CN1025285C - Ring nerve electrode - Google Patents

Ring nerve electrode Download PDF

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Publication number
CN1025285C
CN1025285C CN91103931A CN91103931A CN1025285C CN 1025285 C CN1025285 C CN 1025285C CN 91103931 A CN91103931 A CN 91103931A CN 91103931 A CN91103931 A CN 91103931A CN 1025285 C CN1025285 C CN 1025285C
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China
Prior art keywords
electrode
nerve
ring
shape
arbitrary
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Expired - Fee Related
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CN91103931A
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CN1060219A (en
Inventor
米歇尔·德·门德兹
西尔维·琴克利·加姆伯亚
劳伦·孔塔尔多
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FCI France SA
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Souriau et Cie
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/388Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A61F2210/0019Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0556Cuff electrodes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)

Abstract

Annular neural electrode for producing, in a given working temperature range, an electricl contact on the periphery of a nerve (10) such as to induce electrical excitation. In accordance with the invention, said electrode is made from a shape memory material capable of showing, in said working temperature range, a super elastic effect in conjunction with its transformation under stress from the austenitic phase to the martensitic phase. Application in electrical muscle stimulation.

Description

Ring nerve electrode
The present invention relates to a kind of ring nerve electrode, be used in given operating temperature range, guaranteeing to electrically contact, so that form electricity irritation there with perineural.
The present invention has superior application aspect the total field of the electricity irritation of nerve, can control muscle and other organ, and especially after the spinal fracture, each neural excitation is difficult for being delivered to lower limb muscles and makes it to drop into motion at that time.In the case, electrode of the present invention combines the complicated process of imitation walking, can make paralytic patient recover certain motion, can not transmit the vertebrae of electricity irritation to substitute in self nerve.
Nerve electrode B is meant and a kind ofly excites the electrode of muscle by means of nerve stimulation, and it is different with the epimysium electrode, and the latter directly puts on the muscle adventitia, and its function lacks selectivity.
Be used for guaranteeing to electrically contact on every side with neural with a given operating temperature range, so that the ring nerve electrode that produces electricity irritation there comes from the 9th layer of medicine of IEEE and biological engineering association annual meeting (1987) by PR.Troyk and article that Jpoyezdala writes " the biological root shell type electrode that is used for the electricity irritation of lower limb function ".Ring nerve electrode in this article is a U-shaped body that is made by (Dacron) material that can hurry greatly that has flooded silicones, has placed the stimulating electrode that is made by platinum thereon, and nerve places the inside of U-shaped.Yet as all nerve electrodes, the known electrode of this class also has limitation, and in fact, a nerve can not bear the pressure that surpasses 16 millimetress of mercury, otherwise the irreversible variation of function will be arranged.Especially, former electrodes can not react to accidental increase the in the cross section of nerve, so it is subjected to the too much constraint of electrode, thereby, finally destroyed.On the other hand, remain on very tightly in the electrode in order to avoid nerve veritably, it is enough loose to consider that counter electrode is adjustable to around nerve, and this has just formed and can not guarantee machine performance and reliably electrically contact and the shortcoming that repeats performance.
In addition, the technical problem that purpose of the present invention solved is to realize that a kind of being used for guarantees to electrically contact with neural a given operating temperature range on every side, no matter so that produce there electricity irritation ring nerve electrode it can under what environment, avoid occurring very big stress on the nerve in electrode, and the same good machinery that provides keeps performance.
The solution of the technical problem that is proposed, according to the present invention is to form like this: described electrode is made by shape-memory material, in described operating temperature range, can provide a kind of super-elasticity function, because of under stress, being attended by by the austenite conversion of martensitic phase in opposite directions.
In fact, as everybody knows at austenite conversion finishing temperature A FAn and temperature A F6Between temperature the time, can be owing to applying or long-pending put mechanical stress, and make material become martensitic phase by the austenite phase transformation with shape memory.But this inverse conversion is followed a kind of important super-elasticity function, it is characterized in that having stress and keeps relatively little and constant zone, and this we can say almost that also its stress and distortion of materials are irrelevant.
In addition, ring electrode according to the present invention for example under the effect that diameter nerve increases, is easy to produce distortion, and can produce the big final stress that damages nerve on nerve on a big deformation plance.Therefore, can consider, when will electrode according to the present invention be placed on neural around the time, even contact also is critical manyly than the contact condition of known electrode of the prior art slightly, because well-known, when all virtual conditions, its stress is less than the limit stress of allowing.
On the other hand, ring nerve according to the present invention has extra advantage, promptly utilize the material behavior of shape memory, easy especially when placing electrode, for this reason, consideration is with the material molding in this wise of shape memory, so that guarantee when the shape memory state of Ovshinsky bulk phase, assurance electrically contacts with described nerve.In this form of implementation, electrode is caused into martensitic phase when low temperature, is in open position and is placed on the electrode.Then, utilize single backheat until austenite phase transformation temperature, electrode returns to the make position consistent with original position.
Certainly, can more advantageously utilize two memory functions to replace the function of single shape memory.In the case, the molding in this wise of described shape-memory material so that can guarantee in first shape memory state to guarantee and the electrically contacting of described nerve, and guarantees taking off and inserting of described electrode in second shape memory state.Electrode according to the present invention is being subjected to as after the sort of incubation described in the european patent application 061952, can obtain by first shape memory state to be overcome as long as accomplish the conversion difficulty of described shape-memory material to the reversible conversion of second shape memory state.
Below by of the description of reference accompanying drawing to providing with non-limitative example, will make the better geographical composition of the present invention and how implementing of being situated between of people, its accompanying drawing is:
