CN102411057B - Multi-reagent pre-packing combined reaction cup - Google Patents
Multi-reagent pre-packing combined reaction cup Download PDFInfo
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- CN102411057B CN102411057B CN201010289772.3A CN201010289772A CN102411057B CN 102411057 B CN102411057 B CN 102411057B CN 201010289772 A CN201010289772 A CN 201010289772A CN 102411057 B CN102411057 B CN 102411057B
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Abstract
The invention relates to a multi-reagent pre-packing combined reaction cup used together with a point of care testing (POCT) specific protein analyzer. The combined reaction cup comprises a combined reagent bottle and a reaction cup, wherein the combined reagent bottle can be used for bearing and packing multiple reagents; and the reaction cup can meet the requirements of transmission color comparison, turbidimetric and forward scattering turbidimetric, and a stirring magnetic needle for quickly and uniformly mixing a reaction solution in the reaction cup under the action of a rotary magnetic field can be arranged in the reaction cup. The combined reaction cup can realize safe, quick and accurate measurement of biochemical, immune and specific protein projects.
Description
Technical field
The present invention relates to a kind of medicine equipment, particularly relate to a kind of pre-separately-loaded composite reaction of many reagent cup that can match with a kind of specific protein detection analytical instrument.
Background technology
The specific protein analyser of the use liquid reagent that can see on market at present, uses two or more reagent more, and test mode is mainly the blank method of sample or rate method.Wherein more common is semi-automatic specific protein analyser, with the matching used reaction cup of this specific protein analyser be cylinder or square column type reaction cup, the reaction reagent adding is is mostly to place separately with large packaged form, when adding, need operating personnel to use special dosage instrument quantitatively also to add to accurate timing sample and reagent to reaction cup in manual mode, measure biochemistry, immunity and the specific protein project of sample.
Due to the sample of this semi-automatic specific protein analyser and the repeatedly interpolation of reagent and be mixed operation be all by completing by hand, exist take artificial, manual operation error is large, the slow problem of test speed, the specific protein project that many urgent needs are detected cannot be popularized.And supporting reaction reagent is mainly with being independently packaged as greatly master, when adding, with manual mode, implement, easily cause the use amount of reagent excessive, and the cost of test is improved.
As can be seen here, above-mentioned existing semi-automatic specific protein analyser, in structure and use, obviously still has inconvenience and defect, and is urgently further improved.In order to solve the problem of above-mentioned existence, relevant manufacturer there's no one who doesn't or isn't seeks solution painstakingly, but have no for a long time applicable design always, by development, completed, and common product does not have appropriate structure to address the above problem, this is obviously the problem that the anxious wish of relevant dealer solves.
In view of this, the invention provides out the pre-separately-loaded composite reaction of a kind of many reagent cup, it is the special-purpose combined type reaction cup supporting with a kind of POCT (point of care testing) specific protein analyser, the pre-packing of trace single part, plurality of reagents can be realized, and reaction, colorimetric/than the multiple function such as turbid can be had simultaneously concurrently.
Summary of the invention
The object of the invention is to, overcome existing mensuration biochemical, the complicated operation that the semi-automatic specific protein analyser of immunity and specific protein must repeatedly cause to manually add reagent, take defect artificial and the larger personal error of existence, and provide a kind of pre-separately-loaded composite reaction of many reagent cup of new structure, technical matters to be solved is to propose a kind of new reagent addition manner by product structure of the present invention, to reduce the operation easier in test process, reduce the factor of human intervention impact test, can be simple, fast, measure accurately corresponding biochemical, immunity and specific protein project, thereby be more suitable for practicality.
