CN102511481B - Method for embedding metalaxyl - Google Patents
Method for embedding metalaxyl Download PDFInfo
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- CN102511481B CN102511481B CN 201110415735 CN201110415735A CN102511481B CN 102511481 B CN102511481 B CN 102511481B CN 201110415735 CN201110415735 CN 201110415735 CN 201110415735 A CN201110415735 A CN 201110415735A CN 102511481 B CN102511481 B CN 102511481B
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Abstract
The invention discloses a method for embedding metalaxyl, which belongs to the slow release pesticide preparation method; and relates to the method for embedding metalaxy with high encapsulation rate and good slow release effect. The method comprises the following steps evenly mixing a chitosan solution, a sodium tripolyphosphate solution and a metalaxyl solution according to a volume ratio of 3:1:0.4 to prepare a nano solution; taking a sodium alginate solution in a culture vessel and then drying; uniformly mixing the sodium alginate solution and the nano solution to obtain a mixed liquid; placing the mixed liquid into the dried culture vessel and then drying; placing the sodium alginate solution in the culture vessel which is subjected to secondary drying and then drying, taking the culture vessel which is dried three times, stripping a film attached to the bottom of the culture vessel, then coating a CaCl2 solution on both sides of the film, and placing in an oven with the temperature of 60 DEG C for drying. The invention has the advantages of high encapsulation efficiency and good slow release effect, and is the preparation method for a metalaxyl slow release agent.
Description
Technical field
The present invention relates to a kind of preparation method of sustained-release pesticides, relate in particular to a kind of method of embedding metalaxyl.
Background technology:As everyone knows, pesticide slow-releasing agent can prolong the lasting effect of same dose agricultural chemicals greatly, reduces access times and the total amount of agricultural chemicals, makes residual and significantly reduction of pollution.Though it is a lot of to prepare the method for sustained-release pesticides, at present to metalaxyl seal make sustained release agent technology seldom, main formulation is still based on pulvis or emulsion.Its reason is the envelop rate of metalaxyl very low (about 30%), is difficult to use in actual agricultural production; Therefore how to improve metalaxyl envelop rate, make it to possess good slow release effect and become a problem needing solution in the present pesticide producing badly.
Summary of the invention:In order to overcome the defective that exists in the prior art, the present invention aims to provide the method for the embedding metalaxyl of a kind of envelop rate height, had good sustained release effect.
To achieve these goals, the present invention by the following technical solutions, concrete steps are as follows:
1) chitosan solution, sodium tripolyphosphate solution and the metalaxyl solution volume ratio by 3:1:0.4 is mixed, make nano-solution; Wherein, the pH value of chitosan solution is 4.5, molecular weight is 1,000,000, concentration is 3 ㎎/mL, and the concentration of sodium tripolyphosphate solution is 2 ㎎/mL, and the concentration of metalaxyl solution is 2 ㎎/mL;
2) get concentration be the sodium alginate soln 5mL of 10 ㎎/mL in culture dish, place 60 ℃ baking oven to dry;
3) get concentration be the sodium alginate soln 8.8mL of 10 ㎎/mL in the 25ml small beaker, magnetic agitation is even, slowly adds above-mentioned nano-solution 4.4mL, continues to stir, and makes mixed liquor; Magnetic agitation speed is 1700rpm;
4) above-mentioned mixed liquor is poured into through step 2) oven dry culture dish in, place 60 ℃ baking oven to dry;
5) getting concentration is that the sodium alginate soln 5mL of 10 ㎎/mL pours in the culture dish of step 4) oven dry, places 60 ℃ baking oven to dry;
6) take out the culture dish of drying through step 5), peel the film that is attached to the culture dish bottom, smear CaCl on the two sides of this film then
2Solution places 60 ℃ baking oven to dry; CaCl
2The concentration of solution is 1mol/L.
Compared with the prior art, the present invention is owing to adopted technique scheme, at first utilize shitosan that the metalaxyl nano particle is carried out embedding (envelop rate about 35%) and formation shitosan-metalaxyl nano particle, and then utilize and by sodium alginate and the formed calcium alginate film of calcium chloride this shitosan-metalaxyl nano particle and remaining free metalaxyl nano particle to be carried out integral body and seal, so envelop rate can reach 100%.In the dispenser process, calcium alginate film at first decomposes under the effect of external environments such as sunlight, rainwater, and the free metalaxyl nano particle of being sealed by calcium alginate film (about 70%) is discharged gradually and brings into play drug effect; Afterwards, along with the decomposition of shitosan-metalaxyl nano particle, be embedded in metalaxyl nano particle in the shitosan and progressively discharged and continue to bring into play drug effect; Thereby prolong effectively agricultural chemicals lasting effect, improved slow release effect.Experiment showed, sustainable about 200 hours of the release time of dose of the metalaxyl sustained release agent that adopts the present invention's preparation:
From table 2～3 as can be seen: the chitosan solution that pH value is 4.5, molecular weight is 1,000,000, concentration is 3 ㎎/mL is the highest to the envelop rate of metalaxyl.Be that shitosan can reach 35.2% to the average envelop rate of metalaxyl according to the configuration nano-solution according to this.
