CN102492112A - Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel - Google Patents
Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel Download PDFInfo
- Publication number
- CN102492112A CN102492112A CN2011103723051A CN201110372305A CN102492112A CN 102492112 A CN102492112 A CN 102492112A CN 2011103723051 A CN2011103723051 A CN 2011103723051A CN 201110372305 A CN201110372305 A CN 201110372305A CN 102492112 A CN102492112 A CN 102492112A
- Authority
- CN
- China
- Prior art keywords
- graft copolymer
- polyethylene glycol
- temperature sensing
- temperature
- polyvinyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a graft copolymer, its preparation method and application. The graft copolymer is a polyethylene glycol-polyvinyl alcohol graft copolymer, and a graft copolymer having temperature sensing characteristic is prepared by using different proportions of polyethylene glycol to polyvinyl alcohol. The graft copolymer can reflect the switching performance by rapidly absorbing and releasing water (or solvents) with the change of temperature, thus the polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel prepared by the method has a wide application prospect in biochemistry, medicine and other fields, and solves the problem of the mismatch between the temperature sensing temperature of temperature sensing hydrogel in the prior art and human body temperature range.
Description
Technical field
The invention belongs to polymeric material field, be specifically related to a kind of graft copolymer, adopt polyoxyethylene glycol cheap, wide material sources, Z 150PH prepares a kind of temperature-sensitive hydrogel through grafting copolymerization process and uses.
Background technology
Because temperature-sensitive hydrogel can rapid absorption embody its switch performance with release water (or solvent) with temperature variation, therefore has wide application prospect in biological chemistry, medicine and other fields.As the hydrogel of doing being soaked in the soup soup is permeated in hydrogel, or through the reaction between the reactive group on enzyme and the hydrogel skeleton enzyme is fixed in the hydrogel, this hydrogel can be used for the Clinics and Practices of disease, and can use repeatedly.Why hydrogel is used widely, mainly is because its chemical property torpescence is nontoxic, has excellent biological compatibility and resistance to deterioration, can carry out disinfection and reprocess.The material of preparation aerogel dressing is mainly chitosan, sodium-alginate, Z 150PH etc. at present.But the temperature sensitive temperature of a lot of existing temperature-sensitive hydrogels can not be controlled in the body temperature scope all the time, and this has caused certain obstruction for the release of medicine etc.
Summary of the invention
In order to solve the problems of the technologies described above, the present invention adopts polyoxyethylene glycol, Z 150PH to carry out graft copolymerization, and the preparation method of this multipolymer is provided, and the application of polyethylene glycol-vinyl alcohol temperature-sensitive hydrogel.
Its technical scheme is following:
The polyethylene glycol-vinyl alcohol graft copolymer of preparation is the temperature sensitive behavior of the whole material that causes of the phase transformation owing to grafted chain PEG.The temperature-sensitive hydrogel that therefore will obtain to satisfy the demand has carried out relevant research around PEG, like the molecular weight of PEG, and the content of PEG, the percent crystallinity of PEG etc.
Embodiment:
1. different components ratio, different molecular weight PEG be as reactant, the PEG heating and melting that drying is crossed.
2. add stoichiometry TDI down at 70 ℃, stir and make it to mix reaction 2h.
3. prepolymer is dissolved in and processes 40% concentration solution among the DMF.
4. 5% PVA-DMF solution is slowly added in the pre-polymer solution, stir and make it to mix, product is gel.
5. place 80 ℃ of baking oven 4h to make it abundant reaction obtained gel.Reaction formula is following:
6. adopt alcohol-pickled 24h, remove excessive prepolymer.
7. the product behind the purifying is placed vacuum drying oven 24h, solvent is thoroughly volatilized.
The composition that feeds intake of table one hydrogel
Beneficial effect of the present invention:
1, in 30～60 ℃ of scopes, have the reversible transformation characteristic, can use repeatedly, no PEG reveals.
2, swelling ratio is big in water, forms hydrogel.
3, temperature is increased near the PEG transformation temperature, and the gel deswelling is remarkable, in the considerable change of 20min internal volume.
The temperature sensitive behavior of the hydrogel that 4, is prepared into is similar with the xerogel transformation behavior, and promptly hydrogel has temperature-sensing property in the transformation temperature scope of phase transformation component PEG.
Claims (2)
1. graft copolymer, by Z 150PH and polyoxyethylene glycol according to 5: 5,4: 6,3: 7,2: 8,1: 9 composition proportioning that feeds intake.
2. graft copolymer according to claim 1 is characterized in that, according to following steps is:
(1) different components ratio, different molecular weight PEG be as reactant, the PEG heating and melting that drying is crossed.
(2) add stoichiometry TDI down at 70 ℃, stir and make it to mix reaction 2h.
(3) prepolymer is dissolved in processes 40% concentration solution among the DMF.
(4) 5% PVA-DMF solution is slowly added in the pre-polymer solution, stir and make it to mix, product is gel.
(5) place 80 ℃ of baking oven 4h to make it abundant reaction obtained gel.
(6) adopt alcohol-pickled 24h, remove excessive prepolymer.