The object of the invention to solve the technical problems is to adopt following technical scheme to realize.The pre-separately-loaded composite reaction of the many reagent of the one cup proposing according to the present invention, to support the use with a kind of POCT specific protein analyser, the pre-separately-loaded composite reaction of this many reagent cup comprises: a combined reagent bottle, to be formed by least one cylindricality wide-mouth reagent bottle, the top of this cylindricality wide-mouth reagent bottle is formed with a filling exit, and in the outside of this combined reagent bottle bottom face, corresponding each this cylindricality wide-mouth reagent bottle is provided with a tapered micro holes jet blower outwards protruding out; At least one silica gel plug, is mounted slidably in the filling exit of this at least one cylindricality wide-mouth reagent bottle, with the inner wall sealing coupling of corresponding this cylindricality wide-mouth reagent bottle; And a reaction cup, its upper cup muzzle is located at the outside of this combined reagent bottle bottom, and all these tapered micro holes jet blowers on this combined reagent bottle bottom surface are positioned at the top of this reaction cup inside.
Object of the present invention and solve its technical matters and can also be further achieved by the following technical measures.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, also comprises: a silicagel pad, be arranged at the bottom surface below of this combined reagent bottle, and cover and seal the tapered micro holes jet blower on the bottom surface of this combined reagent bottle.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, also comprise: a reagent bottle collet, for tubular, be sheathed on the outside of this combined reagent bottle and this reaction cup junction, engage location with this combined reagent bottle and this reaction cup, this silicagel pad is arranged in this reagent bottle collet, and this reagent bottle collet coordinates this silicagel pad to seal the tapered micro holes jet blower on this combined reagent bottle bottom surface.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, the top of the barrel inner side of wherein said reagent bottle collet is provided with at least one hook inwardly protruding out, and this hook engages location with this combined reagent bottle bottom.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, wherein said hook is three, and is that those hooks are sticked in the baffle ring of this combined reagent bottle bottom in the along the circumferential direction setting evenly distributedly of top of the barrel inner side of this reagent bottle collet.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, the bottom of the barrel inner side of wherein said reagent bottle collet is provided with a positioning bar, and it engages the unique location producing on circumferencial direction with a detent of this reagent bottle arranged outside.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, the top of wherein said reaction cup is provided with the reaction cup hot pressing film of this reaction cup of sealing.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, wherein stirring needle is preset in the bottom in this reaction cup.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, wherein said combined reagent bottle is to consist of three identical mutual adjacency side by side of cylindrical wide-mouth reagent bottle of structure.
The pre-separately-loaded composite reaction of aforesaid many reagent cup, wherein said reaction cup is a cylindrical reaction cup, the inwardly outstanding inside step that forms is being located in a distance with rim of a cup in the top of its wall of cup, this reaction cup is divided into the bottom that the top of establishing with this combined reagent bottle cover and diameter dwindle than top by this stepped region, this step is kept out in the bottom surface of this combined reagent bottle, and the rim of a cup of this reaction cup is kept out the baffle ring arranging in this combined reagent bottle bottom, realizes this reaction cup and mates with the socket of this combined reagent bottle.
The present invention compared with prior art has obvious advantage and beneficial effect.By technique scheme, the pre-separately-loaded composite reaction of the many reagent of the present invention cup at least has following advantages and beneficial effect: the present invention supports the use with a kind of POCT specific protein analyser, can reduce the operation easier in test process, reduce the factor of human intervention impact test, and then can measure simply, fast and accurately corresponding biochemistry, immunity and specific protein project.
In sum, the invention relates to the pre-separately-loaded composite reaction of a kind of many reagent cup, is the use that matches with a kind of POCT specific protein analyser.It comprises a combined reagent bottle, can be used for carrying and packing plurality of reagents; And a reaction cup, can adapt to transmission colorimetric, than turbid and forward scattering than turbid needs, reaction cup also can be built-in with stirring needle, with under the effect of rotating magnetic field to reaction cup in reactant liquor mix fast.Therefore utilize the present invention can realize the mensuration safely, fast and accurately to biochemistry, immunity and specific protein project.The present invention has significant progress technically, and has obvious good effect, is really a new and innovative, progressive, practical new design.
Above-mentioned explanation is only the general introduction of technical solution of the present invention, in order to better understand technological means of the present invention, and can be implemented according to the content of instructions, and for above and other object of the present invention, feature and advantage can be become apparent, below especially exemplified by preferred embodiment, and coordinate accompanying drawing, be described in detail as follows.
