CN102432522B - Method for preparing substituted 2-indolinone compound - Google Patents
Method for preparing substituted 2-indolinone compound Download PDFInfo
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- CN102432522B CN102432522B CN201110340204.6A CN201110340204A CN102432522B CN 102432522 B CN102432522 B CN 102432522B CN 201110340204 A CN201110340204 A CN 201110340204A CN 102432522 B CN102432522 B CN 102432522B
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Abstract
The invention relates to a method for preparing a substituted 2-indolinone compound, which comprises the following steps of: reducing a substituted isatin compound by triethyl silicane/trifluoroacetic acid; concentrating; and filtering after washing by using an organic solvent so as to obtain the target substituted 2-indolinone compound. In the method, various substituted isatins with wide sources and low price are used as the raw materials; the reaction condition is mild; the substituted 2-indolinone compound is prepared under high yield; and the method has the advantage of convenience and simpleness in posttreatment.
Description
Technical field:
The chemical synthesis process that the invention relates to a kind of indol-2-one compound of various replacements, has the advantages such as reaction conditions gentleness, yield is high, convenient post-treatment is simple.
Background technology:
Substituted indole-2-ketone compound is the important intermediate of some medicines, agricultural chemicals, and in fields such as tyrosine kinase receptor inhibitor, light kinase inhibitor as Sunitibib, Hesperadin etc. obtains a wide range of applications, its structural formula is as follows:
The synthetic method of this compounds mainly contains: 1, take substituted indole as raw material, be aided with chloroperoxidase catalysis, with hydrogen peroxide oxidation obtain substituted indole-2-ketone compound method (Catal Lett 2009,129,457-461).Synthetic route is:
2, take o aminophenylacetic acid ester derivative as initiator, by molecular sieve catalytic, making it cyclization is that (ORGANIC LETTERS 2009,11 (6), 1345-1348) for indole-2-ketone compound.Synthetic route is as follows:
Above two kinds of methods all exist to a certain extent raw material or catalyzer expensive, the defect such as be not easy to obtain.
3, the people such as Wilk, Crestini finds that it is reductive agent that water closes hydrazine, Isatine derivatives can be reduced to indol-2-one compound (Organic Prepara tions and Procedures International 2005,37 (3), 283-285). the advantage of the method is that raw material is cheap and easy to get; Shortcoming is reductive agent for needing to use the hydrazine hydrate that toxicity is higher in reaction, temperature of reaction high (120 ℃), and the separation and purification difficulty of aftertreatment and product, reaction yield is not high, only has 70% left and right, and the appearance luster of product is undesirable.
Summary of the invention:
The present invention adopts the reduction system of triethyl silicane/trifluoroacetic acid, under mild conditions, the isatin compound of replacement is reduced into target compound with high yield, and has aftertreatment advantage simply and easily, and synthetic method is as follows:
Wherein, R
1for the substituting group on phenyl ring, can there is multiple the position of substitution, comprise 4,5,6 and 7.Replacement can be monosubstituted, polysubstituted (comprising that two replacements, three replace or four replacements).R
1middle substituting group comprises:
(1) H, halogen
(2) low alkyl group, as: methyl, ethyl, propyl group, sec.-propyl, butyl, isobutyl-, the tertiary butyl
(3) lower alkoxy, as: methoxyl group, oxyethyl group
(4) hydrogen bond receptor or donor groups, as: hydroxyl, nitro, amino, cyano group
In addition, R
2substituting group on N, comprising:
(1)H
(2) low alkyl group, as: methyl, ethyl, propyl group, sec.-propyl, butyl, isobutyl-, the tertiary butyl
Concrete operation process is as follows:
Under nitrogen protection, by replacing isatin compd A, be dissolved in the mixing solutions of triethyl silicane and trifluoroacetic acid, and then be at room temperature stirred to reaction end; concentrating under reduced pressure is removed after solvent, adds organic solvent, suction filtration after stirring; washing, drains, and after being dried, obtains target compound B.
Embodiment:
Embodiment mono-: the preparation of 5-bromo indole-2-ketone:
Under nitrogen protection, in 250ml reaction flask, add 100ml trifluoroacetic acid and 34.8g (0.3mol) triethyl silicane, after stirring, under room temperature, add 22.6g (0.1mol) 5-bromoisatin in batches, after adding, under room temperature, continue stirring reaction 12hr.Concentrating under reduced pressure, removes trifluoroacetic acid, then adds 50ml ether, stirs 1hr, filters, ether washing, drains, and obtains off-white color solid, after being dried, obtains 19.5g5-bromo indole-2-ketone, yield 91.9%, mp=217～219 ℃ ,-cESI=212.05,1HNMR-δ ((CD
3)
2sO)/300MHz): 10.38 (s, 1H), 7.44-7.31 (m, 2H), 6.74 (d, J=8.0Hz, 1H), 6.27 (d, J=7.7Hz, 1H), 4.86 (d, J=7.6Hz, 1H).
