CN102579382A - Preparation method for slow-release tablet of indapamide-containing medicament - Google Patents
Preparation method for slow-release tablet of indapamide-containing medicament Download PDFInfo
- Publication number
- CN102579382A CN102579382A CN2012100900985A CN201210090098A CN102579382A CN 102579382 A CN102579382 A CN 102579382A CN 2012100900985 A CN2012100900985 A CN 2012100900985A CN 201210090098 A CN201210090098 A CN 201210090098A CN 102579382 A CN102579382 A CN 102579382A
- Authority
- CN
- China
- Prior art keywords
- hpmc
- indapamide
- granule
- slow
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention aims to provide a preparation method for a slow-release tablet of an indapamide-containing medicament. In the method, water is taken as a wetting agent for performing HPMC (Hydroxy Propyl Methyl Cellulose) wet granulation, and the prepared HPMC particles are compact and regular, are porous on the surface and have high liquidity. HPMC particles and a small amount of indapamide can be uniformly mixed by adopting the conventional mixing way, so that preparation of the slow-release tablet is finished. A plurality of other auxiliary materials are not required to be added additionally, an organic solvent is not required for granulating, the slow release controlling effect on the releasing degree of the prepared tablet is good, and granulation can be completed by adopting the conventional granulation equipment.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, particularly prepare a kind of slow releasing preparation that contains the indapamide medicine.
Background technology
Every of present employed indapamide slow release tablet only contains indapamide low dose of about 1.5mg usually.In the indapamide slow release tablet pharmaceutical formulation, the hydroxypropyl emthylcellulose (HPMC) that much adopts the high viscosity specification is as slow-release auxiliary material.As a kind of medicinal high polymer adjuvant commonly used, HPMC runs into the gel group that forms corrosion gradually than meeting swelling behind the big water gaging, can play good slow release control effect.But when producing, in pharmaceutical formulation, contain viscosity higher with (or) HPMC of big consumption, if adopt wet granulation technology, can receive a lot of restrictions.Can not adopt water is exactly one of them as wetting agent or adhesive solvent granulation; Because directly pour water in material restir mixing no matter be; Still under the material stirring, pour water gradually into and mix, all can make the HPMC powder generate unusual thickness, gel group not of uniform size rapidly, in part dry powder is wrapped in; Becoming the machine stirring is difficult to its finely dispersed caking can't be made granule.Although water granulates to have advantage is arranged a lot, adopt conventional at present wet granulation equipment and technology be can't water as wetting agent or adhesive solvent accomplish to contain viscosity higher with (or) greatly consumption HPMC or only contain this single adjuvant of HPMC and granulate.
In practical study and the production; When containing HPMC in the mixed material; If adopt wet granulation technology; The usage ratio of HPMC and viscosity are unsuitable too high, generally also need add a large amount of non-sticky adjuvants and come " dilution " HPMC, and need employing should not cause the high concentration of HPMC gelation or dehydrated alcohol (or acetone) could accomplish as wetting agent or adhesive solvent.HPMC viscosity and ratio are big more in pharmaceutical formulation, and the more difficult enforcement of technology is when particularly having only this single adjuvant of HPMC, even adopt organic solvent also can't accomplish granulation.Patent application CN101756927A discloses a kind of prescription of indapamide slow release tablet and has formed and method for preparing, needs to use other more a large amount of adjuvants to make filler, and binding agent adopts alcoholic solution.Adopt this method, on producing, a lot of defectives are arranged.As: used organic solvent is volatile, makes that the HPMC granule of processing is comparatively loose, low, the surperficial regularity of density is poor.In this method, make easily again during granulate that the HPMC granule powders again, often has a negative impact to follow-up mixing, tabletting.In addition, high levels of organic solvents uses, and at aspects such as safety, cost, environmental pollution and dissolvent residuals open defect is arranged all.