(7) product behind the purifying is placed vacuum drying oven 24h, solvent is thoroughly volatilized.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103723051A CN102492112A (en) | 2011-11-22 | 2011-11-22 | Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103723051A CN102492112A (en) | 2011-11-22 | 2011-11-22 | Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102492112A true CN102492112A (en) | 2012-06-13 |
Family
ID=46183978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103723051A Pending CN102492112A (en) | 2011-11-22 | 2011-11-22 | Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102492112A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105385257A (en) * | 2014-08-20 | 2016-03-09 | 曹人天 | Gel reversible polyvinyl alcohol film |
| CN105646832A (en) * | 2014-11-10 | 2016-06-08 | 合肥杰事杰新材料股份有限公司 | Polyvinyl alcohol composite material and preparation method therefor |
| CN106038515A (en) * | 2016-04-27 | 2016-10-26 | 邬春艳 | A self-heating transdermal drug delivery system having a heat-sensitive substrate and a preparing method thereof |
| CN107383378A (en) * | 2017-07-12 | 2017-11-24 | 马鞍山科信网络科技有限公司 | A kind of method that graft copolymerization prepares temperature sensitive antibacterial type hydrogel |
| WO2019100195A1 (en) * | 2017-11-21 | 2019-05-31 | 深圳大学 | Method for preparing polyurethane hydrogel |
| CN110423331A (en) * | 2019-08-05 | 2019-11-08 | 中电保力（北京）科技有限公司 | A kind of water-swellable flexible flame retardant foamed plastics and preparation method thereof |
| CN111602845A (en) * | 2020-04-27 | 2020-09-01 | 深圳烟草工业有限责任公司 | Cigarette cooling gel particles and application thereof |
| CN113121832A (en) * | 2021-03-10 | 2021-07-16 | 安徽安生生物化工科技有限责任公司 | PVA-g-mPEG graft polymer for preventing drug abuse and preparation method thereof |
-
2011
- 2011-11-22 CN CN2011103723051A patent/CN102492112A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105385257A (en) * | 2014-08-20 | 2016-03-09 | 曹人天 | Gel reversible polyvinyl alcohol film |
| CN105385257B (en) * | 2014-08-20 | 2018-09-21 | 曹人天 | A kind of gel reversible polyvinyl alcohol film |
| CN105646832A (en) * | 2014-11-10 | 2016-06-08 | 合肥杰事杰新材料股份有限公司 | Polyvinyl alcohol composite material and preparation method therefor |
| CN106038515A (en) * | 2016-04-27 | 2016-10-26 | 邬春艳 | A self-heating transdermal drug delivery system having a heat-sensitive substrate and a preparing method thereof |
| CN107383378A (en) * | 2017-07-12 | 2017-11-24 | 马鞍山科信网络科技有限公司 | A kind of method that graft copolymerization prepares temperature sensitive antibacterial type hydrogel |
| WO2019100195A1 (en) * | 2017-11-21 | 2019-05-31 | 深圳大学 | Method for preparing polyurethane hydrogel |
| CN110423331A (en) * | 2019-08-05 | 2019-11-08 | 中电保力（北京）科技有限公司 | A kind of water-swellable flexible flame retardant foamed plastics and preparation method thereof |
| CN111602845A (en) * | 2020-04-27 | 2020-09-01 | 深圳烟草工业有限责任公司 | Cigarette cooling gel particles and application thereof |
| CN111602845B (en) * | 2020-04-27 | 2022-08-09 | 深圳烟草工业有限责任公司 | Cigarette cooling gel particles and application thereof |
| CN113121832A (en) * | 2021-03-10 | 2021-07-16 | 安徽安生生物化工科技有限责任公司 | PVA-g-mPEG graft polymer for preventing drug abuse and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102492112A (en) | Method for preparing polyethylene glycol-polyvinyl alcohol temperature sensing hydrogel | |
| CN100544809C (en) | A kind of polyvinylidene fluoride film hydrophilically modified method | |
| Qi et al. | Salecan polysaccharide-based hydrogels and their applications: a review | |
| CN102174163B (en) | Side chain functionalized amphiphilic polyurethane and preparation method and application thereof | |
| CN101381500B (en) | Chitin/polyvinyl alcohol composite foam material and preparation method thereof | |
| Nkhwa et al. | Poly (vinyl alcohol): physical approaches to designing biomaterials for biomedical applications | |
| CN101280044B (en) | Biodegradable agricultural high-absorbent resin and preparation thereof | |
| CN102321486A (en) | Superabsorbent composite and preparation method thereof | |
| CN104311886B (en) | Liquid agricultural mulching film and its production method | |
| CN105477674A (en) | Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material | |
| CN101691416B (en) | Method for preparing super absorbent resin with cross-linked structure from potato starch phosphate graft co-polymeric acrylic acid and sodium salt thereof | |
| CN103319827B (en) | The preparation method of the inorganic nano combined film of a kind of You Ji – | |
| CN101565482B (en) | Novel PVA-based preserving and packaging coating material and preparation process thereof | |
| CN101302269B (en) | Preparation of super absorbent resin | |
| CN106190652B (en) | A kind of environment-friendly low-temperature soaping agent | |
| CN105482140A (en) | Preparation method of polylactic acid/starch surface grafted sulfuric acid aminated chitosan composite thin film | |
| CN102585265B (en) | Preparation method of gelatin/poli vinyl alcohol (PVA) composite films crosslinked with glutaraldehyde solution | |
| CN104327307A (en) | Method for preparing biodegradable cellulose hydrogel | |
| CN106381090A (en) | Mildew-resistant and environment-friendly glutinous rice wet glue and production method thereof | |
| CN102527247A (en) | Strong acid and strong alkali resistance organic tubular membrane and preparation method thereof, and membrane casting liquid | |
| Liu et al. | Tough, Stimuli‐Responsive, and Biocompatible Hydrogels with Very High Water Content | |
| CN107442086B (en) | A kind of adsorbent material and its preparation method and application causing shape memory function with water | |
| CN106398584A (en) | Rose aroma type glutinous-rice wet adhesive and preparation method thereof | |
| CN104830281B (en) | Intermediate-temperature composite shape-stabilized phase-change heat storage material and preparation method thereof | |
| CN102585460A (en) | Chitosan-polycaprolactone porous composite and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120613 |