CN102397604A - Cylinder valve separated type magnetic damping pneumatic needle-head-free syringe - Google Patents
Cylinder valve separated type magnetic damping pneumatic needle-head-free syringe Download PDFInfo
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- CN102397604A CN102397604A CN2010102756072A CN201010275607A CN102397604A CN 102397604 A CN102397604 A CN 102397604A CN 2010102756072 A CN2010102756072 A CN 2010102756072A CN 201010275607 A CN201010275607 A CN 201010275607A CN 102397604 A CN102397604 A CN 102397604A
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Abstract
The invention discloses a cylinder valve separated type magnetic damping pneumatic needle-head-free syringe which is characterized by comprising a reversing valve 1, a switch 2, a pneumatic pipe fitting 3, a mechanical part and an injection part, wherein the mechanical part comprises a cylinder 4, a permanent magnet 5, an impact piston 6, a spring 7 and an end cover 8.
Description
Affiliated technical field
The present invention relates to the pneumatic needleless injector of a kind of cylinder valve separate type magnetic damping; It is characterized in that being made up of reversal valve 1, switch 2, pneumatic line adnexa 3, mechanical part and injection portion, wherein mechanical part is made up of cylinder barrel 4, permanent magnet 5, impact piston 6, spring 7 and end cap 8.Injection portion is made up of injection ram 9, syringe cylinder 10, can be used in the needleless injection device through strong driving force effect, belongs to medical instruments field.
Background technology
Traditional syringes is through rustless steel syringe needle injection human body; The Stainless Steel syringe needle not only can cause injection pain, and can cause dermatorrhagia, has potential infection risk; For fear of the injection safe in utilization of syringe needle, the needleless injection technique is the focus of international this domain expert's research always.
The main points of needleless injection technique are that the injecting type of realizing medicine imports; Need the strong and dynamical system that respond fast of driving force for this reason; Provide impulsive force to impact and to advance the piston in the sealing medicament reservoir, produce high voltage transient and force medicament from minute aperture, to be extruded, form the microjet of high velocity jet; Penetrate human body or animal body skin rapidly, arrive the drug absorption optimal site.Present existing dynamical system substantially can be divided into three kinds technically: Compressed Gas, fuel and hard spring, relevant patent of invention open at home and abroad or authorize in respect of 20 remainders.
Traditional drug administration by injection mode causes local skin infringement, hemorrhage; Not only pain significantly; It is frightened to make most of patients (particularly child) produce psychology; Cause the danger of injection site infection in addition, long term injections also can cause subcutaneous tissue, nerve and microvascular damage, and promptly becomes the healthy medical waste of threatening environment after a large amount of disposable syringe use; It is high to handle these medical wastes ten minutes inconvenience and expense, so needleless medicine injection technique is appealed to develop always by The World Health Organization (WHO).
The invention of needleless injection technique is intended to realize noinvasive injection, can eliminate pain, significantly reduce damage and be convenient to general amateur operation of medical workers use.These technological main points are that the injecting type of realizing medicine imports; Need the strong and dynamical system that respond fast of driving force for this reason; Provide impulsive force to impact and to advance the piston in the sealing medicament reservoir, produce high voltage transient and force medicament from minute aperture, to be extruded, form the microjet of high velocity jet; Penetrate human body or animal body skin rapidly, arrive the drug absorption optimal site.This shows, seek to operate the key that safe, efficient and cheap dynamical system is the development needleless injector.Present existing dynamical system substantially can be divided into three kinds technically: Compressed Gas, fuel and hard spring, relevant patent of invention open at home and abroad or authorize in respect of 20 remainders.With rocketry mutually type, no doubt enough powerful boosting power can be provided to ignite the mode that fuel produces shock wave, but its potential danger and unstable factor are also troubling really; Method is simple than above-mentioned two kinds as dynamical system with the compression spring; The Equidyne Systems that U.S. Equidyne Corporation company is holding; Inc branch company lasts 8 years and succeeds in developing a kind of spring-like needleless injector, begins its Injex series of products are put on market in batches in July, 2000.This syringe remains in following shortcoming: (1) because need compress spring body before using with in the use, reset, a series of preparation links such as collimation, constraint and safety triggerings afterwards need guarantee especially; Corresponding dynamical system indoor design is very complicated; Manufacturing process is many; Fetch long price ($250/ props up), non-domestic consumer afford to can bear; (2) mechanical stability of spring system self and fatigue problem, in use possible there was a mechanical failure, and spring powered decays the need periodic replacement with the access times increase; Produce during the spring body percussion piston when (3) implementing injection and tremble strongly and send the big sound, bring atypical uncomfortable impression to user; Commercially available spring-like needleless injector not only with the big sound, and can be in the injection site cause visual erythema and even wound owing to needle tubing impacts skin in clinical use.(4) still be the contact injecting method,, still have to recommend use in a large number disposable pencil for preventing cross infection.
