CN102614394A - 用于猩红热的银紫柏皮汤 - Google Patents
用于猩红热的银紫柏皮汤 Download PDFInfo
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Abstract
本发明涉及一种药物配方领域，具体地说是一种用于猩红热的银紫柏皮汤，采用金银花、紫草、紫菀、侧柏叶、牡丹皮、桑叶、茜草、白芷、全蝎、僵蚕、白芍、葛根、地骨皮、防风、白茅根、车前子、甘草为原料用水浸泡，煎熬后去渣得滤液，原料组成以重量百分比计为：金银花7～10％、紫草4～7％、紫菀4～6％、侧柏叶4～7％、牡丹皮5～8％、桑叶4～6％、茜草3～6％、白芷4～6％、全蝎2～3％、僵蚕3～5％、白芍4～7％、葛根6～9％、地骨皮5～8％、防风4～6％、白茅根7～9％、车前子5～7％、甘草2～5％。本发明成本低，治疗猩红热疗效高，无过敏、毒性反应，无副作用，且可防止发生变态反应。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种用于猩红热的银紫柏皮汤。
背景技术
众所周知，猩红热是A组B型链球菌引起的急性呼吸道传染病，传染源主要为病人和带菌者。A组B型溶血性链球菌引起的咽峡炎患者，排菌量大且不易被重视，是重要的传染源。主要经空气飞沫传播，也可经皮肤创伤处或产妇产道而引起“外科型猩红热”或“产科型猩红热”。全年均可发病，但冬春季多，夏秋季少，可发生于任何年龄，但以儿童最为多见。其临床特征为发热，咽峡炎，全身弥漫性鲜红色皮疹和皮疹消退后明显脱屑。少数患者病后可出现变态反应性心、肾、关节损害。临床一般分为普通型、脓毒型、中毒型和外科型四种。实验室检查血象白细胞总数升高可达(10～20)×109/L，中性粒细胞在80％以上，严重患者可出现中毒颗粒，出疹后嗜酸粒细胞增多占5％～10％。尿液如果发生肾脏变态反应并发症，则可出现尿蛋白，红细胞，白细胞及管型。临床治疗急性期主要是卧床休息，进行呼吸道隔离及抗生素药物应用。大量应用抗生素尤其对儿童，易产生过敏反应，毒性反应及发生变态反应。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种成本低，治疗猩红热疗效高，无过敏、毒性反应，无副作用，且可防止发生变态反应，具有清热解毒透痧，辛凉泻热滋阴，益气养血生津，镇惊熄风润喉等功效，对猩红热普通型、脓毒型、中毒型、外科型均有效。
本发明解决上述技术问题采用的技术方案是：一种用于猩红热的银紫柏皮汤，采用金银花、紫草、紫菀、侧柏叶、牡丹皮、桑叶、茜草、白芷、全蝎、僵蚕、白芍、葛根、地骨皮、防风、白茅根、车前子、甘草为原料用水浸泡，煎熬后去渣得滤液，原料组成以重量百分比计为：金银花7～10％、紫草4～7％、紫菀4～6％、侧柏叶4～7％、牡丹皮5～8％、桑叶4～6％、茜草3～6％、白芷4～6％、全蝎2～3％、僵蚕3～5％、白芍4～7％、葛根6～9％、地骨皮5～8％、防风4～6％、白茅根7～9％、车前子5～7％、甘草2～5％。
本发明的有益效果是，成本低，治疗猩红热疗效高，无过敏、毒性反应，无副作用，且可防止发生变态反应，具有清热解毒透痧，辛凉泻热滋阴，益气养血生津，镇惊熄风润喉等功效，对猩红热普通型、脓毒型、中毒型、外科型均有效。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用金银花、紫草、紫菀、侧柏叶、牡丹皮、桑叶、茜草、白芷、全蝎、僵蚕、白芍、葛根、地骨皮、防风、白芦根、车前子、甘草为原料制备而成。其组分(重量％)每付为金银花9.4、紫草6.1、紫菀5.6、侧柏叶6.1、牡丹皮7.5、桑叶5.8、茜草4.1、白芷4.9、全蝎2.1、僵蚕4.5、白芍6.2、葛根7.9、地骨皮6.8、防风5.3、白茅根8.2、车前子6.2、甘草3.3。