Fig. 1 a is the side view according to ring nerve electrode of the present invention;
Fig. 1 b is the profile according to Fig. 1 a hatching line II-II;
Fig. 2 is the stress-deformation curve figure that is in the shape-memory material of superelastic;
Fig. 3 a is the side view of the first enforcement modification of electrode according to the present invention;
Fig. 3 b is the profile according to Fig. 3 a hatching line II-II;
Fig. 4 a is the side view of the second enforcement modification of electrode according to the present invention;
Fig. 4 b is the profile according to Fig. 4 a hatching line II-II;
The front elevation of Fig. 5 first form that to be expression combine according to two electrodes of Fig. 1 b;
Fig. 6 is the front elevation of second form that combines of two electrodes according to Fig. 1 b; And
Fig. 7 is the front elevation according to bipolar electrode of the present invention.
Fig. 1 a and Fig. 1 b have represented a ring nerve electrode with side-looking and the form of analysing and observe, and it is used for guaranteeing and electrically contacting around the neuropeptide 11 0 in given operating temperature range, so that produce electricity irritation there.According to a prominent features of the present invention, the electrode of Fig. 1 a and Fig. 1 b is made by shape-memory material, and can show the excellent elasticity function in operating temperature range, and can be by the austenite phase transformation to the Yu Shi bulk phase under stress.The curve chart of stress 6/ deformation epsilon of a this function of representative is given on Fig. 2.By this curve chart of Fig. 2 as can be seen, the conversion that when being lower than temperature AF(and being higher than this temperature, no longer may produce the austeno-martensite under the stress) time, on a material that is in austenitic state that can keep shape, apply a stress, because a limited stress σ 0Just caused the formation of Ma Shi phase, this formation is accompanied someone with the very big variation of alloy elastic performance of shape memory.Fig. 2 shows that material has the elastic modelling quantity of a definite minimizing, it is characterized by a relatively little variation of stress application and causes significant deformation.On the contrary, the material with shape-memory properties is when the super-elasticity shape, and it not is to be to increase stress that the distortion that takes place is responded equally greatly.Here it is, and ring nerve electrode of the present invention brings the up-to-date characteristic of benefit.For this purpose, the operating temperature range of electrode is chosen between austenite conversion finishing temperature AF and the temperature AF σ.With this understanding, it is contemplated that, if the cross section of neuropeptide 11 0 has produced increase, will deform, thereby excessive additional stress can be applied on the neuropeptide 11 0 at the electrode shown in Fig. 1 a and the 1b.This excessive stress has makes nerve suffer the danger of irreversible damage.The danger that this nerve is damaged is caused by king-sized pressure, thereby this pressure should cautiously be limited.Can consider that nerve can be subjected to a slight stress when static, to guarantee the mechanical grip that it is necessary and to have good electrically contacting.
For the operating temperature range between 35 ℃ to 42 ℃, distortion of materials temperature AF σ should be taken to and equal 42 ℃ less, and austenite conversion finishing temperature maximum is taken as 35 ℃.
More unique is: the characteristic that has shape memory under the effect of temperature can perform well in the operation.Electrode of the present invention can be placed on the nerve exactly, can from nerve it be taken off when needing.
In using the scope of single memory function, make the molding in this wise of the material with shape memory of electrode so that guarantee its in Ovshinsky bulk phase remember condition with the electrically contacting of neuropeptide 11 0.Its installation such as following mode are carried out: for example electrode is caused into martensitic phase near 0 ℃, and the finishing temperature MF of hypothesis martensitic transformation that Here it is and makes electrode be in open position near 0 ℃.Then, after being positioned on the perineural position, under the effect that temperature rises again, this electrode reverts to the clamp position of originally given Ovshinsky bulk phase own again, yet its condition is that austenite conversion initial temperature As should be higher than 0 ℃.
If when utilizing dual memory function, the molding in this wise of this shape-memory material can guarantee that the nerve in first shape memory state keeps electrically contacting, and should guarantee the taking-up and/or the insertion of electrode when second shape memory state.In fact, first and second shape memory state is confirmed as Ovshinsky bulk phase and martensitic phase respectively.The transformation each other of these shape memory states can reversiblely be carried out.As long as owing to overcome the inversion temperature of shape-memory material.For this reason, will stand a cultivating process according to electrode of the present invention, its example has provided in european patent application 0161952.
In addition, also illustrate among Fig. 1 a, electrode has a sheath body 21 in its outside, for example is the sheath body that the silicones by bio-compatible makes, and it can avoid organizing the alloy with composite electrode, as connecing solely between the Nitinol.Described polarization of electrode utilizes a conductor 30 to guarantee.In this form of implementation, be directly to obtain with neural contacting by the shape-memory material that constitutes electrode with the electrical connection of neuropeptide 11 0.For restriction may deleterious reaction between electrode material and biological tissue effectively, as shown on Fig. 3 a and 3b, consideration covers an insulation sheath body 22 in the inside of electrode, be embedded with a contact area thereon, as in the example of 3a and 3b, this contact area is made by a ring-type lead 23, and it is connected with conductor 30.Advantageously, this lead 23 is synthetic by platinum, and its bio-compatible performance is better than Nitinol widely.
The distortion that electrode is implemented among Fig. 4 a and 4b presentation graphs 3a and the 3b electrically contacts therein that district 23 is made up of the conducting strip of making annular distribution on a plurality of electrode inner walls.
Fig. 5, the neural stimulating apparatus of 6 and 7 expressions, it consists essentially of two ring electrodes 20,20 '.These electrodes are used to add potential difference, so that produce electricity irritation longitudinally in the inside of nerve.Fig. 5 and 6 form of implementation are made up of two electrodes identical with electrode shown in Fig. 1 a and the 1b.And conductor 30 and 30 ' is to merge ground in the insulation crust 40 of being drawn by the device end in Fig. 5, and in the example of Fig. 6, shell 50 is by drawing between two electrodes 20 and 20 '.These shells 40 and 50 are synthetic by the epoxy resin as coating.
Fig. 7 represents to add a kind of neural thorn device, and it is depicted as a dual electrode, this dual electrode be by to Fig. 4 a and 4b in similar two electrodes connect together and constitute.This two electrode is joined to one another, so that only constitute a single-piece.Conductor 30 and 30 ' similarly is incorporated in the insulation crust of an epoxy resin.

