CN102429864A - Medicinal compound of fat-soluble vitamin injection (II) and water-soluble vitamin for injection and preparation method thereof - Google Patents
Medicinal compound of fat-soluble vitamin injection (II) and water-soluble vitamin for injection and preparation method thereof Download PDFInfo
- Publication number
- CN102429864A CN102429864A CN2011103877331A CN201110387733A CN102429864A CN 102429864 A CN102429864 A CN 102429864A CN 2011103877331 A CN2011103877331 A CN 2011103877331A CN 201110387733 A CN201110387733 A CN 201110387733A CN 102429864 A CN102429864 A CN 102429864A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- injection
- water
- pharmaceutical composition
- fatsoluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000007924 injection Substances 0.000 title claims abstract description 86
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- 229940093181 glucose injection Drugs 0.000 claims abstract description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 35
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a medicinal compound of fat-soluble vitamin injection (II) and a water-soluble vitamin for injection, in particular to a combined application package. The medicinal compound comprises the fat-soluble vitamin injection (II) and the water-soluble vitamin for the injection. When in use, the medicinal compound is dissolved or thinned by using water for the injection or glucose injection liquid first, and then is respectively instilled in a venous way. By using the combined application package provided by the invention, the vitamins needed by a human body are comprehensively replenished; the defects caused by the usage of a single vitamin are avoided; and the treatment effect is improved greatly.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of injection vitamin, be specifically related to compositions and the method for making and the application packages of a kind of fatsoluble vitamin injection (II) and Vitamin H, belong to medical technical field.
Background technology
Vitamin is the humans and animals one type trace organic substance essential for keeping normal physiological function; In people's bulk-growth, metabolism, growth course, play an important role; Can not normal growth when humans and animals is deficient in vitamin, and specific lesions, promptly so-called avitaminosis take place.
Vitamin has another name called vitamin, and is popular, and the material that promptly earns a bare living is to keep the necessary type organic matter of human life activity, also is the important active substances that keeps health.Vitamin content in vivo seldom, and is but indispensable.Though the chemical constitution of various vitamin and character are different, they have following common ground: 1. vitamin all is present in the food with the form of provitamin (previtamin).2. vitamin is not the constituent that constitutes body tissue and cell, and it can produce power yet, and its effect mainly is the adjusting of participation organism metabolism.3. most vitamin, body can not synthesize or the synthetic quantity deficiency, can not satisfy the needs of body, must be often through obtaining in the food.4. human body is very little to the requirement of vitamin, and daily requirement often calculates with milligram (mg) or microgram (μ g), but in case shortage will cause corresponding avitaminosis, health is caused damage.Vitamin and carbohydrate, fat are different with protein 3 big materials, in natural food, only account for minor proportion, but are that human body institute is essential.Some vitamin such as B6 and K etc. can be synthetic by the antibacterial in the animal intestinal, and synthetic quantity can satisfy the needs of animal.Zooblast can become nicotinic acid (a kind of vitamin B group) with tryptophan transfer, needs but growing amount is deposited; Vitamin C is except that primates (comprising the mankind) and the Cavia porcellus, and other animals can self be synthesized.Plant and most microorganism can both own synthetic vitamins, needn't be by external supply.Many vitamin are ingredients of prothetic group or coenzyme.
Vitamin is humans and animals nutrition, necessary some a small amount of organic compound of growth, and metabolism, growth, growth, the health of body is had effect of the utmost importance.If certain vitamin of long-term lacking will cause the physiological function obstacle and certain disease takes place.
Vitamin is a requisite organic compound in the body metabolism.Human body is constantly carrying out various biochemical reactions just as a very complicated chemical plant.Its reaction has substantial connection with the catalytic action of enzyme.Enzyme will produce activity, must have coenzyme to participate in.Known many vitamin are the coenzyme of enzyme or the ingredient of coenzyme.Therefore, vitamin is the important substance of keeping and regulating the body homergy.Can think that best vitamin is with the form of " bioactive substance ", is present in the tissue.
