CN102429930B - Compound fermented cordyceps fungus powder and baicalin combined drug, - Google Patents
Compound fermented cordyceps fungus powder and baicalin combined drug, Download PDFInfo
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Abstract
The invention provides a compound fermented cordyceps fungus powder and baicalin combined drug, discloses the weight ratios of various raw material compositions of the compound fermented cordyceps fungus powder and baicalin combined drug, and provides preparation steps and the method of the compound fermented cordyceps fungus powder and baicalin combined drug. Capsules, particles and tablets of compound fermented cordyceps fungus powder and baicalin combined drug can be prepared according to the pharmaceutically accepted dosage; the compound fermented cordyceps fungus powder and baicalin combined drug can be used for resisting aging, resisting fatigue, resisting shock, resisting ray radiation, calming, hypoxia tolerance and improving immunity.
Description
The application is dividing an application of domestic formerly patent of invention.And enjoyment domestic priority.Formerly patent application state is China, and the application number of formerly patent application is 201010278624.1, and the applying date is on 09 13rd, 2010, and patent name is " compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) composition of medicine ".
Technical field
Technical characterictic of the present invention is compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) composition of medicine prescription, preparation method, purposes.
Background technology
Current in the world war, natural disaster, survival and development pressure make people's physical and mental health enjoy challenge.This challenge endangers the human body psychosoma not second to traditional disease, must open up this emerging medical treatment field.China is a country that natural disaster takes place frequently, and earthquake, great drought, flood, freezing, typhoon, mud-rock flow belong in the world that the condition of a disaster takes place frequently and one of serious country; In the national economic development process, international financial crisis, trade dispute are frequent, even the prestige of war association; Peaceful development also has major disease not radical cure and disease transmission, the aging of population challenge period, especially will improve veteran revolutionaries, veteran cadre, old expert, all old man's life cycle, quality of life.In order to tackle the challenge of all these natural and man-made calamities, if invention has the medicine that improves China the army and the people body immunity, enhancing resisting fatigue energy, excites defying age vitality, the calm psychology of adjusting, make China the army and the people more effectively tackle above-mentioned human survival and development significant challenge, improve national power, have strategic economic benefit and social benefit.
Cordyceps is called for short Cordyceps, is the human famous and precious natural drug that is handed down over the past thousands of years, and ill curing the disease without treating diseases and making health-care, and is fit to all people and takes, and do not have insulting side effect and untoward reaction.But its resource-constrained, Jiangxi Traditional Chinese Medicine Factory utilizes a large amount of suitability for industrialized production of natural living Chinese caterpillar bacterium artificial fermentation, for production famous medicine fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) is supplied raw materials, this product content is peacilomyce hepiahi Cs-4 mycopowder, perhaps be called again fermented Cordyceps powder, be commonly called as the Cordyceps powder, Cordyceps powder, Cordyceps extract, ferment cordyceps sinensis powder etc.The peacilomyce hepiahi bacterium powder is separating obtained Cordyceps from fresh Cordyceps fungus (cordyceps sinensis (Berk) sacc)---peacilomyce hepiahi (Paecilomyces hepiali Chen ﹠amp; Dai) product of making through liquid submerged fermentation cultivation, filtration, drying, pulverizing, the present invention is defined as fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) to this fermenting and producing Cordyceps powder out, has another name called Cordyceps powder.Cordyceps is the traditional famous and precious medicated nourishing product of China, and the flat sweet in the mouth of its property has the function that tonifying the lung kidney, cough-relieving are coughed, benefit is deficient, support vital essence.According to clinical research, Cordyceps has ten large functions: 1. antibiotic, and 2. immunomodulating, 3. anticancer, 4. antiinflammatory, 6. 5. nourishing kidney improves adrenal cortex alcohol content, 7. arrhythmia, 8. resisting fatigue, 9. eliminating phlegm and relieving asthma, 10. tranquilizing soporific.Utilizing the large industrial fermentation of modern biological project to produce fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) is that historical contribution and the historical productivity are progressive, but the reach a small amount of heavy metal ion and high price iron ion and miscellaneous bacteria that are mingled with in the production process just make good medicine also have blemish in an otherwise perfect thing, and slight stomach upset sense is arranged after minute quantity people takes.Remove above-mentioned slight side effect and the slight untoward reaction of the fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of artificial fermentation production, adding increases its physiological function, can produce new compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) preparation.
