CN102641121A - New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs) - Google Patents
New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs) Download PDFInfo
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- CN102641121A CN102641121A CN2011100386431A CN201110038643A CN102641121A CN 102641121 A CN102641121 A CN 102641121A CN 2011100386431 A CN2011100386431 A CN 2011100386431A CN 201110038643 A CN201110038643 A CN 201110038643A CN 102641121 A CN102641121 A CN 102641121A
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Abstract
The invention relates to new technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs). The effect of the antihypertensive TCMs on improving microcirculation is evaluated through measurement of microvessel blood flow and the curative effects of the TCMs on treating hypertensive diseases and improving prognosis of the complications are further evaluated. The microvessel blood flow can be rapidly, intuitively and effectively measured by measuring the microvessel blood flow volume with a speckle full-frame real-time scanning imaging system in a non-contact and nondestructive manner and generating color images corresponding to measured areas in different perfusions. The new technology can be widely applicable to microcirculation of body surface parts of human bodies and common experimental animals and provides a more valuable basis for comprehensively evaluating the efficacy of the antihypertensive medicines.
Description
Technical field
The invention belongs to medical technical field, the present invention relates to a kind of new technique of estimating the resisting hypertension herbal medicine efficacy, mainly relate to the measuring method of blood capillary blood flow.
Background technology
Hypertension is the disease of serious harm health and quality of life, is one of most important high risk factor of myocardial infarction, heart failure, apoplexy, ESRD and peripheral blood vessel.Pathogenesis of hypertension is very complicated, with hemorheology change, kidney sodium retention, RAS, the transhipment of sodium, vascular reactivity increases thickens with tube wall, the effect of sympathetic nervous system, vasodilation hormone, neuropeptide, insulin resistant etc. are relevant.Microcirculation is the blood circulation in the blood capillary between arteriole and the venule, is the 26S Proteasome Structure and Function unit of basic unit in the blood circulation, comprises arteriole, blood capillary and thin vein.Research shows, exist tangible microcirculation unusual in the primary hypertension patient, and the order of severity of the microcirculation disturbance degree and the state of an illness is proportionate.It is dark violet that the hypertension nail fold microcirculation mainly shows as color; Hemorrhage and the nipple of pipe loop is smooth to be increased, vascular morphology is unusual, intersection, deformity are many; Blood flow is slack-off; Be grain stream, grain linear flow, in the erythrocyte, severe is assembled microcirculation disturbance that the Peripheral resistance of blood circulation is obviously increased, thereby make hypertension; And the hypertension that continues slows down microcirculatory blood flow, and hemocyte is assembled, and further increases the weight of microcirculation dysfunction, and further increases the weight of the infringement of target organ, and microcirculatory function and configuration state have reflected the extent of damage of hypertension to target organ.Vascular morphology is unusual behind the microcirculation disturbance. influenced inside and outside mass exchange area and the speed of blood capillary; The change of blood fluidised form influences the physicochemical character and the oxygen carrying capacity of blood; The change of all states of loop has influenced the homergy of blood vessel surrounding tissue and cell.Great mass of data shows that patients with hypertension microcirculation occurs and changes and the microcirculatory change basically identical of body surface.There are nail fold, bulbar conjunctiva, words, gums, foot wrinkle etc. in the position of body surface microcirculation detection clinically, observes the microcirculatory state of nail fold and has reflected the microcirculatory pathological change of whole body internal organs to a certain extent.
