CN102431101A - Preparation method of nano composite material for intrauterine device - Google Patents
Preparation method of nano composite material for intrauterine device Download PDFInfo
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- CN102431101A CN102431101A CN2011102917952A CN201110291795A CN102431101A CN 102431101 A CN102431101 A CN 102431101A CN 2011102917952 A CN2011102917952 A CN 2011102917952A CN 201110291795 A CN201110291795 A CN 201110291795A CN 102431101 A CN102431101 A CN 102431101A
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Abstract
The invention relates to a preparation method of a nano composite material for an intrauterine device. The method comprises the following steps of: (1) preparing nano copper powder; and (2) preheating on a heat smelting machine, controlling the temperature of a roller to be between 140 and 150 DEG C, adjusting the spacing of the roller to be 2mm, placing polyurethane granules on a double-roller heat smelting machine for heat smelting, performing thin passing for 10 to 15 times, adding polyethylene glycol, adding the prepared nano copper powder, performing hot-pressing vulcanization at the temperature of 170 DEG C for 5 minutes, and thus obtaining the nano composite material for the intrauterine device. In the nano composite material prepared by the preparation method, the release amount and the release speed of active materials can be controlled and designed, so that the phenomenon of explosion release which is harmful to human bodies can be prevented; raw materials has low cost and are common; and the preparation method has a simple process, is low in cost and contributes to industrial production.
Description
Technical field
The present invention relates to the Composite Preparation field, be specifically related to a kind of preparation method who is used for the nano composite material of intrauterine device.
Background technology
The population problem is the significant problem that China faces for a long time, also is the severe problem that All Around The World faces.World population surpassed 6,000,000,000 in 2000, estimated that the year two thousand fifty will be above 9,300,000,000.The key that solves a population difficult problem is to take practicable birth-control measures.Intrauterine device is one of present the most widely used birth-control measures because it can recover characteristics such as fecundity after having long-acting, easy, economical and safe and reliable, taking-up very soon.Existing copper intrauterine devices is contained all to be copper wire or copper pipe, and it is uncontrollable and produce problems such as " burst releases " to exist amount of copper ions released, brings uncomfortable side effects such as dysmenorrhoea clinically to the patient.As the nano composite material of new intrauterine devices care material, one of them basic demand is exactly that " burst release " do not take place for the release of copper ion, and speed is adjustable between 5-50 μ g/day, can design.The suitable hydrophilicity and hydrophobicity of polymer composite of making copper intrauterine devices is one of key factor that influences the release of copper intrauterine devices material copper ion, also is one of focus of studying this year.
Summary of the invention
Technical problem to be solved of the present invention provides a kind of manufacturing approach that can overcome the nano composite material that is used for intrauterine device of above-mentioned defective, the burst size of the active material in the nano composite material that makes through this method and rate of release is controlled, can design, can avoid harmful " burst release " phenomenon.
Technical scheme of the present invention is: a kind of preparation method who is used for the nano composite material of intrauterine device, it is characterized in that, and realize through the following step:
(1) preparation copper nanoparticle;
(2) on warm-up mill preheating and control roll temperature at 140-150 ℃; The dancer rools distance is 2mm; The polyurethane pellet is put on two roller warm-up mills carries out heat refining, thin logical 10-15 back added polyethylene glycol earlier, again the copper nanoparticle for preparing of interpolation; Hot-press vulcanization under 170 ℃ of * 5min conditions makes the nano composite material that is used for intrauterine device.
In a preferred embodiment of the present invention, described preparation copper nanoparticle is through with KBH
4, KOH and deionized water wiring solution-forming A, CuSO
45H
2O is dissolved in and is configured to solution B in the deionized water, while stirring solution A dropwise is added in the solution B, leaves standstill behind the reaction 30min; Layering discards upper solution the powder that obtains is carried out suction filtration, is washed till neutrality repeatedly with deionized water; With acetone dehydration twice, vacuum drying more at last gets copper nanoparticle again.
In a preferred embodiment of the present invention, polyurethane in the step (2), the ratio of quality and the number of copies that gathers ethanol and copper nanoparticle is: 20-30 part: 20-25 part: 4-10 part.
In preferred embodiment of the present invention, described KBH
4, KOH and CuSO
45H
2OH
2The mol ratio of O is 4:1:1.
Compared with prior art; Beneficial effect of the present invention is: the present invention is with polyurethane and polyethylene glycol blending; Utilize the characteristic that polyethylene glycol and water molecules can be lower; Improve the hydrophilicity of polyurethane material, then the polyurethane material after the modification is mixed with copper nanoparticle, the burst size of the active material in the nano composite material that makes through this method and rate of release is controlled, can design, can avoid harmful " burst release " phenomenon; Low in raw material cost of the present invention, common, technology is simple, cost is low, utilize suitability for industrialized production.
The specific embodiment
Below in conjunction with embodiment the present invention is done further to set forth in detail.
Embodiment 1
(1) preparation copper nanoparticle: according to BH
4, KOH and CuSO
45H
2The mol ratio of O is 4:1:1, with KBH
4, KOH and deionized water wiring solution-forming A, CuSO
45H
2O is dissolved in and is configured to solution B in the deionized water, while stirring solution A dropwise is added in the solution B, leaves standstill behind the reaction 30min; Layering discards upper solution the powder that obtains is carried out suction filtration, is washed till neutrality repeatedly with deionized water; With acetone dehydration twice, vacuum drying more at last gets copper nanoparticle again;
(2) on warm-up mill preheating and control roll temperature at 140-150 ℃; The dancer rools distance is 2mm; 20 parts of polyurethane pellets are put on two roller warm-up mills carry out heat refining, thin logical 10-15 back added 20 parts of polyethylene glycol earlier, and the copper nanoparticle for preparing of interpolation is 4 parts again; Hot-press vulcanization under 170 ℃ of * 5min conditions makes the nano composite material that is used for intrauterine device.