In the actual production, adopt direct pressed powder or dry granulation mode can overcome the subproblem of foregoing wet granulation, but these methods are had relatively high expectations to equipment and material performance.Undressed HPMC is the fleeces sprills, mobile and compressibility very poor (specification that viscosity is high more is serious more), and the particle diameter of HPMC and indapamide, density have than big-difference in addition, and the indapamide proportion is little, belongs to the mixing of trace drug.Adopt conventional hybrid mode, directly medicine and HPMC are mixed, be difficult to mix homogeneously; Other adjuvant that needs to add more a large amount of good fluidities improves performance; This has not only limited the use of HPMC, has also increased the complexity of cost and prescription, and the while is because of the density variation of medicine and various adjuvants; Again layering easily in the tabletting, these all make quality of the pharmaceutical preparations control difficulty increase.For example; Patent application CN1943564 discloses a kind of prescription of indapamide slow release tablet and has formed and preparation technology, has adopted HPMC as slow-release material, needs to use other more a large amount of adjuvants to make filler; Preparation technology adopts direct pressed powder, implements comparatively difficulty in the production.
Summary of the invention
The purpose of this invention is to provide a kind of slow releasing tablet method for preparing that contains the indapamide medicine.Realized employing water be wetting agent to the HPMC wet granulation, the densification of made HPMC granule is regular, porous surface, good fluidity.Adopt conventional hybrid mode can realize the indapamide mix homogeneously of HPMC granule and trace, accomplish the preparation of slow releasing tablet.Do not need to add in addition other multiple adjuvant, do not need with an organic solvent to granulate, made tablet release degree controlling slow release is respond well, adopts conventional facility for granulating to accomplish.
For realizing that the technical scheme that the object of the invention adopts is such, a kind of slow releasing tablet method for preparing that contains the indapamide medicine may further comprise the steps:
1) moistening: adopt conventional wet granulator with atomising device; Purified water gets in the blending tank of airtight wet granulator with the atomizing form through said atomising device; Simultaneously; Hydroxypropyl emthylcellulose (HPMC) powder is joined in the said blending tank, and constantly stirring makes the surface of HPMC powder fully contact with water smoke, obtains the HPMC moist wood;
2) granulate: adopt and wave granulation machine, the HPMC moist wood that step 1) obtained is granulated, the gained granule obtains the HPMC granule behind super-dry, granulate.
3) mix: step 2) the HPMC granule that obtained and indapamide, lubricant by weight: 50～100: 1.5: 0.25～1 uniform mixing, the mixture tabletting is with the acquisition indapamide slow release tablet.
In the said method, water is wetting agent, can adopt the pharmaceutical purpose purified water.HPMC is the single thing or the mixture of different viscosities specification, and the high viscosity specification accounts for 30%～100%, and middle low viscosity specification is lower than 70%.Full-bodied HPMC dynamic viscosity is more than 4000～100000 mPas, K4M, K15M, the K100M specification of mainly containing commonly used, and low viscous HPMC dynamic viscosity is 5～100mPas, commonly used have E5, E50, a K100 specification.HPMC processes moist wood after mixing, adopt pharmaceutical field general wave granulation machine, cross suitable order number sieve net and process granule, granulate after drying.
Compare prior art, the present invention has following advantage:
1, adopting water is wetting agent, need not use high concentration or dehydrated alcohol to make wetting agent or binding agent as solvent, more economically, safety, environmental protection.The more closely knit rounding of obtained granule is more suitable for mixing and tabletting.
2, in the HPMC granulating process,, greatly increased the specific surface area of water with adding after the water high atomisation.Because; The HPMC powder surface is to contact with water smoke; Make the HPMC wet processes be with powder surface gradually adsorbed water assign to accomplish, rather than after being soaked by the water part again mechanical dispersion accomplish, this makes HPMC can not form to be difficult to dispersive gel group; Under stirring, can make that wet granulation technology is able to carry out by even moistening to the degree that is fit to granulate.This mode has solved the problem that can not directly adopt water that HPMC is granulated at present, and need not add that a large amount of other is inviscid, dilutes as the adjuvant of filler.
3, HPMC becomes the fine particle of surperficial rounding after granulating, and particle surface is covered with micropore simultaneously, angle of repose≤30 °; Have good fluidity, also medicine is had certain adsorption, be difficult for layering; Thereby adopt conventional hybrid mode, can with the indapamide mix homogeneously of trace.In addition, because of not needing to add the performance that other adjuvant improves material in addition, reduced influencing each other of multiple adjuvant, simplified prescription, made that particulate quality controllability is better, cost is lower.
4. production technology is simple, and adopting industry at present to go up conventional efficient wet granulator and pelletizing machine can normal implementing process, and it also is the industrial device of upward using always that institute increases water atomization equipment.
