CN102504214A - Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium - Google Patents
Process method for catalytic synthesis of poly lactic acid-glycolic acid by using bionic organic guanidinium Download PDFInfo
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- CN102504214A CN102504214A CN2011103552151A CN201110355215A CN102504214A CN 102504214 A CN102504214 A CN 102504214A CN 2011103552151 A CN2011103552151 A CN 2011103552151A CN 201110355215 A CN201110355215 A CN 201110355215A CN 102504214 A CN102504214 A CN 102504214A
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 239000011664 nicotinic acid Substances 0.000 title abstract description 4
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 title abstract 4
- 238000007036 catalytic synthesis reaction Methods 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 title 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 110
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 55
- 239000004310 lactic acid Substances 0.000 claims abstract description 55
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 239000002184 metal Substances 0.000 claims abstract description 9
- 229910052751 metal Inorganic materials 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000006555 catalytic reaction Methods 0.000 claims abstract description 5
- 230000015572 biosynthetic process Effects 0.000 claims abstract 3
- 238000003786 synthesis reaction Methods 0.000 claims abstract 3
- MMGJNINGVUMRFI-UHFFFAOYSA-N 15686-38-1 Chemical compound C1CC2(C3=C(C4=CC=CC=C4N3)C3)CCCCC2C3N1CC1CC1 MMGJNINGVUMRFI-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims description 77
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 64
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 63
- 239000002253 acid Substances 0.000 claims description 57
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 32
- 229940109239 creatinine Drugs 0.000 claims description 32
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 32
- 238000005660 chlorination reaction Methods 0.000 claims description 31
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 28
- 239000000126 substance Substances 0.000 claims description 21
- 229910052786 argon Inorganic materials 0.000 claims description 14
- 238000010792 warming Methods 0.000 claims description 11
- 230000003592 biomimetic effect Effects 0.000 claims description 9
- 238000006297 dehydration reaction Methods 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 7
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 238000006068 polycondensation reaction Methods 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 238000013270 controlled release Methods 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000035484 reaction time Effects 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 abstract description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 4
- 238000012662 bulk polymerization Methods 0.000 abstract 1
- 230000007541 cellular toxicity Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 230000003292 diminished effect Effects 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 238000001291 vacuum drying Methods 0.000 description 9
- 238000012856 packing Methods 0.000 description 5
- 230000002194 synthesizing effect Effects 0.000 description 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 2
- 235000011150 stannous chloride Nutrition 0.000 description 2
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- -1 guanidine compound Chemical class 0.000 description 1
- 150000002357 guanidines Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000783 metal toxicity Toxicity 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000012974 tin catalyst Substances 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
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- Polyesters Or Polycarbonates (AREA)
Abstract
The invention relates to a new method for synthesis of a medical biodegradable material poly lactic acid-glycolic acid by copolycondensation of lactic acid and glycolic acid through a catalysis effect of a bionic creatinine hydrochloride creatininium chloride (creatininium hydrochloride). According to the method, the bionic creatininium chloride is adopted as a catalyst, the industrial-grade lactic acid (LA, 85% aqueous solution) and the glycolic acid (GA, 95%) are adopted as monomers, and bulk solvent-free two-stage copolycondensation is performed to obtain the medical degradable poly lactic acid-glycolic acid with characteristics of high biological safety, no toxicity and no metal. According to the present invention, the method of the present invention has characteristics of green catalyst and solvent-free bulk polymerization; the catalyst creatininium chloride has high biocompatibility and high biological safety, and does not have cell toxicity; the synthesized poly lactic acid-glycolic acid does not contain any metals and other toxic residues, and is applicable for medical and medicinal materials; the process is simple and easy to operate, the raw material cost is low, the operation is simple, and the method is applicable for the industrial implementation.
Description
Technical field
The invention belongs to the medical biodegradable material technical field; Relating to the organic guanidinesalt of biomimetic type---the chlorination creatinine guanidine is a catalyzer, is the method for raw material through the synthetic height of copolycondensation biological safety medical use biological degradable polylactic acid-glycollic acid with lactic acid, oxyacetic acid.