The discovery of vitamin is that the greatness in 20th century one of is found.1897, Ai Keman (Christian Eijkman) found that in the Java rice only eat correct grinding can suffer from vitamin B1 deficiency, can treat this disease without the brown rice of milling.And find to control beriberic material ability water or alcohol extraction, claimed at that time that this material was " water solublity B ".Contain " cofactor " beyond isolating protein, lipid, carbohydrate, inorganic salt and the water in the proof foods in 1906, its amount is very little, but is that growth of animal institute is essential.1911 Casimir Feng Ke (KazimierzFunk) identify that in brown rice, to resist beriberic material be amine (one type of nitrogenous chemical compound), it be earn a bare living necessary, so suggestion called after " Vitamine ".Be Vital (life) amine (amine), the Chinese meaning is " life amine ".Find many vitamin later on successively, their chemical property is different, and physiological function is different, finds that also many vitamin do not contain amine, and is nonnitrogenous, but the name of Feng Ke continuity used, just last alphabetical " e " is removed.The initial vitamin B of finding turned out to be the vitamin B complex afterwards, separate through purifying and find, be several kinds of materials, just character and the distributional class in food seemingly, and majority is a coenzyme.The quantity delivered that has must balance each other, and like vitamin B1, B2 and PP, otherwise can influence physiological action.The vitamin B complex comprises: pantothenic acid, nicotinic acid, biotin, folic acid, vitamin B1 (thiamine), vitamin B2 (riboflavin), pyridoxol (vitamin B6) and cobalamin (vitamin B12).Someone also is included in choline, inositol, PABA (para-amino benzoic acid), carnitine, thioctic acid in the B complex.
Vitamin is extended familys, the present known kind more than 20 that just has, and people are divided into water soluble vitamins and fatsoluble vitamin two big classes to vitamin by its deliquescent difference.Fatsoluble vitamin comprises four kinds of A, D, E, K, and water soluble vitamins comprises vitamin B group (B1, B2, B6, B12 etc.) and vitamin C.
Because the vitamin kind is more, character is different, the therefore vitamin preparation of domestic production at present in the majority with separate constituent, Cernevit-12 is less, and dosage form is main with the oral formulations of tablet and glue.
CN200910061812.6 discloses a kind of injection complex vitamin freeze-dried powder injection in the prior art, and it is formulated by fatsoluble vitamin, water soluble vitamins, solubilizing agent and plasticizer.CN200810138322.7 discloses a kind of stable, aqueous solution preparation that contains fatsoluble vitamin and water soluble vitamins.CN200710190669.1 discloses method for preparing and the production technology that the invention discloses a kind of 13 kinds of composite vitamin injections, and this injection adopts two dosage forms.In fact above-mentioned mix preparation does not solve the technical barrier of vitamin stability well, but also causes the curative effect of vitamin to reduce.
For the curative effect of better performance fatsoluble vitamin injection and Vitamin H, the inventor has proposed a kind of pharmaceutical composition with fatsoluble vitamin injection (II) and Vitamin H and has carried out the Combination application packing according to this situation; Preparation so respectively; Assembly packaging has not only made things convenient for patient's application clinically, and multivitamin is used simultaneously; Therapeutic effect is better, and stability of formulation is also better.
Summary of the invention
One of the object of the invention provides the pharmaceutical composition of a kind of fatsoluble vitamin injection (II) and Vitamin H, and fatsoluble vitamin injection (II) is a sterile water solution, and Vitamin H is aseptic freeze-dried injectable powder.
One of the object of the invention provides the drug regimen application packages of a kind of fatsoluble vitamin injection (II) and Vitamin H, comprises fatsoluble vitamin injection (II) and Vitamin H.
Combination application packing provided by the invention, usage are earlier with water for injection or glucose injection dissolving or dilution, intravenous drip respectively again.
In the Combination application packing of the present invention, fatsoluble vitamin injection (II) per unit dosage is mainly by vitamin A 0.99mg, vitamin D
25 μ g, vitamin E 9.1mg, vitamin K
10.15mg, injection soybean oil 1g, injection lecithin 0.12g, glycerol 0.22g process.
In the Combination application packing of the present invention, Vitamin H per unit dosage is mainly by vitamin B
13.1mg, vitamin B
24.9mg, nicotiamide 40mg, vitamin B
64.9mg, sodium pantothenate 16.5mg, sodium ascorbate 113mg, biotin 60 μ g, folic acid 0.4mg, vitamin B
125 μ g, glycine 300mg, Calcium Disodium Versenate 0.5mg, methyl parahydroxybenzoate 0.5mg process.
