CN102512230A - Spinal column fusion device internally lined with reinforced ribs - Google Patents
Spinal column fusion device internally lined with reinforced ribs Download PDFInfo
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- CN102512230A CN102512230A CN2011104096832A CN201110409683A CN102512230A CN 102512230 A CN102512230 A CN 102512230A CN 2011104096832 A CN2011104096832 A CN 2011104096832A CN 201110409683 A CN201110409683 A CN 201110409683A CN 102512230 A CN102512230 A CN 102512230A
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- fusion device
- spinal fusion
- metal
- reinforcement according
- agent structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
A spinal column fusion device internally lined with reinforced ribs comprises a main body structure and two internally-lined metal reinforced rib structure bodies embedded in the main body structure, wherein the main body structure is of a tubular structure with two hollow holes, each internally-lined metal reinforced rib structure body comprises a metal connecting bridge and two cylinders with internal thread structures, the two cylinders are connected by the metal connecting bridge, and the connecting bridge is embedded in a tube wall of the tubular structure. The horizontal section of the fusion device imitates a spinal column anatomical structure, the whole strength and toughness of the fusion device are improved by a form of internally-lined reinforced ribs, and the selecting range of novel biological materials is enlarged. In the process of an implantation operation, the main body part borne by the internally-lined metal reinforced rib structure is implanted into a body, so that the situation that the fusion device can be damaged due to a bad mechanics environment during the operation to influence an operation success can be avoided.
Description
Technical field
The present invention relates to a kind of spinal fusion device, the concrete spinal fusion device that relates to a kind of liner reinforcement belongs to technical field of medical instruments.
Background technology
Invasive lumbar fusion device has been widely used in the treatment of situation such as spinal fracture, dislocation as an important technology of spinal surgery, especially in the treatment of degeneration spinal disease, has brought into play irreplaceable effect.Spinal fusion device is the effective means of spine disorderses such as treatment spinal tuberculosis, infection, deformity, degeneration and intervertebral disk injury.
The 1950's; Cloward at first proposes the notion of fusion between way of escape lumbar vertebra; See that from biomechanics this is a kind of comparatively ideal spinal fusion, develops into one of spinal surgery basic fundamental, 1979 gradually; Bagby replaces the ilium piece to be used for the cervical intervertebral fusion of horse rustless steel hollow column with holes, claims Bagby cage Bagbybasket.Nineteen eighty-three, Bagby and Kuslich cooperation will be used for people's lumbar vertebra intervertebral fusion, and increase thread surface, and material is a titanium alloy, is B&K.The BAKKuslich SD of 1988 appearance, Corin JD, Bagby GW Spinal Implant.Patent# 5489308; The cylindric hollow threaded BAK of a kind of new titanium alloy, it provides a kind of good carrier that holds the bone grafting thing, has good biomechanics characteristic and histocompatibility; Can effectively strut intervertebral space; Reduce to greatest extent and get the bone amount, can avoid the plant bone mass slippage, keep higher ground bone-graft fusion.After this spinal fusion device develops rapidly, multiple shape occurs, different structure, the fusion device of different materials.
Development along with biomaterial; The material that is suitable for the orthopaedics reparation is more and more; Metal spinal fusion device shortcoming is very obvious; Therefore nonmetal fusion device arises, the representational patent ZL200810119617.X that professor Cui Fuzhai of Tsing-Hua University invention is arranged, " hydroxylapatite ceramic spinal fusion device ".
Spinal fusion device has the intervertebral space of strutting; Make anterior longitudinal ligament in tension, recover intervertebral height; And through ligament tension force around muscle contraction, the vertebral body around the vertebral body, stablize and promote interpyramidal bone property fusion to what the compression of Invasive lumbar fusion device realized Invasive lumbar fusion device from effects such as heavy sensation of the whole body; Keep each to merge the stability of sections,, will have more new material to be applied to the reparation of spinal disease along with development clinical and biomechanics Research and materialogy; But some material is applied to BAK, and its intensity can not satisfy clinical requirement.
The fusion device of using is clinically at present mainly processed by titanium alloy and macromolecule PEEK material, but these two kinds of materials all have significant disadvantages in clinical.
The elastic modelling quantity of metal spinal fusion device is higher than cortical bone far away, causes stress shielding in vivo, complication such as can cause implant site osteoporosis, osteanabrosis, implant site to subside or loosening.Metal material can't pass through X-ray, influences the observation of postoperative to the bone fusion site.