Alprostadil, the former name prostaglandin E
1, become drug use less than 30 years research histories, from the human seminal fluid, separate the earliest, so be called prostaglandin E
1, in fact it is present in human body and all histiocytes of mammal and the body fluid, for fear of with correct to misread, country changes its Alprostadil by name, it also is the material of the natural extensive physiological function character of tool.Its discovery has caused a sensation the world, and nineteen eighty-two has three scientists to obtain simultaneously Nobel Prize.Its physiological function has almost contained human all great physiological functions.The application of prostaglandin has been deep into the every field (Li En, prostaglandin and modern medicine, the 1st edition, Beijing: People's Health Publisher, 1985, synopsis) of medical science, that is to say that it relates to each sick treatment and prevention of planting.Its ultimate principle is: the edible oil that we eat every day, under the serial enzymes effect, generate first gamma-Linolenic acid in vivo, and then generate dihomo-gamma-linolenic acid, generate at last Alprostadil.When human body physiological function needed, it produced in the various histiocytes of human body and body fluid immediately, the various physiological functions of balance the body, and circulate in the organ major parts such as lung, liver, kidney through blood and be inactivated and excrete.The inventor passes through nearly 30 years research theories and facts have proved, especially modern medical theory and facts have proved: lack edible oil at human body, or worn with age, the endocrine disturbance, chemical contamination, rule of life is upset, tired anxiety etc. lose in the body must enzymatic activity or the interior Alprostadil that must enzyme quantity not all has influence on of body secrete in vivo and make human body produce all diseases, if replenish a certain amount of Alprostadil in body, ill people can reach a cure, there is not the people of disease can anti-disease, defying age, resisting fatigue, anxiety, anti-insomnia, keep lasting strong, full of vitality, thinking is clear, improve quality of life, be called again life source material.Alprostadil preparation becomes sales volume the first medicine in the cardiovascular medicament at home.But by separating the Alprostadil resource-constrained with histiocyte from the mammal seminal fluid, so USA and Europe, Japanese chemosynthesis prepare Alprostadil, China Norman Bethune Medical University, Jilin Province Medicine Research Institute have been opened up one and have been utilized the specialties of the Northeast Radix Oenotherae erythrosepalae oil to make raw material, from sheep spermary, extract compound enzyme catalysis, the semi-synthetic route of synthetic Alprostadil prepares Alprostadil, has solved raw material sources restriction bottleneck.The inventor improves again white medical university and the Jilin medicine grinds semi-synthetic route, and invention gas, liquid, solid three's co-absorbed and compound enzyme immobilization carrier and suitability for industrialized production Alprostadil biochemical reactor (China such as inventor is patent of invention formerly, patent name: Alprostadil production of raw medicine technique, the patent No.: 961211350).Realize the suitability for industrialized production Alprostadil, realize that process cycle is external 1/7th, cost is external 1/10th, and quality is the standard substance that are better than external famous expert.Jilin medicine inspecting institute and national drug biological products assay institute substitute foreign standard product (380000 yuans/gram of valency) with your standard substance (7000 yuans/gram of valency) of front sharp ground that the inventor provides.The Alprostadil crude drug of inventor preparation and preparation have overcome injection pain, refrigerator accumulating, the content three big world difficult problems that fall progressively.Serial China of the present invention formerly patent of invention solved that the large suitability for industrialized production of alprostadil liposome preparation is energy-conservation, de-carbon, zero emission technique, equipment, solved fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) fermentation tail gas dedusting, degerming, except phage, eliminate the unusual smell, the increment of de-carbon oxygen enrichment and recycled Processes and apparatus.Make the former and material preparation large suitability for industrialized production of Alprostadil even fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) enter international most advanced level and have the protection of independent IP at technique, equipment, quality, scale, cost, consumption, energy-conservation, reduction of discharging, de-carbon.Substantially possessed the comprehensive Intellectual Property Right Protection System of medicine that exploitation improves national power, raising army fighting capacity, improves the people's life quality.