Background technology
Polylactic acid-glycollic acid PLGA is owing to its degradation rate, mechanical property and intensity can be regulated and control through the composition and the molecular weight that change multipolymer; Become a kind of important medical biodegradable material, have excellent biological compatibility, Bioabsorbable and biological degradability.Polylactic acid-glycollic acid has been widely used in many aspects of biomedical sector: like the property implanted hard tissue repairing material, operating suture, target and controlled release drug carrier.General synthetic PLGA mainly adopts stannous octoate catalysis ring-opening polymerization method and tin protochloride catalysis polycondensation method.Research shows that metallic tin catalyst has cytotoxicity, and used pink salt catalyzer can not thoroughly be removed from polymkeric substance.Therefore caused the deeply concerned of scholar about safety issue and queried that this has also limited PLGA needs the application aspect the field of biological safety highly at those with the synthetic PLGA of tin class catalyzer.Therefore, the green catalyst that how to find no metal toxicity can reach the efficient catalytic effect has again become the new problem of PLGA class biological medical degradable field of materials.
Summary of the invention
The objective of the invention is to solve existing polycondensation method synthesizing polylactic acid-oxyacetic acid uses tin protochloride to cause institute's synthesizing polylactic acid-oxyacetic acid material to be used for human medical drugs as catalyzer to have the problem of security hidden danger with the field, the process method of the direct copolycondensation method of the organic guanidinesalt catalysis of a kind of biomimetic type synthesizing polylactic acid-oxyacetic acid is provided.
The present invention develops first and a kind ofly utilizes nontoxic, no metal biomimetic type chlorination creatinine guanidine to be catalyzer; Lactic acid (LA; 85% aqueous solution) and oxyacetic acid (GA, 95%) be comonomer through the novel method of the synthetic height of body copolycondensation method biological safety bio-medical degradable material polylactic acid-glycollic acid.
The organic guanidinesalt of nontoxic, no metal biomimetic type used in the present invention---chlorination creatinine guanidine (Creatininium Chloride; English abbreviation is: CRCl); Its compound method is that employing creatinine (l-arginine metabolism resultant in the CR, the organic guanidine compound of a kind of biomass---human body) is that raw material and aqueous hydrochloric acid reaction form.
Provided by the invention is that the step of the catalyzer process method of carrying out lactic acid, the medical degradable material polylactic acid-glycollic acid of the direct copolycondensation synthesising biological of oxyacetic acid is following with biomimetic type chlorination creatinine guanidine:
1st, lactic acid oligomer-oxyacetic acid OLGA's is synthetic
With mol ratio is that 1: 9～9: 1 mass content is that 85% technical grade lactic acid aqueous solution LA and mass content are that 95% oxyacetic acid GA is a comonomer, the lactic acid oligomer-oxyacetic acid (oligopolymer of lactic acid oxyacetic acid) of at first synthetic weight-average molecular weight Mw=200～400;
Processing condition: in reaction kettle, pack into lactic acid and oxyacetic acid, repeat to vacuumize-applying argon gas operation three times after, under argon atmospher and normal pressure, be heated to 130～160 ℃, dehydration reaction 1～3 hour; Then reaction kettle being decompressed to 100Torr reacted 1～3 hour down at 130～160 ℃; At last reaction kettle being decompressed to 30Torr reacted 1～3 hour down at 130～160 ℃;
The building-up reactions formula:
2nd, polylactic acid-glycollic acid PLGA's is synthetic
Lactic acid oligomer-oxyacetic acid OLGA is a raw material with the 1st step synthetic, is catalyzer, under reduced pressure carries out the body melt phase polycondensation with nontoxic, no metal biomimetic type chlorination creatinine guanidine, synthesizes the bio-medical degradation property polylactic acid-glycollic acid that obtains the height biological safety;
Synthesising reacting process condition and working method are: add lactic acid oligomer-oxyacetic acid, catalyzer chlorination creatinine guanidine to reaction kettle; The mass ratio of control lactic acid oligomer-oxyacetic acid and biomimetic type chlorination creatinine guanidine is 100～2000; Reaction kettle is decompressed to 10Torr; Be warming up to 150～195 ℃ of reactions after 48～170 hours, promptly obtain the polylactic acid-glycollic acid product, weight average molecular weight range is 1.0～11.1 * 10
4, polymerization degree m scope is 77～854;
The building-up reactions formula:
The inventive method institute synthetic polylactic acid-glycollic acid weight-average molecular weight is 1.0～11.1 * 10
4And polymkeric substance can synthesize through the controlled polymerization reaction times in above-mentioned molecular weight ranges by the molecular weight of actual requirement.