By spinal fusion device such as the polyether-ether-ketone that the macromolecular material of synthetic is processed, PEEK though elastic modelling quantity and vertebral body bone coupling have good corrosion resistance, can see through X-ray, also can cause a series of complication simultaneously: nerve root injury; Fusion device is loosening; Fusion device subsides, and intervertebral space and intervertebral foramina height reduce; Do not merge etc.
Summary of the invention
In order to address the above problem, the present invention provides a kind of spinal fusion device of liner reinforcement.
A kind of spinal fusion device of liner reinforcement; It is characterized in that comprising agent structure and be embedded in metal inner lining reinforced structure body wherein; Said agent structure is the tubular structure that two hollow holes are arranged, and has the diplopore partition between two hollow holes, and said metal inner lining reinforced structure body comprises the cylinder of metal cross structure and two female thread structures that are connected by said metal cross structure; Said metal cross structure is embedded in the tube wall of said tubular structure; The diplopore partition is passed at the middle part of metal cross structure, and the sidewall that said agent structure hollow hole is relative with the diplopore partition is provided with the circular hole that equates with said cylinder external diameter, and said cylinder is embedded in the circular hole; Said agent structure is provided with position, some holes in addition on the hollow out hole wall; Two strip metal cores are being extended perpendicular to the planar direction of metal cross structure in the middle part of said metal cross structure, and said metal-cored length is identical with the height of main body, is embedded in the diplopore partition.
Said agent structure be shaped as the agent structure shape that is applicable to one or more spinal fusion devices in Fructus anacardii type intervertebral disc spinal fusion device, rectangle cube spinal fusion device, chess shape cube lumbar vertebra spinal fusion device, olive shape spinal fusion device, screw-type cylinder spinal fusion device, netted spinal fusion device or the sectional type cylinder spinal fusion device.
Said metal inner lining reinforced structure body is a titanium alloy material.
The openwork hole of the corresponding agent structure of said metal cross structure has two metal bridge cross structure hollow holes that the center is identical; Said metal cross structure width is greater than the width of agent structure hollow hole, and said metal cross structure hollow hole area is less than the area of agent structure hollow hole.
Said female thread is of a size of Φ 2-5CM.
Said female thread is of a size of Φ 3CM.
Said agent structure adopts the injection mo(u)lding of medical PEEK material.
Said metal-cored diameter is 1mm.
Said Kong Weizhong implants guiding osteogenesis material.
Include other absorbable material in the said metal inner lining reinforced structure body.
Technique effect:
The spinal fusion device horizontal section imitation anatomy of spine structure of a kind of liner reinforcement of the present invention, form raising spinal fusion device bulk strength, toughness through the liner reinforcement increase the range of choice of novel biomaterial.In the implant surgery process, mainly get in the body through metal liner muscle structural bearing main part, can avoid spinal fusion device in operation process, maybe because abominable mechanical environment damage, have a strong impact on and perform the operation successfully.Liner reinforced structure body belongs to and implants the part of the force in clinical operation, can bear the impulsive force when implanting, and reduces the danger of being damaged of spinal fusion device main body.This structure is circulated up and down, inserts guiding osteogenesis material at the hollow hole of agent structure and metal inner lining reinforced structure body and the inner space of sidewall circular hole and position, hole, and spinal fusion device and spinal fusion device are in the same place, and reaches the effect that is completely fixed.This structure is widely applicable, is prone to the relatively poor biomaterial coupling of multiple mechanical property.Liner reinforced structure body can improve the whole toughness of fusion device to a great extent, and little to the influence of fusion device material of main part mechanical property.
Liner reinforced structure body belongs to metal material, but since its to account for volume ratio little, see that from fore-and-aft direction projected area is little, can not produce and can't see through the X-ray phenomenon, can not influence postoperative to fusion site observation.Because it is inner at spinal fusion device,, can not produce metal fragment in addition,, influence the fusion of bone so be difficult to produce macrophage, il-1, interleukin-6, PGE2, tumor necrosis factor etc. with spinal column effect on every side though be metal.
Liner reinforced structure body can be produced spinal fusion device with other absorbable materials or the combination of part absorbable material.Absorbable material can induction of bone growth such as hydroxyapatite or devitrified glass.The stress shielding that produces when absorbable material can be avoided just having implanted.The compressive stress that vertebral body can initiatively increase bone grafting stimulates, and can accelerate the fusion of bone grafting.
The cylinder at liner reinforced structure body two ends is connected through the metal cross structure, and metal cross structure width is bigger than the width of hollow hole.Can guarantee that spinal fusion device is implanted assigned address in the operation implantation process under the carrying of liner reinforced structure body.
