CN102499620A - System and method for dectecting oral diseases, and environment light management system - Google Patents
System and method for dectecting oral diseases, and environment light management system Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/24—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the mouth, i.e. stomatoscopes, e.g. with tongue depressors; Instruments for opening or keeping open the mouth
Abstract
Methods and systems related to detecting disease, such as oral cancer, in a patient, using a viewing scope to investigate a patient's tissues. The systems and methods excite and detect fluorescence from the tissue. The fluorescence can then be evaluated, and the possibility of certain diseases such as cancer can be determined. The devices include an ambient light management system ALMS, often referred to as a vestibular device that manages background light in the health practitioner's office. This device can be used with scope systems for fluorescence based detection of abnormal tissue.
Description
The application is to be on April 14th, 2005 applying date, and application number is 200580019353.5, and denomination of invention is divided an application for the application of " detection comprises the system and method and the ambient light management (ALMS) of oral cavity scope disease ".
The cross-reference of related application
The application requires in the U.S. Provisional Patent Application No.60/562469 of submission on April 14th, 2004; The U.S. Provisional Patent Application No.60/618287 that submits on October 12nd, 2004; With the priority of the U.S. Provisional Patent Application No.11/016567 that submitted in 16th in December in 2004, the full content of all these documents all is introduced into as a reference and for all instructions, open and purpose.
Background of invention
All the time, comprise before the cancer detection of cancerous cell and early cancer's cell all be difficult and uncertain process.Wherein a kind of method of identification cancerous cell is to measure the autofluorescence signal of cell, because with respect to healthy cell, cancerous cell has different autofluorescence signals.Other diseases also changes on the autofluorescence signal.But in traditional dentistry and medical environment, it is problematic that autofluorescence detects, because compare with the surround lighting in appearing at inspection chamber, operating room etc. usually, the autofluorescence signal itself is very faint.
Below be some documents that relate to the cancer detection in the oral cavity.As the every other document of quoting here, comprise that the list of references of related application is the same, these documents are introduced this paper in full with it and are used for all their instructions and all purposes as a reference.These documents conclusion is not herein represented any one piece of document yes or no the application's prior art.Zheng; W. wait people's Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images; Lasers Surg.Med. 31:151-157,2002; People such as Utzinger U., Optimal visual perception and detection of oral cavity neoplasia, Cancer 2003Apr 1; 97 (7): 1681-92; Muller, people such as MG, Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma, Cancer 2003; 97:1681-92; Majumder, S., Nonlinear pattern recognition for laser-induced fluorescence diagnosis of cancer, Lasers Surg.Med.33:48-56,2003; Tsai; T. wait the people; In vivo autofluorescence spectroscopy of oral premalignant and malignant lesions:Distortion of fluorescence intensity by submucous fibrosis, Lasers Surg Med 2003; 32 (l): 17-24; Ebihara, A, Detection and diagnosis of oral cancer by light-induced fluorescence, Lasers Surg.Med.32:17-24,2003, PMID:12516066; Zheng W; Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence; Int J Oncol 2002Oct, 21 (4): 763-8; PMID:12239614; Wang CY, Autofluorescence spectroscopy in vivo diagnosis of DMBA-induced hamster buccal pouch pre-cancers and cancers, J Oral Pathol Med 2003Jan; 32 (l): 18-24, PMID:12558954; Onizawa K, Characterization of autofluorescence in oral squamous cell carcinoma, Oral Oncol2003Feb; 39 (2): 150-6, PMID:12509968.
Therefore, exist and a kind ofly unsatisfiedly need utilize cancerous cell or the ability of preceding cancerous cell in common medical treatment or the dental instruments diagnosis target tissue to improve doctor, dentist or other people.The present invention provides these and other advantages.
Summary of the invention
The present invention relates to use observation display detect the patient such as the method and apparatus of diseases such as oral cancer with the research patient tissue.In some embodiments, said system and method excites and detects the fluorescence of self-organizing.Can assess said fluorescence subsequently, and confirm probability such as some diseases such as cancers.Said equipment comprises ambient light management (ALMS is often referred to as " vestibule equipment "): a kind of system that in medical personnel's office, is used to manage bias light.Said equipment can make with such display system and be used for being used for the detection based on the abnormal structure of fluorescence.Present discussion also relates to the detection of unusual oral cavity tissue, and the different elements that relates to system and method.Said discussion comprises the patient that will be diagnosed who implements this test and can be the medical personnel of odontologist, common practitioner or hygienist.
Therefore, the invention relates to the method and system that detects the oral cavity and the abnormal structure of other health openings and other positions etc., its through observing and measure tissue fluorescence or based on other characteristics of light.This can accomplish being in the office under the normal illumination condition of odontologist or doctor.Because the light energy of the fluorescence (AF) that is produced by tissue is very low, preferably in the ambient light background of unusual low degree, operate based on the detection of the abnormal structure of fluorescence, so that interferometry not.Therefore, for operating system suitably, provide to be used to stop surround lighting to get into and absorb the method and apparatus of the diffused light that gets into field of view.
Solution comprises vestibule equipment, such as face shield, bib and mask.Said vestibule equipment is positioned at patient's face or head zone or otherwise is connected to this zone, for example below the eye, so that the inspection illumination does not directly get into patient's eyes, and covers mouth.If desired, said vestibule equipment can be connected to chair or other available structures, and this structure has the connecting device that is connected to patient he or she self or do not have this device, and if necessary, the patient can be provided the glasses of protectiveness.
In the appropriate embodiment of making according to size, be provided with observation port or aperture in the oral cavity, can get into display through their practitioners.Face shield can be fixed to patient's head or other body parts, and this is to realize through the rear portion of their head or the elastic belt or the cord of their ear back, tack or some other similar methods and system.In order to be consistent, aluminum component or other extensible material can also be arranged at nose with patient's face.In other embodiments, said practitioner and/or patient are included within face shield or other vestibule elements.
Illustrative steps comprises as follows:
1. said patient is sitting on the chair during the course as the crow flies.He is not in supine position usually, though if necessary, can adopt this posture.Supine position causes patient's tongue to fall the exposure that throat has limited tissue backward.
2. preferably, said light source, display etc. move freely, vestibule equipment or not constrained motion or do not block odontologist or other practitioners' sight line basically.
3. if necessary, said practitioner can catch and mobile tongue, and does not introduce diffused light and need not interrupt step.
Exemplary device architecture comprises following:
4. said vestibule equipment can comprise cladding material or other guard shield materials that is fit to; It can be inflexible or soft or according to needed and according to given embodiment; In the middle of its soft durometer occupy, for molding can comprise the non-rigid equipment such as the internal rigid member.Be connected to observation display, be connected to light source separately (if existence), and be connected to the instrument system and method for (if existence).Can also comprise the system and method that is connected to the patient.
A. vestibule equipment is to the connection of display: said display or other research equipments through on the valance usually with oral cavity or aligned opening of other target tissues or hole entering observation display, become the part of ALMS in some embodiments.Connect and/or sealing member has increased other elements of darkness and operation vestibule equipment and system and can not introduce the certainty of unwanted light.
B. vestibule equipment is to patient's connection: the extending/plastic material components that accords with nose or buccal profile can be provided, such as around patient's head or be similar to the elastic component of the ear clip of spectacle-frame.Being connected to patient's head can allow odontologist to have bigger degree of freedom equipment is moved to different angles.Be used as the reduction that sealing member has increased surround lighting around nose and buccal molding.
5. in some embodiments, said vestibule equipment is disposablely to propagate between the patient to suppress antibacterial, virus or material.
6. especially, can be in the disposable embodiment at vestibule equipment, it should be cheap.
Vestibule example of equipment property material comprises as follows:
7. said valance material can be any desired, common lighttight material, such as non-woven synthetic material.Said material can also be the given material more than one deck, or other combinations of material.
8. the special component of valance material can depend on the valance characteristic of necessity that cosily covers the patient and do not stop doctor's workflow.
9. the material that constitutes ALMS preferably satisfies inflammable security guide.
10. from the consideration of patient health, said material is preferably through being used for toxicity and the skin irritation test that short-term exposes.
11. material is preferably athermic/cause hypersensitive.
12. the preferred right and wrong PVC of said material uses in Europe with permission.
13. in order not disturb or to change the measurement of being done in some embodiments of research, less basically fluorescence is measured by the common abnormal structure of the ratio preferred non-fluorescent of material or that produce at least in the visible light.
14. material is preferably fully lighttight, so that the exterior light in the odontologist/doctor's of normal illumination (for example normal reading and observation condition) the office will not influence the observation to histofluorescence or other required detection/reflection light basically.
15. surfacing can be that dark-coloured (for example, black, dark green or dark blue) and right and wrong are reflexive, to obtain better measurement result through absorbing the diffused light or the diffused light within it that arrive ALMS.
Vestibule example of equipment property size comprises following:
16. said vestibule equipment does not preferably hinder patient and practitioner, does not for example disturb its moving during the course.
17. vestibule equipment is normally enough big, it will cover patient's mouth, and possible health, and cover at the diverse location place, such as the light (in embodiments, shoulder will be considered) of shoulder place entering.Vestibule equipment can be whole or part be disposable, the entering of its prevention light during enough greatly with mobile device during the course.
18. said vestibule equipment in some embodiments, will be connected to the patient, thus in certain embodiments, it should not have weight that can significantly discover or uncomfortable, for example is less than 100g.
The interface connection that is used for vestibule example of equipment property comprises following:
19. said vestibule equipment can be connected with research equipment/integrate, so that it can not break away from research equipment unintentionally.
20. said vestibule equipment can comprise opening or other inlet points, it allows research equipment to get into the patient's who is observed oral cavity or other body parts.
21. said vestibule equipment can be connected to the patient in the interface, through the sealing member of or other body parts facial with him with manufacturing by molding.In one embodiment, this can realize through the ductile/plastic material components in mask.
22. said cladding material can be enough big and enough flexible, so that the medical personnel can catch and operate tongue or other body parts in the valance material underneath and do not introduce surround lighting.
23. between patient and light source, form the space usually.In order to realize this purpose, for example, the valance material can be relative stiffness, maybe will have upper limb and other form spatial structure with enhanced, more same material of another kind of material and/or sewing.