Accompanying drawing explanation
Fig. 1 is the exploded perspective view of preferred embodiment of the present invention.
Fig. 2 is the schematic diagram of the combined reagent bottle bottom surface micropore jet nozzle of preferred embodiment of the present invention.
Fig. 3 is the combined reagent bottle of preferred embodiment of the present invention and the stereographic map of silica gel plug, silicagel pad and the combination of reagent bottle collet.
Fig. 4 is the exploded perspective schematic diagram of preferred embodiment of the present invention when adding reagent.
Fig. 5 is the combined reagent bottle of preferred embodiment of the present invention and the stereographic map of reaction cup combination.
Embodiment
Technological means and the effect for further setting forth the present invention, for reaching predetermined goal of the invention, taked, below in conjunction with accompanying drawing and preferred embodiment, to its embodiment of the pre-separately-loaded composite reaction of many reagent cup, structure, feature and the effect thereof that propose according to the present invention, be described in detail as follows.
Relevant aforementioned and other technology contents of the present invention, Characteristic can clearly present in the following detailed description coordinating with reference to graphic preferred embodiment.By the explanation of embodiment, when obtaining one more deeply and concrete understanding for technological means and the effect reaching predetermined object and take to the present invention, but appended graphic be only to provide with reference to the use of explanation, be not used for the present invention to be limited.
The pre-separately-loaded composite reaction of many reagent of the present invention cup, is to support the use with a kind of POCT specific protein analyser, realizes the robotization of all operations were except quantitative collection patient's sample.
Refer to shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, Fig. 1 is the exploded perspective view of preferred embodiment of the present invention.Fig. 2 is the schematic diagram of the combined reagent bottle bottom surface micropore jet nozzle of preferred embodiment of the present invention.Fig. 3 is the combined reagent bottle of preferred embodiment of the present invention and the stereographic map of silica gel plug, silicagel pad and the combination of reagent bottle collet.Fig. 4 is the exploded perspective schematic diagram of preferred embodiment of the present invention when adding reagent.Fig. 5 is the combined reagent bottle of preferred embodiment of the present invention and the stereographic map of reaction cup combination.The pre-separately-loaded composite reaction of the many reagent cup of preferred embodiment of the present invention, comprising: combined reagent bottle 1, silica gel plug 4, tapered micro holes jet blower 7 and reaction cup 3.
Above-mentioned combined reagent bottle 1, for carrying the required reagent of reaction.It is to consist of at least one cylindricality wide-mouth reagent bottle, can while quantitative separating plurality of reagents in advance according to the needs of test event.Wherein, the top that is used for each the wide-mouth reagent bottle that forms combined reagent bottle 1 is formed with a filling exit, be used for pouring into reagent, and be provided with a tapered micro holes jet blower 7 (as shown in Figure 2) outwards protruding out at corresponding each reagent bottle in the outside of combined reagent bottle 1 bottom face, the reagent in reagent bottle is imported in reaction cup 3 under the effect of external force.Reagent bottle of the present invention be adopt can not with bottle in reagent react or the macromolecular material that is dissolved is made.In the present embodiment, combined reagent bottle 1 is to form (as shown in Figure 1) by the identical cylindrical wide-mouth reagent bottle of three structures of adjacency mutually arranged side by side, but shape, number and the unitized construction of the reagent bottle of formation combined reagent bottle 1 be not as limit, and for example combined reagent bottle 1 of the present invention can be also side by side in abutting connection with forming by two square column type wide-mouth reagent bottles.
The number of above-mentioned silica gel plug 4 is corresponding to the number of reagent bottle in combined reagent bottle 1, each silica gel plug 4 is arranged in the filling exit of wide-mouth reagent bottle corresponding in combined reagent bottle 1, and mate with the inner wall sealing of this wide-mouth reagent bottle, with reagent quantitative in sealed reagent bottle.Under the effect of external force, silica gel plug 4 is the inwall down sliding along this reagent bottle by the filling exit by reagent bottle, to reagent pressurization in reagent bottle.In the present embodiment, in corresponding combined reagent bottle 1, reagent bottle is provided with three silica gel plugs 4.
