CN102565436A - Self-calibration multi-measurement module of portable detecting instrument, and using method thereof - Google Patents
Self-calibration multi-measurement module of portable detecting instrument, and using method thereof Download PDFInfo
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- CN102565436A CN102565436A CN2012100173942A CN201210017394A CN102565436A CN 102565436 A CN102565436 A CN 102565436A CN 2012100173942 A CN2012100173942 A CN 2012100173942A CN 201210017394 A CN201210017394 A CN 201210017394A CN 102565436 A CN102565436 A CN 102565436A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
Abstract
The invention discloses a self-calibration multi-measurement module of a portable detecting instrument, and a using method of the module. The self-calibration multi-measurement module comprises a base, a movable detection module, a fixed module, a calibration solution pool and a waste liquid pool. The using method of the module comprises the following steps of: a) calibrating calibration solution; and b) detecting liquid to be detected. The invention provides the method and the multi-measurement module which are simple and effective; after being arranged in the portable detecting instrument, one measurement module can be used for measuring samples for hundreds of times; the whole complexity of the module is far lower than that of the existing modular instrument; and the module not only has simplicity and miniaturization of a dry chip instrument, but also has the high reliability and a multi-measurement characteristic of the modular instrument.
Description
Technical field
The present invention relates to liquid detection technique field, relate to a kind of self calibration that is used for portable instrumentation repeatedly measurement module and method of application thereof in particular.
Background technology
Fields such as current medical diagnosis, commercial production, environmental protection all need to measure rapidly and accurately at the scene; To first aid, diagnosis, accident treatment, process monitoring etc. all is very important; Many times or even of vital importance; Therefore, field quick detection also is the at present domestic field of giving priority to analysis and detecting instrument in the world.
In this technical field, mainly be divided into two types; One type is with instrument miniaturization, integrated; Outside attached device that connects of cancellation traditional instrument such as reagent bottle, calibration solution, injector, detecting device; Completely be designed to module to these parts, and be integrated into a less instrument internal, form the integral body that to move easily (the for example United States Patent (USP) of the patent No.: US 5750881,5580790,5637275).Particularly,, adopt detachable mounted consumptive material pack mode, provide, can change at any time, do not need the complicated calibration operation of safeguarding with the mode of consumptive material like sensor, pack etc. to (or number of times) limited parts in serviceable life wherein.Its operation is very easy, and the consumptive material bag can provide repeatedly continuous coverage, and shortcoming is to stablize the indoor environment use; Must use AC power, the reusable version sensor of its configuration generally can not provide the facility of plug and play, needs startup and the stabilization time of long period; The more important thing is; Its volume is relatively large, even a people can move, but it carries, transports very inconvenience.End is got up; It mainly is that the development and application of modern technologies has been arrived in system design and the miniaturization; With traditional large-scale instrument miniaturization, integrated; Thereby the occasion in one type in operating room and ward has been pushed ahead from central laboratory in the field of employment, thereby can be in the on-the-spot directly measurement of sample collecting.
Second type is to separate instrument itself and measuring unit; Instrument itself is carried out and is repeated repeatedly to measure; But need to accomplish the necessary reagent of one-time detection, calibration solution and detecting device and focus on a littler unit; Form disposable chip, each measurement need couple together a chip and instrument, after the completion chip is discarded (the for example United States Patent (USP) of patent No. US 5096669,6750053,7419821).The characteristics of this method are that instrument part is only carried out the electronic signal translation function, do not relate to chemical reagent and liquid handling, so instrument itself can make very for a short time, reach hand-held size, more convenient scene even open-air the use.This system is because its chip contains the required element of whole completion one-shot measurements; Not needing provides reagent in addition, so be called " dry type " chip again, its most outstanding advantage is a plug and play; Do not need any maintenance and special operational, convert the instrument use to deprofessionalization fully.Any medical personnel all can use whenever and wherever possible, use in any place.Its shortcoming mainly is that each measured chip can only be used once; On average single measurement cost, has obvious inferior position; Especially the situation that needs continuous several times to measure, the inferior position of its cost is more obvious, and it is very loaded down with trivial details that operation also seems; Need frequent replacing chip, so but it is to tend to the frequent user a kind of instrument before need not being equipped with again of access times.
These two kinds of classic methods that method compares, main advantage all provides convenience, actual increasing on the single use cost, and waste of material that is produced and also increase to some extent of discarded object.
And at present in this technical field, still incompetent more than enough time the repeated use, and possess conveniently, low-cost, need not safeguard the high benefit of characteristics, the hand-held chip type analytical instrument of hi-tech.
Summary of the invention
The purpose of this invention is to provide a kind of self calibration that is used for portable instrumentation repeatedly measurement module and method of application thereof; Its needs are installed in the portable instrumentation; Just can realize reaching hundreds of times sample measurement, operation is very simple, the single measurement cost is low, measuring accuracy is high.
Another object of the present invention provides a kind of portable instrumentation, and it is simple to operate, has both comprised the simple and easy and microminiaturized of dry type chip type instrument, has comprised the high reliability of modular instrument and measurement characteristics repeatedly again.
In order to solve the problems of the technologies described above, technical scheme of the present invention is following: the self calibration of portable instrumentation is measurement module repeatedly,
Comprise a base;
One is arranged on the stuck-module on the said base;
One is used to detect the mobile detection module with detecting sensor of calibration solution and liquid to be detected;
The one calibration liquid pool that can deposit the calibration solution of enough volumes and be communicated with and when said mobile detection module is positioned at the precalculated position, can be communicated with said mobile detection module with said stuck-module;
One is used to deposit calibration solution and the waste liquid pool of liquid to be detected after the detection.
As preferably; Said mobile detection module comprises movable block; Be provided with measuring cell in the said movable block; The detecting sensor that is used to detect liquid in the measuring cell is arranged in the said measuring cell, and said movable block is provided with liquid capillary mozzle to be detected, the calibration solution capillary mozzle that is communicated with said measuring cell.