Embodiment bis-: the preparation of 5-fluoro indole-2-ketone:
Get 16.5g (0.1mol) 5-fluoro indigo red by the method preparation of embodiment mono-, obtain 13.6g5-fluoro indole-2-ketone, yield 90.3%, mp=141～143 ℃ ,-cESI=150.08,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.25 (s, 1H), 7.12 (dd, J=8.1,2.5Hz, 1H), 7.08-6.96 (m, 1H), 6.76 (dd, J=8.4,4.3Hz, 1H), 6.26 (d, J=7.6Hz, 1H), 4.84 (d, J=7.6Hz, 1H).
Embodiment tri-: the preparation of 5-chloro-indole-2-ketone:
Get 18.2g (0.1mol) 5-chlorisatide by the method preparation of embodiment mono-, obtain 15.6g5-chloro-indole-2-ketone, yield 92.7%, mp=196～198 ℃ ,-cESI=166.87,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.35 (s, 1H), 7.30-7.21 (m, 2H), 6.77 (dd, J=8.1,4.9Hz, 1H), 6.27 (d, J=7.6Hz, 1H), 4.86 (d, J=7.6Hz, 1H).
Embodiment tetra-: the preparation of 5-iodine indol-2-one:
Get 27.3g (0.1mol) 5-iodine isatin by the method preparation of embodiment mono-, obtain 24.0g5-iodine indol-2-one, yield 92.5%, mp=171～174 ℃ ,-cESI=258.42,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.36 (s, 1H), 7.53 (d, J=3.5Hz, 2H), 6.72-6.56 (m, 1H), 6.24 (d, J=7.7Hz, 1H), 4.84 (d, J=7.6Hz, 1H).
Embodiment five: the preparation of 4-bromo indole-2-ketone:
Get 22.6g (0.1mol) 4-bromo-isatin by the method preparation of embodiment mono-, obtain 19.1g4-bromo indole-2-ketone, yield 89.6%, mp=202～208 ℃ ,-cESI=212.07,1H NMR-6 ((CD
3) 2sO)/300MHz): 10.34 (s, 1H), 7.21 (d, J=7.8Hz, 1H), 7.13 (d, J=7.8Hz, 1H), 6.92 (s, 1H), 5.71 (s, 1H), 4.80 (s, 1H).
Embodiment six: the preparation of 6-bromo indole-2-ketone:
Get 22.6g (0.1mol) 6-bromo-isatin by the method preparation of embodiment mono-, obtain 19.2g6-bromo indole-2-ketone, yield 90.1%, mmp=212～215 ℃ ,-cESI=212.06,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.45 (s, 1H), 7.19-7.03 (m, 2H), 6.77 (d, J=7.3Hz, 1H), 6.23 (d, J=8.6Hz, 1H), 4.76 (d, J=8.6Hz, 1H).
Embodiment seven: the preparation of 7-bromo indole-2-ketone:
Get 22.6g (0.1mol) 7-bromo-isatin by the method preparation of embodiment mono-, obtain 19.9g7-bromo indole-2-ketone, yield 93.3%, mp=195～199 ℃ ,-cESI=212.02,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.21 (s, 1H), 7.23-7.11 (m, 2H), 6.82 (d, J=7.5Hz, 1H), 6.26 (d, J=7.7Hz, 1H), 4.85 (d, J=7.6Hz, 1H).
Embodiment eight: the preparation of 6-methoxy-Indole-2-ketone:
Under nitrogen protection, in 250ml reaction flask, add 100ml trifluoroacetic acid and 34.8g (0.3mol) triethyl silicane, after stirring, under room temperature, add 17.7g (0.1mol) 5-bromoisatin in batches, after adding, under room temperature, continue stirring reaction 3hr.Concentrating under reduced pressure, removes trifluoroacetic acid, then adds 50ml toluene, stirs 1hr, filters, toluene wash, drains, and obtains off-white color solid, after being dried, obtains 15.4g6-methoxy-Indole-2-ketone, yield 94.7%, mp=161～164 ℃ ,+cESI=164.25,1HNMR-δ ((CD
3)
2sO)/300MHz): 10.19 (s, 1H), 7.16 (t, J=8.1Hz, 1H), 6.79 (d, J=10.2Hz, 1H), 6.59 (d, J=8.4Hz, 1H), 5.93 (d, J=7.9Hz, 1H), 4.79 (d, J=7.9Hz, 1H), 3.77 (s, 3H).