Above-mentioned reaction cup 3, its upper cup muzzle is located at the outside of combined reagent bottle 1 bottom, to guarantee that all tapered micro holes jet blowers 7 on combined reagent bottle 1 bottom surface are in use positioned at the top of reaction cup 3 inside.Because reaction cup 3 is for carrying reactant liquor and as colorimetric, than turbid cup, being the light transmission under the wavelength that guarantees to need in test event, reaction cup 3 adopts the good macromolecular material manufacture of optical property.In the present embodiment, reaction cup 3 is a cylindrical reaction cup, the inwardly outstanding inside step that forms is being located in a distance with rim of a cup in the top of its wall of cup, and reaction cup 3 is divided into the bottom that the top sheathed with combined reagent bottle 1 and diameter dwindle than top.By this step, keep out in the bottom surface of combined reagent bottle 1, and the rim of a cup of reaction cup 3 keeps out the baffle ring that this combined reagent bottle 1 bottom arranges, realization response cup 3 mates (as shown in Figure 5) with the socket of combined reagent bottle 1.These are only that reaction cup 3 and combined reagent bottle 1 mutually combine for example, but not as limit.
The pre-separately-loaded composite reaction of many reagent of the present invention cup is to guarantee to be sub-packed in advance the unlikely leakage of reagent or the volatilization in reagent bottle in transportation and storage process, need to silicagel pad 5 and reagent bottle collet 6 be set in combined reagent bottle 1 and the junction of reaction cup 3.Wherein:
This silicagel pad 5, is arranged at below the bottom surface of combined reagent bottle 1, covers all tapered micro holes jet blowers 7 on bottom surface, for each micropore jet nozzle 7 of combined sealing reagent bottle 1 bottom surface.
This reagent bottle collet 6, is tubular, is sheathed on the outside of combined reagent bottle 1 and reaction cup 3, and engages location with combined reagent bottle 1 and reaction cup 3, to protect reagent bottle.Silicagel pad 5 is to be arranged in reagent bottle collet 6, to coordinate silicagel pad 5 to realize the sealing to micropore jet nozzle 7 by reagent bottle collet 6.In the present embodiment, the top of the barrel inner side of reagent bottle collet 6 is provided with at least one hook inwardly protruding out 8 (as shown in Figure 3), hook 8 can engage location with the bottom of combined reagent bottle 1, to pour into after reagent, by silica gel plug 4, silicagel pad 5, with the acting in conjunction of reagent bottle collet 6, the reagent in reagent bottle is sealed.The bottom of the barrel inner side of reagent bottle collet 6 is provided with a positioning bar (not shown), and it engages the unique location producing on circumferencial direction with the detent in reagent bottle 3 outsides, to guarantee positional precision.In the present embodiment, reagent bottle collet 6 is cylindrical shape, and three hooks 8 are along the circumferential direction arranged at the top of barrel inner side evenly distributedly, and are sticked on the baffle ring of combined reagent bottle 1.The shape of reagent bottle collet of the present invention, structure, and with combined reagent bottle and reaction cup engage mode not as limit.
Above reaction cup 3, be also provided with the reaction cup hot pressing film 2 (as shown in Figure 1) for sealed reaction cup 3, to protect inner the cleaning of reflection cup.In addition, bottom in reaction cup 3 also can be preset and be stirred needle (not shown), under the effect of rotating magnetic field, needle is in the rotation of the bottom of reaction cup 3, stir liquid in cup, to complete the mixing fast of reactant liquor in reaction cup, hot-die 2 also can prevent that the stirring needle of reflection cup 3 interior placements from dropping out simultaneously.