Summary of the invention
One. compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) composition of medicine and preparation thereof:
(1). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine and preparation process and method:
1, each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Illustrate: here taurine or or baicalin, its molecular formula is C
21H
18O
11, molecular weight is 446.35, its weight fraction in prescription is 0.0500-0.1000.
2. compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine preparation process and method are:
2.1 the fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of drying is pulverized, is made 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder);
2.2 taurine or baicalin, vitamin C are dissolved in the water for injection, and making proportion is the 1.0-1.1 aqueous solution, is that 8% analytical pure hydrochloric acid solution adjust pH is 4.0-6.0 with mass percent, again solution is crossed degerming through 0.22 μ m membrane filtration;
2.3 under 100 grades of sterile purification environment, the 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of 2.1 steps preparation is put into boiling coating-boiling drier, press the well-established law operation, the filtrated air negative pressure is introduced in control makes fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) boiling highly be 400mm-500mm, under 40-50 ℃ of temperature, the proportion that 2.2 steps were made is that the 1.0-1.1 aqueous solution is by vaporific fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) the intensive place of particle that is sprayed on boiling in the nozzle, to fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) coating, it is complete to be controlled in 30-60 minute coating; This temperature range airpillow-dry 20-30 minute, make dry solids moisture less than 1% again;
2.4 press the dosage that pharmaceutics allows, under 100 grades of sterile purification environment, well-established law is made capsule, granule, the tablet of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine.
(2). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine and preparation process and method:
1. each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here taurine or ginsenoside Rg
1, it is that Araliaceae Radix Ginseng or Radix Notoginseng extraction separation obtain monomer, molecular formula is C
42H
72O
14, molecular weight is 830.03, weight ratio is 0.0500-0.1000 in prescription.
2. preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are:
2.1 with anhydrous alcohol solution Alprostadil or ginsenoside Rg
1Extremely just dissolve complete is made Alprostadil or ginsenoside Rg
1Nearly saturated ethanol solution;
2.2 beta-schardinger dextrin-is dissolved in the part water for injection, to dissolve complete just, make near saturated solution, be that 8% analytical pure hydrochloric acid solution adjust pH is 5.0-5.5 with mass percent;
2.3 Alprostadil or ginsenoside Rg with the preparation of 2.1 steps
1Ethanol solution under 60-100 rev/min of stirring, room temperature drops in the beta-schardinger dextrin-near saturated solution of 2.2 step preparations, to Alprostadil dissolving or ginsenoside Rg
1Fully, make Alprostadil or ginsenoside beta-schardinger dextrin-comprise solution;
2.4 the fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of drying is pulverized, is made 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder);
2.5 taurine, reduced glutathion under 60-80 rev/min of stirring, are dissolved in the remaining water for injection, and making proportion is the 1.0-1.2 aqueous solution, the Alprostadil or the ginsenoside Rg that 2.3 steps were prepared again
1The solution that comprises of beta-schardinger dextrin-add, stir, be that 8% analytical pure hydrochloric acid solution adjust pH is 5.0-5.5 with mass percent then, at last solution is crossed degerming through 0.22 μ m membrane filtration;
2.6 under 100 grades of sterile purification environment, the 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of 2.4 steps preparation is put into boiling coating-boiling drier, press the well-established law operation, the filtrated air negative pressure is introduced in control makes fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) boiling highly be 400mm-500mm, under 40-50 ℃ of temperature, 2.5 sterile liquid medicines made of step by vaporific fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) the intensive place of particle that is sprayed on boiling in the nozzle, to fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) coating, it is complete to be controlled in 30-60 minute coating; This temperature range airpillow-dry 20-30 minute, make dry solids moisture less than 1% again;
2.7 press the dosage that pharmaceutics allows, under 100 grades of sterile purification environment, well-established law is made capsule, granule, the tablet of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) group B composition of medicine.