Another object of the present invention has provided the method for making of a kind of fatsoluble vitamin injection (II), may further comprise the steps:
(1) takes by weighing vitamin A, vitamin E, the vitamin D of recipe quantity
2, vitamin K
1, injection soybean oil, injection lecithin and glycerol, fully mix to principal agent and dissolve fully, add 90% water for injection again, stir, benefit adds to the full amount of water for injection, and stirs;
(2) regulate pH value between the 6.5-9.0 with the sodium hydroxide solution of 1mol/L, add the active carbon stirring and adsorbing of 0.03% (g/ml), filter decarburization;
(3) fine straining, fill, 10ml/ props up;
(4) sterilization, 121 ℃ of pressure sterilizings 15 minutes.
Another object of the present invention provides a kind of method for making of Vitamin H, may further comprise the steps:
(1) takes by weighing the supplementary material of recipe quantity respectively; The water for injection of adding 80% stirs, and regulates about pH value to 5.8 with sodium hydroxide solution or the hydrochloric acid solution of 1mol/L; Supplementary material dissolves fully; Benefit adds to the full amount of water for injection, and the active carbon that adds 0.03% (g/ml) adsorbs, and filters decarburization;
(2) fine straining, packing;
(3) lyophilization.
As the preferred embodiment of the present invention, further, freeze-dry process is:
A, pre-freeze: the medicinal liquid that branch is installed is cooled to-50～-35 ℃ by 1～3 ℃ of/minute speed, is incubated freezing 3 hours;
B, distillation: the medicine evacuation that pre-freeze is good, to 15Pa, in 7～9 hours, at the uniform velocity slowly be warming up to-22～-18 ℃ then, be incubated 1～2 hour, in 4～6 hours, at the uniform velocity be warming up to 10～15 ℃ again;
C, drying: the distillation medicine of stage after finishing that finish at the uniform velocity was warming up to 30 ℃ in 4 hours, heat preservation and dryness 3 hours detects qualified back packing and puts in storage.
Preferably:
A, pre-freeze: the medicinal liquid that branch is installed is cooled to-40 ℃ by 2 ℃ of/minute speed, is incubated freezing 3 hours;
B, distillation: the medicine evacuation that pre-freeze is good, to 15Pa, in 8 hours, at the uniform velocity slowly be warming up to-20 ℃ then, be incubated 2 hours, in 5 hours, at the uniform velocity be warming up to 10 ℃ again;
C, drying: the distillation medicine of stage after finishing that finish at the uniform velocity was warming up to 30 ℃ in 4 hours, heat preservation and dryness 3 hours detects qualified back packing and puts in storage.
The present invention also provides the application of pharmaceutical composition in preparation treatment vitamins nutritional supplementation medicine of a kind of fatsoluble vitamin injection (II) and Vitamin H, in order to satisfy the physiological need of every day to vitamin of being grown up.
The present invention also provides the pharmaceutical composition of a kind of fatsoluble vitamin injection (II) and Vitamin H at the adult patient that preparation treatment multivitamin lacks, and has better effect.
Fatsoluble vitamin injection (II) be applicable to adult and ten one-year-old above children, every day 10ml.Under aseptic condition, these article are joined in 500ml fat emulsion injection or 5% glucose injection before using, jog shakes up the back infusion, and in 24 hours, uses up.These article can be used for dissolving Vitamin H, before the use, under aseptic condition, these article 10ml are added one bottle of Vitamin H, join in the fat emulsion injection after the dissolving again.
Vitamin H, adult and the above child of body weight 10kg, one bottle of every day; The child of the discontented 10kg of neonate and body weight, the daily requirement amount is per kilogram of body weight 1ml (with following solution 10ml dissolving back), intravenous drip.Under aseptic condition, originally the available following solution 10ml of article dissolves when compatibility is guaranteed: (1) fatsoluble vitamin injection (II) (supplying adult's child's use more than one-year-old with ten); (2) fat emulsion injection; (3) there is not electrolytical glucose injection; (4) water for injection; Need add behind the fat emulsion injection again through venoclysis with above-mentioned (1) and (2) liquid mixture prepared, also can add in the fat emulsion injection in the glucose sugar injection again through venoclysis and can add with method (3) or (4) liquid mixture prepared.After the dissolving of these article, should under aseptic condition, add in the transfusion immediately, and in 24 hours, use up.