The inventive method synthetic polylactic acid-glycollic acid does not contain any metal and other toxic ingredient, can be used as the property implanted hard tissue repairing material, operating suture, target and controlled release drug carrier.
Advantage of the present invention and beneficial effect:
1. catalyst system therefor has high degree of biocompatibility, biological safety;
2. the synthetic product polylactic acid-glycollic acid has good biocompatibility and biological degradability, does not contain any metal and other toxic components.
3. synthetic product polylactic acid-glycollic acid weight-average molecular weight can be 1.0～11.1 * 10
4Regulation and control in the scope;
4. adopt friendly process (not using any solvent, no toxic products to generate), synthetic green (height biological safety) bio-medical degradable material polylactic acid-glycollic acid;
5. raw materials cost is cheap, technological operation is easy, is easy to industrializing implementation.
Embodiment:
Embodiment 1---synthesizing of lactic acid oligomer-oxyacetic acid
The 45g mass content of in reaction kettle, packing into is that 85% technical grade lactic acid aqueous solution LA, 34g mass content are 95% oxyacetic acid GA, repeats to vacuumize---after the applying argon gas operation three times, under argon atmospher and normal pressure, be heated to 130 ℃, dehydration reaction 3 hours.Then reaction kettle being decompressed to 100Torr reacted 3 hours down at 130 ℃.At last reaction kettle is decompressed to 30Torr and reacted 3 hours down at 130 ℃, obtain lactic acid oligomer-oxyacetic acid OLGA, productive rate is 98.6%, and weight-average molecular weight is 220.
Embodiment 2---synthesizing of lactic acid oligomer-oxyacetic acid
The 45g mass content of in reaction kettle, packing into is that 85% technical grade lactic acid aqueous solution LA, 44.1g mass content are that 95% oxyacetic acid GA repeats to vacuumize---after the applying argon gas operation three times, under argon atmospher and normal pressure, be heated to 160 ℃, dehydration reaction 1 hour.Then reaction kettle being decompressed to 100Torr reacted 1 hour down at 160 ℃.At last reaction kettle is decompressed to 30Torr and reacted 1 hour down at 160 ℃, obtain lactic acid oligomer-oxyacetic acid OLGA, productive rate is 98.2%, and weight-average molecular weight is 320.
Embodiment 3---synthesizing of lactic acid oligomer-oxyacetic acid
The 45g mass content of in reaction kettle, packing into is that 85% technical grade lactic acid aqueous solution LA, 14.6g mass content are that 95% oxyacetic acid GA repeats to vacuumize---after the applying argon gas operation three times, under argon atmospher and normal pressure, be heated to 145 ℃, dehydration reaction 2 hours.Then reaction kettle being decompressed to 100Torr reacted 2 hours down at 145 ℃.At last reaction kettle is decompressed to 30Torr and reacted 2 hours down at 145 ℃, obtain lactic acid oligomer-oxyacetic acid OLGA, productive rate is 98.4%, and weight-average molecular weight is 390.