Discover that it is the first step that hypertension causes target organ damage that little blood flow reduces, after the hypertension, small artery shrinks and even spasm in the brain, and tissue perfusion descends, and causes the interior erythrocyte speed of blood vessel to slow down.Speckle full frame real time scan imaging system is a kind of non-invasi vascular test technology, through observation to the periphery microcirculation blood flow, but the multiple blood circulation diseases on every side of auxiliary diagnosis.At present; Estimate the variation that resisting hypertension Chinese medicine curative effect generally adopts the administration front and back arteriotony of chemical medicine; This method can not reflect that resisting hypertension Chinese medicine is to microcirculatory improvement effect; Can not reflect the prognosis of hypertension and complication thereof, more can not show the characteristics and the advantage of treatment by Chinese herbs hypertension.On the basis of blood pressure determination, utilization new pattern laser Doppler technology is observed the hypotensive effect of resisting hypertension Chinese medicine and to microcirculatory improvement effect, for the prognosis of its resisting hypertension curative effect of thoroughly evaluating and its complication provides foundation.Technology provided by the invention is a kind of brand new technical of resisting hypertension herbal medicine efficacy further investigation, can give prominence to the characteristics and the advantage that show resisting hypertension Chinese medicine.
Summary of the invention
The object of the invention provides a kind of new technique of estimating the resisting hypertension herbal medicine efficacy, adopts this new technique to observe the effect of resisting hypertension Chinese medicine microcirculation improvement blood flow, further estimates the prognosis that it is treated hypertension curative effect and improves complication.
Evaluating drug effect for the treatment hypertension drug among the present invention is to realize through the mensuration to the blood capillary blood flow.Measure microvascular blood flow with no damage through the noncontact of speckle full frame real time scan imaging system, produce corresponding and, can fast, intuitively, effectively measure the blood capillary blood flow with the corresponding coloured image of different perfusion flows with measurement zone.Observe of the influence of resisting hypertension Chinese medicine, for the curative effect of thoroughly evaluating treatment by Chinese herbs hypertension and the prognosis of complication thereof provide foundation, outstanding characteristics and the advantage that shows resisting hypertension Chinese medicine to little blood flow.
Of the present invention applied widely, can comprise the microcirculation of animals such as rat, mice, rabbit adaptable across measuring people and common experimental animal.Its microcirculation location can be the body surface position of human body and animal, comprises the microcirculation at the positions such as ear, face, foot and afterbody of ear, face, foot and animal.
The specific embodiment
Embodiment 1 uses the blood flow of laser-Doppler blood-stream image commercial measurement SHR waking state lower tail root 1cm, observes the influence of Chinese medicine compound Ji beniol to SHR root of the tail portion microcirculatory blood flow.Get 50 of spontaneous hypertensive rats, be divided into five groups at random, normal saline group (NS control), positive controls (captopril), Ji beniol high dose group (jimaitong; 10g/kg), and dose groups in the Ji beniol (jimaitong, 5g/kg), Ji beniol low dose group (jimaitong; 2.5g/kg), nine every group, before the gastric infusion and after the administration 2,4; 6,8, measure its blood capillary blood flow with this method behind the 10h, The data t check.
The result shows; The Ji beniol gastric infusion of various dose has improvement effect in various degree to SHR rat blood capillary blood flow; The influence that high dose is all organized blood flow lasted till 8 hours always; Middle low dose group lasted till always 6 hours that to the influence to blood flow high dose group is the most remarkable to the improvement effect of blood capillary blood flow.Shown that this new technique can be applicable to estimate the effect of compound blood pressure reducing Chinese medicine to microcirculation blood flow.
Table 1 resisting hypertension Chinese medicine compound Ji beniol is to the influence of SHR afterbody microcirculatory blood flow
The treatment group is compared with positive controls:
*P＜0.05
*P＜0.01
Embodiment 2 uses laser-Doppler blood-stream image commercial measurement normal human fingernail position microcirculation blood flow value, and measures pressure value simultaneously, explores dependency between the two.Select 50 of 20～60 years old age volunteers, wherein the man is 15,35 of woman; Press the relevant requirements that human blood-pressure is measured, left hand is measured blood pressure, right finger first position microcirculation blood flow value; Discover; Systolic pressure is divided into three blood pressure level by 92～100mmHg, 101～111mmHg and 112～140mmHg,, explains that blood pressure becomes negative correlation with microcirculatory blood flow along with blood pressure level increases the also corresponding minimizing of microcirculatory blood flow.Explanation can be through this evaluation of new technology compound blood pressure reducing Chinese medicine drug effect, and further predict anti hypertension Chinese medicine microcirculation improvement blood flow and to the protective effect of target organ more can reflect hypertensive characteristics of treatment by Chinese herbs and advantage.