5. method for preparing of the present invention has avoided organic solvents such as employing high concentration or straight alcohol to granulate, except that more economical, and safety and environmental protection more.
The specific embodiment
Below in conjunction with embodiment the present invention is described further, only limits to following embodiment but should not be construed the above-mentioned subject area of the present invention.Under the situation that does not break away from the above-mentioned technological thought of the present invention, according to ordinary skill knowledge and customary means, make various replacements and change, all should comprise within the scope of the present invention.
In an embodiment, a kind of slow releasing tablet method for preparing that contains the indapamide medicine may further comprise the steps:
1) moistening: adopt conventional wet granulator with atomising device; Purified water gets in the blending tank of airtight wet granulator with the atomizing form through said atomising device; Simultaneously; Hydroxypropyl emthylcellulose (HPMC) powder is joined in the said blending tank, and constantly stirring makes the surface of HPMC powder fully contact with water smoke, obtains the HPMC moist wood;
2) granulate: adopt and wave granulation machine, the HPMC moist wood that step 1) obtained is granulated, the gained granule obtains the HPMC granule behind super-dry, granulate.
3) mix: step 2) the HPMC granule that obtained and indapamide, lubricant by weight: 50～100: 1.5: 0.25～1 uniform mixing, the mixture tabletting is with the acquisition indapamide slow release tablet.
Among the embodiment, said wet granulation technology, wetting agent is the pharmaceutical purpose purified water, material has only HPMC.The adding of water is essential satisfies 2 points, and the one, water is essential to reach particle diameter≤10 μ m through atomizing, be preferably≤the mist vapour form of 5 μ m, the 2nd, in HPMC powder and the water smoke contact process, be in continuous stirring.Atomization plant described in the step 1) is ultrasonic atomizatio equipment or high-pressure airless formula nozzle atomization equipment.Further, in the step 1), said atomising device is atomized into purified water the water smoke of particle diameter≤10 μ m.
Among the embodiment, step 2) in, the said granulation machine that waves is processed particle size range 20～30 orders, concentration degree greater than 80% HPMC granule with the HPMC moist wood, its angle of repose≤30 °.This embodiment can be accomplished the mixing to micro-indapamide better, and effect is more excellent.
Embodiment 1～5 through with the comparative illustration of traditional handicraft technique effect of the present invention; Embodiment 6 adopts the disclosed method of the present invention to obtain to close the slow releasing tablet of symbol national drug quality standard.
If do not have to specify, pelletization adopts the efficient wet machine-processed moist wood of granulating among the embodiment, and material is under stirring; The spout of the employing ultrasonic atomizatio of wetting agent through being fixed in efficient wet granulator inner top adds; Cross 20 mesh sieve system wet granulars with waving granulator, behind 60 ℃ of oven dryings, cross the whole dried granule of 16 mesh sieves; With particle grain size distribution behind the sub-sieve mensuration granulate, measure angle of repose with the fixed funnel method.Method is no longer tired in an embodiment to be stated.After water and dehydrated alcohol add,, make the wet granulator stirring paddle receive very big resistance, exceed the equipment normal condition,, can not continue liquid feeding again and stir although material is failed complete wetting because the gel lump that generates is very sticking real.
Embodiment 1:
Compare employing method of granulating of the present invention and direct Jia Shui, added dehydrated alcohol carries out wet granulation to different viscosities HPMC E5 (5 mPas), K4M (4000mPas), K100M (100000mPas) result; Can know from the result; Adopt the inventive method; HPMC to different viscosities can make mode of appearance and the good granule of mobile performance, and adds more the water of volume and also can material viscosity can normally granulate.And directly add water or dehydrated alcohol is granulated to high low viscosity HPMC, and evenly moistening even if add very small amount, all forms the different gel of degree " pimple " rapidly, and can't sieve makes granule.
Respectively the HPMC10kg of different viscosities specification is added in the efficient wet granulator, with 60g/ minute speed add atomized water (particle diameter≤5 μ m) respectively, without the water and the dehydrated alcohol of atomizing, granulate.Measure particle grain size distribution and angle of repose, measure the HPMC powder angle of repose of not granulating simultaneously.The result sees table 1-1,1-2 and 1-3.