Embodiment 4---synthesizing of lactic acid oligomer-oxyacetic acid
The 80g mass content of in reaction kettle, packing into is that 85% technical grade lactic acid aqueous solution LA, 6.7g mass content are that 95% oxyacetic acid GA repeats to vacuumize---after the applying argon gas operation three times, under argon atmospher and normal pressure, be heated to 160 ℃, dehydration reaction 2 hours.Then reaction kettle being decompressed to 100Torr reacted 2 hours down at 160 ℃.At last reaction kettle is decompressed to 30Torr and reacted 2 hours down at 160 ℃, obtain lactic acid oligomer-oxyacetic acid OLGA, productive rate is 98.5%, and weight-average molecular weight is 400.
Embodiment 5---synthesizing of lactic acid oligomer-oxyacetic acid
The 10g mass content of in reaction kettle, packing into is that 85% technical grade lactic acid aqueous solution LA, 68g mass content are that 95% oxyacetic acid GA repeats to vacuumize---after the applying argon gas operation three times, under argon atmospher and normal pressure, be heated to 130 ℃, dehydration reaction 2 hours.Then reaction kettle being decompressed to 100Torr reacted 2 hours down at 130 ℃.At last reaction kettle is decompressed to 30Torr and reacted 2 hours down at 130 ℃, obtain lactic acid oligomer-oxyacetic acid OLGA, productive rate is 98.8%, and weight-average molecular weight is 240.
Embodiment 6---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 700mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 100.Reaction kettle is decompressed to 10Torr, is warming up to 170 ℃ of reactions 48 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 87.0%, and the polymkeric substance weight-average molecular weight is 1.0 * 10
4
Embodiment 7---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 335mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 209, and reaction kettle is decompressed to 10Torr, is warming up to 195 ℃ of reactions 60 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 86%, and the polymkeric substance weight-average molecular weight is 1.2 * 10
4
Embodiment 8---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 140mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 500.Reaction kettle is decompressed to 10Torr, is warming up to 195 ℃ of reactions 125 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 83.6%, and the polymkeric substance weight-average molecular weight is 4.0 * 10
4
Embodiment 9---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid, 70g, catalyzer chlorination creatinine guanidine 70mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 1000.Reaction kettle is decompressed to 10Torr, is warming up to 170 ℃ of reactions 134 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 86.0%, and the polymkeric substance weight-average molecular weight is 4.2 * 10
4
Embodiment 10---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 35mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 2000.Reaction kettle is decompressed to 10Torr, is warming up to 150 ℃ of reactions 72 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 86.5%, and the polymkeric substance weight-average molecular weight is 1.3 * 10
4
Embodiment 11---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine catalyzer chlorination creatinine guanidine 335mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 209.Reaction kettle is decompressed to 10Torr, is warming up to 150 ℃ of reactions 150 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 86.2%, and the polymkeric substance weight-average molecular weight is 6.1 * 10
4
Embodiment 12---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 335mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 209.Reaction kettle is decompressed to 10Torr, is warming up to 195 ℃ of reactions 160 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 83.8%, and the polymkeric substance weight-average molecular weight is 11.1 * 10
4
Embodiment 13---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 335mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 209.Reaction kettle is decompressed to 10Torr, is warming up to 170 ℃ of reactions 165 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 84.1%, and the polymkeric substance weight-average molecular weight is 10.9 * 10
4
Embodiment 14---synthesizing of polylactic acid-glycollic acid
Add lactic acid oligomer-oxyacetic acid 70g, catalyzer chlorination creatinine guanidine 335mg to reaction kettle, the mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 209.Reaction kettle is decompressed to 10Torr, is warming up to 150 ℃ of reactions 170 hours.Behind the stopped reaction, reaction kettle is chilled to room temperature, polymkeric substance is used acetone solution, pour in 0 ℃ the ethanol filtration under diminished pressure into.Products obtained therefrom obtains white solid 50 ℃ of following vacuum-dryings 36 hours, promptly gets polylactic acid-glycollic acid, productive rate 85.1%, and the polymkeric substance weight-average molecular weight is 11.0 * 10