According to another latest report; The research worker of Univ California-Berkeley is off the beaten track has invented a kind of high-precision hypodermic syringe; It is the back wash effect that utilizes piezoelectric effect among the physics; Promptly under certain driven, the electrolyte of some ionic crystals (like ceramic body, quartz etc.) can produce linear strain on direction of exerting pressure, and in fact this can simply reduce a kind of electrostriction effect.The various pick offs and the transducer that utilize piezoelectric effect and back wash effect thereof to process have obtained to use widely in electronic technology and Related product thereof, are used in medicine injection aspect and still belong to the first time.The dynamical system critical component of this syringe is one group of lead titanate piezoelectric ceramics (PZT); Because electricity consumption is driven; And ceramic strain has very high response speed; Thereby the chemical spray that is obtained stream has very high speed (reaching as high as 140 meter per seconds), like this can not need with situation that patient skin contacts under medicine is injected in the body.And prepare in advance and without any need for extra machinery, realizing fast, in the painless injection, avoiding the use of disposable pencil, reduced the chance of cross infection and the quantity of discarded pencil to greatest extent.The mountain is a rigidity ceramic body in power part in addition, has overcome aforementioned Injex product medi-spring body and has been difficult for collimation, is easy to shortcomings such as fatigue.
Obviously, the novel injector that utilizes inverse piezoelectric effect to make, not only the technology realization is more simple and direct, is realizing having the unrivaled superiority of above-mentioned additive method especially aspect the contactless injection.But even we are not difficult also to find that this method itself still exists some to be difficult to overcome fatal defective: the electrostriction coefficient of (1) piezoelectric ceramics own is little, and (100～600ppm), this has just determined this technology to be only applicable to little dose ejection (45～140 receive liter); (2) because the PZT ceramic post sintering is difficult, polarization is difficult, it is difficult to make the large scale product; General finished product is thin slice; This just needs several pieces and even tens of radially to bond together could to satisfy the requirement with the corresponding displacement of required drive; The conjugation of the each several part of whole like this convered structure and rigidity how, can guarantee effectively adding up of each potsherd microstrain, be directly connected to the qualification rate and the service life of product, technically be faced with challenge; (3) ceramic material matter is crisp frangible, repeatedly powerful bounce damage arranged in the piston process maybe; (4) for guaranteeing that ceramic body produces enough strains; Driving voltage often needs up to hundreds of volts even goes up kilovolt; Far above human safety voltage (36V); And under high like this voltage condition, effective isolation and insulating Design difficulty between inner positive and negative electrode of dynamical system and the cylindrical shell are very big, and potential safety hazard can not be ignored really.Remedying of these defectives awaits new technological break-through.
The mode of Needleless injection need be injected liquid (like medicine) in patient or the tame carcass in addition, needs the most tough and tensile part of transdermal---horny layer, and this just needs microjet to have sufficiently high speed, and the particulate matter yardstick in the pharmaceutical preparation simultaneously is enough little.Comprise polypeptide, protein etc. for macromolecular drug, be difficult to realize that through the mode of microjet medicine imports.
Traditional Compressed Gas method need be equipped with high pressure gas storehouse and corresponding air compression plant, and is bulky, involve great expense, during energy charge, use very inconvenience; We are through research repeatedly, have adopted quiet air compression system that power supply control two position three way directional control valve carries out air-flow turnover control as compressed gas source, and it is high successfully to have designed a kind of efficient; Medical personnel's labor intensity is low; Easy to operate, noise is slight, the adjustable within the specific limits pneumatic needleless injector of injection force; Make things convenient for clinical medical and nursing personnel's use, had extraordinary market prospect.
This needleless injector, owing to adopt air pressure to drive, thereby efficient is high, medical personnel's labor intensity is low, and can be through regulating the area of supply gas pressure or injection ram 9, makes injection force scalable within the specific limits.In addition, owing to adopt electric switch control, it is very convenient to operate, and spring 7 has the damping buffering effect in addition, so noise is slight.