Embodiment 2
Compare employing method of granulating of the present invention and direct Jia Shui, added dehydrated alcohol; To containing 30%HPMC (K4M), 70% lactose is the mixture of diluent, carries out the result of wet granulation; Can know from the result; Adopt this method, can make the good granule of mode of appearance and mobile performance, and pelletization more is prone to carry out than embodiment 1.Adopt directly to add dehydrated alcohol, basically evenly moistening has only small amount of gel " pimple ", and the overwhelming majority can be sieved and made better granule.Adopt directly to add water, still generate the serious gel of degree " pimple ", can't sieve makes granule.And the granule that makes with dehydrated alcohol is more loose, and frangible during granulate, fine powder is more.
The HPMC of K4M specification and lactose (3:7) mixture 10kg are added in the efficient wet granulator, with 60g/ minute speed add atomized water (particle diameter≤5 μ m) respectively, without the water and the dehydrated alcohol of atomizing, granulate.Measure particle grain size distribution and angle of repose.The result sees table 2.
Embodiment 3
Compare employing method of granulating of the present invention and directly added dehydrated alcohol; To containing 30%HPMC (K100M), 70% lactose is the mixture of diluent, carries out the result of wet granulation; Can know from the result; Adopt this method, can make the good granule of mode of appearance and mobile performance, and pelletization more is prone to carry out than embodiment 1.Still form more gel " pimple " and directly add dehydrated alcohol, worth granule reluctantly only can partly sieve.
The HPMC of K100M specification and lactose (3:7) mixture 10kg are added in the efficient wet granulator, with 60g/ minute speed add atomized water (particle diameter≤5 μ m) respectively, without the dehydrated alcohol of atomizing, granulate.Measure particle grain size distribution and angle of repose.The result sees table 3.
Can know from the result of embodiment 1～3, adopt method of granulating of the present invention that HPMC is granulated and directly add water or add dehydrated alcohol method granulating efficiency better, also be difficult for realizing also realizing the high viscosity HPMC that granulates granulating for ethanol than existing.In principle, it is better than water atomization wetting effect to adopt atomised form to add affiliation ethanol, but the ethanol of high atomisation is more volatile and sudden and violent fried, and danger is very high, thereby does not adopt.
Embodiment 4
Compared atomize water into≤5 μ m particle diameters and 10-20 μ m particle diameter add the result that HPMC K100M and K4M carry out wet granulation, can know from the result, during water atomization particle diameter≤5 μ m; To all evenly moistenings of HPMC of K100M and K4M specification, all sieving makes granule, during water atomization particle diameter 10-20 μ m; The evenly moistening of K4M specification; All sieving makes granule, and the granulation of can sieving basically of K100M specification, but produces the granulation of can't sieving of small amount of gel lump.Thereby during water atomization particle diameter≤10 μ m, can make the even moistening of HPMC below the viscosity 100000mPas to the degree that is fit to granulate, better effects if during and water atomization particle diameter≤5 μ m.
Respectively the HPMC10kg of K4M and K100M specification is added in the efficient wet granulator, the adjustment supersonic frequency, the atomizing particle size of control water with two scopes of 10-20 μ m in, add respectively with 60g/ minute speed, granulate.Measure particle grain size distribution and angle of repose.The result sees table 4-1 and 4-2.
Embodiment 5
Compared with indapamide respectively with without the ratio of the HPMC K100M that granulates and granulate through the inventive method with 1.5:100; Adopt common double-cone mixer to mix; The result shows; HPMC granule after the granulation mix with indapamide 20 minutes can mix homogeneously, and the HPMC powder similarity condition of not granulating mixes and still failed mix homogeneously in 60 minutes.
Add in the double-cone mixer respectively with making HPMC K100M granule 8kg and 120g indapamide among the embodiment 1; Mix with 12rpm speed; Whenever at a distance from sampling in 10 minutes once, get 6 points at random, each point is got 2g at every turn; According to " indapamide slow release tablet national drug quality standard " (content assaying method among the standard No. WS1-(X-006)-2007Z), the content of indapamide in the mensuration mixture.In addition, the HPMC K100M powder and the indapamide without granulating of equal quality added respectively in the double-cone mixer, operate with method.Blended result sees table 5.
Embodiment 6
Enumerated employing the inventive method; Adopt the HPMC granule of different size, ratio to prepare indapamide slow release tablet as slow-release material, detect by drug release determination method in this kind national drug quality standard, the result shows; The indapamide slow release tablet of different formulations meets 2 hours≤30%; 8 hours 30% ~ 65%, 14 hours>=70% regulation, slow release effect is good.