As preferably; Said stuck-module is positioned at the place ahead of said mobile detection module; It comprises two liquid line enclosed elastic modules to be detected, and when said liquid capillary mozzle free open end to be detected was in one of them inside, said liquid capillary mozzle to be detected was closed; Said stuck-module also comprises the liquid connector to be detected and a calibration solution passage that is communicated with said calibration liquid pool that can be connected with said liquid capillary mozzle to be detected; Between described two liquid line enclosed elastic modules to be detected the fluid passage that is communicated with said waste liquid pool is arranged; Said liquid connector to be detected is arranged in the place ahead of forward that of described two liquid line enclosed elastic modules to be detected; The place ahead of said calibration solution passage is provided with calibration tube enclosed elastic module, and when said calibration solution capillary mozzle free open end was in wherein, said calibration solution capillary mozzle was closed.
As preferably; Described liquid line enclosed elastic module to be detected comprises two elastomer block of being processed by resilient material; Two adjacent sides of said two elastomer block fit, and form the seam of fitting, and said liquid capillary mozzle to be detected is aimed in the centre position of said applying seam.
As preferably, the fit rear end of seam of said two elastomer block is provided with pre-small post-large guiding structure.
As preferably; Said stuck-module also comprises two O type circles that can be passed by said liquid capillary mozzle to be detected; The internal diameter of said two O type circles is less than the external diameter of said liquid capillary mozzle to be detected, and described two O type circles are separately positioned on the rear of said two liquid line enclosed elastic modules to be detected and fit with it.
As preferably, the internal diameter of described O type circle be said liquid capillary mozzle external diameter to be detected 0.75-0.95 doubly.
As preferably, described elastomer block is processed by elastic caoutchouc or elastoplast or polyurethane.
As preferably; Described calibration tube enclosed elastic module comprises two elastic bodys of being processed by resilient material; Two adjacent sides of said two elastic bodys fit; Form the seam of fitting; Said calibration solution capillary mozzle is aimed in the centre position of said applying seam, is provided with the O RunddichtringO that can be passed by said calibration solution capillary mozzle in the said calibration solution passage, and the opening that is communicated with said calibration liquid pool of said calibration solution passage is between described O RunddichtringO and described two elastic bodys.
As preferably, be provided with the preceding O RunddichtringO of fitting with it and can be passed by said calibration solution capillary mozzle in said two elastomeric rear ends; The internal diameter of said preceding O RunddichtringO is 0.75-0.95 a times of said calibration solution capillary mozzle external diameter.
As preferably, be provided with pre-small post-large guiding structure in the rear end of said two elastic bodys applying seam.
As preferably, the internal diameter of described O RunddichtringO be said calibration solution capillary mozzle external diameter 0.75-0.95 doubly.
As preferably, described elastic body is processed by elastic caoutchouc or elastoplast or polyurethane.
As preferably, said liquid capillary mozzle to be detected, calibration solution capillary mozzle are processed by stainless steel or plastics.
As preferably; Said mobile detection module comprises movable block; Be provided with measuring cell in the said movable block, the said detecting sensor that is used to detect liquid in the said measuring cell is arranged in the said measuring cell, and said movable block is provided with the capillary mozzle that is communicated with said measuring cell.
As preferably, said stuck-module is positioned at the place ahead of said mobile detection module, and it comprises two enclosed elastic modules, and when the free open end of said capillary mozzle is in one of them when inner, said capillary mozzle is closed; Said stuck-module also comprises a liquid connector to be detected that can be connected with said capillary mozzle and a passage that is communicated with said calibration liquid pool; Described passage is between described two enclosed elastic modules, and said liquid connector to be detected is arranged in the place ahead of forward that of described two enclosed elastic modules.
As preferably, described enclosed elastic module comprises two elastomer block of being processed by resilient material, and two adjacent sides of said two elastomer block fit, and forms the seam of fitting, and said capillary mozzle is aimed in the centre position of said applying seam.
As preferably, the fit rear end of seam of said two elastomer block is provided with pre-small post-large guiding structure.
As preferably; Said stuck-module also comprises two O type circles that can be passed by said capillary mozzle; Described two O type circles are separately positioned on the rear of said two enclosed elastic modules and fit with it, and described two O type circle internal diameters are less than the external diameter of said capillary mozzle.
As preferably, the internal diameter of described O type circle be said capillary mozzle external diameter 0.75-0.95 doubly.
As preferably, described elastomer block is processed by elastic caoutchouc or elastoplast or polyurethane.
As preferably, said capillary mozzle is processed by stainless steel or plastics.
As preferably, said calibration liquid pool and said waste liquid pool are to be arranged on two cavity volumes of base bottom or to be arranged on two containers on the base.
As preferably, said base is provided with a case.
A kind of portable instrumentation, said portable instrumentation comprise repeatedly measurement module of above-mentioned self calibration.
A kind of self calibration of portable instrumentation is the method for application of measurement module repeatedly, comprises following steps:
A) calibration solution calibration; Said mobile detection module arrives the precalculated position and is communicated with the calibration liquid pool; In the calibration liquid pool, suck the mobile detection module of calibration solution entering; Then calibration solution is entered waste liquid pool; Be discharged in the process of waste liquid pool at calibration solution, calibration solution detects through detecting sensor, and the result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal;
B) liquid to be detected detects; Said mobile detection module arrives precalculated position and fluid connection to be detected; Suck liquid to be detected and get into mobile detection module; After the detecting sensor detection; The result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the liquid to be detected after will detecting then enters waste liquid pool.
As preferably, also comprise the flushing and the secondary calibration of step c); The described precalculated position that said mobile detection module arrives in the said step a) is communicated with the calibration liquid pool; In the calibration liquid pool, suck the mobile detection module of calibration solution entering; Calibration solution after will detecting then enters waste liquid pool, realizes to the flushing of moving detection module with to the secondary calibration of detecting sensor.
A kind of self calibration of portable instrumentation is the method for application of measurement module repeatedly, comprises following steps:
A) calibration solution calibration; Said mobile detection module arrives the precalculated position and is communicated with the calibration liquid pool; In the calibration liquid pool, suck the mobile detection module of calibration solution entering; After the detecting sensor detection; The result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the calibration solution after will detecting then enters waste liquid pool;
B) liquid to be detected detects; Said mobile detection module arrives precalculated position and fluid connection to be detected; Suck liquid to be detected and get into mobile detection module; After the detecting sensor detection; The result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the liquid to be detected after will detecting then enters waste liquid pool.