Summary of the invention
The pneumatic needleless injector of a kind of cylinder valve separate type magnetic damping is made up of reversal valve 1, switch 2, pneumatic line adnexa 3, mechanical part and injection portion, and wherein mechanical part is made up of cylinder barrel 4, permanent magnet 5, impact piston 6, spring 7 and end cap 8.Reversal valve 1 preferred two position three way directional control valve can also be two-position four-way or switch valve with two-position and five-pass; Mechanical part is made up of cylinder barrel 4, impact piston 6, spring 7 and end cap 8, and injection portion is made up of injection ram 9, syringe cylinder 10; The screw thread of pneumatic line adnexa 3 joints is screwed in the screwed hole of cylinder barrel 4 left ends.In the endoporus of cylinder barrel 4, be placed with impact piston 6 and spring 7.Be fixed with permanent magnet 5 in impact piston 6 endoporus, cylinder barrel 4 and the contact site be ferromagnetic material, make to form magnetic damping device between impact piston 6 and the cylinder barrel 4.At the right-hand member of cylinder barrel 4, end cap 8 forms with screw thread and cylinder barrel 4 and is fixedly connected.Injection ram 9 places syringe cylinder 10 endoporus, and syringe cylinder 10 then connects with end cap 8 with screw thread or buckle.
Be in when preparing inject state, between injection ram 9 left sides of impact piston 6 right sides and injecting assembly, one section idle stroke arranged; To guarantee that impact piston 6 has just begun to impact the movement velocity of injection ram 9 left sides, can reach the degree that medicinal liquid penetrates animal or patient skin, thereby avoid causing the part liquid waste.
Be designed with air-vent on the cylinder barrel 4, the effect of air-vent is, when impact piston 6 during to the right or to left movement, makes the gas of intracavity discharge or suck, and the piston 6 that is unlikely to impact can not move because of the gas effect, or motion is less than design attitude.
The material of mechanical part can be selected hard metal material, comprises that specifically steel, ferrum, copper, aluminum and various alloy material are such as aluminium alloy etc.
Injection portion selects for use medical material injection molded, and syringe cylinder 10 has one or more circular micropores, and micro-pore diameter is 30-100um.
Operation principle of the present invention such as accompanying drawing 1,2 and 3 explanations, operating process is described below:
(1) when preparing injection, be full of medicinal liquid in the syringe cylinder 10, through the screw thread of syringe cylinder 10, be screwed on the end cap 8, syringe just is in preparation inject state shown in Figure 1.
(2) prepare under the inject state, switch 2 is in off-state, and two position three way directional control valve 1 is in cut-off state, carries the compressed air of coming by compressed air gas source, can not get in the cylinder barrel 4 through pneumatic line adnexa 3.
(3) start injection; When switch 2 just has been initially located in closure state, carry the compressed air of coming by compressed air gas source, during through pneumatic line adnexa 3; Owing to gas flow causes pressure lower; Be not enough to overcome the resistance of magnetic damping device, thereby can not get in the cylinder barrel 4, impact piston 6 can not move; Mobile until compressed air because of no longer, cause its pressure to be elevated to and get in the cylinder barrel 4 greater than the resistance of magnetic damping device, impact piston 6 will move right with very high acceleration; When crossing one section idle stroke between injection ram 9 left sides of its right side and injecting assembly, speed reaches the designing requirement value, at this moment; Impact piston 6 moves right it at a high speed with injection ram 9 left sides of very high velocity shock injecting assembly, through the medicinal liquid in the extruding syringe cylinder 10; Make medicinal liquid pass through syringe cylinder 10 right-hand member micropores, penetrate, inject with high-speed jet; When injection process finished, impact piston 6 arrived position shown in Figure 3.
(4) after injection process finishes, switch 2 is broken off, the electric magnet dead electricity of two position three way directional control valve 1, reversal valve 1 switches to off-state shown in Figure 1 again, and impact piston 6 resets to the high order end position under the effect of spring 7, inject with preparation next time.
Should be realized that those skilled in the art to mechanical part of the present invention, carries out the modification by a small margin of structure aspects, also can design numerous variations situation and various embodiment.For example, increase rear end cap and make cylinder barrel 4 become the branch body structure, so that processing; Magnetic damping device is designed to multi-form; Do not adopt spring reset, and modes such as employing gravity reset; And design air-vent in other position etc.Therefore be appreciated that protection scope of the present invention, should cover all these simply to change to the embodiment on basis.
Description of drawings
Fig. 1 is that the present invention prepares inject state.
Fig. 2 is a start injection state of the present invention.
Fig. 3 is that the present invention injects done state.