Usage and dosage according to above fatsoluble vitamin injection (II) and Vitamin H can be found out; The two Application of composite has more comprehensively been replenished the needs of human body to vitamin; Also be to use more a kind of composite reagent at present clinically, the inventor is according to this situation, and the inventor has proposed a kind of pharmaceutical composition with fatsoluble vitamin injection (II) and Vitamin H and carried out the Combination application packing; The vitamin that needed by human body is wanted has carried out replenishing in all directions; So not only make things convenient for patient's application clinically, avoided the defective of using single vitamin to cause, improved therapeutic effect greatly.
Benefit of the present invention:
(1) Combination application packing of the present invention greatly facilitates patient's application clinically, has improved the safety that the patient uses.
(2) Combination application of the present invention packing has been practiced thrift cost to the buying of medication unit with make up a prescription very big convenience also is provided.
(3) Combination application of the present invention packing is existing with joining at present, and the stability of each drug alone is of great benefit to, and can improve the clinical practice quality and the bioavailability of medicine.
(4) combination of the present invention is used to treat the adult patient that multivitamin lacks, and has better effect.
The specific embodiment
Embodiment 1The preparation of assembly packaging medicine
1, the preparation of fatsoluble vitamin injection (II)
(1) takes by weighing vitamin A 0.99g, vitamin E 9.1g, the vitamin D of recipe quantity
25mg, vitamin K
10.15g, fully mix to principal agent and dissolve fully with injection soybean oil 1000g, injection lecithin 120g, glycerol 220g, add the water for injection of 9000ml again, stir, add water for injection to 10000ml, stir;
(2) regulate pH value to 8.0 with the sodium hydroxide solution of 1mol/L, add the active carbon stirring and adsorbing of 3g, filter decarburization;
(3) fine straining, fill, 10ml/ props up;
(4) sterilization, 121 ℃ of pressure sterilizings 15 minutes.
2, the preparation of Vitamin H
(1) takes by weighing vitamin B respectively
13.1g, vitamin B
24.9g, nicotiamide 40g, vitamin B
64.9g, sodium pantothenate 16.5g, sodium ascorbate 113g, biotin 60mg, folic acid 0.4g, vitamin B
125mg, glycine 300g, Calcium Disodium Versenate 0.5g, methyl parahydroxybenzoate 0.5g; Add 2400ml water for injection, stir, regulate pH value to 6.0 with sodium hydroxide solution or the hydrochloric acid solution of 1mol/L; Supplementary material dissolves fully; Add water for injection to 3000ml, the active carbon that adds 0.9g adsorbs, and filters decarburization;
(2) fine straining, packing, 3ml/ bottle;
(3) lyophilization: a, pre-freeze: the medicinal liquid that branch is installed is cooled to-40 ℃ by 2 ℃ of/minute speed, is incubated freezing 3 hours; B, distillation: the medicine evacuation that pre-freeze is good, to 15Pa, in 8 hours, at the uniform velocity slowly be warming up to-20 ℃ then, be incubated 2 hours, in 5 hours, at the uniform velocity be warming up to 10 ℃ again; C, drying: the distillation medicine of stage after finishing that finish at the uniform velocity was warming up to 30 ℃ in 4 hours, heat preservation and dryness 3 hours detects qualified back packing and puts in storage.
3, assembly packaging
With the fatsoluble vitamin injection (I) and the Vitamin H difference labeling of preparation, respectively get 1 then and be loaded in the packing box, promptly get.
Comparative Examples 1
Comparative Examples 1 is identical with both compositions of embodiment 1.
Difference is: (1) with water for injection dissolving injection soybean oil, injection lecithin and glycerol, adds active component vitamin A, vitamin E, vitamin D earlier again
2, vitamin K
1(2) fatsoluble vitamin injection (II) is regulated pH value to 6.0;
(3)Freeze-dry process is different, is the disposable step of freeze drying of routine, that is, the medicinal liquid that branch is installed is cooled to-45 ℃ by 2 ℃ of/minute speed, is incubated freezing 3 hours, and heat preservation and dryness 3 hours detects qualified back packing warehouse-in.
Test Example 1The influence factor tests contrast
Because most vitamin are to light, thermally labile, and are exposed to and are prone to oxidizedly in the air, therefore, brown cillin bottle+butyl rubber plug that freeze-dried powder of the present invention is selected good leak tightness in influence factor's test is as inner packing; Injection selects brown ampoule bottle as inner packing, gets the factors influencing of prescription that the foregoing description 1 and Comparative Examples 1 confirm and process high-temperature, illumination.The investigation project mainly comprises pH value, clarity, content etc.