As preferably, also comprise the flushing and the secondary calibration of step c); Said mobile detection module arrives the precalculated position described in the said step a) and is communicated with the calibration liquid pool; In the calibration liquid pool, suck the mobile detection module of calibration solution entering; Calibration solution after will detecting then enters waste liquid pool, realizes to the flushing of moving detection module with to the secondary calibration of detecting sensor.
Beneficial effect of the present invention is: the invention provides a kind of simple, effective method and measurement module; A measurement module is packed into behind the portable instrumentation; Can accomplish reaching hundreds of times sample measurement, its overall complexity had both comprised the simple and easy and microminiaturized of dry type chip type instrument well below the instrument of present modularity; Comprised the high reliability of modular instrument and measurement characteristics repeatedly again, it is very low that single detects cost.
Description of drawings
Below in conjunction with accompanying drawing the present invention is done further explanation:
Fig. 1 is a profile synoptic diagram of the present invention;
Fig. 2 is the structural representation of the embodiment of the invention 1; Liquid capillary mozzle to be detected is in the state of being closed among the figure;
Back calibration solution capillary mozzle is closed Fig. 3, liquid capillary mozzle to be detected is in the view that is communicated with waste liquid pool for mobile detection module in the embodiment of the invention 1 advances;
Back calibration solution capillary mozzle is closed Fig. 4, liquid capillary mozzle to be detected is in the view that is communicated with liquid connector to be detected for mobile detection module in the embodiment of the invention 1 advances;
Fig. 5 is the structural representation of second kind of embodiment of the present invention, and the capillary mozzle is communicated with the calibration liquid pool among the figure;
Fig. 6 is communicated with synoptic diagram for the capillary mozzle of second kind of embodiment of the present invention with liquid connector to be detected.
Among the figure:
The 1-base;
2-moves detection module;
The 201-movable block, 202-measuring cell, 203-liquid capillary to be detected mozzle, 204-flexible pipe, 205-calibration solution capillary mozzle, 206-capillary mozzle, 207-flexible pipe;
3-straight line conveying device;
The 4-stuck-module; 401-liquid line enclosed elastic to be detected module, 401a-elastomer block, 401b-guide frame, 402-liquid connector to be detected, 403-calibration solution passage; The 404-fluid passage, 405-calibration tube enclosed elastic module, 405a-elastic body, 405b-guide frame; 406-O type circle, 407-O RunddichtringO, 408-enclosed elastic module, 408a-elastomer block; The 408b-guide frame, 409-passage, O RunddichtringO before the 410-O type circle, 411-;
5-calibrates liquid pool;
The 6-micropump; The 601-cavity, 602-pump case, 603-import, 604-piston, 605-straight line conveying mechanism;
The 7-waste liquid pool;
The 8-detecting sensor;
The 9-case.
Embodiment
The following stated is merely preferred embodiment of the present invention, is not scope of the present invention is limited.
Embodiment 1, sees accompanying drawing 1,2,3,4, and accompanying drawing 2 is the structural representation of measurement module in this embodiment; Wait in use; It is installed in just constitutes complete portable instrumentation in the portable instrumentation, can use, it comprises a base 1 measurement module; One case 9 is installed on the base 1, mainly is used for each components and parts that are installed on the base are protected; Comprise that also one is arranged on the stuck-module 4 on the base; Have on the base one be used to detect calibration solution can deposit enough volume calibration solutions with the mobile detection module 2 with detecting sensor 8 and of liquid to be detected and be communicated with said stuck-module 4 and when said mobile detection module 2 is positioned at the precalculated position, can be used to deposit detection with the calibration liquid pool 5, that said detection module 2 is communicated with after calibration liquid and the waste liquid pool 7 of liquid to be detected.Also be provided with the micropump 6 that is used to carry calibration liquid and liquid to be detected in addition in the portable instrumentation, make mobile detection module 2 can on said base 1, do the straight line conveying device 3 of straight reciprocating motion, use matches with measurement module.In this embodiment, calibration liquid pool 5 is two cavity volumes that are arranged on base 1 bottom with waste liquid pool 7, and two containers can certainly be set to be served as; These two containers can be fixed, and also can be dismountable, wherein; The solvent of waste liquid pool is greater than the calibration liquid pool; According to the number of times that uses and each amount of using, enough calibration solutions are set in the calibration liquid pool, general amount is that enough detections are advisable for about 500 times.
Move detection module 2 and driven by straight line conveying device 3, on base, do straight reciprocating motion, the straight line conveying device is linear electric motors, minitype cylinder, miniature electric push rod; Also can be other known device or the components and parts that can realize straight reciprocating motion etc.; It is arranged in the portable instrumentation, and what generally adopt is linear electric motors, moves detection module 2 and comprises movable block 201; Movable block is fixedly connected with linear electric motors; Drive to be realized straight reciprocating motion being provided with measuring cell 202 in the movable block 201 by linear electric motors, the detecting sensor 8 that is used to detect liquid in the measuring cell 202 is arranged in the measuring cell 202; Measuring cell 202 is the places that are used to measure calibration solution and liquid to be detected; Detecting sensor 8 is connected with the signal processing unit of portable instrumentation simultaneously, can the result of detection be issued the signal processing unit of portable instrumentation with the form of electric signal, is compared by signal processing unit; Movable block 201 is provided with the liquid capillary mozzle to be detected 203 and calibration solution capillary mozzle 205 that is communicated with measuring cell 202; Liquid capillary mozzle to be detected 203, calibration solution capillary mozzle 205 are fixed on the place ahead of movable block, and micropump 6 imports 603 also are communicated with measuring cell 202, and calibration solution capillary mozzle 205 is parallel to each other with liquid capillary mozzle 203 to be detected.In this embodiment; Measuring cell has two openings; One is communicated with liquid capillary mozzle 203 to be detected, and another is communicated with micropump 6 imports 603, calibration solution capillary mozzle, and detecting sensor 8 is then between these two openings; Liquid capillary mozzle to be detected 203, calibration solution capillary mozzle 205 all are hard capillary mozzles, are processed by stainless steel or plastics.Move because move detection module 2, so, be communicated with through flexible pipe 207 between mobile detection module 2 and micropump 6 imports 603.