The invention provides a kind of ambient light management (ALMS) that designs for medical application; Said ALMS is designed to assemble around the part of the patient body that comprises the target tissue that is subjected to an examination; And stop all surround lightings to arrive said target tissue basically; Said system comprises lighttight basically vestibule equipment; Said vestibule equipment comprises at least one guard shield, the size of said guard shield is configured to and said guard shield be designed to form the said at least health of covering said part vestibule and allow hands of user at least or can contact the said part of the said health in the said vestibule by the instrument that user is controlled, said vestibule equipment also comprises opening; Said opening is positioned the pathways for vision that can see said target to be provided and to be designed to connect observation display basically light tightly; Said observation display is designed to operationally viewer is connected to said target, and said ALMS also comprises light source, and said light source is designed to said target light is provided.
ALMS provided by the present invention also can comprise the said observation display that is connected to opening.
Observation display also can comprise eyepiece.
Observation display also can comprise imaging sensor.
ALMS also can comprise spectral measurement equipment.
ALMS can comprise said instrument.
Said instrument can be connected to observation display.
Said instrument can not be connected to said observation display.
Vestibule equipment can be lighttight fully and stop all surround lightings to arrive target.
Guard shield can be inflexible basically.
Guard shield can be semirigid.
Guard shield can be flexible.
Guard shield can not only comprise rigid element but also comprise the toughness part.
Observation display can removably be connected to the opening of vestibule equipment.
Observation display can removably be connected to the opening of vestibule equipment through the bayonet socket connected mode.
Observation display can removably be connected to the opening of vestibule equipment through the screw socket connected mode.
Observation display can removably be connected to the opening of vestibule equipment through the mode of being connected.
Observation display can removably be connected to the opening of vestibule equipment through the screw socket connected mode.
Observation display can permanently be connected to the opening of vestibule equipment.
A large portion at least of observation display can be one with the opening of vestibule equipment.
Light source can be designed to launch light through the opening that is used for observation display.
Light source can be designed to from observation display emission light.
ALMS can be designed so that light source through launching light with isolating second light outlets of the opening that is used for observation display.
Light source can be designed as a launching excitation light basically; Said exciting light can be designed at least one fluorescence excitation of organizing from the target; And observation display can comprise long wave pass filter, and said long wave pass filter is designed to stop said exciting light and through said fluorescence.
Light source can be designed as the light of only launching basically between about 410nm and the 500nm.
Light source can be designed as the emission white light.
Light source can be designed as only launches infrared light basically.
Exciting light can be designed as induced fluorescence at least one cancer cell or pre-cancer cell.
Vestibule equipment can comprise dark-coloured valance, its comprise non-fluorescence basically, non-reflexive material basically.
At least the inner surface of dark-coloured valance can be lacklustre black.
Vestibule equipment can also comprise at least one ductile stay, and said stay is designed to place on patient's the nose, and be ductility to meet patient's nose and to close on the profile of facial zone.
Vestibule equipment can also comprise at least one inflexible basically member, and said member can be set up and design opening is remained on the predetermined at least distance from the patient, so that opening does not contact the patient.
Vestibule equipment can also comprise interconnective a plurality of inflexible basically member, and said member can be designed to form cover, and said cover remains on the predetermined at least distance from the patient with opening, so that opening does not contact the patient.
At least one inflexible basically member can be set up and design to keep guard shield basically fully not in the light path between target tissue and opening.
At least one inflexible basically member can be outstanding from ductile stay.
At least one inflexible basically member can not be connected to ductile stay.
The size of vestibule equipment is set for and vestibule equipment is designed to and can assembles around people's oral cavity target.
The size of vestibule equipment is set for and vestibule equipment is designed to cover patient's eyes portion.
The size of vestibule equipment is set for and vestibule equipment is designed to not cover patient's eyes portion.
The size of ALMS is set for and ALMS is designed to and can assembles around patient's department of obstetrics and gynecology medical science target.
The size of ALMS is set for and ALMS is designed to and can assembles around at least one eye target of patient.
The size of ALMS is set for and ALMS is designed to and can assembles around patient's epidermis target.
These with other embodiments in (except clearly illustrate that or otherwise clearly from context), all embodiments of the invention, aspect, characteristic etc. can be mixed in any desired way with compare, make up and the change order.
These of being stated among the application and other aspects, characteristic and embodiment comprise following detailed description and accompanying drawing.In addition, the various documents that this paper provides have comprised the cross reference of related application, and it has discussed some system, device, method and other information; All these documents are incorporated herein by reference in full and are used for all their instructions and open, and no matter where these documents possibly appear at the application.
Brief Description Of Drawings
Fig. 1 has described the sketch map of the ALMS (ambient light management) that is designed to medical application.
Fig. 2 has described the side schematic view according to ALMS of the present invention.
The embodiment that Fig. 3 and 4 describes is substantially similar to the embodiment among Fig. 2, except guard shield be basically black and equipment be designed to be placed below patient's eye.
Fig. 5 and 6 has described schematic front view and the side view of the ALMS that comprises upper limb.
Fig. 7 is a schematically positive side view of having described the embodiment of the ALMS that is applicable to supine patient.
Fig. 8 has described the sketch map of the vestibule equipment of bib shape.
Fig. 9 has described the sketch map of the equipment that comprises flange and hangers parts.
Figure 10-12 has schematically described and has been applicable to the different embodiments that ALMS is remained to patient's sealing member.
Figure 13-13A described can be used to observation display, illumination light, instrument or with as the various difformities of the opening of required other equipment.
Figure 14 illustrate schematicallys the forelock key that is connected to observation display movably.
Figure 15 A-C has described the sketch map of forelock key, and it can be used for observation display is connected to the lighttight basically vestibule equipment of ALMS.
Figure 16 illustrate schematicallys another embodiment of vestibule equipment.
Figure 17 has described difform schematical top view, and this shape can be used to form the vestibule space with vestibule equipment.
Figure 18 has described a plurality of difformities, and it can form spatial vestibule equipment with vibrating part or other and together use.
Figure 19 has described and has been suitable for the lath that in the vibrating part of vestibule equipment, uses.
Figure 20 has described the other embodiment that is used to connect observation display and vestibule equipment.
Figure 21 is the side view of observation display, and it is connected to multilamellar guard shield and the opening of describing among Figure 20.
Figure 22 A-C has described keyway and the far-end of tube opening 151 and corresponding observation display in the guard shield.
Figure 23 has described such as an embodiment before the maker of the guard shield of describing among Figure 22 A 68.
Figure 24 has described the front plan view of embodiment of the outer branch mask class of the guard shield that comprises said opening.
Figure 25 has described the amplification front plan view of said guard shield and the opening of Figure 24.
Figure 26 has described the side sectional view such as the docking facilities of the vestibule equipment of describing in Figure 24 and 25.
Figure 27-28 has described the rotation that slips into opening and the horizontal frontal plane view of latch-up structure.
Figure 29 has described the enlarged side view of opening and vestibule equipment, and said vestibule equipment comprises multiply cloth and has the opening of difform passage with the interference fit that is formed for observation display.
Figure 30 is the perspective view according to the observation display of an embodiment of this paper innovation and creation.
Figure 31 has described the side view of observation display subelement.
Figure 32 has described the side sectional view of observation display.
Figure 33 has described the cross sectional side view of the head of the observation display of describing among Figure 32.
Figure 34-43 has described schematic, the cutaway view that connects the various connecting devices of various device in the system.
Figure 44 provides the other embodiment of transducer, wherein power supply and light source the two all be maintained in the transducer self.
Figure 45 has described the cutaway view of the embodiment of hand-held observation display, and wherein said observation display comprises light source and the power supply in the handle.
Figure 46 describes the perspective view of the sketch map of ALMS.
Figure 47 has described the top perspective of observation display, its have can with external power source and the isolating pipeline of light source.
Figure 48 has described observation display, and it is connected to external power source and light source through pipeline and plug-in type transducer.
Figure 49 has described the instrument 288 that comprises the extension 290 with protuberance 300, and it is designed to be connected to the far-end of observation display.
Figure 50 is the positive side view of the equipment of Figure 49.
Figure 51 has described the decomposition diagram of observation display.
Figure 52 has described the binocular embodiment according to the ALMS of the invention.
Specify
The present invention relates to observation display, be referred to as " Velscopes " in some embodiments here, it is applicable to the light such as fluorescence etc. that detection is sent from the patient.In some embodiments, said innovation relates to the observation display that is used to detect infringement, the cancer in said infringement such as oral cavity or the vaginal area.Usually; Observation display be designed to detect the fluorescence that sends from target tissue or other very faint light and be used in combination such as ALMS such as guard shield or vestibules, said ALMS has covered target region basically and has stoped basically and anyly got into viewing area with all light of not expecting such as environmental chamber light etc.
Still normally, said vestibule comprises at least one opening, and it is according to the size manufacturing and be designed to be operably connected to display, usually far-end (be connected to one or more multi-link to the equipment of display and between display and guard shield, extend).To describe and discuss the various embodiments of display and guard shield here.
Accompanying drawing is discussed
Fig. 1 has described the sketch map of the ALMS (ambient light management) that is designed to medical personnel's use.Briefly; ALMS is designed to install around the part (oral cavity among Fig. 1) of patient body; Said body part comprises target tissue; Tongue shown in embodiment, buccal or gums, or such as the cervical region in other embodiments, vagina, ear or epidermis tissue, and or even the tissue seen through observation of intra-operative; If particularly these organize the cell or tissue relevant with cancer that contain under a cloud, such as neoplasia, malignant tumor, benign tumor, abnormal development etc.
Among Fig. 1, ALMS 50 comprises opening 52 and guard shield or valance 68.Guard shield or valance are fixed to stop that basically all surround lightings arrive target tissue and are designed to form the vestibule that covers the health of part at least that is observed.In addition, guard shield 68 is according to the size manufacturing and be designed to allow at least one hands of user and/or can contact the body part of being observed in the vestibule by the instrument that user is controlled.Such instrument is meant actual physical equipment; Such as from end portion; Or even from the mechanical projection of the distal extension of observation display, but can also be through other opening and/or through extending into the mechanical ridge in the interrogation zone even without the observation opening that is connected to observation display.Such instrument does not comprise the things that sends from observation display, such as light or electric current.As what noticed; The vestibule equipment 50 of ambient light management (ALMS) 51 also comprises opening 52; It is positioned the pathways for vision that can see target to be provided and to be designed to connect observation display basically light tightly, and this observation display is designed to operationally display is connected to the target that is observed.In other accompanying drawings of discussing in this paper other places, describing, in certain embodiments, ALMS also comprises light source, and it is designed to target light is provided, such as the exciting light that is used to produce fluorescence.In the embodiment of some expectation, said light source can provide multiple multi-form light, handles (PDT) light etc. such as exciting light, conventional white light, IR, light, light power.