Embodiment nine: the preparation of 5-hydroxyl-6-methoxy-Indole-2-ketone:
Get 19.3g (0.1mol) 5-hydroxyl-6-methoxyl group isatin by the method preparation of embodiment eight, obtain 16.7g5-hydroxyl-6-methoxy-Indole-2-ketone, yield 93.1%, mp=270～272 ℃ ,-cESI=178.09,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.01 (s, 1H), 8.38 (s, 1H), 6.66 (s, 1H), 6.41 (s, 1H), 3.72 (d, J=2.3Hz, 3H), 3.30 (s, 2H).
Embodiment ten: the preparation of 5-amino-6-methoxy-Indole-2-ketone:
Get 19.2 (0.1mol) 5-amino-6-methoxyl group isatin by the method preparation of embodiment eight, obtain 16.4g5-amino-6-methoxy-Indole-2-ketone, yield 92.4%, mp=254～257 ℃ ,-cESI=177.07,1H NMR-δ ((CD
3) 2sO)/300MHz): 10.90 (s, 1H), 8.68 (s, 2H), 7.83 (s, 1H), 6.58 (d, J=2.2Hz, 1H), 6.35 (dd, J=7.3,2.4Hz, 1H), 4.91 (d, J=7.1Hz, 1H), 3.96 (d, J=2.4Hz, 3H).
Embodiment 11: the preparation of 4,5,6-methoxy-Indole-2-ketone:
Get 23.7g (0.1mol) 4,5,6-trimethoxy isatin is pressed the method preparation of embodiment eight, obtains 21.1g4,5,6-methoxy-Indole-2-ketone, yield 94.6%, mp=158～161 ℃ ,+cESI=224.10,1H NMR-δ ((CD
3)
2sO)/300MHz): 10.27 (s, 1H), 6.21 (s, 1H), 3.85 (s, 3H), 3.73 (s, 3H), 3.60 (s, 3H), 3.52 (s, 2H).
Embodiment 12: the preparation of 5,6,7-methoxy-Indole-2-ketone:
Get 23.7g (0.1mol) 5,6,7-methoxyl group isatin is pressed the method preparation of embodiment eight, obtains 21.7g 5,6,7-methoxy-Indole-2-ketone, yield 97.3%, mp=144～147 ℃ ,+cESI=224.09,1H NMR-δ ((CD
3)
2sO)/300MHz): 10.19 (s, 1H), 6.78 (s, 1H), 6.10 (d, J=7.6Hz, 1H), 4.74 (d, J=7.0Hz, 1H), 3.73 (d, J=3.4Hz, 9H).
Embodiment 13: N-methyl-4, and the preparation of 5,6-methoxy-Indole-2-ketone:
Under nitrogen protection, in 250ml reaction flask, add 100ml trifluoroacetic acid and 34.8g (0.3mol) triethyl silicane, after stirring; under room temperature, add 25.1g (0.1mol) N-methyl-4 in batches; 5,6-trimethoxy isatin continues stirring reaction 3hr under room temperature after adding.Concentrating under reduced pressure, removes trifluoroacetic acid, then adds 50ml hexanaphthene, stir 1hr, filter, hexanaphthene washing, drain, obtain off-white color solid, after being dried, obtain 22.1gN-methyl-4,5,6-methoxy-Indole-2-ketone, yield 93.2%, mp=102～104 ℃ ,+cESI=238.16,1H NMR-δ ((CD3) 2SO)/300MHz): 6.48 (s, 1H), 3.86 (s, 3H), 3.81 (s, 3H), 3.62 (s, 3H), 3.58 (s, 2H), 3.08 (s, 3H).
Claims (4)
1. a kind of preparation method of substituted indole-2-ketone compound, comprises the steps:
The isatin (A) replacing is dissolved in triethyl silicane and trifluoroacetic acid, is stirred to reaction and finishes, after concentrating, add organic solvent agitator treating, the indol-2-one compound (B) that must replace after filtration;
Wherein, R
1be selected from H, halogen, methyl, ethyl, propyl group, sec.-propyl, butyl, isobutyl-, the tertiary butyl, methoxyl group, oxyethyl group, hydroxyl or amino;
R
2be selected from H, methyl, ethyl, propyl group, sec.-propyl, butyl, isobutyl-or the tertiary butyl.
2. a kind of preparation method of substituted indole-2-ketone claimed in claim 1, the molar ratio that it is characterized in that replacing isatin and triethyl silicane is 1:1～1:50.
3. method claimed in claim 1, is characterized in that temperature of reaction is 10 ℃～50 ℃.
4. a kind of preparation method of substituted indole-2-ketone claimed in claim 1, is characterized in that washing organic solvent used and is a kind of in tetrahydrofuran (THF), ether, dioxane, toluene, normal hexane, hexanaphthene, sherwood oil or their mixture.
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| JP2006249048A (en) * | 2005-03-14 | 2006-09-21 | Air Water Chemical Inc | Method for producing 2-oxyindole |
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