In this embodiment, the micropump 6 that is arranged in the portable instrument is ram pump, and it comprises the pump case 602 with cavity 601; Pump case is cylindric, and import 603 is arranged on the pump case 602, and communicates with cavity 601; One piston 604 is arranged in the cavity 601, be connected with one on the piston 604 and drive piston 604 is done linear reciprocating motion in said cavity 601 straight line conveying mechanism 605, straight line conveying mechanism 605 is linear electric motors or cylinder or electric pushrod; Be generally linear electric motors, and movable in the cavity of pump case for the ease of piston, lubricant grease can be set on piston; Can also increase sealing like this, piston is drawn back, and makes cavity produce vacuum; Can liquid adsorption be come in, can also be certainly other can be with in the liquid suction pump and then the pump of discharging.
Stuck-module 4 is positioned at the place ahead of moving detection module 2; When mobile detection module 2 moves forward; Can liquid capillary mozzle 203 to be detected and calibration solution capillary mozzle 205 be inserted its inside; Stuck-module 4 comprises two liquid line enclosed elastic modules to be detected 401, the liquid connector 402 to be detected and a calibration solution passage 403 that is communicated with said calibration liquid pool 5 that can be connected with liquid capillary mozzle 203 to be detected; When the free open end of liquid capillary mozzle 203 to be detected is in two liquid line enclosed elastic modules to be detected in one of them the time; It is closed, and two liquid line enclosed elastic modules to be detected one in front and one in back are provided with, wherein; Before that is away from liquid capillary mozzle to be detected 203; Between two liquid line enclosed elastic modules 401 to be detected the fluid passage 404 that is communicated with waste liquid pool 7 is arranged, because in this embodiment, calibration liquid pool 5, waste liquid pool 7 are two cavity volumes that are arranged in the base; So calibration liquid pool, waste liquid pool can be communicated with calibration solution passage, fluid passage through fabrication hole or pipeline, liquid connector 402 to be detected is arranged in the place ahead of forward that of two liquid line enclosed elastic modules to be detected 401; So that be connected with the container of outside liquid to be detected, the front end of calibration solution passage 403 is provided with the calibration tube enclosed elastic module 405 that when calibration solution capillary mozzle 205 is in wherein, is closed.And liquid line enclosed elastic module 401 to be detected comprises two elastomer block 401a that processed by resilient material, and resilient material can be elastic caoutchouc or elastoplast or polyurethane.Two adjacent sides of said two elastomer block 401a fit; Form the seam of fitting; Said liquid capillary mozzle 203 to be detected is aimed in the centre position of said applying seam; The bearing of trend of applying seam is identical with liquid capillary mozzle working direction to be detected; When said liquid capillary mozzle to be detected 203 inserts between said two elastomer block, the contraction that is squeezed of two the adjacent applying sides of said two elastomer block 401a and said liquid capillary mozzle 203 contacted parts to be detected.Process because elastomer block is a resilient material, two elastomer block are fixed simultaneously, so when liquid capillary mozzle to be detected inserts between two elastomer block; Can the side extruding of two elastomer block be made it to shrink; Simultaneously not with two elastomer block between the time lateral parts that contact continue applying, be in the state that is sealed when making between two elastomer block, liquid capillary mozzle to be detected is sealed up; In order to obtain better sealing effectiveness; Can on the side that two elastomer block are fitted, Seal Oil or seal grease be set, with the enhancing sealing effectiveness, and fluid passage 404 two ends that are communicated with waste liquid pool 7 are all sealed up by two elastomer block; Make that it just is communicated with waste liquid pool when not having liquid capillary mozzle to be detected to insert.Simultaneously; Also comprise two O type circles 406 that can be passed by said liquid capillary mozzle 203 to be detected; The internal diameter of two O type circles 406 is less than the external diameter of liquid capillary mozzle 203 to be detected; Two O type circles 406 are separately positioned on the rear of two liquid line enclosed elastic modules 401 to be detected and fit with it, and one of them O type circle 406 is positioned at fluid passage 404, and fit to increase the sealing to fluid passage with the trailing flank of two elastomer block 401a that constitute liquid line enclosed elastic module 401 to be detected; These two O type circles can also be wiped the residual liquid of liquid capillary mozzle outer wall to be detected in addition; Avoid cross pollution, general, the internal diameter of O type circle 406 is 0.75-0.95 a times of said liquid capillary mozzle 203 external diameters to be detected.Calibration tube enclosed elastic module 405 comprises the elastic body 405a that is processed by two resilient materials, and resilient material is generally elastic caoutchouc or elastoplast or polyurethane, and elastic body is fixed and can not moves; Two adjacent sides of two elastic body 405a fit; Form the seam of fitting, the bearing of trend of the seam of fitting is identical with calibration solution capillary mozzle working direction, and said calibration solution capillary mozzle 205 is aimed in the centre position of said applying seam; When said calibration solution capillary mozzle 205 inserts between said two elastic body 405a; The contraction that is squeezed of two the adjacent applying sides of said two elastic body 405a and said calibration solution capillary mozzle 205 contacted parts, this part contraction is the contraction of resilient material itself, the part of contact does not continue to fit; Calibration solution capillary mozzle 205 is sealed up; Be provided with one in the said calibration solution passage and can be calibrated the O RunddichtringO 407 that liquid capillary mozzle passes, the opening that is communicated with said calibration liquid pool 5 of said calibration solution passage 403 is between described O RunddichtringO 407 and two elastic body 405a, and is general; The internal diameter of O RunddichtringO 407 is 0.75-0.95 a times of said calibration solution capillary mozzle external diameter; When calibration solution capillary mozzle passed O RunddichtringO 407 and gets into calibration solution passage 403, whole calibration solution passage 403 was sealed, not with external communications like this; Only be communicated with the calibration liquid pool; Be convenient to calibration solution capillary mozzle and draw calibration solution, O RunddichtringO 407 can also be wiped the liquid of calibration solution capillary mozzle 205 outer walls simultaneously, avoids cross pollution.
For those two the elastic body 405a that increase in the place ahead and the sealing between the calibration solution passage, the rear end of said two elastic body 405a is provided with the preceding O RunddichtringO 411 of fitting with it and can be passed by said calibration solution capillary mozzle 205; The internal diameter of said preceding O RunddichtringO 411 is 0.75-0.95 a times of said calibration solution capillary mozzle 205 external diameters, and simultaneously, preceding O RunddichtringO 411 can also be wiped the liquid of calibration solution capillary mozzle 205 outer walls, avoids cross pollution.