Prescription 1:
Indapamide 1.5mg
HPMC?K100M?80mg
Magnesium stearate 0.4mg
Prescription 2:
Indapamide 1.5mg
HPMC?K15M?46mg
HPMC?E50 88mg
Magnesium stearate 0.7mg
Prescription 3:
Indapamide 1.5mg
HPMC?K4M?55mg
HPMC?E5 73mg
Magnesium stearate 0.7mg
Prescription 4:
Indapamide 1.5mg
HPMC?K4M?55mg
HPMC?K100?95mg
Magnesium stearate 0.8mg
Method for preparing and drug release determination: by formula proportion HPMC is added in the efficient wet granulator, atomizes water into particle diameter≤5 μ m states, add, make dried granule after, press formula ratio and indapamide, magnesium stearate mix homogeneously after, tabletting makes.Press two appendix of Chinese Pharmacopoeia version in 2010, adopt cuvette oar method, measure releases degree, release medium is a 150ml water, oar rotating speed 75rpm, and behind 2,8,14 hours sampling filterings, the photograph ultraviolet spectrophotometry is measured in the 240nm wavelength.The drug release determination result of each prescription sees table 6.
Claims (4)
1. a slow releasing tablet method for preparing that contains the indapamide medicine is characterized in that, may further comprise the steps:
1) moistening: adopt conventional wet granulator with atomising device; Purified water gets in the blending tank of airtight wet granulator with the atomizing form through said atomising device; Simultaneously; Hydroxypropyl emthylcellulose (HPMC) powder is joined in the said blending tank, and constantly stirring makes the surface of HPMC powder fully contact with water smoke, obtains the HPMC moist wood;
2) granulate: adopt and wave granulation machine, the HPMC moist wood that step 1) obtained is granulated, the gained granule obtains the HPMC granule behind super-dry, granulate;
3) mix: step 2) the HPMC granule that obtained and indapamide, lubricant by weight: 50～100: 1.5: 0.25～1 uniform mixing, the mixture tabletting is with the acquisition indapamide slow release tablet.
2. a kind of slow releasing tablet method for preparing that contains the indapamide medicine according to claim 1 is characterized in that: atomization plant described in the step 1) is ultrasonic atomizatio equipment or high-pressure airless formula nozzle atomization equipment.
3. a kind of slow releasing tablet method for preparing that contains the indapamide medicine according to claim 1 is characterized in that: in the step 1), said atomising device is atomized into purified water the water smoke of particle diameter≤10 μ m.
4. a kind of slow releasing tablet method for preparing that contains the indapamide medicine according to claim 1 is characterized in that: step 2) in, the said granulation machine that waves is processed particle size range 20～30 orders, concentration degree greater than 80% HPMC granule with the HPMC moist wood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100900985A CN102579382A (en) | 2012-03-30 | 2012-03-30 | Preparation method for slow-release tablet of indapamide-containing medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100900985A CN102579382A (en) | 2012-03-30 | 2012-03-30 | Preparation method for slow-release tablet of indapamide-containing medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102579382A true CN102579382A (en) | 2012-07-18 |
Family
ID=46468995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100900985A Pending CN102579382A (en) | 2012-03-30 | 2012-03-30 | Preparation method for slow-release tablet of indapamide-containing medicament |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579382A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103691336A (en) * | 2013-12-19 | 2014-04-02 | 贵州景峰注射剂有限公司 | Liquid adding method for wet mixing of materials |
| CN105012275A (en) * | 2015-08-20 | 2015-11-04 | 广东安诺药业股份有限公司 | Method for preparing indapamide sustained-release preparation |
| WO2023001880A1 (en) | 2021-07-22 | 2023-01-26 | Krka, D. D., Novo Mesto | Bilayer tablet comprising telmisartan and indapamide |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394604A (en) * | 2002-07-12 | 2003-02-05 | 严洁 | Indapamide slowly-releasing tablet |
| CN1397278A (en) * | 2002-07-12 | 2003-02-19 | 严洁 | Process for preparing slow-releasing indapamide tablet |