Table 2 normal human blood pressure and microcirculation blood flow value
Claims (4)
1. a new technique of estimating the resisting hypertension herbal medicine efficacy is characterized in that the mensuration through the blood capillary blood flow, observes the effect of resisting hypertension Chinese medicine microcirculation improvement, further estimates the prognosis that it is treated hypertension curative effect and improves complication.For thoroughly evaluating resisting hypertension Chinese medicine provides foundation to the prognosis of hypertension and complication thereof, highlight the characteristics and the advantage of resisting hypertension Chinese medicine.
2. a kind of new technique of estimating the resisting hypertension herbal medicine efficacy according to claim 1; It is characterized in that: a certain regional inner tissue of continuous measurement non-contactly hemoperfusion amount; Produce corresponding and with the corresponding coloured image of different perfusion flows with measurement zone; Can fast, intuitively, effectively measure the blood capillary blood flow, estimate the curative effect and the advantage of resisting hypertension Chinese medicine.
3. a kind of new technique of estimating the resisting hypertension herbal medicine efficacy according to claim 1 is characterized in that and can comprise the microcirculation of animals such as human body and rat, mice, rabbit adaptable across measuring people and common experimental animal.
4. a kind of new technique of estimating the resisting hypertension herbal medicine efficacy according to claim 1; It is characterized in that the microcirculation location can be the body surface position of human body and animal, comprises the microcirculation at the positions such as ear, face, foot and afterbody of ear, face, foot and animal.
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| CN2011100386431A CN102641121A (en) | 2011-02-16 | 2011-02-16 | New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs) |
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| CN2011100386431A CN102641121A (en) | 2011-02-16 | 2011-02-16 | New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110811593A (en) * | 2019-11-07 | 2020-02-21 | 天津中医药大学第二附属医院 | Method for judging liver hemodynamics characteristics of hypertension traditional Chinese medicine syndrome |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1853702A (en) * | 2005-04-26 | 2006-11-01 | 杨吉星 | Chinese medicinal preparation for lowering blood sugar, blood fat and blood pressure, improving blood flow and immune and its making method |
| WO2010029032A1 (en) * | 2008-09-15 | 2010-03-18 | Robert Bosch Gmbh | Measurement device and measurement method |
| CN101784227A (en) * | 2007-07-06 | 2010-07-21 | 工业研究有限公司 | laser speckle imaging systems and methods |
| CN101928757A (en) * | 2009-06-26 | 2010-12-29 | 上海主健生物工程有限公司 | Detection of curative effect of antihypertensive drug |
-
2011
- 2011-02-16 CN CN2011100386431A patent/CN102641121A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1853702A (en) * | 2005-04-26 | 2006-11-01 | 杨吉星 | Chinese medicinal preparation for lowering blood sugar, blood fat and blood pressure, improving blood flow and immune and its making method |
| CN101784227A (en) * | 2007-07-06 | 2010-07-21 | 工业研究有限公司 | laser speckle imaging systems and methods |
| WO2010029032A1 (en) * | 2008-09-15 | 2010-03-18 | Robert Bosch Gmbh | Measurement device and measurement method |
| CN101928757A (en) * | 2009-06-26 | 2010-12-29 | 上海主健生物工程有限公司 | Detection of curative effect of antihypertensive drug |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110811593A (en) * | 2019-11-07 | 2020-02-21 | 天津中医药大学第二附属医院 | Method for judging liver hemodynamics characteristics of hypertension traditional Chinese medicine syndrome |
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Application publication date: 20120822 |