Claims (14)

1, is used for guaranteeing to electrically contact on every side with neural (10) a given operating temperature range, so that produce the ring nerve electrode of electricity irritation there, it is characterized in that: described electrode is made by a kind of shape-memory material, can in described operating temperature range, provide the super-elasticity function, under stress, be accompanied by by the austenite conversion of martensitic phase in opposite directions.
2, according to the ring nerve electrode of claim 1, it is characterized in that: the temperature AF δ of described shape-memory material equals 42 ℃ at least, and under stress, the conversion of austeno-martensite is impossible when surpassing this temperature.
3, according to the ring nerve electrode in arbitrary claim in claim 1 or 2, it is characterized in that: the austenite conversion finishing temperature AF of described shape-memory material is 35 ℃ to the maximum.
4, according to the ring nerve electrode of arbitrary claim in the claim 1 to 3, it is characterized in that: the molding in this wise of described shape-memory material, so that guarantee in the shape memory state of Ovshinsky bulk phase and the electrically contacting of described nerve (10).
5, according to the ring nerve electrode of arbitrary claim among the claim 1-3, it is characterized in that: the molding that described shape-memory material is such, electrically contact so that guarantee in first shape memory state to form, and described electrode is taken off and/or inserts in the distortion when guaranteeing to utilize martensitic state with described nerve (10).
6, ring nerve electrode according to claim 5, it is characterized in that: described electrode is handled by a kind of cultivation, so that it obtains second shape memory state, reach first shape memory state and reversibly carry out, be overcome as long as accomplish the conversion difficulty of the material of described shape memory to the conversion of second shape memory state.
7, according to the ring nerve electrode of arbitrary claim among the claim 4-6, it is characterized in that: described shape-memory material martensitic transformation finishing temperature MF is for approaching 0 ℃; And corresponding austenite conversion initial temperature As is greater than 0 ℃.
8, according to the ring nerve electrode of arbitrary claim among the claim 1-7, it is characterized in that: this electrode has one and is insulated the outside that sheath body (21) covers.
9, ring nerve electrode according to Claim 8 is characterized in that: this electrode has an interior contact portion that is provided with an insulation sheath body (22), and at least one is embedded in the contact area (23) on the described insulation sheath body.
10, according to the ring nerve electrode of claim 9, it is characterized in that: described contact area (23) are ring-type leads.
11, according to the ring nerve electrode of claim 9, it is characterized in that: described contact area (23) are made up of the conducting strip of a plurality of annular distribution.
12, nerve stimulation device, it is characterized in that: this device is by two ring nerve electrodes (20 according to arbitrary claim among the claim 1-11,20 ') form, each electrode has a polarization conductor (30,30 '), described polarization conductor is incorporated in the same insulation crust (40) of described stimulation end.
13, nerve stimulation device, it is characterized in that: this device is by two ring nerve electrodes (20 according to arbitrary claim among the claim 1-11,20 ') form, each electrode has a polarization conductor (30,30 '), described polarization conductor is incorporated in the same insulation crust (50) that is positioned between two electrodes (20,20 ').
14, nerve stimulation device is characterized in that: this device is made of dual electrode, and this dual electrode is: being linked together by two electrodes according to arbitrary claim of claim 9-11 constitutes.
CN91103931A 1990-05-21 1991-05-21 Ring nerve electrode Expired - Fee Related CN1025285C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9006314A FR2662084A1 (en) 1990-05-21 1990-05-21 ANNULAR NEURAL ELECTRODE.
FR9006314 1990-05-21