Insert the applying seam of two elastic body 405a for the ease of calibration solution capillary mozzle; The rear end of the applying seam of two elastic body 405a is provided with pre-small post-large guiding structure 405b; In this embodiment, the opening that guiding structure 405b narrows down forward for the rear end from the seam of fitting gradually.Same, insert for the ease of liquid capillary mozzle 203 to be detected; Rear end at said two elastomer block 401a applying seam is provided with pre-small post-large guiding structure 401b, the opening that guiding structure 401b narrows down forward for the rear end from the seam of fitting gradually.
The detection method of measurement module repeatedly comprises following steps:
A) calibration solution calibration; Utilize the straight line conveying device 3 in the portable instrumentation being with said mobile detection module 2 on said base 1, to move forward; Make said mobile detection module 2 arrival precalculated positions be communicated with calibration liquid pool 5, detection module 2 is moved in the calibration solution entering that utilizes micropump 6 to draw in the calibration liquid pool, in getting into micropump 6; And then the calibration solution in the micropump discharged; Get into waste liquid pool, in the calibration solution discharge process, the calibration solution of discharging from micropump is full of whole measuring cell and fluid passage; After detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal; In this embodiment; The calibration solution passage 403 that the precalculated position of moving detection module arrival is exactly and calibration liquid pool 5 is communicated with; The free open end that moves the calibration solution capillary mozzle of detection module gets in the calibration solution passage, is communicated with the calibration liquid pool through calibration solution passage 403; At this moment; Liquid capillary mozzle 203 to be detected is positioned at liquid line enclosed elastic module to be detected, is sealed, because the micropump that adopts is a piston pump; So will calibrate earlier in the calibration solution sucker pump in the liquid pool 5 through piston pump; The linear electric motors band movable block of said mobile detection module continues to move forward then, makes liquid capillary mozzle 203 to be detected be communicated with through fluid passage 404 with waste liquid pool, at this moment; Calibration solution capillary mozzle liquid line enclosed elastic to be detected module sealing is lived; Liquid can not come out from this capillary mozzle, and piston pump is started working then, calibration solution is discharged in the pump get into waste liquid pool measuring cell is full of calibration solution;
B) liquid to be detected detects; After accomplishing the calibration solution health check-up and surveying, straight line conveying device 3 moves before continuing be with mobile detection module 2, makes said mobile detection module 2 arrival precalculated positions and fluid connection to be detected; In this process, calibration solution capillary mozzle liquid line enclosed elastic to be detected always module sealing is lived, and this locates described precalculated position; It is exactly the position that liquid capillary mozzle 203 to be detected is communicated with liquid connector 402 to be detected; The piston pump that move on the detection module 2 this moment is started working, and extracts liquid to be detected and gets into the measuring cell that moves detection module 2, after detecting through detecting sensor 8; The result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal; Then, straight line conveying device 3 is being with mobile detection module 2 backs to move, and makes liquid capillary mozzle to be detected be positioned at fluid passage 404; Be communicated with waste liquid pool, piston pump enters waste liquid pool 7 with the liquid behind to be detected in the pump.General, completing steps a) with step b) after, also comprise step c); Flushing and secondary calibration; Said mobile detection module 2 is under the drive of straight line conveying device; Arriving the precalculated position described in the said step a) is communicated with calibration liquid pool 5; At this moment; Liquid capillary mozzle to be detected is closed, and the free open end of calibration solution capillary mozzle gets in the calibration solution passage, is communicated with the calibration liquid pool through calibration solution passage 403; Suck calibration solution in the calibration liquid pool and get into and move detection module 2, the calibration solution after will detecting then enters waste liquid pool 7, realizes to the flushing of mobile detection module 2 with to the secondary calibration of detecting sensor 8; Micropump sucks calibration solution through measuring cell in the calibration liquid pool, micropump is discharged calibration solution more then, passes through measuring cell again; And it is full of; Twice action makes calibration solution to wash measuring cell, for measurement next time is prepared, simultaneously; Detecting sensor 8 also can be measured calibration solution, obtains calibrating signal.
In above-mentioned measuring process; The measurement of twice liquid to be detected maybe be at interval for a long time; The sensitivity of the detecting sensor in the measuring cell during this time possibly drifted about, so can be set in regular time, carries out the primary calibration operation; Calibration solution in measuring cell and the passage is upgraded once, keep the accuracy of detecting sensor.
The suction calibration solution of step a) and two steps of step b) and the volume ratio of liquid to be detected relation is for about V1/V2=4, the amount of the liquid to be detected of promptly sampling be the filling liquid passage the calibration solution total amount about 1/4th.This relation has the clean enough calibration solution that whole passage is cleaned to state to be measured after satisfying each the measurement, and is ready for measure next time, exceeds waste reagent simultaneously again; In step a; Can be as required, the detection that repeats calibration solution repeatedly is to wash away the liquid residue to be detected that reaches in the measuring cell in the liquid capillary mozzle to be detected; Guarantee the accuracy of measurement result; The process that this repeated detection is calibrated can realize through being provided with of program, can avoid interference, and obtains calibration result the most accurately.Portable instrumentation compares two testing results in step a) and the step b); And then judging that liquid characteristic index to be detected, so-called characteristic index are meant the result who obtains after the detection contrast, this result can be the result of data contrast; Also can be the result of curve contrast; If detection blood sugar, after then the detection numerical value that obtains of step a) and step b) compares, just know that blood sugar is height or low; If what detect is whether a kind of liquid is contaminated by heavy metals; After the detection numerical value/curve that obtains after then the detection of step a) and step b) is accomplished compares, just know whether heavy metal such as iron, the chromium etc. in the liquid have surpassed national examination criteria, if detection is the turbidity of tap water; After the testing result that obtains after then the detection of step a) and step b) is accomplished compares, can know all whether the turbidity of tap water has exceeded standard.
In this embodiment; Move detection module 2 and comprise movable block 201, movable block is connected with straight line conveying device 3, is provided with measuring cell 202 in the said movable block 201; The said detecting sensor 8 that is used to detect liquid in the said measuring cell 202 is arranged in the said measuring cell 202; Said movable block 201 is provided with the capillary mozzle 206 that is communicated with said measuring cell 202, and the capillary mozzle is a hard capillary mozzle, is processed by stainless steel or plastics.