Embodiment 2
(1) preparation copper nanoparticle: according to BH
4, KOH and CuSO
45H
2The mol ratio of O is 4:1:1, with KBH
4, KOH and deionized water wiring solution-forming A, CuSO
45H
2O is dissolved in and is configured to solution B in the deionized water, while stirring solution A dropwise is added in the solution B, leaves standstill behind the reaction 30min; Layering discards upper solution the powder that obtains is carried out suction filtration, is washed till neutrality repeatedly with deionized water; With acetone dehydration twice, vacuum drying more at last gets copper nanoparticle again;
(2) on warm-up mill preheating and control roll temperature at 140-150 ℃; The dancer rools distance is 2mm; 25 parts of polyurethane pellets are put on two roller warm-up mills carry out heat refining, thin logical 10-15 back added 23 parts of polyethylene glycol earlier, and the copper nanoparticle for preparing of interpolation is 10 parts again; Hot-press vulcanization under 170 ℃ of * 5min conditions makes the nano composite material that is used for intrauterine device.
Embodiment 3
(1) preparation copper nanoparticle: according to BH
4, KOH and CuSO
45H
2The mol ratio of O is 4:1:1, with KBH
4, KOH and deionized water wiring solution-forming A, CuSO
45H
2O is dissolved in and is configured to solution B in the deionized water, while stirring solution A dropwise is added in the solution B, leaves standstill behind the reaction 30min; Layering discards upper solution the powder that obtains is carried out suction filtration, is washed till neutrality repeatedly with deionized water; With acetone dehydration twice, vacuum drying more at last gets copper nanoparticle again;
(2) on warm-up mill preheating and control roll temperature at 140-150 ℃; The dancer rools distance is 2mm; 30 parts of polyurethane pellets are put on two roller warm-up mills carry out heat refining, thin logical 10-15 back added 25 parts of polyethylene glycol earlier, and the copper nanoparticle for preparing of interpolation is 10 parts again; Hot-press vulcanization under 170 ℃ of * 5min conditions makes the nano composite material that is used for intrauterine device.
The above; Be merely the specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any those of ordinary skill in the art are in the technical scope that the present invention disclosed, and variation or the replacement that can expect without creative work all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (4)
1. a preparation method who is used for the nano composite material of intrauterine device is characterized in that, realizes through the following step:
(1) preparation copper nanoparticle;
(2) on warm-up mill preheating and control roll temperature at 140-150 ℃; The dancer rools distance is 2mm; The polyurethane pellet is put on two roller warm-up mills carries out heat refining, thin logical 10-15 back added polyethylene glycol earlier, again the copper nanoparticle for preparing of interpolation; Hot-press vulcanization under 170 ℃ of * 5min conditions makes the nano composite material that is used for intrauterine device.
2. the preparation method who is used for the nano composite material of intrauterine device according to claim 1 is characterized in that, described preparation copper nanoparticle is through with KBH
4, KOH and deionized water wiring solution-forming A, CuSO
45H
2O is dissolved in and is configured to solution B in the deionized water, while stirring solution A dropwise is added in the solution B, leaves standstill behind the reaction 30min; Layering discards upper solution the powder that obtains is carried out suction filtration, is washed till neutrality repeatedly with deionized water; With acetone dehydration twice, vacuum drying more at last gets copper nanoparticle again.
3. the preparation method who is used for the nano composite material of intrauterine device according to claim 1 is characterized in that, polyurethane pellet in the step (2), and the ratio of quality and the number of copies of polyethylene glycol and copper nanoparticle is: 20-30 part: 20-25 part: 4-10 part.
4. the preparation method who is used for the nano composite material of intrauterine device according to claim 2 is characterized in that, described KBH
4, KOH and CuSO
45H
2The mol ratio of O is 4:1:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102917952A CN102431101A (en) | 2011-09-30 | 2011-09-30 | Preparation method of nano composite material for intrauterine device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102917952A CN102431101A (en) | 2011-09-30 | 2011-09-30 | Preparation method of nano composite material for intrauterine device |
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| CN102431101A true CN102431101A (en) | 2012-05-02 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775191A (en) * | 2005-11-26 | 2006-05-24 | 商丘雅康药械有限公司 | Nano silver intrauterine device |
| CN101934099A (en) * | 2010-08-03 | 2011-01-05 | 华中科技大学 | Porous-structure composite material for IUD (Intrauterine Device) and producing method thereof |
| CN101934100A (en) * | 2010-08-03 | 2011-01-05 | 华中科技大学 | Composite material copper-containing intrauterine device with porous structure |
-
2011
- 2011-09-30 CN CN2011102917952A patent/CN102431101A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775191A (en) * | 2005-11-26 | 2006-05-24 | 商丘雅康药械有限公司 | Nano silver intrauterine device |
| CN101934099A (en) * | 2010-08-03 | 2011-01-05 | 华中科技大学 | Porous-structure composite material for IUD (Intrauterine Device) and producing method thereof |
| CN101934100A (en) * | 2010-08-03 | 2011-01-05 | 华中科技大学 | Composite material copper-containing intrauterine device with porous structure |
Non-Patent Citations (2)
| Title |
|---|
| 王珏等: "热塑性聚氨酯/纳米铜复合材料的制备与表征", 《合成材料老化与应用》 * |
| 许玉芳等: "热塑性聚氨酯/聚乙二醇/纳米铜复合材料的制备与表征", 《生物医学工程学杂志》 * |
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Application publication date: 20120502 |