CN102379897A - Preparation method of calamine lotion - Google Patents
Preparation method of calamine lotion Download PDFInfo
- Publication number
- CN102379897A CN102379897A CN2010102672876A CN201010267287A CN102379897A CN 102379897 A CN102379897 A CN 102379897A CN 2010102672876 A CN2010102672876 A CN 2010102672876A CN 201010267287 A CN201010267287 A CN 201010267287A CN 102379897 A CN102379897 A CN 102379897A
- Authority
- CN
- China
- Prior art keywords
- calamine
- calamine lotion
- product
- distilled water
- compound method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 239000008338 calamine lotion Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 238000000034 method Methods 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000012153 distilled water Substances 0.000 claims abstract description 14
- 235000014692 zinc oxide Nutrition 0.000 claims abstract description 14
- 239000011787 zinc oxide Substances 0.000 claims abstract description 14
- 229940105847 calamine Drugs 0.000 claims abstract description 9
- 229910052864 hemimorphite Inorganic materials 0.000 claims abstract description 9
- 229950008882 polysorbate Drugs 0.000 claims abstract description 9
- 229920000136 polysorbate Polymers 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 11
- 238000012856 packing Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 239000004677 Nylon Substances 0.000 claims description 9
- 229920001778 nylon Polymers 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 9
- 125000001246 bromo group Chemical group Br* 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 7
- 239000004575 stone Substances 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 abstract description 11
- 201000004624 Dermatitis Diseases 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 208000010668 atopic eczema Diseases 0.000 abstract description 3
- 208000024780 Urticaria Diseases 0.000 abstract description 2
- 230000001154 acute effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000820 nonprescription drug Substances 0.000 abstract description 2
- 238000004062 sedimentation Methods 0.000 abstract description 2
- 208000017520 skin disease Diseases 0.000 abstract description 2
- 229940102213 injectable suspension Drugs 0.000 abstract 2
- 208000010201 Exanthema Diseases 0.000 abstract 1
- 206010027627 Miliaria Diseases 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 201000005884 exanthem Diseases 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 201000004169 miliaria rubra Diseases 0.000 abstract 1
- 206010037844 rash Diseases 0.000 abstract 1
- 239000000047 product Substances 0.000 description 14
- 239000004744 fabric Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 241000475481 Nebula Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 230000003260 anti-sepsis Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 241001448624 Miliaria Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical class O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a preparation method of a calamine lotion, and the product belongs to the field of pharmacy. The calamine lotion is the over the counter drug of dermatological pharmacy, is the light pink injectable suspension in appearance, is precipitated after being placed, but is the uniform injectable suspension after being shaken out. Calamine and zinc oxide which are contained in the product have the constriction and protection effects, and also have weaker antiseptic function, so the calamine lotion can be applied in acute pruritus skin diseases and various rashes, such as urticaria, prickly heat, eczema and the like. The product is produced from the raw materials of: calamine powder, zinc oxide powder, glycerol, polysorbate, bromogeramine and distilled water. The calamine lotion which is prepared by the method is fine, has low layered sedimentation velocity, is not easy to block after long-term storage, and is the calamine lotion with good quality.
Description
Technical field:
Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of Calamine Lotion.
Background technology:
Calamine Lotion is a bentoquatam class nonprescription drugs medicine, and outward appearance is the suspension of pale pink, can precipitate after the placement, but after jolting, should become uniform suspension.Contained Calamina of these article and zinc oxide have convergence, protective effect, and more weak antisepsis is also arranged, and can be used for acute itching skin disease, and various erythra are like urticaria, miliaria, eczema etc.These article are medicine for external use, can not be oral, should avoid contacting eyes and other mucosa; Zest to intact skin is little, possibly cause of short duration mild pain after the medication, generally can not cause severe pain; If illing skin has breakage or sepage, just might cause tangible pain, so should not be used to have the skin of sepage; Intact skin illing skin " decortication " possibly occur after using, and this belongs to normal phenomenon, need not to worry.The main component of Calamine Lotion is Calamina, zinc oxide, glycerol, and wherein Calamina is a primary raw material, and the main component of Calamina is a zinc carbonate, and its function is the detoxifcation improving acuity of vision and removing nebula; The antipruritic skin ulcer of holding back of removing dampness can be used for conjunctival congestion and swelling pain, marginal blepharitis; Nebula film bulbar conjunctiva polyp, ulcer being unable to heal, pus is dripping; Eczema, diseases such as skin pruritus use these article that convergence, antipruritic, antibacterial and slight effect such as anticorrosion are arranged at department of dermatologry; Zinc oxide has deodorization, antimicrobial function, and has certain antisepsis; Glycerol is as solvent.The out-of-date methods of preparing Calamine Lotion are: get calamine stone, oxide powder and zinc, cross the 4# sieve respectively, mixing adds a small amount of distilled water and is ground into pasty state, and other gets in the glycerol gradation adding paste, and with adding with grinding, last adding distil water grinds well promptly and gets.Less with this method amount of preparation, and the finished product sedimentation velocity is fast, results in hand cramps to packing, needs fill limit, limit to stir, and can cause the packing finished product inhomogeneous slightly accidentally, influences product quality.