(3). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine and preparation process method thereof:
1. each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Illustrate: here danshensu or curcumin, the curcumin molecular formula is C
21H
20O
6,, molecular weight is 368.37, its weight ratio is 0.1000-0.3000 in prescription.
Danshensu is that danshensu is the water solubility extract of Salvia miltiorrhiza Bge, is the main component of FUFANG DANSHEN DIWAN, chemistry β by name-(3,4-dihydroxy phenyl) lactic acid.
Gamma-Linolenic acid claims again vitaminF, and the initiation material of its preparation is Radix Oenotherae erythrosepalae oil.
2. compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine preparation process and method are:
2.1 with the anhydrous alcohol solution gamma-Linolenic acid, make the gamma-Linolenic acid ethanol solution, or gamma-Linolenic acid and curcumin be dissolved in the dehydrated alcohol jointly, even make the solution that gamma-Linolenic acid and curcumin are dissolved in dehydrated alcohol jointly;
2.2 beta-schardinger dextrin-is dissolved in the part water for injection, to dissolve complete just, make near saturated solution, be that 8% analytical pure hydrochloric acid solution adjust pH is 5.0-5.5 with mass percent;
2.3 under 60-100 rev/min of stirring, room temperature drops in the beta-schardinger dextrin-near saturated solution of 2.2 steps preparation with the ethanol solutions of 2.1 step preparations, till the gamma-Linolenic acid dissolve complete, or gamma-Linolenic acid and curcumin be all till the dissolve complete,
Make the beta-cyclodextrin inclusion compound solution of gamma-Linolenic acid, or the solution that jointly comprised by beta-schardinger dextrin-of gamma-Linolenic acid and curcumin;
2.4 the fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of drying is pulverized, is made 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder);
2.5 with danshensu under 60-80 rev/min of stirring, be dissolved in the comprising in the solution of beta-schardinger dextrin-of the gamma-Linolenic acid of 2.3 step preparations, and with remaining water for injection under the prerequisite that stirs, adjusting solution proportion is 1.0-1,1, be that 8% analytical pure hydrochloric acid solution adjust pH is 5.0-5.5 with mass percent again, at last solution crossed degerming through 0.22 μ m membrane filtration; Or curcumin is when substituting danshensu, it is 1.0-1.1 with remaining water for injection adjustment solution proportion that the gamma-Linolenic acid of 2.3 step preparations and curcumin are comprised solution by beta-schardinger dextrin-jointly, be that 8% analytical pure hydrochloric acid solution adjust pH is 5.0-5.5 with mass percent again, at last solution crossed degerming through 0.22 μ m membrane filtration;
2.6 under 100 grades of sterile purification environment, the 120-150 order fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) of 2.4 steps preparation is put into boiling coating-boiling drier, press the well-established law operation, the filtrated air negative pressure is introduced in control makes fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) boiling highly be 400mm-500mm, under 40-50 ℃ of temperature, the 2.5 danshensu sterile liquid medicines made of step or curcumin sterile liquid medicine (when replacing danshensu by curcumin) by vaporific fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) the intensive place of particle that is sprayed on boiling in the nozzle, to fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) coating, it is complete to be controlled in 30-60 minute coating; This temperature range airpillow-dry 20-30 minute, make dry solids moisture less than 1% again;
2.7 press the dosage that pharmaceutics allows, under 100 grades of sterile purification environment, well-established law is made capsule, granule, the tablet of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine.
Two. the advantage of medicine of the present invention:
(1). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine advantage:
1. compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A has increased taurine on fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) basis; main disease curing range is controlled the kidney effect except keeping fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) to control lung; expand to and control hypertension, hyperglycemia, cardiovascular and cerebrovascular disease, resisting fatigue, defying age, shock, radioprotective.