取上述17味中草药总重量173克，在室温下将17味中草药加水至1100～1200ml，浸泡3～4小时，然后用武火煮沸文火煎熬至60～70分钟，去渣得滤液300ml左右药汁，药渣再加水300～400ml，煎熬30～40分钟，去渣得滤液100ml，共得400ml左右药汁，即制得银紫柏皮汤，装入无菌玻璃瓶内，密封瓶盖备用。每日1剂分3次口服，每次空腹服80ml。余160ml药汁放入保温瓶中，用时先加温，先用热气熏洗患部皮肤，待药液降温后再以消毒棉签蘸药汁涂擦患部皮肤。如果是外伤型，可用棉签蘸取药汁从伤口处涂擦，每日二次，每次20～30分钟。一般应用1周左右。
本发明主药金银花药理作用：抑菌试验：本品在试管内对金黄色葡萄球菌、白色葡萄球菌、甲型溶血性链球菌、乙型溶血性链球菌、非溶血性链球菌、伤寒杆菌、志贺氏痢疾杆菌、人型结核杆菌、肺炎双球菌均有抑制作用，金银花能与胆固醇结合，从而可减少家兔肠道对胆固醇的吸收。性味甘、寒，归肺、心、胃经。具有清热解毒，凉散风热功效。用于痈肿疔疮、喉痹、丹毒、热毒血痢、风热感冒，温病发热。紫草对家兔试验性发热，口服紫草煎剂有缓和的解热作用。紫草有明显的抑制小鼠动情周期和生育力的效果，并有明显的抗垂体促性腺激素及抗绒毛膜促性腺激素的作用。抑菌试验：紫草生理盐水浸液对絮状表皮癣菌、羊毛状小芽胞癣菌等皮肤真菌均有抑制作用。性味甘、咸、寒，归心、肝经。具有凉血、活血、解毒透疹功效，用于血热毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤。紫菀皂素能使动物呼吸道分泌物增加，而有祛痰作用。紫菀对艾氏腹水癌有抗癌作用，抑菌实验，对金黄色葡萄球菌、宋内氏痢疾杆菌、变形杆菌、伤寒杆菌、副伤寒杆菌、大肠杆菌及绿脓杆菌等均有抑制作用。对常见致病性皮肤真菌亦有抑制作用，其水煎剂在鸡胚尿囊中对流感病毒有明显的抑制作用。性味辛、苦、温、归肺经。具有润肺下气、消痰止咳功效，用于痰多喘咳、新久咳嗽、劳嗽咳血。侧柏叶性味苦、涩、寒、归肺、肝、脾经，具有凉血止血、生发乌发功效，用于吐血、衄血、咯血、便血、崩漏下血、血热脱发、须发早白。牡丹皮性味苦、辛、微寒，归心、肝、肾经。具有清热凉血、活血化瘀，用于温毒发斑、吐血衄血、夜热早凉、无汗骨蒸、经闭痛经、痈肿疮毒、跌扑伤痛。桑叶性味甘、苦、寒，归肺、肝经。具有疏散风热、清肺润燥、清肝明目功效，用于风热感冒、肺热燥咳、头晕头痛、目赤昏花。茜草性味苦、寒，归肝经。具有凉血、止血、祛瘀、通经功效，用于吐血、衄血、崩漏、外伤出血、经闭瘀阻、关节痹痛、跌扑肿痛。白芷性味辛、温，归胃、大肠、肺经。具有散风除湿、通窍止痛、消肿排脓功效，用于感冒头痛、眉棱骨痛、鼻塞、鼻渊、牙痛、白带、疮疡肿痛。全蝎性味辛、平、有毒，归肝经，具有息风镇痉、攻毒散结、通络止痛功效，用于小儿惊风、抽搐痉挛、中风口呙、半身不遂、破伤风、风湿顽痹、偏正头痛、疮疡、瘰疬。僵蚕性味咸、辛、平，归肝、肺、胃经。具有祛风定惊、化痰散结功效，用于惊风抽搐、咽喉肿痛、皮肤瘙痒、颌下淋巴结炎、面神经麻痹。白芍性味辛、酸、微寒，归肝、脾经。具有平肝止痛、养血调经、敛阴止汗功效，用于头痛眩晕、胁痛、腹痛、四肢挛痛、血虚萎黄、月经不调、自汗盗汗。葛根性味甘、辛、凉，归脾、胃经。具有解肌退热、生津、透疹、升阳止泻功效，用于外感发热头痛、项背强痛、口渴、消渴、麻疹不透、热痢、泄泻、高血压颈项强痛。地骨皮性味甘、寒，归肺、肝、肾经。具有凉血除蒸、清肺降火功效，用于阴虚潮热、骨蒸盗汗、肺热咳嗽、咯血、衄血、内热消渴。防风性味辛、甘、温，归膀胱、肝、脾经。具有解表祛风、胜湿、止痉功效，用于感冒头痛、风湿痹痛、风疹瘙痒、破伤风。白茅根性味甘、寒，归肺、胃、膀胱经。具有凉血止血、清热利尿功效，用于血热吐血，衄血、尿血，热病烦渴、黄疸、水肿、热淋涩痛、急性肾炎水肿。