CN102379897A - Preparation method of calamine lotion - Google Patents
Preparation method of calamine lotion Download PDFInfo
- Publication number
- CN102379897A CN102379897A CN2010102672876A CN201010267287A CN102379897A CN 102379897 A CN102379897 A CN 102379897A CN 2010102672876 A CN2010102672876 A CN 2010102672876A CN 201010267287 A CN201010267287 A CN 201010267287A CN 102379897 A CN102379897 A CN 102379897A
- Authority
- CN
- China
- Prior art keywords
- calamine
- calamine lotion
- product
- distilled water
- compound method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a preparation method of a calamine lotion, and the product belongs to the field of pharmacy. The calamine lotion is the over the counter drug of dermatological pharmacy, is the light pink injectable suspension in appearance, is precipitated after being placed, but is the uniform injectable suspension after being shaken out. Calamine and zinc oxide which are contained in the product have the constriction and protection effects, and also have weaker antiseptic function, so the calamine lotion can be applied in acute pruritus skin diseases and various rashes, such as urticaria, prickly heat, eczema and the like. The product is produced from the raw materials of: calamine powder, zinc oxide powder, glycerol, polysorbate, bromogeramine and distilled water. The calamine lotion which is prepared by the method is fine, has low layered sedimentation velocity, is not easy to block after long-term storage, and is the calamine lotion with good quality.
Description
Technical field:
Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of Calamine Lotion.
Background technology:
Calamine Lotion is a bentoquatam class nonprescription drugs medicine, and outward appearance is the suspension of pale pink, can precipitate after the placement, but after jolting, should become uniform suspension.Contained Calamina of these article and zinc oxide have convergence, protective effect, and more weak antisepsis is also arranged, and can be used for acute itching skin disease, and various erythra are like urticaria, miliaria, eczema etc.These article are medicine for external use, can not be oral, should avoid contacting eyes and other mucosa; Zest to intact skin is little, possibly cause of short duration mild pain after the medication, generally can not cause severe pain; If illing skin has breakage or sepage, just might cause tangible pain, so should not be used to have the skin of sepage; Intact skin illing skin " decortication " possibly occur after using, and this belongs to normal phenomenon, need not to worry.The main component of Calamine Lotion is Calamina, zinc oxide, glycerol, and wherein Calamina is a primary raw material, and the main component of Calamina is a zinc carbonate, and its function is the detoxifcation improving acuity of vision and removing nebula; The antipruritic skin ulcer of holding back of removing dampness can be used for conjunctival congestion and swelling pain, marginal blepharitis; Nebula film bulbar conjunctiva polyp, ulcer being unable to heal, pus is dripping; Eczema, diseases such as skin pruritus use these article that convergence, antipruritic, antibacterial and slight effect such as anticorrosion are arranged at department of dermatologry; Zinc oxide has deodorization, antimicrobial function, and has certain antisepsis; Glycerol is as solvent.The out-of-date methods of preparing Calamine Lotion are: get calamine stone, oxide powder and zinc, cross the 4# sieve respectively, mixing adds a small amount of distilled water and is ground into pasty state, and other gets in the glycerol gradation adding paste, and with adding with grinding, last adding distil water grinds well promptly and gets.Less with this method amount of preparation, and the finished product sedimentation velocity is fast, results in hand cramps to packing, needs fill limit, limit to stir, and can cause the packing finished product inhomogeneous slightly accidentally, influences product quality.
Summary of the invention:
In order to overcome above-mentioned defective, compound method to be improved, new method is the washing paddling process; With the Calamine Lotion of this method preparation, exquisite quality, delaminating deposition speed is slow; Store prevented from caking for a long time; Save time during preparation, played good action, can produce high-quality Calamine Lotion improving pharmaceutical effectiveness.The raw material of producing this product use has: calamine stone 1.6%, oxide powder and zinc 0.6%, glycerol 5%, Polysorbate 0.01%, bromo geramine 0.01%, distilled water 92.78%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation Calamine Lotion is characterized in that being made up of following steps:
1. in capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, raise temperature again, add surfactant Polysorbate, bromo geramine, and then add glycerol, stir.
2. with nylon plastic(s) mesh bag dress zinc oxide and calamine stone, gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye).
3. add remaining distilled water again, stir energetically.
4. product is sent into the disinfect box sterilization, sterilization back packing obtains finished product.
The beneficial effect of product of the present invention is: with the Calamine Lotion of this method preparation, and exquisite quality, delaminating deposition speed is slow; Store prevented from caking for a long time; Save time during preparation, Polysorbate and bromo geramine are surfactant, and stronger emulsification is arranged; Also be effectively external antibacterial, played good action improving pharmaceutical effectiveness.
