processing with the amount of the dry sorghum seeds of 500ml/100kg, thus obtain the seed of processing.

Seed treatment embodiment 2

Rotation seed processing machine for the flowed preparation of preparation in example of formulations 2 (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of 50ml/10kg Herba Rorippae seed, thereby obtains the seed of processing.

Seed treatment embodiment 3

Rotation seed processing machine for the flowed preparation of preparation in example of formulations 3 (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of the dry corn seed of 40ml/10kg, thereby obtains the seed of processing.

Seed treatment embodiment 4

Flowed preparation, 5 parts of pigment BPD6135 (Sun Chemical production) and 35 parts of water of preparation in five (5) parts of example of formulations 4 are mixed to prepare mixture.Rotation seed processing machine for this mixture (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of the dry rice of 60ml/10kg, thereby obtains the seed of processing.

Seed treatment embodiment 5

The powder formulation of preparation in example of formulations 5 is used for to pulvis Cotton seeds with the amount of the dry corn seed of 50g/10kg, thereby obtains the seed of processing.

Seed treatment embodiment 6

Rotation seed processing machine for the emulsion of preparation in example of formulations 1 (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of the dry beet seed of 500ml/100kg, thereby obtains the seed of processing.

Seed treatment embodiment 7

Rotation seed processing machine for the flowed preparation of preparation in example of formulations 2 (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of the dry soya seeds of 50ml/10kg, thereby obtains the seed of processing.

Seed treatment embodiment 8

Rotation seed processing machine for the flowed preparation of preparation in example of formulations 3 (seed medicine stirring device, Hans-Ulrich Hege GmbH produces) is used for smearing processing with the amount of the dry wheat seed of 50ml/10kg, thereby obtains the seed of processing.

Seed treatment embodiment 9

The flowed preparation of preparation in five (5) parts of example of formulations 4,5 parts of pigment BPD6135 (Sun Chemical production) and 35 parts of water are mixed, and by rotation seed processing machine (seed medicine stirring device for the mixture obtaining, Hans-Ulrich Hege GmbH produces) be used for smearing processing with the amount of 70ml/10kg potato tubers piece (tuber pieces), thus obtain the seed of processing.

Seed treatment embodiment 10

The flowed preparation of preparation in five (5) parts of example of formulations 4,5 parts of pigment BPD6135 (Sun Chemical production) and 35 parts of water are mixed, and by rotation seed processing machine (seed medicine stirring device for the mixture obtaining, Hans-Ulrich Hege GmbH produces) be used for smearing processing with the amount of 70ml/10kg sunflower seeds, thus obtain the seed of processing.

Seed treatment embodiment 11

The pulvis of preparation in example of formulations 5 is used for to pulvis Cotton seeds with the amount of the dry cotton seeds of 40g/10kg, thereby obtains the seed of processing.

Test example 1

Prepare respectively dimethyl sulfoxide (DMSO) (the being abbreviated as below DMSO) solution of Guardian and the DMSO solution of Avermectin B, and these solution are mixed to prepare the DMSO mixed solution of the Avermectin B of the Guardian that comprises 1% weight and 1% weight.Mix five (5) g corn (Pioneer) seeds and 12.5 μ L DMSO mixed solutions by rocking in 50-ml conical pipe, the seed that then makes its hold over night process with preparation.Polypots is loaded with sandy soil, and sowed in the above the seed of processing, cover with the sandy soil of the wheat bran culture that is mixed with pythium damping off cause of disease (abnormal female corruption is mould) afterwards.The seed of sowing is watered, then under 15 DEG C, certain humidity, cultivate 2 weeks.Check the quantity of germinating corn seedling, and calculate disease incidence by equation 1.

In order to calculate controlling value, also check disease incidence when seed is not processed by this test compounds therein.

Controlling value is calculated based on definite thus disease incidence by equation 2.

The results are shown in table 1.

" equation 1 "

The incidence of disease={ (sum of the seed broadcasting sowing)-(sprouting the quantity of seedling) } × 100/ (sum of the seed broadcasting sowing)

" equation 2 "

Controlling value=100 × (A-B)/A

A: the disease incidence of not using the plant of any test compounds processing

B: with the disease incidence of the plant of test compounds processing.

Table 1

Test compounds	Active component dosage (g/100kg seed)	Controlling value
			Guardian+Avermectin B	2.5 + 2.5	86

Test example 2

Prepare respectively the DMSO solution of Guardian and the DMSO solution of Avermectin B, and these solution are mixed to prepare the DMSO mixed solution of the Avermectin B of the Guardian that comprises 2% weight and 1% weight.Mix ten (10) μ L DMSO mixed solutions and 1 g cucumber (Sagamihanjiro) seed by rocking in 15-ml conical pipe, the seed that then makes its hold over night process with preparation.Polypots is loaded with sandy soil, and sowed in the above the seed of processing, cover with the sandy soil of the wheat bran culture that is mixed with pythium damping off cause of disease (abnormal female corruption is mould) afterwards.The seed of sowing is watered, then under 18 DEG C, certain humidity, cultivate 1 week.Check the quantity of sprouting cucumber seedling, and calculate disease incidence by equation 1.

The results are shown in table 2.

Table 2

Test compounds	Active component dosage (g/100kg seed)	Controlling value
			Guardian+Avermectin B	10 + 5	100

Test example 3

Prepare respectively the DMSO solution of Guardian and the DMSO solution of Avermectin, and these solution are mixed to prepare the Guardian and the DMSO mixed solution of Avermectin of 1% weight and the DMSO mixed solution of the Avermectin of the Guardian that comprises 1% weight and 1% weight that comprise 2% weight.Mix 25 (25) μ L DMSO mixed solution and 10g corn (Pioneer) seed separately by rocking in 50-ml conical pipe, the seed that then makes its hold over night process with preparation.Polypots is loaded with sandy soil, and sowed in the above the seed of processing, cover with the sandy soil of the wheat bran culture that is mixed with pythium damping off cause of disease (Pythium ultimum) afterwards.The seed of sowing is watered, then under 18 DEG C, certain humidity, cultivate 2 weeks, and check and control effect.As a result of, in the seed separately with Guardian and Avermectin processing, observe the excellent effect for controlling plant disease.

Industrial applicibility

The present invention can provide have excellent active for the composition of disease and pest control with for the effective method of disease and pest control.

Claims

1. for the composition of disease and pest control, it comprises as the Guardian of active component and Avermectin, the scope that wherein weight ratio of Guardian and Avermectin is 1:1-2:1.

2. seed treatment, it comprises as the Guardian of active component and Avermectin, the scope that wherein weight ratio of Guardian and Avermectin is 1:1-2:1.

3. for the method for disease and pest control, it comprises the Guardian of effective dose and Avermectin is applied to damage by disease and insect, plant or the soil for growing plant, the scope that wherein weight ratio of Guardian and Avermectin is 1:1-2:1.

4. Guardian and Avermectin are for the use in conjunction of disease and pest control, the scope that wherein weight ratio of Guardian and Avermectin is 1:1-2:1.