Liner reinforced structure body can mate with spinal fusion device fully, can perforate on the cross structure, also can not perforate, and pore size only otherwise influence the intensity of cross structure does not have specific (special) requirements to the hollow hole size.
The liner reinforced structure preferably adopts titanium alloy material, good biocompatibility.
The liner reinforced structure has designed metal-cored, the essential tantalum wire of X-ray development in alternative other fusion devices.
There is the cylinder female thread structure at liner reinforced structure body two ends, and when implanting spinal fusion device, operation tool is threaded through this.
Description of drawings
Fig. 1 faces schematic perspective view for the embodiment of the invention 1;
Fig. 2 is the embodiment of the invention 1 a rear perspective sketch map;
Fig. 3 is the embodiment of the invention 1 a metal cross structure sketch map;
Fig. 4 is the embodiment of the invention 1 vertical view;
Fig. 5 overlooks half-sectional view for the embodiment of the invention 1;
Fig. 6 overlooks the semi-section schematic perspective view for the embodiment of the invention 1.
Each label is listed as follows among the figure:
The 1-agent structure, 2-liner reinforced structure body, 3-engaging tooth, 4-spill arc wall, 5-convex arc wall, 6-plane; The 7-hollow hole, 8-diplopore partition, 9-circular hole, position, 10-hole, 11-bottom surface; The 12-cylinder, the 13-female thread, 14-metal cross structure, 15-is metal-cored, 16-metal bridge hollow hole.
The specific embodiment:
The present invention is described further content of the present invention in order better to explain below in conjunction with concrete embodiment.
Embodiment 1
Like Fig. 1-shown in Figure 6 is the sketch map of present embodiment, and spinal fusion device agent structure 1 is the Fructus anacardii type, overall wide 14mm; Long 25mm, high 10mm, wall thickness 2.5mm; Two bottom surfaces 11 have anatomical structure up and down, and the engaging tooth 3 on it highly is 0.5mm, also can take to increase the Any shape of roughness.Two bottom surface 11 basal planes are parallel, and shape is identical.The circular arc wall of principal length direction is bent to a lateral bending simultaneously, forms a side spill arc wall 4, and an other side convex arc wall 5 is the left-right symmetric body.Both sides circular arc wall is a plane 6 at interlude, and agent structure comprises that 7, two hole shapes of two hollow holes are identical, and horizontal direction does not communicate between the Kong Yukong.The cross sectional shape of hollow hole 7 is with the smooth connection of straight line two ends circular arc.The cross section takes up space and can adjust, and is as the criterion not influence main body intensity.Reserving certain thickness vertical diplopore partition 8 is in order to improve the intensity between main part spill arc wall 4 and the convex arc wall 5.There is the circular hole 9 perpendicular to wall at 6 places, circular arc wall interlude plane, main body both sides, and its internal diameter just equates with cylinder 12 external diameters of liner reinforced structure body 2.In the left and right sides of spill arc wall 4, be drilled with position, 2 holes 10 respectively, communicate with the hollow hole 7 of main body, the size in aperture will suit, and the diameter sum in two holes is no more than the half the of spill arc wall 4 height.The left and right sides at an other side convex arc wall 5 has position, a hole 10 respectively, also communicates with the hollow hole 7 of main body.Position, hole 10 quantity can change, only otherwise influencing agent structure 1 intensity gets final product.Liner reinforced structure body 2 flexural center section centrages and agent structure 1 curved cutplanes centrage coincide, and promptly liner reinforced structure body 2 is embedded in the center of agent structure 1.
Liner reinforced structure body 2 thickness are 1mm, length 25mm, and there are cylinder 12 female thread structures 13 at liner reinforced structure body 2 two ends, and female thread 13 is of a size of the Φ 3 of standard.The cylinder 12 at two ends is connected through metal cross structure 14; Metal cross structure 14 width are bigger than the width of hollow hole 7; Width than agent structure 1 is little, and middle have metal-cored 15, metal-cored 15 of two vertical directions highly to follow the height of agent structure 1 identical; Metal-cored 15 diameters are littler than diplopore partition 8 thickness, just in time are embedded in the middle of the vertical diplopore partition 8.In the fusion device implant surgery, metal-cored 15 can substitute the essential tantalum wire of X-ray development in other fusion devices.The metal bridge hollow hole 16 of vertical direction is also arranged in the middle of the metal cross structure 14, be of a size of 2mm, identical with hollow hole 7 centers of main body, size can change.