The specific embodiment:
Embodiment 1:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 40 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product
Embodiment 2:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 45 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product
Embodiment 3:
In capacity is 500 liters rustless steel container, at first add the distilled water that accounts for total amount 75% volume, be increased to 50 ℃ to temperature again, add and account for total amount 0.01% surfactant Polysorbate, 0.01% bromo geramine, and then add 5% glycerol, stir; Packing into the nylon plastic(s) mesh bag accounts for total amount 1.6% calamine stone and 0.6% oxide powder and zinc, and gradation washes in the above solution, (nylon plastic(s) mesh bag density is 3# screen cloth eye); Add remaining distilled water again, stir energetically; Product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product.
Claims (5)
1. the compound method of a Calamine Lotion, it is characterized in that: with calamine stone 1.6%, oxide powder and zinc 0.6%, glycerol 5%, Polysorbate 0.01%, bromo geramine 0.01%, distilled water 92.78% is raw material, obtains finished product through following steps.
2. the compound method of a kind of Calamine Lotion according to claim 1; The characteristic of its first step is: in capacity is 500 liters rustless steel container; At first add the distilled water that accounts for total amount 75%, raise temperature again, add surfactant Polysorbate, bromo geramine; And then adding glycerol, stir.
3. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its second step is: with nylon plastic(s) mesh bag shove charge Calamina powder and oxide powder and zinc, gradation washes in the above solution.
4. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its 3rd step is: add remaining distilled water, stir energetically.
5. the compound method of a kind of Calamine Lotion according to claim 1, the characteristic in its 4th step is: product is sent into the disinfect box sterilization, and sterilization back packing obtains finished product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102672876A CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102672876A CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102379897A true CN102379897A (en) | 2012-03-21 |
Family
ID=45819998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102672876A Pending CN102379897A (en) | 2010-08-30 | 2010-08-30 | Preparation method of calamine lotion |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102379897A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104173377A (en) * | 2014-09-04 | 2014-12-03 | 湖南尔康湘药制药有限公司 | Method for producing calamine pastes |
CN104940137A (en) * | 2015-06-02 | 2015-09-30 | 湖南尔康湘药制药有限公司 | Preparation method of calamine lotion |
CN108210455A (en) * | 2016-12-19 | 2018-06-29 | 湖南尔康湘药制药有限公司 | A kind of zinc carbonate nano-micelle preparations and preparation method |
-
2010
- 2010-08-30 CN CN2010102672876A patent/CN102379897A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104173377A (en) * | 2014-09-04 | 2014-12-03 | 湖南尔康湘药制药有限公司 | Method for producing calamine pastes |
CN104940137A (en) * | 2015-06-02 | 2015-09-30 | 湖南尔康湘药制药有限公司 | Preparation method of calamine lotion |
CN104940137B (en) * | 2015-06-02 | 2019-03-01 | 湖南尔康制药股份有限公司 | A kind of preparation method of calamine lotion |
CN108210455A (en) * | 2016-12-19 | 2018-06-29 | 湖南尔康湘药制药有限公司 | A kind of zinc carbonate nano-micelle preparations and preparation method |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2885221B1 (en) | Water-soluable packaging with bittering agent | |
JP2017500356A (en) | Topical gel composition comprising polycaprolactone polymer and method for enhancing topical application of benefit agent | |
CN102379897A (en) | Preparation method of calamine lotion | |
CN101073556A (en) | Eyes preparation for divergent pupil and its making method | |
CN103877067B (en) | A kind of Capsules controlling disintegration and preparation method thereof | |
CN102946855B (en) | Topical ophthalmic section suspensoid containing tobramycin and dexamethasone | |
KR101740163B1 (en) | Use of 3-n-butyl-1-isoindolinone in preparation of drugs for preventing and treating cerebral infarction | |
CN103272133A (en) | Preparation method of fermented substance for diminishing inflammation and stopping bleeding | |
CN103361202A (en) | Perfumed soap with belly slimming function | |
KR102239796B1 (en) | Cold press soap and manufacturing method for the same | |
CN104000745B (en) | Spraying cleansing water without irritating to eyes and preparing method of spraying cleansing water | |
CN104531396A (en) | Traditional-Chinese-medicine soap and preparation method thereof | |
CN104189004B (en) | A kind of production method of Calamine Lotion | |
CN103932975A (en) | External use hydrogel composition and preparation thereof | |
CN102885852A (en) | Povidone iodine ointment and preparation method thereof | |
JP6253756B2 (en) | Ophthalmic aqueous composition | |
CN106137955B (en) | Antiperspirant application of external tiotropium bromide preparation | |
CN103720630A (en) | Skin-care product containing bird-nest extract and preparation method thereof | |
CN206380543U (en) | A kind of effervescent tablet type plant growth regulator | |
CN101632631A (en) | Nitrate itraconazole vaginal suppository and preparation method thereof | |
KR102129355B1 (en) | Composition for pack | |
CN103405382B (en) | Formula and preparation technology of chitosan-iodine suppository | |
CN104721130B (en) | A kind of brinzolamide inclusion compound eye-drops preparations and preparation method thereof | |
CN107397745A (en) | Azole compounds eye-drops preparations | |
CN110859793B (en) | High-affinity gel mask and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120321 |