And waste liquid pool 7 is communicated with the outlet of micropump 6, and the import of micropump then is communicated with measuring cell 202.Micropump is ram pump or vane pump or other known pumps with import and outlet such as centrifugal pump or peristaltic pump; What this embodiment adopted is peristaltic pump; The peristaltic pump import is communicated with through flexible pipe 204 with measuring cell 202; Outlet is passed through soft pipe connection with waste liquid pool, and peristaltic pump is in being arranged on portable instrumentation.In this embodiment, have only a capillary mozzle, rather than two, calibration liquid and liquid to be detected all are to get into measuring cell through this capillary mozzle, are detected by detecting sensor.
In this embodiment, said stuck-module 4 is positioned at the place ahead of said mobile detection module 2, and it comprises two enclosed elastic modules 408, and when the free open end of said capillary mozzle 206 was in one of them inside, capillary mozzle 206 was closed; Stuck-module 4 also comprises a liquid connector 402 to be detected that can be connected with said capillary mozzle 206 and a passage 409 that is communicated with said calibration liquid pool 5; Passage 409 is between described two enclosed elastic modules 408; Lived by two enclosed elastic module sealing; Only communicate with the calibration liquid pool, liquid connector 402 to be detected is arranged in the place ahead of forward that of described two enclosed elastic modules 408.Described enclosed elastic module 408 comprises two elastomer block 408a that processed by resilient material, general employing elastic caoutchouc or elastoplast or polyurethane, and two adjacent sides of said two elastomer block 408a fit; Form the seam of fitting; The bearing of trend of applying seam is identical with capillary mozzle working direction, and said capillary mozzle 206 is aimed in the centre position of said applying seam, is convenient to the capillary mozzle and inserts; When said capillary mozzle 206 inserts between said two elastomer block 408a; The contraction that is squeezed of two the adjacent applying sides of said two elastomer block 408a and said capillary mozzle 206 contacted parts, this part contraction is the contraction of resilient material itself, the part of contact does not continue to fit; Capillary mozzle 206 is sealed up; Stuck-module 4 also comprises two O type circles 410 that can be passed by said capillary mozzle 206, and described two O type circles 410 are separately positioned on the rear of said two enclosed elastic modules 408 and fit with it, match with two enclosed elastic modules; Can better seal passage; These two O type circles can also be wiped the liquid of capillary mozzle outer wall simultaneously, avoid cross pollution, and described two O type circle 410 internal diameters are less than the external diameter of said capillary mozzle 206.General, the internal diameter of described O type circle 410 is 0.75-0.95 a times of said capillary mozzle 206 external diameters.
Be the insertion for the capillary mozzle of being more convenient for equally, the rear end of said two elastomer block 408a applying seam is provided with pre-small post-large guiding structure 408b, the opening that guide frame narrows down forward for the rear end from the seam of fitting gradually.
Can find out that from said structure than embodiment 1, the structure of this embodiment is simplified greatly, structure becomes simply, is easy to make, and volume is littler, is more convenient for carrying and installing, and the parts of employing also tail off, and have reduced price, have improved competitive power.Below, according to the structure of this embodiment measurement module, summary is its method of application down,
A) calibration solution calibration; Straight line conveying device 3 is being with said mobile detection module 2 on said base 1, to move forward; Make said mobile detection module 2 arrival precalculated positions be communicated with calibration liquid pool 5; The calibration solution that utilizes micropump 6 to draw in the calibration liquid pool gets into mobile detection module 2; After detecting through detecting sensor 8, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the calibration solution after the detection enters waste liquid pool 7; In this embodiment, the passage 409 that the precalculated position of moving detection module arrival is exactly and calibration liquid pool 5 is communicated with, the free open end that moves the capillary mozzle of detection module is communicated with the calibration liquid pool through passage 409; Because the micropump that this embodiment adopts is a peristaltic pump, the wriggling delivery side of pump is communicated with waste liquid pool, and the movable block of mobile detection module when the linear electric motors band moves forward; Make when capillary mozzle free open end is positioned at passage 409 that peristaltic pump rotates, the calibration solution in the calibration liquid pool is passed through in the capillary mozzle suction pump; In the process in getting into pump; Calibration solution detects through the detecting sensor in the measuring cell through measuring cell, obtains testing result; Calibration solution after to be detected then gets into waste liquid pool through the delivery side of pump of wriggling, and whole detection action is very simple, quick; After detecting completion calibration solution completion calibration; Begin to detect liquid to be detected;
B) liquid to be detected detects; Straight line conveying device 3 continues be with said mobile detection module 2 to move forward; Make said mobile detection module 2 arrival precalculated positions and fluid connection to be detected; Micropump 6 is started working and is drawn the mobile detection module 2 of liquid entering to be detected; After detecting through detecting sensor 8, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the liquid to be detected after the detection enters waste liquid pool 7; This locates described precalculated position, is exactly the position that the capillary mozzle is communicated with liquid connector to be detected, and this moment, peristaltic pump was started working; Draw liquid to be detected and get into the measuring cell that moves detection module 2; After detecting through detecting sensor 8, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, simultaneously; Liquid to be detected gets into waste liquid pool through the wriggling delivery side of pump, accomplishes the action of discharging waste liquid.
General, completing steps a) with step b) after, also comprise step c); Flushing and secondary calibration; Said mobile detection module 2 arrives the precalculated position described in the said step a) and is communicated with calibration liquid pool 5 under the drive of straight line conveying device, at this moment, in the free open end admission passage of capillary mozzle, is communicated with the calibration liquid pool through passage; In the calibration liquid pool, suck in the measuring cell of the mobile detection module 2 of calibration solution entering; Measuring cell is washed; Remove residual liquid to be detected; Simultaneously detecting sensor detects calibration solution, realizes to the flushing of moving detection module 2 with to the secondary calibration of detecting sensor 8, for measurement next time is prepared.
In above-mentioned measuring process; The measurement of twice liquid to be detected maybe be at interval for a long time; The sensitivity of the detecting sensor in the measuring cell during this time possibly drifted about, so can be set in regular time, carries out the primary calibration operation; Calibration solution in measuring cell and the passage is upgraded once, keep the accuracy of detecting sensor.