Fig. 2 has described ALMS 51, and it comprises the vestibule equipment 50 with opening 52.In the embodiment of Fig. 2, valance 68 makes up with operating room (OR) face shield 63.Said OR face shield also provides the fixture (not shown), and it makes ALMS 51 be connected to the patient easily.
The embodiment that Fig. 3 and 4 describes is substantially similar to the embodiment of Fig. 2, except guard shield 68 is being designed to be placed below patient's eye with said equipment of black basically.In this embodiment, valance or guard shield 68 comprise that (in the embodiment, weight can be the 1.91oz/ sign indicating number to two polypropylene for medical article squares that link together
2).Also connected elastic webbing and plastic bonding jumper 80, it helps face shield is centered around the suitable position of patient face and stops the light of not expecting to arrive target region.Described like all the other places of this paper; This with great majority other embodiments in; Material be black and right and wrong epipolic unreflecting; So that all in fact light only is made up of any illumination/exciting light in certain embodiments basically in the interrogation zone, these light are provided by the light that the patient sends by user and any AF, Raman or other.
Fig. 5 and 6 has described the sketch map of the ALMS that discusses like this paper, and wherein said ALMS also comprises the vibrating part (brow piece) 82 that forms upper limb 83.As described, vibrating part 82 is inflexible basically (in the embodiment, said upper limb can be formed as the N95 face shield that is substantially similar to the OR Duckbill type) with upper limb 83, cuts into any desired shape.Vibrating part 82 has increased the size and the rigidity of the vestibule region in the vestibule equipment 50 of ALMS 51.
Fig. 7 has described the vestibule equipment 50 that is used for ALMS 51.As described, vestibule equipment 50 comprises opening 52, and it is according to the size manufacturing and be designed to light, display, instrument etc., and comprises the spatial top shape 53 of formation.In the embodiment that illustrates, forming spatial top laminate 53 is circular basically, but can use any desired shape, such as oval, square, hexagon, octagon etc.Because top shape 53, rigid member are (for example; Shaft-like, firm parts basically; If necessary, it can be joined together to form cover) form pipe 54, can use the display (not shown) to see through this pipe user; And if necessary, user can be controlled the target of being observed in this pipe.Rigid member 55 is visible in cutaway view, and can form the shape and the structure of any needs.In addition, if necessary, material can be designed to not have seam, or is not that the pleated sewing is to help to keep the shape of ALMS.Vestibule equipment 50 also comprises open end 56; It places around the target of being discussed; Described like this paper other places; It is patient's oral cavity in this embodiment, but can be the chamber of any other expectation, such as being suitable for colposcope detection, skin site or even the inside of surgery location or the zone of outside.
The length 57 of vestibule equipment 50 can be any desired length, as long as it can enough stop such as unwanted light such as surround lightings satisfactorily.If desired, vestibule equipment 50 can also comprise that binding agent or other viscosity or sticking material is to help vestibule equipment and to be bonded to patient 60.In addition, the edge of vestibule equipment (and other parts, can form if necessary), and the material 62 of certain valance 68 has reduced the propagation and the formation of light in the vestibule space by plastic material 61.If necessary, seam and bar structure can folding formings 59.
Fig. 8 has described the sketch map of vestibule equipment 64, and it comprises that lighttight basically material 66 comprises the valance 68 of opening 70 with formation, and wherein vestibule equipment 50 is formed as the bib shape.Said bib comprises Connection Element 72; For example be binding agent or other binding compsns; When bib is described hang; It is at the lateral surface of bib, but when bib was upwards placed and surpassed patient 60 face, attaching components helped vestibule equipment 64 is remained on the position of expecting in patient 60 faces.The embodiment that illustrates also comprises neck ring 74, and it is connected to the patient with bib shape ALMS 51.
Fig. 9 has described the vestibule equipment 76 of ALMS 51, and this ALMS 51 comprises vibrating part 82, opening 84 and valance 86.Vestibule equipment 76 comprises the hangers parts 78 that vestibule equipment are connected to the patient, and it also helps vestibule equipment is remained on the position of expectation.This equipment is specially adapted to check that lie on the back, that recline and complete axial patient.Said embodiment also comprises sealing member 80, and it is normally ductile and help vestibule equipment 76 is fixed to the position that patient and/or patient expect on one's body.
Figure 10-12 illustrate schematicallys the embodiment of horn shape sealing member 80 and bending sealing member 80, and it can be designed as the nose 88 around the patient.Certainly, for other parts of health, preferably other structures.Just as described in Figure 11, said equipment can be horn shape or bending, or is two kinds of shapes.In addition, though the embodiment of describing is only used single sealing device, can or use continuously or use simultaneously or use multiple arrangement with other modes of expectation.Shown in figure 12, sealing member 80 is normally ductile, turn 90 degrees the position that moves to an expectation so that the part 92 of sealing member can be revolved.In addition, if desired, sealing member 80 can be made or otherwise made it to form even shape so that shipment, storage etc. form the non-flat forms shape then in use again.
Figure 13-13A has described and has been used for the various difformities of said opening, and this opening is used for observation display, illumination light, instrument or required like other.In the embodiment that illustrates, said opening by molding so that can be connected to the tip part of observation display, normally far-end with keeping.As what can see, said opening 94 can be circular, but can also be other different shapes, such as rectangle, ellipse, rhombus etc. so that said opening can be snapped merge latched position and with the structure of the lock & key type of observation display.In addition, like what describe in some embodiments, said shape needs accurately symmetry, and it can help avoid the display locality that has some setbacks and be connected to said opening.
Figure 14 illustrate schematicallys end piece 96, and it can be connected to observation display, light source etc. movably.Preferably, transportable end piece is disposable or aseptic so that it can be reused a plurality of patients, or after single patient uses, abandons, and two embodiments have all reduced the probability of a patient to next patient contamination.
Figure 15 A-C has described an embodiment of connection device 97, and it is suitable for the instrument 104 of observation display or light source or non-other expectation is connected to the opening of ALMS.In the described embodiment, the far-end 99 of connection device 97 comprises forelock key 98, and it is connected with the lockable that pairs of openings is provided by molding.Represent that like other accompanying drawings of this paper various other shapes also will be fit to.What movably end piece 96 also comprised other connecting devices that are fit to of being designed to hold joint or screw thread or observation display 104 holds group 100.Movable part 96 can be made according to the mode that disposable mode maybe can reuse.If particularly make end piece for repeated use, preferred so usually end piece is applicable to such as sterilization technologies such as autoclaving, disinfecting cleanings.As described, the joint 102 that observation display 104 is included in observation display 104 peripheries is to be connected with end piece 96 movably.
Figure 16 illustrate schematicallys another embodiment of the vestibule equipment 108 when vestibule equipment 108 comprises lath 110.Such lath is inflexible basically equipment, is processed by the material of plastics, aluminum or other expectations usually, and it is sewed up or otherwise fix or be adhered to valance or guard shield 68.In the embodiment that illustrates, lath is positioned at the point midway of vestibule equipment 108 and is used to make vestibule equipment and patient's head and cervical region to keep spatial separated.As also in Figure 16 embodiment, describe, vestibule equipment is fixed to head through the headband 109 that centers on head basically.
Get back to Figure 15 A-C, in the embodiment that illustrates movably end piece 96 also comprise window 106.Said window is useful especially for the embodiment of this innovation, and said innovation relates to observes the oral cavity, because patient's breathing can be discharged contamination particle, it can influence observation display self and other equipment.If necessary, no matter be used for the oral cavity or be used for other body structures, said equipment can be manufactured to does not have window.In some embodiment, said window can act as outer transparent barrier separately reduce polluting or to make material transfer to the probability of opposite side from vestibule one side, and/or said window opening can provide filtering functions, and it comprises illumination light or detects light.In some embodiment; Said window opening can be selected as non-fluorescent basically, unreflecting; And in addition to observe, detect, tissue excites, further function such as treatment is inert basically, it can use the system of this paper and equipment to be implemented.
Figure 17 illustrate schematicallys the top view of a plurality of vibrating parts 112, this vibrating part 112 can and the valance 114 of vestibule equipment together use to form the space between the vestibule equipment and patient in the vestibule equipment.Vibrating part can be single structure, overall structure or as other the required structures in the two-part structure.
Figure 18 has described the top view of a plurality of different embodiments of space formation member, and said parts are suitable for using according to the flange in the vestibule equipment of ALMS discussed herein or other positions.As what can see, the pillar 118 of said equipment supports so that the vibrating part 116 shown in the side view.So that various any other structures of locating to discuss; This vibrating part 116 can be valuable and deformable to be applicable to the various shape and structure by the user wish with pillar 118, for example better to meet or to be suitable for the characteristic of facial or other body parts of given patient.
Figure 19 has described another embodiment of vibrating part 120, and this flange place comprises lath 122 so that the formation space structure to be provided, and this structure helps to make flange to remain on the position of expectation.
Figure 20 has described another embodiment that is used to form the detachable opening in the guard shield of discussing like its elsewhere of this paper.In the embodiment of Figure 20, open assembly 124 comprises by the opening 126 that is sandwiched in O type ring 128 definition between the two-layer at least guard shield material 132.In certain embodiments, though also can use as required or lighter or heavier material, material different layer 134,136 is processed less than about 2 ounces every square yard material by weight.In the embodiment of expectation, the diameter of said opening 126 approximately is 1 inch, though also can provide as required from about 1mm to 1 centimetre (cm) to 3cm to 5cm or bigger any desired opening size.If desired, the one deck at least in the tissue layer can comprise slit 130, and it is designed to allow pipe and gets into, and gets into said opening such as the end of observation display.Said material layer 134,136 can be through any required being connected to each other such as devices such as sewing, binding agents; Said binding agent such as those from adhesiversearch.com, Glenrock; The binding agent of PA comprises, for example Removable Adhesive System; AR c/o 8561, the removable binding agent of AS-124M.In addition, if one deck guard shield is lighttight fully at least, another layer can be transparent or translucent so, and for example, wherein one deck can be designed as lining, and it comprises the clear polymer of 2 mil silicidation.