Exposure experiments to light: get embodiment 1 and put into lighting box with the fatsoluble vitamin injection (II) of Comparative Examples 1 preparation with the Vitamin H sample and carry out exposure experiments to light, respectively at sampling detection in 5,10 days, light intensity was 4500Lx.
Hot test: the fatsoluble vitamin injection (II) of getting embodiment 1 and Comparative Examples 1 preparation and Vitamin H sample were put into 60 ℃ of baking ovens and are carried out high temperature and investigate test, respectively at sampling detection in 5,10 days.
The result sees table 1.
Claims (9)
1. a pharmaceutical composition that comprises fatsoluble vitamin injection (II) and Vitamin H is characterized in that fatsoluble vitamin injection (II) is a sterile water solution, and Vitamin H is aseptic freeze-dried injectable powder.
2. a pharmaceutical composition that comprises fatsoluble vitamin injection (II) and Vitamin H is characterized in that fatsoluble vitamin injection (II) per unit dosage is mainly by vitamin A 0.99mg, vitamin D
25 μ g, vitamin E 9.1mg, vitamin K
10.15mg, injection soybean oil 1g, injection lecithin 0.12g, glycerol 0.22g process;
Vitamin H per unit dosage is mainly by vitamin B
13.1mg, vitamin B
24.9mg, nicotiamide 40mg, vitamin B
64.9mg, sodium pantothenate 16.5mg, sodium ascorbate 113mg, biotin 60 μ g, folic acid 0.4mg, vitamin B
125 μ g, glycine 300mg, Calcium Disodium Versenate 0.5mg, methyl parahydroxybenzoate 0.5mg process.
3. method for preparing fatsoluble vitamin injection (II) is characterized in that may further comprise the steps:
(1) takes by weighing vitamin A, vitamin E, the vitamin D of recipe quantity
2, vitamin K
1, injection soybean oil, injection lecithin and glycerol, fully mix to principal agent and dissolve fully, add 90% water for injection again, stir, benefit adds to the full amount of water for injection, and stirs;
(2) regulate pH value between the 6.5-9.0 with the sodium hydroxide solution of 1mol/L, add the active carbon stirring and adsorbing of 0.03% (g/ml), filter decarburization;
(3) fine straining, fill, 10ml/ props up;
(4) sterilization, 121 ℃ of pressure sterilizings 15 minutes.
4. method for preparing Vitamin H is characterized in that may further comprise the steps:
(1) takes by weighing the supplementary material of recipe quantity respectively; The water for injection of adding 80% stirs, and regulates about pH value to 5.8 with sodium hydroxide solution or the hydrochloric acid solution of 1mol/L; Supplementary material dissolves fully; Benefit adds to the full amount of water for injection, and the active carbon that adds 0.03% (g/ml) adsorbs, and filters decarburization;
(2) fine straining, packing;
(3) lyophilization.
5. according to the method for claim 4, it is characterized in that the lyophilization of step (3) is preferably:
A, pre-freeze: the medicinal liquid that branch is installed is cooled to-50～-35 ℃ by 1～3 ℃ of/minute speed, is incubated freezing 3 hours;
B, distillation: the medicine evacuation that pre-freeze is good, to 15Pa, in 7～9 hours, at the uniform velocity slowly be warming up to-22～-18 ℃ then, be incubated 1～2 hour, in 4～6 hours, at the uniform velocity be warming up to 10～15 ℃ again;
C, drying: the distillation medicine of stage after finishing that finish at the uniform velocity was warming up to 30 ℃ in 4 hours, heat preservation and dryness 3 hours detects qualified back packing and puts in storage.
6. according to 1 described pharmaceutical composition, it is characterized in that this pharmaceutical composition can pack for Combination application.
7. according to the application of each described pharmaceutical composition of claim 1-6 in preparation treatment vitamins nutritional supplementation medicine, in order to satisfy the physiological need of every day of being grown up to vitamin.
8. according to each described pharmaceutical composition of claim 1-6, it is characterized in that earlier with water for injection or glucose injection dissolving or dilution, intravenous drip respectively again.