Portable instrumentation compares two testing results in step a) and the step b), and then judges liquid characteristic index to be detected; So-called characteristic index is meant and detects the result who obtains after the contrast; This result can be the result of data contrast, also can be the result of curve contrast, if detect blood sugar; After then the detection numerical value that obtains of step a) and step b) compares; Just know that blood sugar is height or low, if detection is whether a kind of liquid is contaminated by heavy metals, after the detection numerical value/curve that obtains after then the detection of step a) and step b) is accomplished compares; Just know whether heavy metal such as iron, chromium etc. in the liquid have surpassed national examination criteria; If what detect is the turbidity of tap water, after the testing result that obtains after then the detection of step a) and step b) is accomplished compares, can know all whether the turbidity of tap water has exceeded standard.
Can find out from above-mentioned testing process, the detection method of this embodiment, very rapidly, the action in the testing process is also few, quicker.
Claims (29)
1. the self calibration of portable instrumentation measurement module repeatedly is characterized in that:
Comprise a base (1);
One is arranged on the stuck-module (4) on the said base (1);
One is used to detect the mobile detection module (2) with detecting sensor (8) of calibration solution and liquid to be detected;
The one calibration liquid pool (5) that can deposit the calibration solution of enough volumes and be communicated with said stuck-module (4) and can be communicated with said mobile detection module (2) when being positioned at the precalculated position at said mobile detection module (2);
One is used to deposit calibration solution and the waste liquid pool (7) of liquid to be detected after the detection.
2. the self calibration of portable instrumentation according to claim 1 measurement module repeatedly; It is characterized in that: said mobile detection module (2) comprises movable block (201); Be provided with measuring cell (202) in the said movable block (201); The detecting sensor (8) that is used to detect the interior liquid of measuring cell (202) is arranged in the said measuring cell (202), and said movable block (201) is provided with liquid capillary mozzle to be detected (203), the calibration solution capillary mozzle (205) that is communicated with said measuring cell (202).
3. the self calibration of portable instrumentation according to claim 2 measurement module repeatedly; It is characterized in that: said stuck-module (4) is positioned at the place ahead of said mobile detection module (2); It comprises two liquid line enclosed elastic modules to be detected (401); When said liquid capillary mozzle to be detected (203) free open end was in one of them inside, said liquid capillary mozzle to be detected (203) was closed; Said stuck-module (4) also comprises a liquid connector to be detected (402) that can be connected with said liquid capillary mozzle to be detected (203) and a calibration solution passage (403) that is communicated with said calibration liquid pool (5); The fluid passage (404) that is communicated with said waste liquid pool (7) is arranged between described two liquid line enclosed elastic modules to be detected (401); Said liquid connector to be detected (402) is arranged in the place ahead of forward that of described two liquid line enclosed elastic modules to be detected (401); The place ahead of said calibration solution passage (403) is provided with calibration tube enclosed elastic module (405), and when said calibration solution capillary mozzle (205) free open end was in wherein, said calibration solution capillary mozzle (205) was closed.
4. the self calibration of portable instrumentation according to claim 3 measurement module repeatedly; It is characterized in that: described liquid line enclosed elastic module to be detected (401) comprises two elastomer block of being processed by resilient material (401a); Two adjacent sides of said two elastomer block (401a) fit; Form the seam of fitting, said liquid capillary mozzle to be detected (203) is aimed in the centre position of said applying seam.
5. the self calibration of portable instrumentation according to claim 4 measurement module repeatedly is characterized in that: the fit rear end of seam of said two elastomer block (401a) is provided with pre-small post-large guiding structure (401b).
6. the self calibration of portable instrumentation according to claim 4 measurement module repeatedly; It is characterized in that: said stuck-module (4) also comprises two O type circles (406) that can be passed by said liquid capillary mozzle to be detected (203); The internal diameter of said two O type circles (406) is less than the external diameter of said liquid capillary mozzle to be detected (203), and described two O type circles (406) are separately positioned on the rear of said two liquid line enclosed elastic modules to be detected (401) and fit with it.
7. the self calibration of portable instrumentation according to claim 6 measurement module repeatedly is characterized in that: the internal diameter of described O type circle (406) be said liquid capillary mozzle to be detected (203) external diameter 0.75-0.95 doubly.
8. the self calibration of portable instrumentation according to claim 4 measurement module repeatedly is characterized in that: described elastomer block (401a) is processed by elastic caoutchouc or elastoplast or polyurethane.
9. according to the self calibration of claim 3 or 4 or 5 or 6 or 7 or 8 described portable instrumentations measurement module repeatedly; It is characterized in that: described calibration tube enclosed elastic module (405) comprises two elastic bodys of being processed by resilient material (405a); Two adjacent sides of said two elastic bodys (405a) fit; Form the seam of fitting; Said calibration solution capillary mozzle (205) is aimed in the centre position of said applying seam; Be provided with the O RunddichtringO (407) that can be passed by said calibration solution capillary mozzle (205) in the said calibration solution passage (403), the opening that is communicated with said calibration liquid pool (5) of said calibration solution passage (403) is positioned between described O RunddichtringO (407) and described two elastic bodys (405a).
10. the self calibration of portable instrumentation according to claim 9 measurement module repeatedly is characterized in that: be provided with the preceding O RunddichtringO (411) of fitting with it and can be passed by said calibration solution capillary mozzle (205) in the rear end of said two elastic bodys (405a); The internal diameter of said preceding O RunddichtringO (411) is 0.75-0.95 a times of said calibration solution capillary mozzle (205) external diameter.
11. the self calibration of portable instrumentation according to claim 9 is measurement module repeatedly, it is characterized in that: the rear end at said two elastic bodys (405a) applying seam is provided with pre-small post-large guiding structure (405b).
12. the self calibration of portable instrumentation according to claim 9 is measurement module repeatedly, it is characterized in that: the internal diameter of described O RunddichtringO (407) is 0.75-0.95 a times of said calibration solution capillary mozzle (205) external diameter.
13. the self calibration of portable instrumentation according to claim 9 is measurement module repeatedly, it is characterized in that: described elastic body (405a) is processed by elastic caoutchouc or elastoplast or polyurethane.
14. the self calibration of portable instrumentation according to claim 3 is measurement module repeatedly, it is characterized in that: said liquid capillary mozzle to be detected (203), calibration solution capillary mozzle (205) are processed by stainless steel or plastics.