Present embodiment is applicable to patient L5/S1 intervertebral disc prolapse.The spinal fusion device material therefor is the medical embedded property PEEK material of German EVONIK company import.Metal inner lining reinforced structure body 2 is to mate fully together with agent structure 1, and both cooperate seamless.The spinal fusion device horizontal section imitation anatomy of spine structure of present embodiment liner reinforcement, form raising spinal fusion device bulk strength, toughness through the liner reinforcement increase the range of choice of novel biomaterial.In the implant surgery process, mainly carry agent structures 1 and get in the body through metal inner lining reinforced structure body 2, can avoid spinal fusion device in operation process, maybe because abominable mechanical environment damage, have a strong impact on and perform the operation successfully.This structure is circulated up and down, inserts guiding osteogenesis material in the inner space of hollow hole 7, metal bridge hollow hole 16 and sidewall circular hole 9 and position, hole 10, and spinal fusion device and spinal fusion device are in the same place, and reaches the effect that is completely fixed.This structure is widely applicable, is prone to the relatively poor biomaterial coupling of multiple mechanical property.
The physical dimension of spinal fusion device is with embodiment 1, and the liner reinforced structure is also with embodiment 1.The spinal fusion device material therefor is the medical embedded property PEEK material of German EVONIK company import.
The physical dimension of spinal fusion device is with embodiment 1, but the inclination angle of low 5 degree in high back before fusion device has.Wide 14mm, long 25mm, the high 10mm of downside, wall thickness 2.5mm, upper and lower surfaces has anatomical structure.Material therefor is the medical embedded property PEEK material of German EVONIK company import, is applicable to patient L4/L5.
Embodiment 4
The spinal fusion device agent structure is selected rectangle cube, wide 13mm, long 13mm, high 6mm, wall thickness 2.5mm.Upper and lower surfaces has anatomical structure, and the tooth engaged height on it is 0.5mm.Be applicable to patient L5/S1 intervertebral disc prolapse.Liner reinforced structure thickness is 1mm, length 13mm, and interior hollow out is of a size of 1.5mm, and metal-cored height is 6mm.Two terminal circle cylinder female thread structure, female thread are of a size of the Φ 3 of standard.
The spinal fusion device agent structure is selected chess shape cube, wide 28mm, long 34mm, high 14mm, wall thickness 2.5mm.Upper and lower surfaces has anatomical structure, and the tooth engaged height on it is 0.5mm.Be applicable to patient L4/L5 prolapse of lumbar intervertebral disc.Liner reinforced structure thickness is 1mm, length 34mm, and interior hollow out is of a size of 4mm, and metal-cored height is 14mm.Two terminal circle cylinder female thread structure, female thread are of a size of the Φ 3 of standard.
Other embodiment
The spinal fusion device agent structure is selected the olive shape spinal fusion device, screw-type cylinder spinal fusion device, netted spinal fusion device, the spinal fusion device of sectional type cylinder spinal fusion device or multiple combination of shapes.Upper and lower surfaces has anatomical structure, and the tooth engaged height on it is 0.5mm.Liner reinforced structure body profile size is with the agent structure coupling.Can make the spinal fusion device of corresponding construction according to different therapentic parts.
Should be understood that; The above specific embodiment can make those skilled in the art more fully understand the invention; But do not limit the present invention in any way creation; All do not break away from the technical scheme and the improvement thereof of the spirit and the scope of the invention, and it all is encompassed in the middle of the protection domain of the invention patent.
Claims (10)
1. the spinal fusion device of a liner reinforcement; It is characterized in that comprising agent structure and be embedded in metal inner lining reinforced structure body wherein; Said agent structure is the tubular structure that two hollow holes are arranged, and has the diplopore partition between two hollow holes, and said metal inner lining reinforced structure body comprises the cylinder of metal cross structure and two female thread structures that are connected by said metal cross structure; Said metal cross structure is embedded in the tube wall of said tubular structure; The diplopore partition is passed at the middle part of metal cross structure, and the sidewall that said agent structure hollow hole is relative with the diplopore partition is provided with the circular hole that equates with said cylinder external diameter, and said cylinder is embedded in the circular hole; Said agent structure is provided with position, some holes in addition on the hollow out hole wall; Two strip metal cores are being extended perpendicular to the planar direction of metal cross structure in the middle part of said metal cross structure, and said metal-cored length is identical with the height of main body, is embedded in the diplopore partition.
2. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that being shaped as of said agent structure is applicable to the agent structure shape of one or more spinal fusion devices in Fructus anacardii type intervertebral disc spinal fusion device, rectangle cube spinal fusion device, chess shape cube lumbar vertebra spinal fusion device, olive shape spinal fusion device, screw-type cylinder spinal fusion device, netted spinal fusion device or the sectional type cylinder spinal fusion device.
3. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that said metal inner lining reinforced structure body is a titanium alloy material.
4. the spinal fusion device of a kind of liner reinforcement according to claim 1; The openwork hole that it is characterized in that the corresponding agent structure of said metal cross structure has two metal bridge cross structure hollow holes that the center is identical; Said metal cross structure width is greater than the width of agent structure hollow hole, and said metal cross structure hollow hole area is less than the area of agent structure hollow hole.
5. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that said female thread is of a size of Φ 2-5CM.
6. the spinal fusion device of a kind of liner reinforcement according to claim 5 is characterized in that said female thread is of a size of Φ 3CM.
7. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that said agent structure adopts the injection mo(u)lding of medical PEEK material.
8. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that said metal-cored diameter is 1mm.
9. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that said Kong Weizhong implants guiding osteogenesis material.
10. the spinal fusion device of a kind of liner reinforcement according to claim 1 is characterized in that including other absorbable material in the said metal inner lining reinforced structure body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011104096832A CN102512230B (en) | 2011-12-09 | 2011-12-09 | Spinal column fusion device internally lined with reinforced ribs |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104096832A CN102512230B (en) | 2011-12-09 | 2011-12-09 | Spinal column fusion device internally lined with reinforced ribs |
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| CN102512230A true CN102512230A (en) | 2012-06-27 |
| CN102512230B CN102512230B (en) | 2013-06-05 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622767A (en) * | 2013-12-11 | 2014-03-12 | 广州聚生生物科技有限公司 | Lumbar fusion cage for intervertebral foramen approach |
| CN106109064A (en) * | 2016-06-15 | 2016-11-16 | 东北大学 | A kind of spinal fusion device |
| CN106999217A (en) * | 2014-11-04 | 2017-08-01 | 海普瑞万迅公司 | Implant for consolidating knochenbruch or non-knochenbruch |
| CN107468382A (en) * | 2017-08-23 | 2017-12-15 | 北京爱康宜诚医疗器材有限公司 | Ankle joint fusion cage |
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| CN101296669A (en) * | 2005-09-26 | 2008-10-29 | 华沙整形外科股份有限公司 | Hybrid intervertebral spinal fusion implant |
| US20090088765A1 (en) * | 2007-09-27 | 2009-04-02 | Butler Michael S | Spinal Interbody Distractor |
| CN101616642A (en) * | 2006-10-16 | 2009-12-30 | 先锋外科技术公司 | Fusing device |
| US20110071635A1 (en) * | 2009-09-23 | 2011-03-24 | Zimmer Spine, Inc. | Composite implant |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101296669A (en) * | 2005-09-26 | 2008-10-29 | 华沙整形外科股份有限公司 | Hybrid intervertebral spinal fusion implant |
| CN101616642A (en) * | 2006-10-16 | 2009-12-30 | 先锋外科技术公司 | Fusing device |
| US20090088765A1 (en) * | 2007-09-27 | 2009-04-02 | Butler Michael S | Spinal Interbody Distractor |
| US20110071635A1 (en) * | 2009-09-23 | 2011-03-24 | Zimmer Spine, Inc. | Composite implant |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622767A (en) * | 2013-12-11 | 2014-03-12 | 广州聚生生物科技有限公司 | Lumbar fusion cage for intervertebral foramen approach |
| CN106999217A (en) * | 2014-11-04 | 2017-08-01 | 海普瑞万迅公司 | Implant for consolidating knochenbruch or non-knochenbruch |
| CN106999217B (en) * | 2014-11-04 | 2021-04-13 | 海普瑞万迅公司 | Implant for stabilizing fractured or non-fractured bones |
| CN106109064A (en) * | 2016-06-15 | 2016-11-16 | 东北大学 | A kind of spinal fusion device |
| CN107468382A (en) * | 2017-08-23 | 2017-12-15 | 北京爱康宜诚医疗器材有限公司 | Ankle joint fusion cage |
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| CN102512230B (en) | 2013-06-05 |
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Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee after: Aojing Medical Technology Co., Ltd Address before: 100085 Zhongguancun biological medicine Park, No. 5, Pioneer Road, Beijing, Haidian District, A409 Patentee before: Beijing Allgens Medical Science and Technology Co.,Ltd. |
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