CN102614559A - Automatic drug delivery system and drug delivery method for hydroxylcamptothecin injection - Google Patents
Automatic drug delivery system and drug delivery method for hydroxylcamptothecin injection Download PDFInfo
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- CN102614559A CN102614559A CN2012100952710A CN201210095271A CN102614559A CN 102614559 A CN102614559 A CN 102614559A CN 2012100952710 A CN2012100952710 A CN 2012100952710A CN 201210095271 A CN201210095271 A CN 201210095271A CN 102614559 A CN102614559 A CN 102614559A
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Abstract
The invention discloses an automatic drug delivery system and a drug delivery method for hydroxycamptothecin injection. The automatic drug delivery system comprises an infusion module, a human-computer interaction module, a display module, a timing module, a motor execution module, an alarm monitoring module and a computer processing module. The drug delivery method includes: inputting prepared liquid medicine into the infusion module, setting or confirming drug delivery amount, drug delivery time, intermittent time, drug delivery times and alarm information; monitoring whether warning information exists or not, and if not, operating first-time drug delivery while the timing module starts timing; when the set drug delivery time is up, allowing a motor to pause to enter a low-power-consumption mode while timing is unstopped; when the set intermittent time is up, automatically increasing the drug delivery times by one, and allowing a motor module to reoperate to start next-time drug delivery; and finishing drug delivery when drug delivery times in operation is larger than the initially set drug delivery times. Using the system and the method can improve curative effects of hydroxycamptothecin and reduce drug toxic and side effects, and accordingly quality of life can be improved for patients.
Description
Technical field
The present invention relates to a kind of drug-supplying system and medication thereof, is intermittently the automatic chemical feeding system and the medication thereof of administration that a kind of spy is used for the hydroxycamptothecin injection specifically.
Background technology
Hydroxycamptothecin (being called for short HCPT) is a kind of natural alkaloid that from China endemic plant Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), extracts; Be the antineoplastic agent of China in the independent development seventies in 20th century; Because this medicine clinical efficacy is reliable, safety is good, and HCPT has obtained extensive clinical practice in many countries.
HCPT is two-compartment model, t in vivo
1/2 αBe 0.0523-0 613h, t
1/2 βBe 1.03-2.42h, Vd:5.4-11.40 L, plasma protein binding rate is 65%～99%.Bone marrow depression is the dose limitation property untoward reaction of HCPT, shows as granulocyte and descends, and is dose dependent, and 1-2 all interior granulocytes return to normal level after the drug withdrawal.Digestive tract reaction: feel sick, vomit I one II degree, mostly the persistent period is 2-3d.Diarrhoea increases with dosage, and the generation ratio is dose dependent, and low middle dosage degree is lighter.Part patient has abnormal liver function, and hematuria, erythra appear in few patients.
The pharmacology of hydroxycamptothecin different modes of administration compares, clinical dosage 12mg/m
2d
-1HCPT is dissolved in 0.9% sodium chloride injection by the body surface area conversion.Constant speed intravenous drip in 30 minutes, logotype 5 days; Constant speed intravenous drip in 4 hours, logotype 10 days; Constant speed intravenous drip in 8 hours, logotype 10 days.In these three kinds of medications, the instillation time is that 4,8 hours rate of adverse reactions was than 30 minutes lacked.
Administration a period of time; Stop the mode of this administration at intermittence of a period of time; Can reach effective blood drug concentration fast; Avoid blood drug level occurring with situation more than the minimum toxic dose below the MEC, improved the curative effect of hydroxycamptothecin, reduced untoward reaction generation and poisonous side effect of medicine.
But; Existing automatic chemical feeding system; Generally be the even administration within a certain period of time of certain dosage, and be not suitable for the mode of this administration at intermittence of hydroxycamptothecin, in order to improve curative effect; Reduce untoward reaction, need a kind of spy to be used for the intermittently automatic chemical feeding system of administration of hydroxycamptothecin administration.
Summary of the invention
The present invention is directed to the deficiency of prior art; A kind of automatic chemical feeding system and medication thereof of hydroxycamptothecin injection are provided, have controlled instillation time and blanking time automatically, infusion monitoring is crossed title in real time; Noresidue liquid is the administration implementation of a kind of high accuracy, high safety.