15. the self calibration of portable instrumentation according to claim 1 is measurement module repeatedly; It is characterized in that: said mobile detection module (2) comprises movable block (201); Be provided with measuring cell (202) in the said movable block (201); The said detecting sensor (8) that is used to detect the interior liquid of said measuring cell (202) is arranged in the said measuring cell (202), and said movable block (201) is provided with the capillary mozzle (206) that is communicated with said measuring cell (202).
16. the self calibration of portable instrumentation according to claim 15 is measurement module repeatedly; It is characterized in that: said stuck-module (4) is positioned at the place ahead of said mobile detection module (2); It comprises two enclosed elastic modules (408); When the free open end of said capillary mozzle (206) was in one of them inside, said capillary mozzle (206) was closed; Said stuck-module (4) also comprises a liquid connector to be detected (402) that can be connected with said capillary mozzle (206) and a passage (409) that is communicated with said calibration liquid pool (5); Described passage (409) is positioned between described two enclosed elastic modules (408), and said liquid connector to be detected (402) is arranged in the place ahead of forward that of described two enclosed elastic modules (408).
17. the self calibration of portable instrumentation according to claim 16 is measurement module repeatedly; It is characterized in that: described enclosed elastic module (408) comprises two elastomer block of being processed by resilient material (408a); Two adjacent sides of said two elastomer block (408a) fit; Form the seam of fitting, said capillary mozzle (206) is aimed in the centre position of said applying seam.
18. the self calibration of portable instrumentation according to claim 17 is measurement module repeatedly, it is characterized in that: the rear end of said two elastomer block (408a) applying seam is provided with pre-small post-large guiding structure (408b).
19. according to the self calibration of claim 16 or 17 or 18 described portable instrumentations measurement module repeatedly; It is characterized in that: said stuck-module (4) also comprises two O type circles (410) that can be passed by said capillary mozzle (206); Described two O type circles (410) are separately positioned on the rear of said two enclosed elastic modules (408) and fit with it, and described two O type circles (410) internal diameter is less than the external diameter of said capillary mozzle (206).
20. the self calibration of portable instrumentation according to claim 19 is measurement module repeatedly, it is characterized in that: the internal diameter of described O type circle (410) is 0.75-0.95 a times of said capillary mozzle (206) external diameter.
21. the self calibration of portable instrumentation according to claim 17 is measurement module repeatedly, it is characterized in that: described elastomer block (408a) is processed by elastic caoutchouc or elastoplast or polyurethane.
22. the self calibration of portable instrumentation according to claim 15 is measurement module repeatedly, it is characterized in that: said capillary mozzle (206) is processed by stainless steel or plastics.
23. according to the self calibration of claim 1 or 3 or 15 described portable instrumentations measurement module repeatedly, it is characterized in that: said calibration liquid pool (5) and said waste liquid pool (7) are for being arranged on two cavity volumes bottom the base (1) or being arranged on two containers on the base.
24. according to the self calibration of claim 1 or 3 or 15 described portable instrumentations measurement module repeatedly, it is characterized in that: said base (1) is provided with a case (9).
25. a portable instrumentation is characterized in that: said portable instrumentation comprises repeatedly measurement module of any described self calibration of claim 1-24.
26. the self calibration of a portable instrumentation as claimed in claim 1 is the method for application of measurement module repeatedly, it is characterized in that comprising following steps:
A) calibration solution calibration; Said mobile detection module (2) arrives the precalculated position and is communicated with calibration liquid pool (5); In the calibration liquid pool, suck the mobile detection module (2) of calibration solution entering; Then calibration solution is entered waste liquid pool (7); Be discharged in the process of waste liquid pool (7) at calibration solution, calibration solution detects through detecting sensor (8), and the result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal;
B) liquid to be detected detects; Said mobile detection module (2) arrives precalculated position and fluid connection to be detected; Suck liquid to be detected and get into mobile detection module (2); After detecting sensor (8) detection; The result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the liquid to be detected after will detecting then enters waste liquid pool (7).
27. the self calibration of a kind of portable instrumentation according to claim 26 is the method for application of measurement module repeatedly, it is characterized in that: the flushing and the secondary calibration that also comprise step c); The described precalculated position that said mobile detection module (2) arrives in the said step a) is communicated with calibration liquid pool (5); In the calibration liquid pool, suck the mobile detection module (2) of calibration solution entering; Calibration solution after will detecting then enters waste liquid pool (7), realizes to the flushing of moving detection module (2) with to the secondary calibration of detecting sensor (8).
28. the self calibration of a portable instrumentation as claimed in claim 1 is the method for application of measurement module repeatedly, it is characterized in that comprising following steps:
A) calibration solution calibration; Said mobile detection module (2) arrives the precalculated position and is communicated with calibration liquid pool (5); In the calibration liquid pool, suck the mobile detection module (2) of calibration solution entering; After detecting sensor (8) detection; The result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the calibration solution after will detecting then enters waste liquid pool (7);
B) liquid to be detected detects; Said mobile detection module (2) arrives precalculated position and fluid connection to be detected; Suck liquid to be detected and get into mobile detection module (2); After detecting sensor (8) detection; The result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, and the liquid to be detected after will detecting then enters waste liquid pool (7).
29. the self calibration of a kind of portable instrumentation according to claim 28 is the method for application of measurement module repeatedly, it is characterized in that: the flushing and the secondary calibration that also comprise step c); Said mobile detection module (2) arrives the precalculated position described in the said step a) and is communicated with calibration liquid pool (5); In the calibration liquid pool, suck the mobile detection module (2) of calibration solution entering; Calibration solution after will detecting then enters waste liquid pool (7), realizes to the flushing of moving detection module (2) with to the secondary calibration of detecting sensor (8).
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| CN 201210017394 CN102565436B (en) | 2012-01-19 | 2012-01-19 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
| PCT/CN2012/084712 WO2013107207A1 (en) | 2012-01-19 | 2012-11-16 | Self-calibration multi-measurement module for portable detection instrument and use method therefor |
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| CN 201210017394 CN102565436B (en) | 2012-01-19 | 2012-01-19 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
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| WO2013107207A1 (en) * | 2012-01-19 | 2013-07-25 | 湖州凯立特医疗器械有限公司 | Self-calibration multi-measurement module for portable detection instrument and use method therefor |
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| CN102565436B (en) | 2013-09-18 |
| WO2013107207A1 (en) | 2013-07-25 |
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