Figure 21 describes the observation display 104 with light path 142; This light path propagates light to luminous source and patient or patient and pick off; Or from said luminous source and patient or patient and pick off propagates light; Usually, directly the light path 143 of observation operationally propagates into the eyes such as user such as dentist or doctors with light from target tissue, and user can be seen tissue through the eyepiece 145 of eye parts.As what seen; Said open assembly 124 in said face shield or guard shield 138 is preferably dismountable; Can be meshed with prominent lip 140 or other connecting devices of observation display 104, as described observation display comprise eyepiece eye parts 145, like described dichroic mirror 141 and handle 147.Usually, the direct observation end of display will be included in the one or more optical filters in illumination path and any light path that detects light path or two light paths.
Figure 22 A-C has described keyway and tube opening 151 and the far-end of corresponding key and observation display 104 in the guard shield 68.In brief, guard shield 68 is described with the form of cutaway view and comprises that keyway and tube opening 151, this tube opening 151 comprise the window 150 that is arranged in the opening 152, and opening 152 is arranged on again in the keyway 148.As described, keyway 148 is rhombuses, is any desired shape but can also make, and comprises symmetric shape.Figure 22 B intercepting the side view of keyway and tube opening 151, it partly slides on the end 155 of observation display 104.Observation display 104 comprises limit collar 146, the shape complementarity of itself and keyway 148.Figure 22 C shows the exemplary shape of limit collar 146.In addition, limit collar 146 can comprise two kinds of shapes, and for example annular, it is positioned at the position of far-end on the rhombus so that said annular extends into and pass opening 152, and rhombus can removably mesh with corresponding rhombus keyway 148 simultaneously.
Figure 23 has described and has made guard shield 68 embodiment in the past of describing such as Figure 22 A.In this embodiment, ground floor material 156 has rhombus keyway 148, itself and 158 combinations of the second layer material with annular basically opening 152.As a rule, second layer material 158 is guard shield 68 sides towards the patient.Materials at two layers can make up in any desired way, for example uses the connected mode of sewing 160 or gluing, interface coupling or other expectations.
Figure 24 illustrate schematicallys the vestibule equipment that is formed by face shield 162, and this face shield 162 comprises the joint unit 166 and a plurality of rigid members 164 that the top gets into.Selectable rigid member can be processed by aluminum, plastics, other any light materials of molding face shield 162 that help.If desired, face shield can be manufactured to and not be with any extra rigid member.On the whole, the quantity of rigid member is many more, and/or the rigidity of rigid member is big more, its shape of maintenance that said mask will be firm more, and no matter external pressure or other influences.On the other hand, reduce or eliminate these rigid members or its rigidity provides more softish face shield.Figure 25 provides the near-sighted enlarged drawing of the joint unit of describing among Figure 24 166.In brief, joint unit 166 bar code 173 that has housing 170 and illustrate in embodiments.Opening 171 is fabricated to nozzle 168 according to size and closely cooperates.In the embodiment that illustrates, such closely cooperating realizes that through two projections 175 this projection 175 is designed to hold nozzle 168 with bearing and nozzle 168 is remained on the position that opening 171 fronts are expected.Among Figure 25, the passages 172 in the housing 170 by reversing so that the equipment among Figure 25 is the equipment of bottom surface charging, opposite with the equipment of end face charging among Figure 24.Certainly, the equipment of side-fed and other face chargings also can be used.
Distinguished symbol 173, it is a bar code in the embodiment that illustrates, but can also be 3-D bar code, other sentinels that can scan, and the identification of mechanical engagement or other recognition systems.Such as correct source (right source) or observation display-owing to a variety of causes, specific mechanical engagement can be particularly advantageous between vestibule equipment and the removable end parts.For example; End piece and/or vestibule equipment and/or observation display etc. can be configured to have this type of identification equipment and used by correct to guarantee specific filter set component; Or guarantee that other specific embodiments are by correct use; For example guarantee the ALMS system; Anti-cross-contamination window wherein is positioned at guard shield itself, and this system uses with end piece (if any) movably and the observation display that do not have a this window, so that unnecessary optical interference can not be introduced in the system; Also guarantee to use this vestibule equipment simultaneously, because will be the patient and more set up the other path of opening between the eyeglass of expensive direct observation display and the machinery etc. relatively with window.In addition; The optical filter that can be used to confirm manufacturer like this with through careful other optical filters of selecting by suitable use; Suitably be arranged in all parts of system so that be applicable to the system of FLUORESCENCE STUDY, with specially do not mixed for the system of IR research design.Distinguished symbol 173 can be placed in the position of any needs; For example; As described, on the surface of butt joint opening, local in the another one of vestibule equipment, in the ring of vestibule equipment or other butted parts so that vestibule equipment will only be suitable for the checkout facility, instrument of special expectation etc., or instrument and checkout equipment certainly on one's body; Or it is on end piece movably or on a plurality of such structures, or required like other.
Figure 26 has described joint unit 166, and it comprises housing 170, and it can be processed by the material of mylar, cardboard or any other expectation, keyhole 174 and backing 176, and all these are connected to face shield 178.Figure 27 and 28 has verified the butt joint of light source 180 (or observation display etc.); When observation display according to the described that kind of Figure 27; Oval nozzle 168 is rotated earlier so that can be pushed through passage 172; And whole light source 180 is turned clockwise 90 ° so that projection 175 engagements of oval nozzle 168 and housing 170, make that light source 180 rotations are got back to initial position and are pulled out before, can not moving nozzle.Figure 29 has described another embodiment of this docking system, and the outer fabric 184 of its split shed 182 has defined oval-shaped basically hole, and inner fabric 186 has defined circular basically hole.Each passage is by seam or 188 definition of prominent lip, and if necessary, said seam or prominent lip 188 can be designed to have rigidity.
Figure 27-28 has described the rotation that slips into opening and the front plan view of closing component structure.
Figure 29 has described the near-sighted enlarged side view of opening and vestibule equipment, and said vestibule equipment comprises multiply cloth and has the opening of difform passage with the interference fit that is formed for observation display.
Figure 30 has described the perspective view of the observation display 104 with far-end 190 and most proximal end 192.Most proximal end 192 comprises eye cup 194, and it provides comfortable position placing their eye as the eye parts of eyepiece and to user, and has stoped inquiring after of most of ambient light interference user simultaneously.Far-end 190 comprises the adapter zone, and it is shown as and comprises annular basically flange and prominent lip; Other structures also are fit to.In addition; Observation display 104 comprises handle 198; It is depicted as in embodiments and is connected to pipeline 200; It leads to the localized object in any outside, such as power supply, light source, such as CCD, CID, CMOS or other numerals or the similarly imaging device, imaging device etc. of video camera etc., and such as spectral analysis apparatus such as spectrometer, spectroradiometer, spectrogrphs.In the embodiment that illustrates, the head 201 of observation display 104 is basically by foreshorten with respect to handle.This structure also is fit to; But the short basically head 201 that is provided has some advantage in certain embodiments; Because the short relatively length of head allows doctor, dentist or other user also can also in the space of closure, can observe from various directions easily near target tissue as much as possible, in the time of such as vagina or examination of mouth.In addition, even in the embodiment that illustrates, observation display is connected to external power source or other equipment, and if desired, whole system can be retained as independent, the complete portable equipment that does not connect anything.Figure 31 has described the side view of the subelement of observation display 104.
Figure 31 has described the side view of the subelement of observation display, and wherein some element of head and handle has been taken away to allow to observe inner element.In the embodiment that illustrates; Projection/collecting pipe 206 is arranged on the tip part towards the observation display 104 that has wavelength selectivity optics element; Said optical element such as spectroscope 204; Basic setup is in the head of observation display 104 in fact for it, and optical filter 202 is arranged on the forefield of head.The handle component 208 that remains in the handle also is illustrated.
Figure 32 has described the side sectional view of the observation display 104 that comprises far-end 190 and most proximal end 192.Said equipment also comprises eye cup 194 and spectroscope 204.This spectroscope 204 allows through pipeline 200 light to be throwed the into inner space 207 of observation display 104.Said then light upwards projection passes optical element 209 entering spectroscopes 204, and this spectroscope is through the passage reflected light on the far-end 190.Described like other places, said light can comprise exciting light, and it is suitable for the light of the other types of induced fluorescence, white light, infrared ray or user expectation.In addition, if necessary, can light be provided so that it can optionally be rotated or changed and/or between different observations or light illumination mode, switch by user.In addition, said light can be used for based on reflection illumination, based on the illumination of fluorescence-excite, be used for therapeutic purposes, be used for diagnostic purpose or as other required purposes.In the embodiment that illustrates, patient's vaginal area is checked by user.The light that returns from the patient is collected through projection/collecting pipe 206.As can see, projection/collecting pipe 206 is removably in opening 52 places and 50 engagements of vestibule equipment.Light transmission selectivity optics element 204 that sends from the patient and the eye that arrives user.If desired, from patient's emission light can also through spectroscope 204 broadcast to passback be passed down through handle arrive one or more video cameras, such as analytical equipment or other analysis elements such as spectro-metres.In addition, if desired, observation display 104 can comprise one or more optical filters, for example optical filter 211 and 213.If desired, this optical filter can only filter illumination light, only filters emission light; The situation of the embodiment that illustrates; Optical filter will be placed in before or after the spectroscope usually, or if desired, and optical filter can act as and both filter illumination light and also filter emission light; At this moment usually optical filter is placed before the spectroscope, shown in this embodiment.
Figure 33 has described the side sectional view of the head of the observation display of describing among Figure 32 104.In addition, be arranged at before the spectroscope 204 with afterwards the 3rd optical filter 215 and the 4th optical filter 217 and be identified.
Figure 34-43 has described the schematic cross sectional side view that connects the different connecting device of various device in the connected system.
Figure 34 has described and has been applicable to observation display 104 is connected to pipeline 200, or is used to connect the exemplary coupling assembling of the removable end parts of far-end.Figure 34 A and 34B all comprise light path 210, nose 219 and recessed, hold end 221.Among Figure 34 A, nose 219 is retained as through compressible O type ring 212 and operationally is connected with recessed end 221, and this O type ring is assemblied in the holding tank 223.Said end only needs can be connected and separate with they being drawn back just through they being pushed away together.Similarly, among Figure 34 B, nose 219 is retained in the recessed end 221 through wide flexible material 214, and this flexible material 214 closely is assemblied in the complementary sipes 225.Said O type ring, flexible material etc. can be processed by any suitable material, such as plastics, sponge, rubber etc.As visible, in required embodiment, optical path is calibrated and is used to be operably connected.