Embodiment:Below in conjunction with the invention will be further described with specific embodiment:
Embodiment 1
1) chitosan solution, sodium tripolyphosphate solution and the metalaxyl solution volume ratio by 3:1:0.4 is mixed, make nano-solution; Wherein, the pH value of chitosan solution is 4.5, molecular weight is 1,000,000, concentration is 3 ㎎/mL, and the concentration of sodium tripolyphosphate solution is 2 ㎎/mL, and the concentration of metalaxyl solution is 2 ㎎/mL;
2) get concentration be the sodium alginate soln 5mL of 10 ㎎/mL in culture dish, place 60 ℃ baking oven to dry;
3) get concentration be the sodium alginate soln 8.8mL of 10 ㎎/mL in the 25ml small beaker, magnetic agitation is even, dropwise adds above-mentioned nano-solution 4.4mL, continues to stir 1 minute, makes mixed liquor; Magnetic agitation speed is 1700rpm;
4) above-mentioned mixed liquor is poured into through step 2) in the culture dish of oven dry, guarantee that mixed liquor evenly is covered with the culture dish bottom, places 60 ℃ baking oven to dry then;
5) getting concentration is that the sodium alginate soln 5mL of 10 ㎎/mL pours in the culture dish of step 4) oven dry, places 60 ℃ baking oven to dry;
6) take out the culture dish of drying through step 5), the film that will be attached to the culture dish bottom with blade from the edge peels, with having dipped in CaCl
2The cotton balls of solution is smeared the two sides of this film, places 60 ℃ baking oven oven dry to get final product then; CaCl
2The concentration of solution is 1mol/L.
Claims (1)
1. the method for an embedding metalaxyl is characterized in that concrete steps are as follows:
1) chitosan solution, sodium tripolyphosphate solution and the metalaxyl solution volume ratio by 3:1:0.4 is mixed, make nano-solution; Wherein, the pH value of chitosan solution is 4.5, molecular weight is 1,000,000, concentration is 3 ㎎/mL, and the concentration of sodium tripolyphosphate solution is 2 ㎎/mL, and the concentration of metalaxyl solution is 2 ㎎/mL;
2) get concentration be the sodium alginate soln 5mL of 10 ㎎/mL in culture dish, place 60 ℃ baking oven to dry;
3) get concentration be the sodium alginate soln 8.8mL of 10 ㎎/mL in the 25ml small beaker, magnetic agitation is even, slowly adds above-mentioned nano-solution 4.4mL, continues to stir, and makes mixed liquor; Magnetic agitation speed is 1700rpm;
4) above-mentioned mixed liquor is poured into through step 2) oven dry culture dish in, place 60 ℃ baking oven to dry;
5) getting concentration is that the sodium alginate soln 5mL of 10 ㎎/mL pours in the culture dish of step 4) oven dry, places 60 ℃ baking oven to dry;
6) take out the culture dish of drying through step 5), peel the film that is attached to the culture dish bottom, smear CaCl on the two sides of this film then
2Solution places 60 ℃ baking oven to dry; CaCl
2The concentration of solution is 1mol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110415735 CN102511481B (en) | 2011-12-14 | 2011-12-14 | Method for embedding metalaxyl |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110415735 CN102511481B (en) | 2011-12-14 | 2011-12-14 | Method for embedding metalaxyl |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102511481A CN102511481A (en) | 2012-06-27 |
| CN102511481B true CN102511481B (en) | 2013-10-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110415735 Expired - Fee Related CN102511481B (en) | 2011-12-14 | 2011-12-14 | Method for embedding metalaxyl |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939960B (en) * | 2012-11-06 | 2014-07-02 | 绍兴文理学院 | Sustained-release herbicide microparticle preparation and preparation method thereof |
| CN103146036B (en) * | 2013-03-02 | 2015-05-27 | 福建农林大学 | High-strength and high-antibacterial property sodium alginate film for food packaging and preparation method thereof |
| CN107258802A (en) * | 2017-08-08 | 2017-10-20 | 浙江禾本科技有限公司 | A kind of water-soluble agricultural composite Nano bactericide and preparation method thereof |
| CN110574762B (en) * | 2019-08-30 | 2022-01-21 | 华南农业大学 | Water surface floating directional slow-release pesticide preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2275902A (en) * | 2000-12-19 | 2002-07-01 | Hae-Jun Park | A method for producing the sustained-releasing agricultural chemicals |
| CN1813687A (en) * | 2005-11-25 | 2006-08-09 | 浙江大学 | Method for preparing tinidazole biological composite membrane |
| CN102090395B (en) * | 2011-01-05 | 2013-09-04 | 贵州省烟草科学研究所 | Abscisic acid-embedded chitosan nanoparticles and preparation method thereof |
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| CN102511481A (en) | 2012-06-27 |
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Granted publication date: 20131009 Termination date: 20171214 |