2. taurine also is intrinsic biological active substances in the animal body, and its function has:
2.1 antiinflammatory, antiallergic;
2.2 immunologic enhancement;
2.3 ischemic cardiac myocyte, hypoxic pulmonary arterial endothelial cell, Hypoxic cerebral arteries endotheliocyte are had protective effect;
2.4 the increase myocardial contraction, arrhythmia, shock, defying age, resisting fatigue, radioprotective;
2.5 blood pressure lowering, blood sugar lowering;
2.6 arteriosclerosis;
2.7; Improve one's memory the treatment dysthymia;
2.8 anti-intestinal endotoxin shifts, treatment viral myocarditis, treatment upper respiratory tract infection.
Baicalin is that the plant scutellariae,radix extracts monomer, above-mentioned functions is also arranged, the ginsenoside Rg
1The taurine above-mentioned functions is also arranged.
3. compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A has also increased the antioxidant vitamin C, the present invention also uses taurine and vitamin C that fermented Cordyceps powder (peacilomyce hepiahi C s-4 mycopowder) is carried out coating, avoid fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) in manufacturing, accumulating, use procedure in vitro and in vivo oxidation, peroxidating and the side effect that produces and bad should; It also is used for: vitamin C deficiency prevention and treatment, acute and chronic infectious disease or convalescent period, During Wound Healing replenish the cardiogenic shock treatment after being ill, hepatic injury and the treatment of chronic poisoning hepatic injury, be used for anemia, anaphylaxis dermatosis treatment, promote wound healing, to flu, cancer, hyperlipidemia treatment.
4. the present invention produces compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A under 100 grades of sterile purification environment, than injection production rank also high (injection is the local laminar flow environment purification under ten thousand grades), also have the medicinal liquid Entkeimung to reach except high price precipitation of iron ions thing, except insoluble particle, favourable raising product quality avoids miscellaneous bacteria and oxidant to make product rotten.This is the production technology of uniqueness of the present invention;
(2). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine advantage:
1. compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) B increases Alprostadil on compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A prescription basis, except keeping compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A treatment and pre-diseases prevention kind, because Alprostadil has antibody mediated immunity complex exceptional function in the human body of removing, make antigen not reach in vivo morbidity concentration, antigen is entered in the body in time please be removed, both made morbidity, disease is very light.Also have inhibition tumor cell, the differentiation tumor cell develops to normal cell.Emphasis increases antitypy unknown virus infectious disease, biochemical reagents viral disease and the infectious disease known, unknown retrovirus of control hostile nations.Also emphasis increases prevention and treats the sick kind such as tumor, acquired immune deficiency syndrome (AIDS), serious symptom hepatitis, viral hepatitis.Therefore compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) B basically can reach wartime, extraordinary serious natural calamities period, peaceful development and improves the needs that the army and the people's muscle power, psychology are deposited stressed, vitality, national power and answering pressure period.
2. the present invention replaces vitamin C among compound fermented aweto mycopowder (the peacilomyce hepiahi Cs-4 mycopowder) A with the antioxidant reduced glutathion, and reduced glutathion also is the important physiologically substance that exists in the human body.Participate in the interior tricarboxylic acid cycle of body and carbohydrate metabolism, promotion fat, protein metabolism, make human body obtain high-energy; Detoxifcation; Lonizing radiation, chemical substance, damage there is protective effect; Antiallergic; Protect the liver eye protection; Symptom palliates a disease.
3. medicine of the present invention all is intrinsic with human body or natural drug is made raw material, finds a swollen seat of local government ill medicine in quality, curative effect, safety three aspects: quality higher but deliver at newspaper than nearest U.S. a company on the net.A kind of medical treatment Various Diseases developing direction of exploitation is arranged in the world, and with saving resource, energy-saving and emission-reduction make things convenient for medication.Medicine of the present invention is more advanced than them, and unique distinction is more arranged.
4. compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B carries out coating with taurine and reduced glutathion to fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder), and coating effect among compound fermented aweto mycopowder (the peacilomyce hepiahi Cs-4 mycopowder) A is also arranged.
5. preparation compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B method also has the advantage of preparation compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A.