9. the pharmaceutical composition of described a kind of fatsoluble vitamin injection of claim 1 (II) and Vitamin H and the described Combination application of claim 6 are packaged in preparation and treat the application in the adult patient of multivitamin shortage.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040845A (en) * | 2013-01-21 | 2013-04-17 | 西安安健药业有限公司 | Fat emulsion injection for supplementing fat-soluble vitamins |
| CN103169755A (en) * | 2013-02-04 | 2013-06-26 | 海南百思特医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamins for injection and fat emulsion injection |
| CN103169756A (en) * | 2013-02-04 | 2013-06-26 | 海南百思特医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamin injection and fat emulsion injection |
| CN105663144A (en) * | 2016-01-06 | 2016-06-15 | 施维雅(青岛)生物制药有限公司 | Fat-soluble vitamin water-based preparation for animals and preparing method and use method thereof |
| CN105663145A (en) * | 2016-01-06 | 2016-06-15 | 施维雅(青岛)生物制药有限公司 | Fat-soluble vitamin injection liquid for animals and preparing method and use method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824309A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Method of preparing soluble vitamin for injection using ultra sonic wave oscillation technology and its medicinal preparation |
| CN101366712A (en) * | 2008-09-26 | 2009-02-18 | 北京博时安泰科技发展有限公司 | Method for preparing fat-soluble vitamin for injection |
| CN101537012A (en) * | 2009-04-24 | 2009-09-23 | 武汉普生制药有限公司 | Complex vitamin freeze-dried powder injection and preparation method thereof |
-
2011
- 2011-11-29 CN CN 201110387733 patent/CN102429864B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824309A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Method of preparing soluble vitamin for injection using ultra sonic wave oscillation technology and its medicinal preparation |
| CN101366712A (en) * | 2008-09-26 | 2009-02-18 | 北京博时安泰科技发展有限公司 | Method for preparing fat-soluble vitamin for injection |
| CN101537012A (en) * | 2009-04-24 | 2009-09-23 | 武汉普生制药有限公司 | Complex vitamin freeze-dried powder injection and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040845A (en) * | 2013-01-21 | 2013-04-17 | 西安安健药业有限公司 | Fat emulsion injection for supplementing fat-soluble vitamins |
| CN103040845B (en) * | 2013-01-21 | 2014-07-16 | 西安安健药业有限公司 | Fat emulsion injection for supplementing fat-soluble vitamins |
| CN103169755A (en) * | 2013-02-04 | 2013-06-26 | 海南百思特医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamins for injection and fat emulsion injection |
| CN103169756A (en) * | 2013-02-04 | 2013-06-26 | 海南百思特医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamin injection and fat emulsion injection |
| CN103169755B (en) * | 2013-02-04 | 2014-04-16 | 海南百思特医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamins for injection and fat emulsion injection |
| CN103169756B (en) * | 2013-02-04 | 2014-07-02 | 海南圣欣医药科技有限公司 | Pharmaceutical composition of water-soluble vitamins for injection, fat-soluble vitamin injection and fat emulsion injection |
| CN105663144A (en) * | 2016-01-06 | 2016-06-15 | 施维雅(青岛)生物制药有限公司 | Fat-soluble vitamin water-based preparation for animals and preparing method and use method thereof |
| CN105663145A (en) * | 2016-01-06 | 2016-06-15 | 施维雅(青岛)生物制药有限公司 | Fat-soluble vitamin injection liquid for animals and preparing method and use method thereof |
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Address after: 570216 No. 8 workshop, Haikou Free Trade Zone, Hainan Patentee after: Hainan Ling Kang Pharmaceutical Group Limited by Share Ltd. Address before: 570216 No. 8 workshop, Haikou Free Trade Zone, Hainan Patentee before: Hainan Lingkang Pharmaceutical Co.,Ltd. |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130926 Address after: 570216 Hainan Province, Haikou city Jinpan Industrial Development Zone Industrial Village No. 3-6 building Patentee after: Hainan Lingkang Pharmaceutical Co.,Ltd. Address before: 570216 No. 8 workshop, Haikou Free Trade Zone, Hainan Patentee before: Hainan Ling Kang Pharmaceutical Group Limited by Share Ltd. |
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| CB03 | Change of inventor or designer information |
Inventor after: Tao Linggang Inventor after: Gong Changchun Inventor after: Mei Zesheng Inventor after: Shen Weiqi Inventor before: Tao Linggang Inventor before: Gong Changchun |
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| CB03 | Change of inventor or designer information |