The pre-separately-loaded composite reaction of many reagent of the present invention cup in use, refers to shown in Fig. 4 and Fig. 5.First the hook of reagent bottle collet 68 is outwards broken into two with one's hands, taken off reagent bottle collet 6, and be arranged at the interior silicagel pad 5 of reagent bottle collet 6 in company with removing, then remove reaction cup hot pressing film 2.Then combined reagent bottle 1 and reaction cup 3 are connected together.Under the promotion of a kind of POCT specific protein analyser inner depression bar supporting with it, silica gel plug 4 moves down along the inwall of reagent bottle, give reagent pressurization in reagent bottle, make reagent in combined reagent bottle 1 be column through tapered micro holes jet blower 7 and be injected in reaction cup 3, complete the interpolation of reagent.Due to the aperture of micropore jet nozzle 7 and most advanced and sophisticated sectional area very little, and reagent is to spray with higher speed, " hang and the drip " phenomenon in the time of therefore can significantly reducing reagent and add reaction cup 3 is guaranteed the precision of reagent dosage.
In reaction cup due to the pre-separately-loaded composite reaction of many reagent of the present invention cup, can preset stirring needle, its under the effect of rotating magnetic field, can realize reaction cup in the mixing fast of reactant liquor, the pre-separately-loaded composite reaction of many reagent of the present invention cup can be had concurrently be simultaneously mixed, reaction, colorimetric/than the multiple function such as turbid.Thereby make the pre-separately-loaded composite reaction of many reagent of the present invention cup when supporting the use with a kind of special POCT specific protein analyser, can realize the robotization of all operations were except quantitative collection patient's sample.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, although the present invention discloses as above with preferred embodiment, but not in order to limit the present invention, any those skilled in the art are not departing within the scope of technical solution of the present invention, when can utilizing the technology contents of above-mentioned announcement to make a little change or being modified to the equivalent embodiment of equivalent variations, in every case be the content that does not depart from technical solution of the present invention, any simple modification of above embodiment being done according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (10)
1. the pre-separately-loaded composite reaction of reagent a more than cup, is characterized in that it is to support the use with a kind of POCT specific protein analyser, and the pre-separately-loaded composite reaction of this many reagent cup comprises:
One combined reagent bottle, to be formed by least one cylindricality wide-mouth reagent bottle, and respectively this cylindricality wide-mouth reagent bottle that forms this combined reagent bottle adjacency mutually arranged side by side, the top of this cylindricality wide-mouth reagent bottle is formed with a filling exit, and in the outside of this combined reagent bottle bottom face, corresponding each this cylindricality wide-mouth reagent bottle is provided with a tapered micro holes jet blower outwards protruding out;
At least one silica gel plug, is mounted slidably in the filling exit of this at least one cylindricality wide-mouth reagent bottle, with the inner wall sealing coupling of corresponding this cylindricality wide-mouth reagent bottle; And
One reaction cup, its upper cup muzzle is located at the outside of this combined reagent bottle bottom, and all these tapered micro holes jet blowers on this combined reagent bottle bottom surface are positioned at the top of this reaction cup inside.
2. the pre-separately-loaded composite reaction of many reagent according to claim 1 cup, characterized by further comprising: a silicagel pad, be arranged at the bottom surface below of this combined reagent bottle, and cover and seal the tapered micro holes jet blower on the bottom surface of this combined reagent bottle.
3. the pre-separately-loaded composite reaction of many reagent according to claim 2 cup, characterized by further comprising: a reagent bottle collet, for tubular, be sheathed on the outside of this combined reagent bottle and this reaction cup, engage location with this combined reagent bottle and this reaction cup, this silicagel pad is arranged in this reagent bottle collet, and this reagent bottle collet coordinates this silicagel pad to seal the tapered micro holes jet blower on this combined reagent bottle bottom surface.
4. the pre-separately-loaded composite reaction of many reagent according to claim 3 cup, is characterized in that the top of the barrel inner side of wherein said reagent bottle collet is provided with at least one hook inwardly protruding out, and this hook engages location with this combined reagent bottle bottom.