(3). compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine advantage:
1. medicine of the present invention is fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) and the combination of natural product danshensu.Radix Salviae Miltiorrhizae have defying age, coronary artery dilator, inhibition platelet T XA
2Synthetic, anticoagulation, improve microcirculation, arteriosclerosis, anti-oxidative damage, blood fat reducing, inhibition endogenous cholesterol synthetic, to liver protection and anti-fibrosis effect, sedation, antitumor action.Curcumin is that zingiberaceous plant Dioscorea zingiberensis rhizome extracts monomer, and the above-mentioned effect of danshensu is also arranged.
2. medicine of the present invention is with gamma-Linolenic acid, and namely vitaminF is antioxidant, and strong reducing property is arranged, and it derives from Radix Oenotherae erythrosepalae oil.VitaminF is intrinsic material in the human body.The physiological function of vitaminF has: defying age, arteriosclerosis, guarantor's kidney and control renal insufficiency, blood pressure lowering, blood sugar lowering, blood fat reducing, fat-reducing, skin whitening, anti-gastric-ulcer, antiinflammatory, control women's premenstrual syndrome, control carbuncle of breast.
3. medicine of the present invention comprises vitaminF with cyclodextrin, and the vitaminF that comprises with cyclodextrin again and curcumin are to fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) coating.Prevent fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) in vivo and in vitro oxidation and peroxidating.
4. compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine also is to prepare under strict sterile purification condition, preparation compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is also arranged and prepare attached side's fermented Cordyceps powder (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine advantage.
The specific embodiment:
Embodiment 1:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Here taurine or baicalin, the baicalin components by weight is 0.05.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine are described with the front.
Embodiment 2:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Here baicalin or taurine.The taurine components by weight is 0.10.
Preparation method and the step of multiple compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine of the present invention are described with the front.
Embodiment 3:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Here taurine or baicalin, the baicalin components by weight is 0.10.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine are described with the front.
Embodiment 4:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Here taurine or baicalin, the baicalin components by weight is 0.05
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine are described with the front.
Embodiment 5:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine is:
Here taurine or baicalin, the baicalin components by weight is 0.08.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) A composition of medicine are described with the front.
Embodiment 6:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here ginsenoside Rg
1Or taurine, the taurine components by weight is 0.4500.
Preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are described with the front.
Embodiment 7:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here taurine or ginsenoside Rg
1, ginsenoside's components by weight is 0.1000.
Preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are described with the front.
Embodiment 8:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here taurine or ginsenoside Rg
1, ginsenoside's components by weight is 0.1000.
Preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are described with the front.
Embodiment 9:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here taurine or ginsenoside Rg
1, ginsenoside's components by weight is 0.0500.
Preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are described with the front.
Embodiment 10:
Each raw material components weight ratio of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine is:
Here taurine or ginsenoside Rg
1, ginsenoside's components by weight is 0.0760.
Preparation process and the method for compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) B composition of medicine are described with the front.
Embodiment 11:
Each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Here danshensu or curcumin, the curcumin components by weight is 0.1000.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine are described with the front.
Embodiment 12:
Each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Here danshensu or be curcumin, the curcumin components by weight is 0.3000.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine are described with the front.
Embodiment 13:
Each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Here danshensu or be curcumin, the curcumin components by weight is 0.3000.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine are described with the front.
Embodiment 14:
Each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Here danshensu or be curcumin, the curcumin components by weight is 0.1000.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine are described with the front.
Embodiment 15:
Each component raw material weight ratio of compound fermented aweto mycopowder (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine is:
Here curcumin or be danshensu, the danshensu components by weight is 0.37.
Preparation method and the step of compound fermented aweto mycopowder of the present invention (peacilomyce hepiahi Cs-4 mycopowder) C composition of medicine are described with the front.
The pharmacodynamics demonstration test: following test all is to entrust the test of the Experimental Animal Center well-established law of specialty.