The automatic chemical feeding system of hydroxycamptothecin injection of the present invention comprises infusion module, human-computer interaction module, display module, timing module, motor execution module, alarm monitoring module, computer processing module;
Infusion module is to store the hydroxycamptothecin medicinal liquid prepare, infuse to the disposable operative installations of human body, packs through sterilization, connects with motor execution module and alarm monitoring module;
Human-computer interaction module is used for the setting or the affirmation of dosage regimen, the operation of equipment, the setting of warning and only ring;
Display module is used for the demonstration of device content, comprises operating demonstration on-screen-display messages such as " which time administration, remaining times ", and the information of warning shows;
Timing module is used for timing instillation time and interval dwell time;
The motor execution module is used for the infusion pipeline that the motor running drives cam extruding infusion module;
The alarm monitoring module is used in the running monitoring whether cautions such as bubble, obstruction, aneroid, battery electric quantity deficiency being arranged, as long as accomplish monitoring by optocoupler, touch force sensor, reports to the police when information warning occurring, and reporting to the police the back drug-supplying system can be out of service automatically;
Computer processing module is used to receive all command informations of whole drug-supplying system, comprises human-computer interaction module, display module, motor execution module, alarm monitoring module, timing module, and described functional module is given in concurrent load instruction;
Human-computer interaction module, display module, timing module, motor execution module, alarm monitoring module connect with computer processing module respectively, the continuous recursive call human-computer interaction module of computer processing module, display module, timing module, motor execution module, alarm monitoring module.
And, the automatic chemical feeding system of described hydroxycamptothecin injection, wherein, described human-computer interaction module includes keyboard button.
And, the automatic chemical feeding system of described hydroxycamptothecin injection, wherein, described alarm monitoring module is provided with buzzer.
And, the automatic chemical feeding system of described hydroxycamptothecin injection, wherein, but the display screen display reminding is reported to the police and the buzzer call warning during warning.
And; The user uses for ease; For the user who always uses a kind of dosage regimen, computer processing module also has memory function, can remember the parameter that was provided with when moving last time; Before memory function can continue until and effectively revises parameter next time, shutdown or outage did not influence the memory of parameter yet.
And the affirmation of described dosage regimen comprises information such as confirming administration total amount, administration time, intermittent time, administration number of times, warning.
And described dosage regimen is administration total amount 100 ~ 200ml, administration time 20 ~ 40min, intermittent time 20 ~ 40min, administration number of times 5 ~ 15 times.
The medication of the automatic chemical feeding system of hydroxycamptothecin of the present invention may further comprise the steps:
(1) the hydroxycamptothecin medicinal liquid for preparing is put into infusion module;
(2) pass through human-computer interaction module setting or affirmation administration total amount, administration time, intermittent time, administration number of times, warning message;
(3) whether monitoring has information warnings such as bubble, stopping state, just takes corresponding measure to get rid of earlier if having, and like the administration for the first time that then do not bring into operation, timing module picks up counting simultaneously;
When (4) reaching the administration time of setting, the motor operation suspension gets into low-power consumption mode, and timing does not stop;
When (5) reaching the intermittent time of setting, administration number of times adds 1 automatically, and motor module turns round again and begins administration next time;
(6) when the administration number of times in when operation during greater than the administration number of times of initial setting, administration finishes.
And whole process is monitored by the alarm monitoring module, can set the situation that needs warning as required before the administration; When appearance needed the caution situation of warning, computer processing module control motor module was out of service, timing pause TP; The display module display reminding is reported to the police and buzzer call is reported to the police; After these situation were got rid of, motor reruned administration, and timing begins.
The intermittently administration of this hydroxycamptothecin automatic chemical feeding system divides administration instillation time and dwell time at intermittence, most preferably 1 of injection hydroxycamptothecin (specification 10mg) is dissolved in 0.9% sodium chloride injection of 100ml; Inject infusion module; Each administration 30 minutes stops 30 minutes, administration 10 times; Amount to 5 hours instillation time, logotype 5 days.The administration of this kind method can reach effective blood drug concentration fast, and effective blood drug concentration can stable maintenance, drug effect is able to continue, give full play to, and has avoided blood drug level occurring with situation more than the minimum toxic dose below the MEC; Simultaneously, can improve the curative effect of hydroxycamptothecin, reduce poisonous side effect of medicine, reaching increases the toleration of human body to medicine, improves patient's quality of life.
In addition, this automatic chemical feeding system also has memory function, can remember the parameters that be provided with last time automatically, need not to use all Reparametrizations at every turn, and is also very convenient for the patient of a kind of dosage regimen of life-time service.
And the automatic chemical feeding system and the medication administration thereof of hydroxycamptothecin injection of the present invention are even, easy and simple to handle, flexible, automaticity is higher, safe and reliable.
Description of drawings
Fig. 1 is the module diagram of the automatic chemical feeding system of hydroxycamptothecin injection of the present invention.