5. the pre-separately-loaded composite reaction of many reagent according to claim 4 cup, it is characterized in that wherein said reagent bottle collet is cylindrical shape, described hook is three, and those hooks are the along the circumferential direction settings evenly distributedly of top in the barrel inner side of this reagent bottle collet.
6. the pre-separately-loaded composite reaction of many reagent according to claim 3 cup, the bottom that it is characterized in that the barrel inner side of wherein said reagent bottle collet is provided with a positioning bar, and it engages the unique location producing on circumferencial direction with a detent of this reagent bottle arranged outside.
7. according to the pre-separately-loaded composite reaction of the many reagent cup described in arbitrary claim in claim 1 to 6, it is characterized in that the top of wherein said reaction cup is provided with the reaction cup hot pressing film of this reaction cup of sealing.
8. the pre-separately-loaded composite reaction of many reagent according to claim 7 cup, is characterized in that wherein stirring needle is preset in the bottom in this reaction cup.
9. the pre-separately-loaded composite reaction of many reagent according to claim 1 cup, is characterized in that wherein said combined reagent bottle is to consist of three identical mutual adjacency side by side of cylindrical wide-mouth reagent bottle of structure.
10. the pre-separately-loaded composite reaction of many reagent according to claim 9 cup, it is characterized in that wherein said reaction cup is a cylindrical reaction cup, the inwardly outstanding inside step that forms is being located in a distance with rim of a cup in the top of its wall of cup, this reaction cup is divided into the bottom that the top of establishing with this combined reagent bottle cover and diameter dwindle than top by this stepped region, this step is kept out in the bottom surface of this combined reagent bottle, and the rim of a cup of this reaction cup is kept out the baffle ring arranging in this combined reagent bottle bottom, thereby realizing this reaction cup mates with the socket of this combined reagent bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201010289772.3A CN102411057B (en) | 2010-09-21 | 2010-09-21 | Multi-reagent pre-packing combined reaction cup |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010289772.3A CN102411057B (en) | 2010-09-21 | 2010-09-21 | Multi-reagent pre-packing combined reaction cup |
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| CN102411057A CN102411057A (en) | 2012-04-11 |
| CN102411057B true CN102411057B (en) | 2014-04-23 |
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| CN201010289772.3A Expired - Fee Related CN102411057B (en) | 2010-09-21 | 2010-09-21 | Multi-reagent pre-packing combined reaction cup |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103954783B (en) * | 2014-04-14 | 2015-07-22 | 珠海森龙生物科技有限公司 | Disposable excrement reaction cup |
| CN105107449B (en) * | 2015-09-11 | 2016-05-04 | 南京天纵易康生物科技股份有限公司 | A kind of combined type reaction cup |
| DE202016100399U1 (en) | 2015-12-03 | 2016-02-10 | Nanjing Tzong Blotechnology Co., Ltd. | Convenient combined reaction device |
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|---|---|---|---|---|
| JP2008246363A (en) * | 2007-03-30 | 2008-10-16 | Doshisha | Multiple dispenser |
| JP2009115752A (en) * | 2007-11-09 | 2009-05-28 | Fujirebio Inc | Separating apparatus |
| CN201382952Y (en) * | 2009-04-17 | 2010-01-13 | 武汉医尔特科技有限公司 | Reagent distribution system for novel full-automatic blood analyzer |
| CN201796038U (en) * | 2010-09-21 | 2011-04-13 | 傅宇光 | Multi-reagent prepackaged combined reaction cup |
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2010
- 2010-09-21 CN CN201010289772.3A patent/CN102411057B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008246363A (en) * | 2007-03-30 | 2008-10-16 | Doshisha | Multiple dispenser |
| JP2009115752A (en) * | 2007-11-09 | 2009-05-28 | Fujirebio Inc | Separating apparatus |
| CN201382952Y (en) * | 2009-04-17 | 2010-01-13 | 武汉医尔特科技有限公司 | Reagent distribution system for novel full-automatic blood analyzer |
| CN201796038U (en) * | 2010-09-21 | 2011-04-13 | 傅宇光 | Multi-reagent prepackaged combined reaction cup |
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