Figure 35 has described interchangeable adapter, and wherein the nose 219 of pipeline 200 is connected to the recessed end 221 of handle 198.Said connection realizes through screw thread 218.If desired, this equipment can also comprise window 216, and it is normally non-fluorescent, transparent and non-reflexive.
Figure 36 has described bulge and groove fit, and its effect is similar to the embodiment of discussing in the aforementioned figures.In this embodiment, provide the interlock of swelling on 220 to strengthen two ends to each other retentivity.
Figure 37 has described another speed and has torn cooperation open, and wherein bolt rod 222 removably and securely is fixed together nose and recessed end with load on spring formula pin 226 synergism.In the embodiment that illustrates, the O type ring 224 and the groove in the recessed end 219 227 that remain in the nose 221 interact.Load on spring formula pin 226 interacts two ends are locked together and be provided for stationary device more firmly thus with bolt rod 227 synergistically, even applied sizable pressure unintentionally, this device also is not easy to separate.
Figure 38 has described the embodiment of the removable end parts 96 of the eyeglass that relates to illumination and collect.In brief, removable end parts 56 slip on the projection 229 that is fit to of observation display 104.Illumination pathways 111 can be hollow pipe, fibre-optic cable, fiber illuminated, liquid light guide pipe or any other required light guide; It sees through and passes illumination pathways 228 from the illumination light of observation display 104, then through bandpass filter 232, calibration lens 234 and output lens 240.Then, said light passes to patient's arm,, passes to collecting lens 236 subsequently from the fluorescence of patient's arm, reflected light, Raman signal or other emission light here, sees through high-pass filter 238 with calibration lens 234 and get in the receiving light path 230.In the embodiment that illustrates; Optical filter 234 is bandpass filters; It only sees through basically and is applicable in fluorogen (or AF group; Or the fluorogen that provides through medicine, fluorescent agent etc.) exciting light of induced fluorescence in, high-pass filter 238 has stopped all exciting lights basically and has only seen through the fluorescence that sends from the patient basically simultaneously.
In the embodiment among Figure 38, bandpass filter 232 puts in the complementary receptor 221 the transducer 96 from projection 229, thereby suitable identification and equipment management system is provided, so that illumination path and collection light path in use can not be confused.Figure 39 has described the similar embodiment that on eyeglass, focuses on.
Among Figure 39, this eyeglass comprises fibre bundle 232, and other light guides that are fit to also can be used certainly, and output lens 240, bandpass filter 232, collecting lens 236 and high-pass filter 238.In this embodiment, said equipment does not have the receptor of describing among protectiveness bandpass filter 232 and corresponding Figure 38 231, but so the optics in the various elements of equipment connect the operation signal that will depend on that usually user is confirmed.
Figure 40 provides the cutaway view of transducer 96, and it comprises that lens and mirror are to provide the viewed ability.Illumination path 228 passes receptor 231 and moves ahead through calibrating lens 234 and arriving on the oblique eyeglass 244, and this eyeglass is drawn light and passed output lens 240, and this output lens 240 is positioned on the side of transducer 96.Collect light path 230 and collect the light that passes collecting lens 236, it sees through oblique eyeglass 234, the most closely passes calibration lens 234 then and arrives observation display.Figure 41 has described interchangeable transducer side view.Among Figure 41, transducer 96 comprises light guide 246,248, and they make the bendingof light from the observation display (not shown), and then through collection eyeglass 246 separately and throw light on eyeglass 248 projections and collection light.
Figure 42 and 43 has described the side view of two flexible transducers.Among Figure 42, undulatory gooseneck 250 is provided, this gooseneck can be bent according to the needs of user and reverse, and receives the restriction of the material of selecting for structure equipment.Figure 43 provides flexible rubber hose 252, and it can and reverse by random bending, and connector 254, and it is used to make transducer to become as needed firm and hold it in a certain position.
Figure 44 has described the side sectional view of transducer, and it comprises power supply and light source.In brief, the projection 229 of transducer 96 comprises battery 266, and it is operably connected to the light source 264 such as LED.As described, lead 258 is through current limliting depositor 260, so that light intensity that light source 264 sends and possible color, can be according to configuration by control changeably.Battery 266 is activated through switch 256 with light source 264 and controls; The light that sends from light source 264 sees through transducer via optical filter 262 and arrives the patient, then through be similar to that its elsewhere of those this paper is described or as the collection light path 268 of other designs of needing collect the light that returns.In the embodiment that illustrates, the light that projects OS from transducer is used for the cervical region inspection, and the light that returns likewise returns from OS.In some embodiment, the equipment of side view that this paper discusses is particularly advantageous for such inspection.
Figure 45 has described the cutaway view of the observation display 104 with most proximal end 102 and far-end 90.Handle shown in Figure 45, power supply, eyeglass etc. maybe can be set in the hand-held device that forms actual observation display itself, or it is suitable for being connected to the far-end of observation display.
Handle 198 comprises a plurality of elements so that energy and light to be provided, and it comprises energy recording cell 274, is used for refrigerative fan 272 and also helps refrigerative fin 270.274 pairs of light sources 264 that illumination light is transmitted in the optical filter 262 of energy recording cell provide energy, and said optical filter 262 provides the light that gets into illumination light conduit 242 again, is used to pass to far-end 190.Energy, light source etc. are through switch 256 controls, and as described, it can advantageously place on the nearest side of the handle that is similar to trigger, but can also be placed in other any desired positions.Figure 46 has described the perspective view of ALMS sketch map.In this embodiment, if shell 277 comprises light source, power supply, video camera and other the required analysis elements or the image-forming component that exist.Nearest side 276 comprises opening 279, and the pipeline that passes this opening extension comprises light guide, electric wire and other required elements.Pipeline 200 passes to observation display 104 with required signal, light etc., and it comprises optical wand 278 and transducer 96.In the embodiment that illustrates, power supply 282 is placed in the position of supporting shell 277, and has the cable that extends to observation display 104 from the energy drag device.Light source and power supply all are inserted into wall power sockets 284.
Figure 47 has described has far-end 190 and the observation display 104 of most proximal end 192 and the pipeline 200 of drawing from the pedestal of handle 198.As being seen, pipeline is very long (approximately the 4-15 foot is long usually) and ends in the plug of transducer 284 that it is designed to removably be inserted into extra power and light source.Figure 48 has described observation display and the pipeline of Figure 47, and it is connected to outside power supply and light source.
The observation display 104 that Figure 48 describes is connected to external power source and light source 286 through pipeline 200 and transducer 284 interior plugs.External power source and light source 286 comprise holder 288, and its shape complementarity is in observation display 104, and are fabricated to the position that observation display is fixed on the expectation on the holder according to size.
Figure 49 has described instrument 288, and it comprises the extension 290 with protuberance 300.It is designed to be connected to the far-end of observation display.Figure 49 has described the perspective view that is suitable for through the instrument 288 of split ring 302 connections.This split ring is to slide, slide, to cooperate or otherwise to be connected to observation display at split ring 302 places, usually at far-end.Instrument 288 comprises extension 290, and it is designed to keep not desirable tissue not in sight clear line.Therefore, extension 290 can be designed as tongue compressor, vagina sidewall compressor or as other required compressors.Instrument 288 can be designed as when it is connected to observation display and rotates; Or it can be designed as connection and remains on single position or removable position; Wherein frictional force or other power remain on given position with instrument, and user moves to given position with instrument.In addition, if desired, extension 290 can be designed as extendible and retractable, or can have single length like what describe.
Figure 50 is the positive side view of the equipment of Figure 49.
Figure 51 has described the decomposition view of observation display 104.Handle 198 is held head through bolt 304, and for purpose aesthstic and cleaning, said bolt 304 is covered by two lids 306.Side handle 304 is the internal stent 308 that make different elements remain on desired location and additional strength also is provided.Support, handle, head etc. are processed by plastics or other light materials usually; But can also process by metal or other medically acceptable materials; And also made so that it can use liquid sterilizing liquid autoclave sterilization, sterilization usually, or otherwise handled to keep the integrity of medical treatment or tooth environment.Observation display 104 is described with instrument 288 combinations.Instrument 288 is two instruments shown in the embodiment, and it comprises ring 302, and it is snapped to the far-end 190 of observation display 104 through sealed 316 connected systems of bayonet socket.
The extension 290 of instrument 288 is snapped on the ring 300 then.Retainer ring 300 comprises a plurality of stop protuberances 318, and it is snapped on the extension 290 and is fixed in place.As can see, extension 290 can be connected and is disassembled and can be placed the almost any position on the adjacent loops 302.
Support 308 contains a plurality of optical elements, such as optical filter and eyeglass, can see them through their supporting construction.For example, lacking pass filter 314 is maintained at light source and is used for the structure between the supporting construction of dichroic mirror 141.In the embodiment of describing; Short pass filter 314 only sees through blue light basically; Be the light of wavelength less than about 450-500nm; It is the light (the potential adverse effect that does not have UV light) of safety basically that projects on the human body, also has enough energy simultaneously causing fluorescence, such as AF or from the fluorescence of the fluorogen that provides.Other optical filters with other characteristics also can be set at this position, and if desired, interchangeable slot or other structures can be set up, so that different optical filter can be inserted in the independent observation display or from its taking-up.Alternately, a plurality of observation displays that have a combination of different optical filters can be set up.
The window 303 of dichroic mirror 141 far-end 190 and the instrument 288 through observation display 104 is from source reflection light.Pass dichroic mirror 141 from the light that the patient returns back from window 303.In described embodiment, dichroic mirror 141 plays long wave pass filter, and it is by the light of about 475-480nm, and promptly it stops that the light of shorter wavelength also sees through light of longer wavelength.In described embodiment, dichroic mirror 141 has stopped that basically all see through the exciting light of short wave pass filter 314.Near dichroic mirror 141 be the supporting construction that is used for second long wave pass filter 310, it has been eliminated all basically and has seen through unwanted light of color mirror 141.In such embodiment, as far as viewer, all unwanted light have all been filtered basically.If necessary, optical filter can also be set further, such as trap optical filter 312, it remains on along the downstream of the supporting construction of second long wave pass filter 310.In one embodiment, the light between about 585-595nm, the trap optical filter can see through all light basically.This specific embodiment is particularly advantageous for detecting oral cavity cancer, cervical cancer and other cancers, and partly cause is because filter transfers such light to help viewer to distinguish pathological tissues and non-pathological tissues.This trap optical filter also is useful especially for detecting other damages, and the damage that detects according to the relevant fluorescence signal red shift of the disease of existence or the state of an illness is particularly useful.