1. defying age test:
1.1 the spontaneously hypertensive rat model with 4 monthly ages.Be divided into food and contain Oleum Helianthi 2.4%, contain the treatment group that oleum lini core oil 7.9% matched group and food contain the feedstuff of medicine 3% of the present invention, its crapulous syncope contains 15 groups of the medicines that medication therapy groups of the present invention is divided again the preparation of embodiment 1-15 example, totally 17 groups.Every group 12, experiment is to getting hematometry triglyceride meansigma methods and highdensity lipoprotein-cholesterol meansigma methods 16 weeks.Result of the test sees Table:
1.2 get the healthy mice model, every 18-20g, 10 every group.Matched group was with oleum lini 4ml/kg gavage 10 days, and 15 groups for the treatment of groups are respectively with the each 200mg/kg gavage of the medicine of the present invention of embodiment 1-15, every day twice, gavage 10 days.Blood sampling in 1 hour after the last administration is with H
2O
2Be substrate, survey the trap value at ultraviolet spectrophotometer 230nm place, to fill with H in the oleum lini Mouse Blood
2O
2It is 100% that meansigma methods is made as the resistive to hydrogen peroxide enzyme activity.With H in the medicine group Mouse Blood of the present invention
2O
2Reduce meansigma methods divided by filling with H in Caulis et Folium Lini line of oils Mouse Blood
2O
2Meansigma methods is resistive to hydrogen peroxide enzyme activity improvement value.Result of the test is as follows:
2. resisting fatigue, hypoxia endurance test:
Healthy mice, body weight 18-22g, random packet.Two groups of matched groups, 10 every group, every caudal vein injecting normal saline 0.3ml organizes and tail vein injection protocatechualdehyde 300mg/kg (being dissolved in the 0.5ml normal saline) group; Treatment group tail vein injection medicine 300mg/kg of the present invention water extract concentrates in the water for injection of 0.5ml volume, every group of 10 mices.After the medication 5 minutes, place in the wide mouthed bottle of airtight normal pressure 1000ml.Calculate and respectively to organize mouse survival average time.Result of the test is as follows:
3. raising immunity:
3.1 nonspecific immunity: healthy mice, body weight 18-20g.15 of matched groups, every day, normal saline 0.5ml gavage was 2 times.15 groups of medicine gavage groups of the present invention, are used 500mg/kg medicine gavage of the present invention, every day 2 times at every turn by 15 every group.Put to death afterwards in 10 days, and measured blood rosettes vigor by measuring thymosin rosettes vigor method (national drug standards have been stipulated algoscopy).Take normal saline matched group blood piece rare colored vigor as 100%.Calculate relative activity, relative activity is higher, and immunity is stronger.Result of the test is as follows:
3.2 specific immunity: healthy mice, body weight 18-20g.15 of matched groups, every day, normal saline 0.5ml gavage was 2 times.15 groups of medicine gavage groups of the present invention, are used 500mg/kg medicine gavage of the present invention, every day 2 times at every turn by 15 every group.Put to death afterwards in 15 days, and measured the anti-sheep red blood cell (SRBC) antibody titer meansigma methods that anti-sheep red blood cell (SRBC) antibody test in the blood serum (entrusting the Experimental Animal Center test) obtains.And tire as 100% take normal saline gavage group, calculating each group, to resist mutually sheep red blood cell (SRBC) antibody relative potency higher, and immunity is stronger.Result of the test is as follows:
4. sedation: matched group: injection 0.1ml water for injection in 1 tricorn of conscious dogs, test group: at matched group conscious dogs side injection of brain water for injection after 48 hours, the aqueous extract 0.2ml that contains again medicine 2mg of the present invention at the side injection of brain, from injection embodiment 1 medicine, injected next embodiment medicine aqueous extract every 48 hours.Inject to begin to measure the generation of brain wave slow wave in rear 10 minutes and observe dog and have or not sedation.Result of the test is as follows:
5. shock: healthy mice, body weight 18-20g.20 of endotoxin groups, lumbar injection endotoxin 300mg/kg (being dissolved in the 0.5ml normal saline); Test group: get at random 10 of endotoxin injection mices, lumbar injection medicine 300mg/kg of the present invention aqueous extract (being dissolved in the 0.5ml water for injection) is immediately observed to mice existence digit rate in the medicine of the present invention 6 hours.Put to death mice after 6 hours, core, liver, kidney, brain, measure respectively malonaldehyde in these tissues (MDA) amount and endotoxin.Take endotoxin group MDA content as 100%, calculate the relative MDA% of test group.Result of the test is as follows:
6. anti-light radiation: healthy mice, body weight 18-20g.10 of matched groups are fed water for injection 1.0ml, every day 2 times at every turn; Test group is fed medicine 300mg/kg of the present invention, every day 2 times at every turn.Shine after 30 minutes at medicine feed after 5 days
60C
o9.0G γ 1 time.Medicine feed is 7 days again, and the existence mice is put to death end product malonaldehyde (MDA) amount of surveying lipid peroxidation in blood, the heart, liver, kidney, the brain and feeds the contrast of water for injection group.Take matched group MDA content as 100%, the relative MDA% of experiment with computing group.Result of the test is as follows:
Above pharmacodynamics demonstration test as seen, medicine of the present invention, improve the army and the people's fighting capacity, viability needs in the time of can satisfying war, burst natural disaster fully, in peacetime, can satisfy the army and the people fully improves work energy, prolongs the worker and organize age, height old people's life-span, improve old people's self-care ability and vitality needs, in a word, medicine tool of the present invention improves national power substantial economics and great social benefit.
Claims (2)
1. compound fermented aweto mycopowder composition of medicine, it is characterized in that, aseptic baicalin and aseptic vitamin C composition are to the fermented Cordyceps powder aseptic composite granule that airpillow-dry makes behind boiling coating under the aseptic condition, coatings is aseptic baicalin and vitamin C composition, inside the coatings of composition grain is fermented Cordyceps powder, and the components by weight of this each raw material of composition medicine granule is:
Fermented Cordyceps powder 0.30-0.70
Baicalin 0.0500-0.1000
Vitamin C 0.10-0.20
Preparation process and the method for this composition of medicine are:
1.1 the fermented Cordyceps powder of drying is pulverized city processed 120-150 order fermented Cordyceps powder;
1.2 baicalin, vitamin C are dissolved in the water for injection, and making proportion is the 1.0-1.1 aqueous solution, is that 8% analytical pure hydrochloric acid solution adjust pH is 4.0-6.0 with mass percent, again solution is crossed degerming through 0.22 μ m membrane filtration;
1.3 under 100 grades of sterile purification environment, the 120-150 order fermented Cordyceps powder of 1.1 steps preparation is put into boiling coating-drying machine, press the well-established law operation, introducing the filtrated air negative pressure makes the fermented Cordyceps powder boiling highly be 400-500mm, under 40 ℃ of-50 ℃ of temperature, 1.2 proportions made of step be the 1.0-1.1 aqueous solution by the vaporific intensive place of ferment cordyceps sinensis powder that is sprayed on boiling of nozzle, to the fermented Cordyceps powder coating, it is complete to be controlled in 30-60 minute coating; Dry 20-30 minute of this temperature range, make dry solids moisture content less than 1% again;
1.4 press the dosage that pharmaceutics allows, under 100 grades of sterile purification environment, well-established law is made capsule, granule, the tablet of compound fermented aweto mycopowder baicalin composition of medicine.
2. according to the described compound fermented aweto mycopowder of claim 1, baicalin, ascorbic composition of medicine, it is characterized in that, be used for that defying age, resisting fatigue, shock, the anti-light width of cloth are penetrated, calm, anoxia enduring.
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Non-Patent Citations (2)
| Title |
|---|
| 中药喷雾粉末的沸腾干燥制粒工艺;唐雪梅等;《华西药学杂志》;20050626;第20卷(第3期);第1.3.2节 * |
| 唐雪梅等.中药喷雾粉末的沸腾干燥制粒工艺.《华西药学杂志》.2005,第20卷(第3期),第246-248页. |
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