| CN1943564A (en) * | 2006-10-31 | 2007-04-11 | 宁夏康亚药业有限公司 | Indapamide slow release tablet and its preparing method |
| CN101756927A (en) * | 2008-12-23 | 2010-06-30 | 北京科信必成医药科技发展有限公司 | Indapamide sustained release tablet and preparation method thereof |
| CN102058554A (en) * | 2010-12-28 | 2011-05-18 | 哈药集团三精制药股份有限公司 | Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states |
-
2012
- 2012-03-30 CN CN2012100900985A patent/CN102579382A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394604A (en) * | 2002-07-12 | 2003-02-05 | 严洁 | Indapamide slowly-releasing tablet |
| CN1397278A (en) * | 2002-07-12 | 2003-02-19 | 严洁 | Process for preparing slow-releasing indapamide tablet |
| CN1943564A (en) * | 2006-10-31 | 2007-04-11 | 宁夏康亚药业有限公司 | Indapamide slow release tablet and its preparing method |
| CN101756927A (en) * | 2008-12-23 | 2010-06-30 | 北京科信必成医药科技发展有限公司 | Indapamide sustained release tablet and preparation method thereof |
| CN102058554A (en) * | 2010-12-28 | 2011-05-18 | 哈药集团三精制药股份有限公司 | Method for preparing sustained-release tablets through granulating by adopting bonding agents in atomizing states |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103691336A (en) * | 2013-12-19 | 2014-04-02 | 贵州景峰注射剂有限公司 | Liquid adding method for wet mixing of materials |
| CN105012275A (en) * | 2015-08-20 | 2015-11-04 | 广东安诺药业股份有限公司 | Method for preparing indapamide sustained-release preparation |
| CN105012275B (en) * | 2015-08-20 | 2018-03-27 | 广东安诺药业股份有限公司 | Indapamide slow release agent preparation method |
| WO2023001880A1 (en) | 2021-07-22 | 2023-01-26 | Krka, D. D., Novo Mesto | Bilayer tablet comprising telmisartan and indapamide |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rege et al. | Spray-dried chitinosans: Part I: Preparation and characterization | |
| CN102134281A (en) | Method for producing high-flowability pregelatinized starch | |
| CN103610646B (en) | Composition containing everolimus and preparation method thereof, and pharmaceutical preparation containing composition | |
| CN109925290B (en) | Theophylline sustained release tablet and preparation process thereof | |
| CN102579382A (en) | Preparation method for slow-release tablet of indapamide-containing medicament | |
| CN103040774B (en) | Granulating and coating process of esomeprazole magnesium contained in esomeprazole magnesium enteric-coated tablet | |
| CN113975241B (en) | Preparation process of trelagliptin succinate tablets | |
| CN103127011B (en) | Roflumilast tablet and preparation method thereof | |
| CN107951849B (en) | Amlodipine besylate tablet and preparation method thereof | |
| CN113244180A (en) | Hydroxychloroquine sulfate pharmaceutical preparation | |
| CN101390840B (en) | Production method of high-assay calcium ascorbate granules capable of directly being compressed | |
| CN104840427A (en) | Pharmaceutical composition containing montelukast sodium | |
| CN113304117B (en) | Preparation method of sodium valproate sustained release tablet | |
| CN104523638A (en) | Tablet containing escitalopram oxalate and preparation method thereof | |
| CN104352465B (en) | Prucalopride succinate pharmaceutical composition free of silicon dioxide and preparation method of prucalopride succinate pharmaceutical composition | |
| US20110287168A1 (en) | Wet Granulation System Comprising at Least One Ultrasonic Nozzle | |
| CN102106824A (en) | Eszopiclone solid preparation and preparation method thereof | |
| CN104434892A (en) | Naproxen dispersible tablet | |
| CN102600475B (en) | Pharmaceutical pellet cores and preparation method thereof | |
| CN101904918B (en) | Cough-relieving tablets and preparation method thereof | |
| CN118286170B (en) | Humidification tabletting process with strong hygroscopicity of main medicine | |
| CN105168179A (en) | Clopidol controlled-release microparticle preparation and preparation method thereof | |
| CN105395508A (en) | Ibuprofen-codeine phosphate compounding preparation and preparation method therefor | |
| CN104548115A (en) | Pharmaceutic adjuvant microcrystalline cellulose pellet core and preparation method thereof | |
| Cheng et al. | Low-viscosity hydroxypropyl methylcellulose obtained by electron beam irradiation and its performance in spray drying |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120718 |