CN102603607B - Preparation method of (R)-oxiracetam - Google Patents
Preparation method of (R)-oxiracetam Download PDFInfo
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- CN102603607B CN102603607B CN201110024526.XA CN201110024526A CN102603607B CN 102603607 B CN102603607 B CN 102603607B CN 201110024526 A CN201110024526 A CN 201110024526A CN 102603607 B CN102603607 B CN 102603607B
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- ethyl ester
- oxiracetam
- exchange resin
- glycine ethyl
- thick product
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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CN201110024526.XA CN102603607B (en) | 2011-01-21 | 2011-01-21 | Preparation method of (R)-oxiracetam |
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CN201110024526.XA CN102603607B (en) | 2011-01-21 | 2011-01-21 | Preparation method of (R)-oxiracetam |
Publications (2)
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CN102603607A CN102603607A (en) | 2012-07-25 |
CN102603607B true CN102603607B (en) | 2014-06-11 |
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CN201110024526.XA Active CN102603607B (en) | 2011-01-21 | 2011-01-21 | Preparation method of (R)-oxiracetam |
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CN105330582B (en) * | 2014-08-07 | 2018-08-07 | 重庆润泽医药有限公司 | (R) preparation method of-Esomeprazole |
KR20170137910A (en) * | 2015-05-18 | 2017-12-13 | 충칭 룬즈 파마슈티컬 컴퍼니 리미티드. | Application of R-oxylacetam in pharmaceutical field |
EP3530272A4 (en) * | 2016-10-24 | 2020-03-25 | Chongqing Runze Pharmaceutical Company Limited | Novel crystalline form of dextral oxiracetam, preparation method therefor and use thereof |
JP2019531323A (en) * | 2016-10-24 | 2019-10-31 | チョンキン ランゼ ファーマスーティカル カンパニー リミテッド | (R) -4-Hydroxy-2-oxo-1-pyrrolidineacetamide crystal form, preparation method, use |
EP3530271A4 (en) | 2016-10-24 | 2020-03-25 | Chongqing Runze Pharmaceutical Company Limited | Crystalline form ii of dextral oxiracetam, preparation method therefor and use thereof |
CN108299267A (en) * | 2017-01-12 | 2018-07-20 | 重庆润泽医药有限公司 | (R) crystal form and its preparation method and application of -4- hydroxyls -2- oxygen -1- pyrrolidine acetamides |
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CN110384671A (en) * | 2018-04-20 | 2019-10-29 | 重庆润泽医药有限公司 | Fluidized bed granulation prepares dextrorotation oxiracetam capsule and preparation method thereof |
CN110384672A (en) * | 2018-04-20 | 2019-10-29 | 重庆润泽医药有限公司 | The good dextrorotation oxiracetam capsule and preparation method thereof of stability |
CN110384666A (en) * | 2018-04-23 | 2019-10-29 | 重庆润泽医药有限公司 | A kind of method of wet granule compression tablet preparation dextrorotation Oxiracetam tablet |
CN110384667A (en) * | 2018-04-23 | 2019-10-29 | 重庆润泽医药有限公司 | The method of dry granulation tabletting preparation dextrorotation Orazitan dispersion tablet |
CN110384665A (en) * | 2018-04-23 | 2019-10-29 | 重庆润泽医药有限公司 | Crystal type dextrorotation oxiracetam tablet and preparation method thereof |
CN110393706A (en) * | 2018-04-24 | 2019-11-01 | 重庆润泽医药有限公司 | Dextrorotation oxiracetam enteric coatel tablets and preparation method thereof |
CN110393707A (en) * | 2018-04-24 | 2019-11-01 | 重庆润泽医药有限公司 | Dextrorotation Oxiracetam enteric coatel tablets and preparation method thereof |
CN110393704A (en) * | 2018-04-24 | 2019-11-01 | 重庆润泽医药有限公司 | A kind of dextrorotation Orazitan dispersion tablet and preparation method thereof |
CN110393802A (en) * | 2018-04-24 | 2019-11-01 | 重庆润泽医药有限公司 | Dextrorotation oxiracetam dispersible tablet and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1956953A (en) * | 2004-05-25 | 2007-05-02 | 安国药品株式会社 | Process for the preparation of optically pure 4-hydroxy-2-oxo-1-pyrrolidine acetamide |
CN101367757A (en) * | 2008-10-13 | 2009-02-18 | 重庆润泽医疗器械有限公司 | Preparation method for (S)-4-hydroxyl-2-oxo-1-pyrrolidine ethanamide |
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2011
- 2011-01-21 CN CN201110024526.XA patent/CN102603607B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1956953A (en) * | 2004-05-25 | 2007-05-02 | 安国药品株式会社 | Process for the preparation of optically pure 4-hydroxy-2-oxo-1-pyrrolidine acetamide |
CN101367757A (en) * | 2008-10-13 | 2009-02-18 | 重庆润泽医疗器械有限公司 | Preparation method for (S)-4-hydroxyl-2-oxo-1-pyrrolidine ethanamide |
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CN102603607A (en) | 2012-07-25 |
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