The numbering explanation:
1, the syringe cylinder of two position three way directional control valve 2, switch 3, pneumatic line adnexa 4, cylinder barrel 5, permanent magnet 6, impact piston 7, back-moving spring 8, end cap 9, injection ram 10, band micropore
Specific embodiment:
The device design is like Fig. 1,2, shown in 3.
Be filled the liquid of preform injection in the syringe cylinder 10, through the screw thread of syringe cylinder 10, be screwed on the end cap 8, syringe just is in preparation inject state shown in Figure 1.
Prepare under the inject state, switch 2 is in off-state, and two position three way directional control valve 1 is in cut-off state, carries the compressed air of coming by compressed air gas source, can not get in the cylinder barrel 4 through pneumatic line adnexa 3.
Inject state begins; When switch 2 just has been initially located in closure state, carry the compressed air of coming by compressed air gas source, during through pneumatic line adnexa 3; Owing to gas flow causes pressure lower; Be not enough to overcome the resistance of magnetic damping device, thereby can not get in the cylinder barrel 4, impact piston 6 can not move; Mobile until compressed air because of no longer, cause its pressure to be elevated to and get in the cylinder barrel 4 greater than the resistance of magnetic damping device, impact piston 6 will move right with very high acceleration; When crossing one section idle stroke between injection ram 9 left sides of its right side and injecting assembly, speed reaches the designing requirement value, at this moment; Impact piston 6 moves right it at a high speed with injection ram 9 left sides of very high velocity shock injecting assembly, through the medicinal liquid in the extruding syringe cylinder 10; Make medicinal liquid pass through syringe cylinder 10 right-hand member micropores, penetrate, inject with high-speed jet; When injection process finished, impact piston 6 arrived position shown in Figure 3.
After injection process finishes, switch 2 is broken off, the electric magnet dead electricity of two position three way directional control valve 1, reversal valve 1 switches to off-state shown in Figure 1 again, and impact piston 6 resets to the high order end position under the effect of spring 7, inject with preparation next time.
Claims (10)
1. the pneumatic needleless injector of cylinder valve separate type magnetic damping; It is characterized in that being made up of reversal valve 1, switch 2, pneumatic line adnexa 3, mechanical part and injection portion, wherein mechanical part is made up of cylinder barrel 4, permanent magnet 5, impact piston 6, spring 7 and end cap 8.
2. according to the pneumatic needleless injector of the said a kind of cylinder valve separate type of claim 1 magnetic damping; It is characterized in that being fixed with permanent magnet 5 in impact piston 6 endoporus; Cylinder barrel 4 and 5 contact site are ferromagnetic material, make to form magnetic damping device between impact piston 6 and the cylinder barrel 4.
3. according to the pneumatic needleless injector of cylinder valve separate type magnetic damping in the claim 1, when it is characterized in that impact piston 6 is in off working state, between injection ram 9 left sides of its right side and injecting assembly, can also design one section idle stroke.
4. according to the pneumatic needleless injector of the said a kind of cylinder valve separate type of claim 1 magnetic damping, it is characterized in that to be designed with air-vent on the said cylinder barrel 4.
5. according to the pneumatic needleless injector of the said a kind of cylinder valve separate type of claim 1 magnetic damping; It is characterized in that injection portion is made up of injection ram 9 and the syringe cylinder 10 that has micropore; Select for use medical material injection molded; Syringe cylinder 10 has one or more circular micropores, and micro-pore diameter is 30-100um.
6. according to the pneumatic needleless injector of the said a kind of cylinder valve separate type of claim 1 magnetic damping; Wherein reversal valve 1 preferred two position three way directional control valve can also be two-position four-way or switch valve with two-position and five-pass, it is characterized in that preparing under the inject state; Switch 2 is in off-state; Two position three way directional control valve 1 is in cut-off state, carries the compressed air of coming by compressed air gas source, can not get in the cylinder barrel 4 through pneumatic line adnexa 3; Start injection; When switch 2 just has been initially located in closure state, carry the compressed air of coming by compressed air gas source, during through pneumatic line adnexa 3; Owing to gas flow causes pressure lower; Be not enough to overcome the resistance of magnetic damping device, thereby can not get in the cylinder barrel 4, impact piston 6 can not move; Mobile until compressed air because of no longer, cause its pressure to be elevated to and get in the cylinder barrel 4 greater than the resistance of magnetic damping device, impact piston 6 will move right with very high acceleration; When crossing one section idle stroke between injection ram 9 left sides of its right side and injecting assembly, speed reaches the designing requirement value, at this moment; Impact piston 6 moves right it at a high speed with injection ram 9 left sides of very high velocity shock injecting assembly, through the medicinal liquid in the extruding syringe cylinder 10; Make medicinal liquid pass through syringe cylinder 10 right-hand member micropores, penetrate, inject with high-speed jet; When injection process finished, impact piston 6 arrived position shown in Figure 3.