Figure 52 has described the sketch map of binocular assembly 326, and it is included in the binocular vision device 320 shown in the embodiment, and it is designed to glass basically, comprises independently lens, and each is used for eyes, lens 330 and leg of spectacles 328.Binocular vision device 320 is suitable for removably being connected to binocular opening 322 at joint 323, and transducer 324 light path that will be used for each binocular lens is combined to through what opening 332 sent and inquires after light path separately subsequently.In other the embodiment, usually therefore, the binocular vision ability of this embodiment can be extended in the actual inquires zone, and it comprises observation opening and isolating field of illumination (if desired) separately.This is particularly advantageous in some cases for this, because the light of the light of different wave length or different rays has other different qualities such as different polarization characteristic etc., can be set to be used for detecting independently the zones of different or the same area of each eye of user.
Further overall the argumentation
In some embodiment; Display provides fluorescent exciting; For example white light is through (for example, via seeing through or reflection) optical filter, and this optical filter only excites light in the scope (in some embodiment through for example 400-500nm basically; It preferably uses the light of only being longer than about 400nm basically, so that self possibly be that dangerous UV light is not included in such light).Exemplary optical filter comprises short wave pass filter and bandpass filter.
Then, exciting light contact target.Reflected light sends from said target through fluorescence usually subsequently, although except fluorescence or alternative fluorescence, can also use sometimes reflected light with other such as light such as IR light or Raman.Then; Display apparatus self is handled through the emission light of display collection and with it and is propagated into viewer (and if desired; Propagate into other equipment, such as video camera, such as video detecting devices such as CCD, CID, CMOS, or computer or spectrometer or other spectral measurement equipment).
The detection light path of display has at least one long wave pass filter usually, or the optical filter of other expectations, and it has stopped exciting light basically, so that only there is the light of longer wavelength to be seen.In the embodiment; Stopping through providing like this can realize (promptly by the dichroic mirror of about 475-480nm; The light that it stops the light of shorter wavelength and sees through longer wavelength); Be " green glass " optical filter subsequently, it has also stopped the light of the wavelength shorter than about 475-480nm and has seen through the light of being longer than these wavelength.
In some embodiment, display also comprises at least one optical filter of handling light, so that filtered basically or its energy and intensity when reducing basically when other wavelength bands, the different wave length band that detects light keeps visible.For example, downward from long wave pass filter, display can have the trap optical filter, and it is basically through all light, except the light between about 585-595nm.This specific embodiment is particularly advantageous for detecting oral cancer with some other infringement.
Other trap optical filters that are fit to also can be set up, and for example with the identification between enhanced oxidation and the deoxidation blood (that is, HbO2 Oxyhemoglobin is to deoxyhemoglobin), or between the medicine of activatory or inactivation or diagnostic flag, distinguish.If desired; One or wavelength ratio optical filter more how variable or non-variable ratio (scaling filter); The ratio separately of the different wavelength bands that sees through also can be provided such as what U.S. Pat 6110106 discussed, so that can be different in the embodiment of expectation.The additional examples of many bandpass filter combinations can also be discussed in U.S. Pat 6021344.As stated, these two kinds of documents are incorporated herein by reference in full, are used for all their instructions and open, comprise the discussion of their endoscope, optical filter, suitable cymoscope and light source etc.
If desired, display of the present invention can be a hollow housing basically, and it comprises and is placed in usually on the handle with wieldy optical filter.In some embodiments; This equipment can also comprise the extension component that is designed to be connected to display far-end (like its elsewhere that can needs); This extension component can be used to the visual field of releasing display such as the interference tissue of buccal, tongue or vaginal wall etc. or body structure, so that can better be observed.The example of some embodiments of such equipment is sometimes referred to as " retractor ", is included in the incidental here accompanying drawing.In the embodiment of an expectation, organize mobile device to be connected to display rotatably, so that it can be in the oral cavity of being observed or other bodily cavities are indoor is more prone to or moves effectively.
The physical set of display is divided according to the certain desired of user and demand and by significant change.For example; As previously discussed, display can only be the box that has the hollow basically of required eyeglass, it only transmits light toward target tissue from outside (normally immediate position) light source; (eyepiece eye parts are the eye cup normally then light to be turned back to the eyepiece eye parts of display from target tissue; But can also be other eyepiece equipment that are fit to, such as ground glass, and as needed can be monocular instrumnent or binocular).If desired; Display can be replacedly or additionally is designed to comprise one or more internal light source; The light source of distal position (such as LEDs); And/or the immediate light source in position and one or more fiber optic conduit, fibre-optic cable or other such optical transmission conduits, except or be not the light guide that forms by the hollow case that has the suitable optical element that this paper discusses.
Usually, display comprises the power supply that is suitable for providing light.This power supply can be an external power source, and such as the set of cells that is connected by lead, set of cells remains on other place in the handle or in display self, or socket or other connection device or other power supplys to wall power sockets that is fit to.Accompanying drawing has shown exemplary electricity/combination of light sources.In some embodiments, the main body of light source comprises and is designed to the maintenance structure of fixing display when not in use.
Foregoing, if desired, display can comprise one or more non-human cymoscopes, such as comprising pick offs such as CCDs, CIDs, CMOSs, and/or one or multi-display equipment more, such as CRTs, flat faced display, computer display etc.In addition, if desired, display system can comprise one or multicomputer more, its control, handles and/or explain the difference in functionality of display, comprises the function of for example diagnosis, research and/or treatment.
Computer is a kind of equipment, and it can control other elements of the apparatus and method of optical filter, selective light actuator, cymoscope or this paper discussion.For example; The open/close state (such as charge (CCD) or electric charge injection device (CID)) of the optic communication characteristic that said controller can controlled selection property light regulator, the pixel of control pixel light detector; And/or from the compilation data of cymoscope, it comprises when feedback and uses with the control illumination light time such data with manufacturing or reconstructed image or such as other elements of equipment as herein described such as diagnosis or treatment and method.Usually, computer comprises central processing unit (CPU) or other logic actuating equipments, and for example independent computer such as desk-top and laptop computer, has the computer of ancillary equipment, hand-held, LAN or the Internet etc.Computer is extensively known, and within the scope that is chosen in those skilled in the art according to the hypothetical computer that is used for particular aspects or characteristic of the present disclosure.
In the exemplary, the system of this paper comprises light source, hand-held display, vestibule equipment (ALMS), retractor or (buccal pusher), light-path, light box (light source), light guide and at the eyepiece of display most proximal end.Said light path from illumination path extend to target, to user and within hand-held observation display; This display comprise successively collimator, 430+/-30nm optical filter (optical filter 1), dichroic filter (optical filter 2), lucifuge absorber (lightto avoid absorber), windowpane, mucosal tissue or other target tissues, dichroic filter (optical filter 2 (light is oppositely through identical dichroic filter)) 475, long wave pass filter (optical filter 3), 590nm trap optical filter (optical filter 4), eyepiece.This optical filter can or isolating (discrete) or (for example, the reflective coating) of combination.This system can also or can instead comprise binocular, such as ring/filter glass or have/do not have a sunglasses/protective eye lens of enlargement ratio, and treatment light (curing light).This treatment light can have multi-wavelength system (for example, having second head that separates optical filter) and the treatment light wavelength can be controlled through independently optical filter and/or filter wheel etc.Some other characteristic that can be comprised is filter glass or the LED on the rod or the intraoral video camera of optical wand, eyeglass and/or normally calibration; It can have the pipe box that has optical filter so that the light of special needs to be provided in the end, and therefore act as optical wand and therefore act as light source or act as the additional source of light that is used for fluorescence or other required reflections.
In the oral cavity design of video camera can have within the video camera with outside the light of the multi-wavelength handled.Said light can pass system along pipeline, maybe can introduce light source, maybe can be the sleeve pipe that separates (or other optical transmitting sets that are fit to) that has the light of oneself.Said sleeve pipe can have suitable wavelength emission/exciter filter.If required function is implemented, the position of optical filter and other optical elements can change in path.
Illumination light path and sight clear line can be as being combined in some accompanying drawing, perhaps as in having the light source of magnifier/glasses, be isolating.Said path can strengthen the standard method of ability to have observation and to throw light on that user uses equipment.Check the viewpoint in oral cavity simultaneously from two people, the two has illuminated different structure observation visual angle, therefore sees different tissues, possibly make different diagnosis so.Tripod is used to reduce the difference of standardization height and angle sometimes.The size of the interrogation position in some embodiments is fabricated to according to size whole infringement and normal structure is on every side compared, and its enhancing is used for the anatomic landmark of localized observation and identification.
In some embodiments, intensity is optimised to shrouding tissue with diagnostic exciting light, produces signal to excite necessary fluorogen.In some embodiments, wavelength is optimized for identification oral cavity and interior certain type the cancer of finding of other target tissues.Wavelength/fluorescence has strengthened the ability of displacement in the identification fluorescence emission spectrum to allow normal cancerous tissue of difference and unusual cancerous tissue.For example, strengthened cytoactive detection from about 475-585 with from about 595 with the double check of above two wavelength bands for metabolism cofactor NAD and FAD.NAD and FAD have produced the fluorescence that under this wavelength, has peak level.
In some embodiment; What be supposed to is to obtain energy as much as possible and do not have too much ambiguous transmitting; Keeping narrow output spectrum to stop Stokes shift, and get rid of UV light to avoid illumination/emission light in emission band (overlapping fluorescence).
In some embodiment, this system can also comprise scattering object so that the luminous point size is more regular, remove focus etc.Also sometimes desired is that collimator makes the optical alignment that sends from optical filter; And restriction the dispersing of the enhanced light beam of energy density; Or use the liquid light guide pipe and do not use optical filter, and reach the better transmission of every cost and the aperture of higher numeral (it is collected higher light and contributes) so that obtain bigger efficient through the wasting space that reduces between the optical filter.Still in other embodiments; Said system can also comprise metal halide light strengthening the energy in some transmitting boundary, dichroic filter or similarly optical element to strengthen overlapping observation and illumination path (can guide simultaneously illumination light away from light source and emission light away from organizing).Glass or other transparent windows before the display can keep clean.
Some oral cavity with other embodiments in, use about 4 " the display slave unit get back to oral cavity or other targets; If necessary, spacer can be set.Display interior can be black with the indirect illumination light that absorbs diffusion and the fluorescence (unwanted fluorescence feedback) of release.