Publications (2)

Publication Number Publication Date
CN1060219A CN1060219A (en) 1992-04-15
CN1025285C true CN1025285C (en) 1994-07-06

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CN91103931A Expired - Fee Related CN1025285C (en) 1990-05-21 1991-05-21 Ring nerve electrode

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CN (1) CN1025285C (en)
AU (1) AU7963191A (en)
FR (1) FR2662084A1 (en)
WO (1) WO1991017791A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5375594A (en) * 1993-03-29 1994-12-27 Cueva; Roberto A. Removable medical electrode system
US5344438A (en) * 1993-04-16 1994-09-06 Medtronic, Inc. Cuff electrode
DE4433111A1 (en) * 1994-09-16 1996-03-21 Fraunhofer Ges Forschung Cuff electrode
US5899933A (en) * 1997-06-16 1999-05-04 Axon Engineering, Inc. Nerve cuff electrode carrier
US6308105B1 (en) * 1999-07-15 2001-10-23 Medtronic Inc. Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms
FR2797275B1 (en) * 1999-08-04 2001-11-23 Mat Inov METHOD FOR STORING TWO GEOMETRIC STATES OF A PRODUCT MADE IN A SHAPE MEMORY ALLOY AND APPLICATIONS OF THIS PROCESS TO PRODUCTS IN THE MEDICAL, DENTAL, VETERINARY OR OTHER AREAS
US7113816B2 (en) * 2002-06-18 2006-09-26 Nippon Cable System Inc. Ultra-miniature in-vivo electrode used for measuring bioelectrical neural activity
CA2586802A1 (en) * 2004-11-08 2006-05-11 Continence Control Systems International Pty Ltd. An implantable electrode arrangement
KR101278555B1 (en) * 2005-09-26 2013-06-25 각코우호우진 지치 이카다이가쿠 Instrument for endoscopic treatment
FR2959420B1 (en) * 2010-04-30 2012-08-03 Univ Paris Curie THREE-DIMENSIONAL GEOMETRY IMPLANT FOR THE ELECTRICAL STIMULATION OF A NERVOUS STRUCTURE
CN103976734A (en) * 2014-05-09 2014-08-13 思澜科技(成都)有限公司 Electrode ring for mammary electrical impedance tomography
WO2018005365A1 (en) 2016-06-27 2018-01-04 Board Of Regents, The University Of Texas System Softening nerve cuff electrodes
CN107029350B (en) * 2017-03-15 2020-06-19 清华大学 Micro-needle array electrode for optic nerve prosthesis
CN110841186B (en) * 2019-11-19 2021-11-19 华中科技大学 Implanted peripheral nerve electrode

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US3654933A (en) * 1968-11-18 1972-04-11 Medtronic Inc Implatable electrode
US3738368A (en) * 1970-12-14 1973-06-12 R Avery Implantable electrodes for the stimulation of the sciatic nerve
US3890977A (en) * 1974-03-01 1975-06-24 Bruce C Wilson Kinetic memory electrodes, catheters and cannulae
US4602624A (en) * 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4750499A (en) * 1986-08-20 1988-06-14 Hoffer Joaquin A Closed-loop, implanted-sensor, functional electrical stimulation system for partial restoration of motor functions

Also Published As

Publication number Publication date
FR2662084B1 (en) 1995-04-21
FR2662084A1 (en) 1991-11-22
CN1060219A (en) 1992-04-15
AU7963191A (en) 1991-12-10
WO1991017791A1 (en) 1991-11-28

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