Summary of the invention:
In order to overcome above-mentioned defective, compound method to be improved, new method is the washing paddling process; With the Calamine Lotion of this method preparation, exquisite quality, delaminating deposition speed is slow; Store prevented from caking for a long time; Save time during preparation, played good action, can produce high-quality Calamine Lotion improving pharmaceutical effectiveness.The raw material of producing this product use has: calamine stone 1.6%, oxide powder and zinc 0.6%, glycerol 5%, Polysorbate 0.01%, bromo geramine 0.01%, distilled water 92.78%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation Calamine Lotion is characterized in that being made up of following steps:
1. in capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, raise temperature again, add surfactant Polysorbate, bromo geramine, and then add glycerol, stir.
2. with nylon plastic(s) mesh bag dress zinc oxide and calamine stone, gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye).
3. add remaining distilled water again, stir energetically.
4. product is sent into the disinfect box sterilization, sterilization back packing obtains finished product.
The beneficial effect of product of the present invention is: with the Calamine Lotion of this method preparation, and exquisite quality, delaminating deposition speed is slow; Store prevented from caking for a long time; Save time during preparation, Polysorbate and bromo geramine are surfactant, and stronger emulsification is arranged; Also be effectively external antibacterial, played good action improving pharmaceutical effectiveness.
The specific embodiment:
Embodiment 1:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 40 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product
Embodiment 2:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 45 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product
Embodiment 3:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 50 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product.
Claims (5)
1. the compound method of a Calamine Lotion, it is characterized in that: with calamine stone 1.6%, oxide powder and zinc 0.6%, glycerol 5%, Polysorbate 0.01%, bromo geramine 0.01%, distilled water 92.78% is raw material, obtains finished product through following steps.
2. the compound method of a kind of Calamine Lotion according to claim 1; The characteristic of its first step is: in capacity is 500 liters rustless steel container; At first add the distilled water that accounts for total amount 75%, raise temperature again, add surfactant Polysorbate, bromo geramine; And then adding glycerol, stir.
3. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its second step is: with nylon plastic(s) mesh bag shove charge Calamina powder and oxide powder and zinc, gradation washes in the above solution.
4. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its 3rd step is: add remaining distilled water, stir energetically.
5. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its 4th step is: product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672876A CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672876A CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102379897A true CN102379897A (en) | 2012-03-21 |
Family
ID=45819998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102672876A Pending CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102379897A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173377A (en) * | 2014-09-04 | 2014-12-03 | 湖南尔康湘药制药有限公司 | Method for producing calamine pastes |
| CN104940137A (en) * | 2015-06-02 | 2015-09-30 | 湖南尔康湘药制药有限公司 | Preparation method of calamine lotion |
| CN108210455A (en) * | 2016-12-19 | 2018-06-29 | 湖南尔康湘药制药有限公司 | A kind of zinc carbonate nano-micelle preparations and preparation method |
-
2010
- 2010-08-30 CN CN2010102672876A patent/CN102379897A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173377A (en) * | 2014-09-04 | 2014-12-03 | 湖南尔康湘药制药有限公司 | Method for producing calamine pastes |
| CN104940137A (en) * | 2015-06-02 | 2015-09-30 | 湖南尔康湘药制药有限公司 | Preparation method of calamine lotion |
| CN104940137B (en) * | 2015-06-02 | 2019-03-01 | 湖南尔康制药股份有限公司 | A kind of preparation method of calamine lotion |
| CN108210455A (en) * | 2016-12-19 | 2018-06-29 | 湖南尔康湘药制药有限公司 | A kind of zinc carbonate nano-micelle preparations and preparation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120321 |