Fig. 2 is the administration schematic flow sheet of the medication of embodiment according to the invention.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Be dissolved in 100ml 0.9% sodium chloride injection with 1 of injection hydroxycamptothecin (specification 10mg), administration 30 minutes stops 30 minutes, and administration is for ten times an example.
With reference to the module diagram of Fig. 1 and the administration schematic flow sheet of Fig. 2, as shown in the figure, the hydroxycamptothecin medicinal liquid for preparing is put into infusion module, the keyboard button through human-computer interaction module is confirmed dosage regimen: the administration total amount is 100ml, administration 30 minutes, stop 30 minutes, administration ten times, mechanical disorder, obstruction, bubble, aneroid, battery electric quantity is not enough, transfusion will finish, infuse, and end is all reported to the police; Computer processing module receives signal, and storage dosage regimen, alarm monitoring module begin to detect whether information warnings such as bubble or obstruction are arranged; If then the motor execution module does not bring into operation, cam extruding pipeline carries out administration first time, the timing of starting working of while timing module; When administration reaches 30 minutes, send signal, computer processing module control motor module operation suspension to computer processing module; Get into low-power consumption mode, begin to wait for that timing module does not stop timing; When timing reached 1 hour, administration number of times added 1, motor operation beginning administration for the second time; Constantly circulation in this way, when administration number of times during greater than 10 times, administration finishes; Motor module is out of service, and whole process is monitored by the alarm monitoring module, when mechanical disorder, obstruction, bubble, aneroid occur, battery electric quantity is not enough, transfusion will finish, infuse end etc. warned situation; Computer processing module control motor module is out of service, and timing pause TP, display module display reminding are reported to the police and buzzer call is reported to the police; After these situation were got rid of, motor reruned administration, and timing begins.
And the user uses for ease, for use for a kind of user of dosage regimen always; Computer processing module also has memory function, can remember the parameter when moving last time, before memory function can continue until and effectively revises parameter next time; Shutdown does not influence the memory of operational factor yet, and with above-mentioned dosage regimen, still can remember total amount when next drug-supplying system moves is 100ml; Administration 30 minutes stops 30 minutes, administration ten times; Only need but this scheme is confirmed just administration, and need not to reset again the adjustment data.
In addition, before the administration, can close or open some warning function, when closing certain warning function, this kind situation drug-supplying system occur, display prompts and buzzing can not take place yet report to the police still by setting operation according to user's needs.
The HCPT half-life is short, and metabolism is very fast in vivo; Apparent volume of distribution is little, and it is limited to distribute, and organizes affinity low; High with plasma protein binding rate, medicine is difficult in people's cell.The pharmacokinetics character of HCPT has limited it again to a certain extent in Clinical Application.Therefore adopt above-mentioned automatic chemical feeding system to continue medication to reduce drug toxicity, improve curative effect, enlarge clinical application range.
Above embodiment only supplies to explain the present invention's usefulness, but not limitation of the present invention, the technical staff in relevant technologies field under the situation that does not break away from the spirit and scope of the present invention, can also make various conversion or variation.Therefore, all technical schemes that are equal to also should belong to category of the present invention, should be limited each claim.
Claims (9)
1. the automatic chemical feeding system of a hydroxycamptothecin injection is characterized in that, comprises infusion module, human-computer interaction module, display module, timing module, motor execution module, alarm monitoring module, computer processing module;
Infusion module is used to store the hydroxycamptothecin medicinal liquid, infuses to human body, connects with motor execution module and alarm monitoring module;
Human-computer interaction module is used for the setting or the affirmation of dosage regimen, the operation of equipment and stopping, the setting of warning and end ring;
Display module is used for the demonstration of device content, and the information of warning shows;
Timing module is used for timing instillation time and interval dwell time;
The motor execution module is used for the infusion pipeline that the motor running drives cam extruding infusion module;
The alarm monitoring module is used in the running monitoring whether information warning being arranged, and when finding information warning, reports to the police, and accomplishes monitoring by optocoupler, touch force sensor, and connects with infusion module;
Computer processing module is used to receive the command information of whole drug-supplying system, comprises human-computer interaction module, display module, motor execution module, alarm monitoring module, timing module, and described functional module is given in concurrent load instruction;
Human-computer interaction module, display module, timing module, motor execution module, alarm monitoring module connect with computer processing module respectively, and computer processing module calls human-computer interaction module, display module, timing module, motor execution module, alarm monitoring module.
2. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 1 is characterized in that described human-computer interaction module comprises keyboard button.
3. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 1 is characterized in that, described alarm monitoring module is provided with buzzer.
4. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 3 is characterized in that, the display screen display reminding is reported to the police and the buzzer call warning during warning.
5. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 1 is characterized in that, the parameter information that once moves before the described computer processing module memory.
6. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 1 is characterized in that described dosage regimen comprises administration total amount, administration time, intermittent time, administration number of times.
7. the automatic chemical feeding system of hydroxycamptothecin injection according to claim 1 is characterized in that, described dosage regimen is administration total amount 100 ~ 200ml, administration time 20 ~ 40min, intermittent time 20 ~ 40min, administration number of times 5 ~ 15 times.
8. the medication based on the automatic chemical feeding system of the said hydroxycamptothecin injection of claim 1 is characterized in that this method comprises the following steps:
(1) medicinal liquid for preparing is put into infusion module;
(2) setting or affirmation administration total amount, administration time, intermittent time, administration number of times, warning message;
(3) whether monitoring has information warning, the administration for the first time that then do not bring into operation, and timing module picks up counting simultaneously;
When (4) reaching the administration time of setting, the motor operation suspension gets into low-power consumption mode, and timing does not stop;
When (5) reaching the intermittent time of setting, administration number of times adds 1 automatically, and motor module turns round again and begins administration next time;
When (6) administration number of times in when operation was greater than the administration number of times of initial setting, administration finished.
9. medication according to claim 8 is characterized in that whole process is monitored by the alarm monitoring module; When the caution situation occurring, computer processing module control motor module is out of service, timing pause TP; The display module display reminding is reported to the police, buzzer call is reported to the police; After the caution situation was got rid of, motor reruned administration, and timing begins.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210095271.0A CN102614559B (en) | 2012-04-01 | 2012-04-01 | Automatic drug delivery system for hydroxylcamptothecin injection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210095271.0A CN102614559B (en) | 2012-04-01 | 2012-04-01 | Automatic drug delivery system for hydroxylcamptothecin injection |
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| CN102614559B CN102614559B (en) | 2014-04-09 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2577853Y (en) * | 2002-10-21 | 2003-10-08 | 霍丁格·包尔文(苏州)电子测量技术有限公司 | Infusion controller |
| US20040077997A1 (en) * | 2002-10-22 | 2004-04-22 | Jasperson Keith E. | Drug infusion system programmable in flex mode |
| CN101052930A (en) * | 2004-05-28 | 2007-10-10 | 施曼信医疗Md公司 | Medical infusion pump capable of learning bolus time patterns and providing bolus alerts |
| CN101618244A (en) * | 2009-07-09 | 2010-01-06 | 葛锋 | Implementation method of digital transfusion monitoring and alarming system |
-
2012
- 2012-04-01 CN CN201210095271.0A patent/CN102614559B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2577853Y (en) * | 2002-10-21 | 2003-10-08 | 霍丁格·包尔文(苏州)电子测量技术有限公司 | Infusion controller |
| US20040077997A1 (en) * | 2002-10-22 | 2004-04-22 | Jasperson Keith E. | Drug infusion system programmable in flex mode |
| CN101052930A (en) * | 2004-05-28 | 2007-10-10 | 施曼信医疗Md公司 | Medical infusion pump capable of learning bolus time patterns and providing bolus alerts |
| CN101618244A (en) * | 2009-07-09 | 2010-01-06 | 葛锋 | Implementation method of digital transfusion monitoring and alarming system |
Non-Patent Citations (4)
| Title |
|---|
| 《中国临床药理学杂志》 20011130 李苏 等 羟基喜树碱（HCPT）不同给药方式的药理学比较 第427-430页 1-7 第17卷, 第6期 * |
| 《医用生物力学》 20081031 高辞修 等 实体肿瘤药物输运与给药方式的集中参数模型及实验研究 第132-133页 7 第23卷, * |
| 李苏 等: "羟基喜树碱（HCPT）不同给药方式的药理学比较", 《中国临床药理学杂志》 * |
| 高辞修 等: "实体肿瘤药物输运与给药方式的集中参数模型及实验研究", 《医用生物力学》 * |
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Effective date of registration: 20200724 Address after: 435000, 108 East st Wang Road, Huangshi economic and Technological Development Zone, Hubei, China Patentee after: HUANGSHI YANWU PHARMACEUTICAL Co.,Ltd. Address before: 430073, Hubei, East Lake province Wuhan New Technology Development Zone, South Industrial Park, South Lake Avenue 81, Huangshi Li Shizhen Pharmaceutical Group Wuhan Li Shizhen Pharmaceutical Co., Ltd. Patentee before: HUANGSHI LISHIZHEN PHARMACEUTICAL GROUP WUHAN LISHIZHEN PHARMACEUTICAL Co.,Ltd. |
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Granted publication date: 20140409 Termination date: 20200401 |
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