It is comfortable that the shape of display can preferably be set to the ergometrice, optimizes to excite and launch path.Immediate eyepiece can be set up length; So that the immediate optical filter that tilts (for example; 590nm trap optical filter) form geometry, the light that the surround lighting that gets at the back from user like this can be reduced and see through can be reflected to the absorption inner tube surface.Reduced reflection like this and prevented that user from seeing themselves.For example, immediate optical filter can be tilted to the top that makes it near the doctor bottom near dichroic mirror so that form reflecting surface, and its light that will come in causes in the bottom surface of optical path pipe.
Dismountable eyepiece can allow to insert the transducer that is used for video camera.In some embodiment, video camera is as far as possible near dichroic the connection, it has reduced the light-path that is used for video camera in the display, and this has reduced the probability/trend of camera automatic focusing to the VELScope inside.This also can be important because the fluorescence that produces can be LOIHT (high ISO film/setting, long shutter are opened the time), yet can trigger automatic focus through miscellaneous part, because it trends towards focusing on the brightest things in the visual field.
Can cheek retractor or other tissue manipulation equipment on the far-end of display.In patient's oral cavity, some are arranged separately through observing inaccessible zone.The retractor of buccal and tongue has strengthened near the ability of tissue like this, and has given-one of clinician " pickpocket " and hold display, second hand control tongue, and " the 3rd " retract buccal.If the clinician must work independently, this possibly be a particular importance.
Retractor can be processed by base and dismountable arm, and can be designed as also as antipollution medicated cap.In some embodiment, or for ease, retractor can have a plurality of positions around the display end, and eight positions along circumference for example can placing retractor should preferably different angles.The arm of retractor can be dismountable, so that ought be when not required, it will can not disturb this process, such as through pinking operator and/or patient.It can only need to get into about 10% oral cavity.
The arm of retractor can be angled, is similar to the mirror of dental.This can be designed as other instruments that the operator uses and stops lip and/or buccal to slide that are similar to.It can be by molding, so that can only see that the fraction retractor to reduce the blocking of sight clear line, allows the operator always can know the position of tip simultaneously.Ambient light management (ALMS) also is used to enclosed environment light.
Cheek retractor can have meshing device and need not its slave unit is removed with the angle that allows the adjusting range cheek retractor.For the purpose that writes down, the precalculated position of retractor can provide the qualification position that is used for equipment, for example, and " when equipment is in the NW position, I can see in the space ... ".Sealing between other parts of retractor and VELScope can be rub fully or have notch or groove on the circumference of equipment to be fixed to suitable position.Replace eight positions, VELScope is last can to have perfectly smooth ring, and it allows location (unlimited position) continuously, if for example angle recordings is unessential.Replacing eight positions, can be six (for example, being with or without top and bottom), four (for example, if square front expects that it has square window is useful), or the position of any other number.
In some embodiment; This system can also comprise one or more removable head that is used to treat more; And can be modular assembly system with a plurality of heads that are used for a light source; For example be used for treatment, be used for the fluorescence excitation of cancer detection and be used for the fluorescence excitation of dental caries at 405nm at 430nm at 476nm.Different parts can be connected to each other with any form, for example quick detachment, frictional fit, screw on etc.Said head can comprise different optical filters according to said task, and said task is the diagnosis/treatment of dental caries tooth/gingivitis for example.
In order to treat; Possibly not expect the combination of observation/illumination pathways (or sight clear line is provided really) in certain embodiments, because the operator can not need to see target, but can be some deutero-benefits; For example; See its (normally deleterious UV light) because illumination can be filtered out with the prevention user, so the optical filter on the light source can be that for example the combination of bandpass filter and trap optical filter is with the wavelength through wide region; Comprise blue light up to HONGGUANG, then at intermediary big notch to remove every other light.In other words, be exposed in the blue light, in HONGGUANG, observe, but Fluirescence observation is unnecessary.
In some embodiment, said system also comprises sight pointing out where viewer is being observed, or has another laser or ambient light, such as dual surface LED so that aiming light to be provided.In the different embodiments, the treatment head can be an optical filter of selecting required illumination light wavelength, and treatment head guiding illumination.The treatment head can be or permanently connect or (Consumer off the shef) that consumer can take off (COTS) pattern that it can be connected to the optical filter head movably in the time of needs.The treatment head can be standard, optical fiber, free space, light pipe etc., obtain any required method that light arrives tissue from optical filter.
Described like other place, individual monitor can be provided with the many places light source sometimes.If desired for white-light visualization, the output of bigger bandwidth can be provided.Bigger bandwidth can be through having additional light (LED, halogenide etc.) or using different optical filters to obtain through the outfan at independent light source.This system can also provide the illumination with multi-peak.For example, the pharmacology of biomarker/physiology's test can be used it sometimes, is used for when under different ion/pH condition, and the fluorescence that sends (through tissue, labelling or chemical signal) changes.This can also be used to provide standard, because the energy of the fluorescence that produces through each wavelength can be by relatively, and relative to each other standardization.In some embodiment, said system comprises that also intervalometer is to wait other purposes and close black out for treatment time of defining or such as energy-conservation.
In some embodiment, display comprises that shock mount is to isolate the optical path in the VELScope.This can be, for example around the second ectoskeleton packaging material of the first ectoskeleton packaging material, but through air and be clipped in the elastomeric O-rings shock mount place contact between path pipeline and the shell and separating with it.Also there is the short-cut method of change equipment color in this, and need not the expensive mould technology of crossing.Internal path is the absorption that is used for light of black normally, though black is because of its dull characteristic and because cleaning makes it look dirty from rubber gloves residue and powder, so possibly be without the color that is usually used in armarium.Shell can be a various colors, such as white, cream-coloured or other normally used colors with around these tissues.
In some embodiment, said system comprises square window or opening, and it can be to manufacture more cheaply than circular window, owing to pay close attention to processing and manufacturing, such as hole saw vs. straight cuts, and reduces consume.In addition, such structure (or other non-circular structures) can help user to pass through between ALMS and display, to form frictional fit/respective outer side edges and operation A LMS.Can also expect to be used for the square window of the relatively cheap non-fluorescent glass/material of optical path, the material of even now can also be used to other geometries.
The far-end of VELScope can have recessed opening, and it can be square in distal-most end, but if desired, it is circular that optical path keeps.The last opening of VELScope can be nonvolatil or dismountable to allow to use the ALMS pattern of difform window or standard.The shape of ALMS can be such so that see from the operator on patient's the distal face that more material can be arranged.This has reduced the interference of practitioner to ALMS, and has utilized the blocking capability of practitioner to natural light, and ALMS can have the otch that is used to get into nose.
In some embodiment, for the effect of " memo pastes (Post-it note) ", said system has used the binding agent that can turn over subsides again of weak intensity.If necessary, can adjust position and do not have remaining trace or to the permanent attachment of glass.This has allowed to reuse the glass of protectiveness and has handled the ALMS that is polluted.Use this binding agent, also have the probability that ALMS is provided with the form of " multilamellar " that be incorporated into scratch pad, new as required here one deck can be torn off.The size of ALMS can not only cover display but also cover hand.Said material can be that the illumination light and the surround lighting of deceiving or other dark-coloured materials reflect with absorption also absorb the AF that sends from ALMS self.For cheap and tractable purpose, it can be processed by polypropylene or other ideal materials.Weight can be selected so that valance can the excessive interference operator.
The vocabulary that all this paper use except context or pointing out, uses according to their common implications with defining removing.Only if outside otherwise clearly pointing out, " or " use comprise " with " and vice versa.Only if clearly illustrate that, or clear from context point out that outside otherwise pointing out, that infinite vocabulary is not used to be interpreted as is restrictive (for example, " comprise ", " having " and " comprising " ordinary representation " include, without being limited to ").Similarly form (be included in right power require in) comprises plural connotation such as " one ", " a kind of " and " said ", only if explanation clearly, or the pointing out of context removing, otherwise point out.
The display of native system and method etc. had both comprised that device added function, comprised that also step adds the conception of function.But; The described vocabulary of the application will not be interpreted as the relation that shows " device adds function " in claim; Only if vocabulary " device " is quoted specially in claim; And in claim, will be interpreted as the relation that shows " device adds function ", vocabulary " device " is introduced in the claim specially here.Similarly; The said vocabulary of the application is not interpreted as " step the adds function " relation that shows in method or step claim; Only if vocabulary " step " is introduced in the claim specially; And in claim, will be interpreted as show " step adds function " relation, vocabulary " step " is introduced in the claim specially here.
The creation of this paper not only comprises equipment that this paper discusses, system etc.; Also comprise the method that all are relevant, comprise the method for manufacturing system, manufacturing system element such as special installation etc., said equipment such as ALMS or display; And the method for using display and system; Such as, for example ALMSs is connected to display, and using system is to inquire after tissue (or otherwise using display to carry out the diagnosis that stops, treatment etc.).In some embodiments, the invention comprises that the method for using display is used for diagnosis and dental treatment, and the sicker that for example uses the cyanoacrylate adhesive class connects artificial tooth or other materials or is adhered to intraoral treatment.
Embodiment
Embodiment 1: use observation display to discern intraoral main abnormal development
Utilize observation display to discern intraoral main abnormal development (N=49) based on AF.The light path of display have successively collimator, 430+/-30nm optical filter (optical filter 1), dichroic filter (optical filter 2), lucifuge absorber, windowpane, mucosal tissue or other target tissues, dichroic filter (optical filter 2 (light is oppositely through identical dichroic filter)) 475, long wave pass filter (optical filter 3), 590nm trap optical filter (optical filter 4), eyepiece.This display uses with the vestibule equipment that has opening, and said opening is operably connected to display, and stops all surround lightings to arrive target basically.
For the main infringement among the patient who does not have the oral cancer medical history, display has correctly been discerned most of abnormal development (70%), infringement (86%) before the especially senior canceration.It also is male that display is used in about 18% non-abnormal development infringement.Said display has also improved the clinician and has distinguished the ability that non-abnormal development is damaged.Use standard technique, in 11 this non-abnormal development infringements nine is to damage before the canceration of oral cavity by clinical diagnosis, but uses display, and only two also is male in these false positives.
Among some other the result; Ten tissue biopsies from infringement use display to be accredited as the positive, and it is actual to be dysplastic, also have the tissue biopsy from contiguous normal appearance zone; Use display, said zone correctly is accredited as non-abnormal development.