车前子性味甘、微寒，归肝、肾、肺小肠经。具有清热利尿、渗湿通淋、明目、祛痰功效，用于水肿胀满、热淋涩痛、暑湿泄泻、目赤肿痛、痰热咳嗽。甘草性味甘、平，归心、肺、脾胃经。具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药功效，用于脾胃虚弱、倦怠无力、心悸气短、咳嗽痰多、脘腹、四肢挛急疼痛、痈肿疮毒、缓解药物毒性、烈性。17味中草药巧妙组方，科学配伍，药物相互协调作用，共奏猩红热之特效。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现。其加工工艺与实施例1相同。
下面结合我院，即山东省威海市文登中心医院进行的临床预试验对本发明作进一步、详细地描述：
1、病例选择：所选病例为临床上具有猩红热特征性表现，实验室检查白细胞数高达(10～20)*109/L，中性粒细胞占80％以上，胞质内可见中毒颗粒，出疹后嗜酸性粒细胞增多，可占5％甚至10％。咽拭子，脓液培养获得A组链球菌为确诊依据，结合病史诊断为猩红热患者61例，年龄9～46岁；男34例，女27例，其诊断符合杨绍基，任红主编的《传染病学》第7版诊断标准。
诊断标准：中医诊断标准参照国家中医药管理局发布的《中医病证诊断疗效标准》。
2、治疗方法：每日1剂分3次口服，每次空腹服80ml左右。余160ml左右药汁放入保温瓶中，用时先加温，先用热气熏洗患部皮肤，待药液降温后再以消毒棉签蘸药液涂擦患部皮肤。如果是外伤型，可用棉签蘸取药汁从伤口外涂擦，每日二次，每次20～30分钟，应用1周。
3、疗效判断：
治愈：体温正常，咽部炎症及皮疹消失，病程已达7天以上，鼻咽部分泌物培养阴性，实验室检查细胞数恢复正常。
好转：体温基本恢复正常，临床症状体征明显好转，病程已达7天，鼻咽部分泌物培养弱阳性，实验室检查细胞数仍高于正常。
无效：患者体温不降，临床症状体征无改变或略减轻，咽拭子培养阳性，实验室检查细胞数居高不下。
4、治疗效果：使用本发明61例，按照疗效评价标准进行治疗效果评价，治愈49例，好转7例，无效5例，总有效率为91.8％。
Claims (1)
1.一种用于猩红热的银紫柏皮汤，其特征是：采用金银花、紫草、紫菀、侧柏叶、牡丹皮、桑叶、茜草、白芷、全蝎、僵蚕、白芍、葛根、地骨皮、防风、白茅根、车前子、甘草为原料用水浸泡，煎熬后去渣得滤液，原料组成以重量百分比计为，金银花7～10％、紫草4～7％、紫菀4～6％、侧柏叶4～7％、牡丹皮5～8％、桑叶4～6％、茜草3～6％、白芷4～6％、全蝎2～3％、僵蚕3～5％、白芍4～7％、葛根6～9％、地骨皮5～8％、防风4～6％、白茅根7～9％、车前子5～7％、甘草2～5％。
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| CN104721566A (zh) * | 2015-03-25 | 2015-06-24 | 郑巧丹 | 一种用于治疗毒侵肺卫型烂喉痧的中药 |
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| CN103446274A (zh) * | 2013-09-09 | 2013-12-18 | 陈欣 | 一种治疗小儿猩红热的中药口服液及其制备方法 |
| CN103446274B (zh) * | 2013-09-09 | 2014-08-20 | 李秀玲 | 一种治疗小儿猩红热的中药口服液及其制备方法 |
| CN104721566A (zh) * | 2015-03-25 | 2015-06-24 | 郑巧丹 | 一种用于治疗毒侵肺卫型烂喉痧的中药 |
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