7. when switch 2 was in closure state, the electric magnet of two position three way directional control valve 1 got electric, and reversal valve 1 switches to conducting state shown in Figure 2, carried the compressed air of coming by compressed air gas source, got in the cylinder barrel 4 through reversal valve 1 and pneumatic line adnexa 3; After injection process finishes; Switch 2 is broken off, the electric magnet dead electricity of two position three way directional control valve 1, reversal valve 1 switches to off-state shown in the figure again; Impact piston 6 resets to the high order end position under the effect of spring 7; Inject with preparation, wherein switch 2 preferred film switches can also be the mechanical key switches next time.
8. the pneumatic needleless injector of a kind of cylinder valve separate type according to claim 1 magnetic damping; It is characterized in that in the endoporus of cylinder barrel 4, be placed with impact piston 6 and spring 7, be fixed with permanent magnet 5 in impact piston 6 endoporus; Right-hand member at cylinder barrel 4; End cap 8 forms with screw thread and cylinder barrel 4 and is fixedly connected, and injection ram 9 places syringe cylinder 10 endoporus, and syringe cylinder 10 then connects with end cap 8 with screw thread or buckle.
9. the pneumatic needleless injector of a kind of cylinder valve separate type according to claim 1 magnetic damping is characterized in that being used for intradermal injection, subcutaneous injection or intramuscular injection, carries the liquid of doses to animal or human's body.
10. liquid according to claim 8; It is characterized in that the liquid of drawing preferably has active chemical compound; It can be micromolecular compound; Also can be macromolecule polyalcohol, such as: chemicals, growth hormone, insulin, polypeptide, protein, oligonucleotide, nucleic acid and polysaccharide etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102756072A CN102397604A (en) | 2010-09-08 | 2010-09-08 | Cylinder valve separated type magnetic damping pneumatic needle-head-free syringe |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102756072A CN102397604A (en) | 2010-09-08 | 2010-09-08 | Cylinder valve separated type magnetic damping pneumatic needle-head-free syringe |
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| CN102397604A true CN102397604A (en) | 2012-04-04 |
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| CN2010102756072A Pending CN102397604A (en) | 2010-09-08 | 2010-09-08 | Cylinder valve separated type magnetic damping pneumatic needle-head-free syringe |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977483A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Electromagnetic energy storage type needleless injector |
| CN103977481A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Pneumatic energy storage needleless syringe |
| CN103977484A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Pneumatic magnetic energy storage needleless syringe |
| WO2015172686A1 (en) * | 2014-05-14 | 2015-11-19 | 苏州大学张家港工业技术研究院 | Pneumatic accumulating needleless syringe |
| CN110440137A (en) * | 2019-08-09 | 2019-11-12 | 江苏丞宇米特医疗科技有限公司 | Gas source dynamical system and its cart |
| CN110694146A (en) * | 2019-10-25 | 2020-01-17 | 刘苏衡 | Needleless injector |
| CN112412733A (en) * | 2020-11-17 | 2021-02-26 | 武汉大学 | Double-channel needleless injection device with controllable jet velocity and method |
-
2010
- 2010-09-08 CN CN2010102756072A patent/CN102397604A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977483A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Electromagnetic energy storage type needleless injector |
| CN103977481A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Pneumatic energy storage needleless syringe |
| CN103977484A (en) * | 2014-05-14 | 2014-08-13 | 苏州大学张家港工业技术研究院 | Pneumatic magnetic energy storage needleless syringe |
| WO2015172686A1 (en) * | 2014-05-14 | 2015-11-19 | 苏州大学张家港工业技术研究院 | Pneumatic accumulating needleless syringe |
| CN110440137A (en) * | 2019-08-09 | 2019-11-12 | 江苏丞宇米特医疗科技有限公司 | Gas source dynamical system and its cart |
| CN110694146A (en) * | 2019-10-25 | 2020-01-17 | 刘苏衡 | Needleless injector |
| CN112412733A (en) * | 2020-11-17 | 2021-02-26 | 武汉大学 | Double-channel needleless injection device with controllable jet velocity and method |
| CN112412733B (en) * | 2020-11-17 | 2021-11-23 | 武汉大学 | Double-channel needleless injection device with controllable jet velocity and method |
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Application publication date: 20120404 |