4
Claims (3)
1. the process method of a chlorination creatinine guanidine catalysis lactic acid, oxyacetic acid copolycondensation synthesis of medical biodegradable material polylactic acid-glycollic acid; It is characterized in that this method is with nontoxic, no metal biomimetic type creatinine hydrochloride; Be the chlorination creatinine guanidine be catalyzer, technical grade lactic acid and oxyacetic acid be comonomer, through the solvent-free second order copolycondensation of body; Obtain the medical degradation property polylactic acid-glycollic acid of height biological safety, concrete synthesis step comprises:
1st, lactic acid oligomer-oxyacetic acid OLGA's is synthetic
With mol ratio is that 1: 9～9: 1 technical grade mass content is that 85% lactic acid aqueous solution LA and mass content are that 95% oxyacetic acid GA is a comonomer, the lactic acid oligomer-oxyacetic acid of at first synthetic weight-average molecular weight Mw=200～400;
Processing condition: in reaction kettle, pack into lactic acid and oxyacetic acid, repeat to vacuumize-applying argon gas operation three times after, under argon atmospher and normal pressure, be heated to 130～160 ℃, dehydration reaction 1～3 hour; Then reaction kettle being decompressed to 100Torr reacted 1～3 hour down at 130～160 ℃; At last reaction kettle being decompressed to 30Torr reacted 1～3 hour down at 130～160 ℃;
The building-up reactions formula:
2nd, polylactic acid-glycollic acid PLGA's is synthetic
Lactic acid oligomer-oxyacetic acid OLGA is a raw material with the 1st step synthetic, is catalyzer with nontoxic, no metal biomimetic type chlorination creatinine guanidine, under reduced pressure carries out the body melt phase polycondensation, the synthetic bio-medical degradation property polylactic acid-glycollic acid that obtains the height biological safety;
Synthesising reacting process condition and working method are: add lactic acid oligomer-oxyacetic acid, catalyzer chlorination creatinine guanidine to reaction kettle; The mass ratio of control lactic acid oligomer-oxyacetic acid and chlorination creatinine guanidine is 100～2000; Reaction kettle is decompressed to 10torr; Be warming up to 150～195 ℃ of reactions after 48～170 hours, promptly obtain the polylactic acid-glycollic acid product, weight average molecular weight range is 1.0～11.1 * 10
4, polymerization degree m scope is 77～854;
The building-up reactions formula:
2. method according to claim 1 is characterized in that institute's synthetic polylactic acid-glycollic acid weight-average molecular weight is 1.0～11.1 * 10
4, and polymkeric substance can synthesize through the controlled polymerization reaction times in above-mentioned molecular weight ranges by the molecular weight of actual requirement.
3. the application of the said method synthetic of claim 1 polylactic acid-glycollic acid: the property implanted hard tissue repairing material, operating suture, target and controlled release drug carrier.
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Cited By (2)
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| CN113582965A (en) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | Method for preparing high-purity lactide based on catalytic cracking of organic guanidine complex |
| CN116393174A (en) * | 2023-04-04 | 2023-07-07 | 大连理工大学 | Catalyst for preparing glycolide and polyglycolide simultaneously and preparation method thereof |
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| CN102161752A (en) * | 2011-03-14 | 2011-08-24 | 南京大学 | Process method for synthesizing medical biodegradable polylactic acid by polycondensation of lactic acid in presence of creatinine catalyst |
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| CN102161752A (en) * | 2011-03-14 | 2011-08-24 | 南京大学 | Process method for synthesizing medical biodegradable polylactic acid by polycondensation of lactic acid in presence of creatinine catalyst |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113582965A (en) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | Method for preparing high-purity lactide based on catalytic cracking of organic guanidine complex |
| CN113582965B (en) * | 2021-08-23 | 2022-04-26 | 扬州惠通科技股份有限公司 | Method for preparing lactide based on catalytic cracking of organic guanidine complex |
| CN116393174A (en) * | 2023-04-04 | 2023-07-07 | 大连理工大学 | Catalyst for preparing glycolide and polyglycolide simultaneously and preparation method thereof |
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