Claims (18)
1. direct observation display; It is used to supply the observer to come direct observation patient's target tissue; Said observation display comprises the box of hollow; The box of said hollow comprises that most proximal end and diameter approximately are 1 inch far-ends; Said display is configured to optionally collect at least the fluorescence that sends from said target tissue; And said light directly is sent to user's eyes through the box of said hollow; So that the said most proximal end place of fluorescence to the box that is positioned at said hollow or near eyepiece eye parts optionally only to be provided in fact, the far-end of said observation display comprises the localized light source in distally that is arranged in the far-end of the box of said hollow or near the ring the far-end of the box of said hollow, and said light source in fact only is configured to optionally the blue excitation light of induced fluorescence is impinged upon on the said target tissue.
2. observation display as claimed in claim 1, the localized light source in wherein said distally comprises a plurality of light emitting diodes, said a plurality of light emitting diodes are arranged to a circle in fact, and are configured in fact only send blue light.
3. according to claim 1 or claim 2 observation display; Wherein said observation display is set up size and is configured to wireless with hand-heldly, and wherein said display comprises T shape shape, wherein; Handle from the box of said hollow in fact to extending below; And wherein, said observation display also comprises battery, saidly is connected to said light source to said light source electric power to be provided battery-operatedly.
4. as the described observation display of arbitrary aforementioned claim, wherein, said observation display also comprises high ISO imaging sensor, and said high ISO imaging sensor is configured to the fluorescence imaging that sends from said target tissue.
5. like the described observation display of arbitrary aforementioned claim, wherein, the localized light source in said distally is configured to optionally provide the only blue excitation light of substantial induced fluorescence, and also is configured to white light is impinged upon on the said target tissue.
6. like the described observation display of arbitrary aforementioned claim, wherein, the said far-end of said observation display also comprises movably, window non-in fact fluorescence, non-reflection, and said window covers the tip of said observation display in fact.
7. like the described observation display of arbitrary aforementioned claim, the localized light source in wherein said distally also is configured to white light is impinged upon on the said target tissue.
8. like the described observation display of arbitrary aforementioned claim, wherein, said window also comprises optical filter, and said optical filter is configured to optionally stop the light of the wavelength of not expecting, and the light of the wavelength of transmission expectation.
9. as the described observation display of arbitrary aforementioned claim, wherein, said window is maintained in the split ring, said split ring be connected removedly said hollow box far-end or near.
10. like the described observation display of arbitrary aforementioned claim; Wherein, Said observation display also comprises and is configured to provide the light source with the illumination path of illumination on said target tissue; Said display is configured to optionally collect at least the fluorescence that sends from said target tissue; And said light is transmitted the box through said hollow along a receiving light path; So that the said most proximal end place of fluorescence to the box that is positioned at said hollow or near eyepiece eye parts optionally only to be provided in fact, wherein said observation display comprises at least one in collimation optical elements or the focusing optical element, and is transferred to the only alignment light of said target tissue or at least one in the focused light.
11. observation display as claimed in claim 10, wherein, said observation display also comprises diffusive optical element, makes the light that is transferred to said target tissue in light beam, have intensity in fact uniformly.
12. like claim 10 or 11 described observation displays, wherein, said light source is configured to optionally provide the light that changes wavelength.
13. like each described observation display in the claim 10 to 12, wherein, said observation display is configured to make that said illumination path and said collection light path are conllinear.
14. observation display as claimed in claim 13, wherein, for each at least a portion in said illumination path and the said collection light path, said illumination path is advanced along identical path with said collection light path.
15. observation display; It is used to supply the observer to observe patient's target tissue; Said observation display comprises the box of hollow; The box of said hollow comprises that most proximal end and diameter approximately are 1 inch far-ends; Said display is configured to optionally collect at least the fluorescence that sends from said target tissue, and said light is transmitted the box through said hollow, so that the said most proximal end place of fluorescence to the box that is positioned at said hollow or near eyepiece eye parts optionally only to be provided in fact; The said far-end of said observation display also comprises movably, window non-in fact fluorescence, non-reflection, and said window covers the tip of said observation display in fact.
16. observation display; It is used to supply the observer to observe patient's target tissue, and said observation display comprises the box of hollow and be configured to the light source of illumination on said target tissue that the box of said hollow comprises that most proximal end and diameter approximately are 1 inch far-ends; Said display is configured to optionally collect at least the fluorescence that sends from said target tissue; And said light transmitted the box through said hollow, so that the said most proximal end place of fluorescence to the box that is positioned at said hollow or near eyepiece eye parts optionally only to be provided in fact, wherein said observation display be set up size and be configured to wireless with hand; Wherein, Said observation display is a T shape haply, make handle from the box of said hollow in fact to extending below, and wherein; Said observation display also comprises battery, saidly is connected to said light source to said light source electric power to be provided battery-operatedly.
17. observation display; It is used to supply the observer to observe patient's target tissue; Said observation display comprises the box and the light source of hollow; The box of said hollow comprises that most proximal end and diameter approximately are 1 inch far-ends, and said light source is configured to provide with the illumination path of illumination on said target tissue, and said display is configured to optionally collect at least the fluorescence that sends from said target tissue; And said light is transmitted the box through said hollow along a receiving light path; So that the said most proximal end place of fluorescence to the box that is positioned at said hollow or near eyepiece eye parts optionally only to be provided in fact, wherein said observation display comprises at least one in collimation optical elements or the focusing optical element, and is transferred to the only alignment light of said target tissue or at least one in the focused light.
18. observation display as claimed in claim 17, wherein, said observation display also comprises diffusive optical element, makes the light that is transferred to said target tissue in light beam, have intensity in fact uniformly.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56246904P | 2004-04-14 | 2004-04-14 | |
| US60/562,469 | 2004-04-14 | ||
| US61828704P | 2004-10-12 | 2004-10-12 | |
| US60/618,287 | 2004-10-12 | ||
| US11/016,567 | 2004-12-16 | ||
| US11/016,567 US20050234526A1 (en) | 2004-04-14 | 2004-12-16 | Systems and methods for detection of disease including oral scopes and ambient light management systems (ALMS) |
Related Parent Applications (1)
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| CNA2005800193535A Division CN1968644A (en) | 2004-04-14 | 2005-04-14 | Systems and methods for detection of disease including oral scopes and ambient light management systems (ALMS) |
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| CN102499620A true CN102499620A (en) | 2012-06-20 |
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| CN201110312203.0A Pending CN102499620A (en) | 2004-04-14 | 2005-04-14 | System and method for dectecting oral diseases, and environment light management system |
Country Status (5)
| Country | Link |
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| EP (1) | EP1755442A4 (en) |
| JP (2) | JP2007532208A (en) |
| CN (1) | CN102499620A (en) |
| AU (1) | AU2005232350A1 (en) |
| CA (1) | CA2604491A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814740A (en) * | 2014-09-16 | 2015-08-05 | 赵益民 | Image collection method and apparatus |
| CN110226946A (en) * | 2019-06-12 | 2019-09-13 | 杭州市第三人民医院 | Urological surgery specimen trap |
| CN110868914A (en) * | 2017-07-11 | 2020-03-06 | 高露洁-棕榄公司 | Oral care assessment system and method |
| CN113509284A (en) * | 2021-07-14 | 2021-10-19 | 德州可恩口腔医院股份有限公司 | Multi-functional telescopic root canal measuring apparatu |
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| US8720438B2 (en) | 2007-12-06 | 2014-05-13 | Cpair, Inc. | Breathing mask with sticky edge |
| JP5881307B2 (en) | 2011-04-08 | 2016-03-09 | オリンパス株式会社 | An observation device that can detect the tip position of the insertion section using external light |
| JP6623544B2 (en) * | 2015-04-20 | 2019-12-25 | ウシオ電機株式会社 | Diagnosis device and imaging method for tumor site |
| KR102306048B1 (en) * | 2017-01-30 | 2021-09-29 | 메디비콘 아이엔씨. | Method for Non-Invasive Monitoring of Fluorescent Tracers with Diffuse Reflectance Correction |
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| GB1470760A (en) * | 1973-11-12 | 1977-04-21 | Alphametrics Ltd | Ultraviolet camera system for dental photography and mouth pieces therefor |
| DE2630606A1 (en) * | 1976-07-07 | 1978-01-12 | Alois Hoerl | Luminescence radiation analyser for living organisms - uses optical light guide and waveguide on screened measuring head |
| US4534360A (en) * | 1983-05-27 | 1985-08-13 | Williams Martin D | Detection of lung cancer using breath luminescence |
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- 2005-04-14 CN CN201110312203.0A patent/CN102499620A/en active Pending
- 2005-04-14 AU AU2005232350A patent/AU2005232350A1/en not_active Abandoned
- 2005-04-14 EP EP05735631A patent/EP1755442A4/en not_active Withdrawn
- 2005-04-14 JP JP2007507640A patent/JP2007532208A/en active Pending
- 2005-04-14 CA CA002604491A patent/CA2604491A1/en not_active Abandoned
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2012
- 2012-11-30 JP JP2012262066A patent/JP5681162B2/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814740A (en) * | 2014-09-16 | 2015-08-05 | 赵益民 | Image collection method and apparatus |
| CN104814740B (en) * | 2014-09-16 | 2017-05-03 | 赵益民 | Image collection method and apparatus |
| CN110868914A (en) * | 2017-07-11 | 2020-03-06 | 高露洁-棕榄公司 | Oral care assessment system and method |
| CN110226946A (en) * | 2019-06-12 | 2019-09-13 | 杭州市第三人民医院 | Urological surgery specimen trap |
| CN110226946B (en) * | 2019-06-12 | 2022-05-17 | 杭州市第三人民医院 | Urinary surgery operation specimen collector |
| CN113509284A (en) * | 2021-07-14 | 2021-10-19 | 德州可恩口腔医院股份有限公司 | Multi-functional telescopic root canal measuring apparatu |
| CN113509284B (en) * | 2021-07-14 | 2022-08-16 | 德州可恩口腔医院股份有限公司 | Telescopic root canal measuring apparatu |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2604491A1 (en) | 2005-10-27 |
| JP2007532208A (en) | 2007-11-15 |
| EP1755442A4 (en) | 2007-08-22 |
| EP1755442A1 (en) | 2007-02-28 |
| AU2005232350A1 (en) | 2005-10-27 |
| JP2013135845A (en) | 2013-07-11 |
| JP5681162B2 (en) | 2015-03-04 |
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