CN1023766C - Spraying desiccation process for producing tasteless micro capsule for medicine - Google Patents
Spraying desiccation process for producing tasteless micro capsule for medicine Download PDFInfo
- Publication number
- CN1023766C CN1023766C CN 90105089 CN90105089A CN1023766C CN 1023766 C CN1023766 C CN 1023766C CN 90105089 CN90105089 CN 90105089 CN 90105089 A CN90105089 A CN 90105089A CN 1023766 C CN1023766 C CN 1023766C
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- microcapsule
- tasteless
- medicine
- capsule
- dehydrated alcohol
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Abstract
The present invention relates to a preparation method of a tasteless microcapsule, which comprises the steps that medicinal fine powder, such as pipemidic acid, nitrofurantoin, sulfadiazine, trimethoprim, etc., are mixed and suspended in organic solvents of macromolecular materials with gastric solubility, such as acrylic resin E100, etc., to prepare a suspension uniformly dispersed; after additives, such as talcum powder, etc., are added to the suspension, the mixture is spray-dried in a spray dryer. The method has the characteristics of simple technology, low cost, no taste for oral administration, and easy acceptance by children and patients with chronic illness.
Description
The invention belongs to and adopt spray drying method fine drug powder to be encapsulated as a kind of preparation method of no herbal medicine microencapsulation.
Still the tasteless micro capsule for medicine that does not have the children taking of being applicable at present both at home and abroad.And therefore the microcapsule of this prepared can be covered oral administration and react with the caused disagreeable taste of medicine because of being can not or to discharge medicine in the neutral aqueous solution on a small quantity at PH.Like this, can remove medication person's misery, particularly chronic and child.
Now the drying process with atomizing of Cai Yonging is only applicable to prepare conventional microcapsule, and for example liquid medicine packs into microcapsule etc.Do not see the report that does not have the herbal medicine microencapsulation with spray drying method for preparation so far as yet.
The object of the present invention is to provide a kind of spray drying method, make the new technology of the preparation tasteless micro capsule for medicine of solvent with dehydrated alcohol.
The object of the present invention is achieved like this: Eudragit E 100 3%-5% with gastric solubility, put in 200 ml containers, and add dehydrated alcohol, after placement made Eudragit E 100 swellings, heating in water bath made dissolving, as capsule material solution, placed cooling.
Other gets it filled thing fine powder (≤30 microns) (3%-5%W/V), and additives (Pulvis Talci) 1%-2% puts in the mortar, the capsule material solution that adds a small amount of aforesaid propylene acid resin E100 dehydrated alcohol, after grinding well, add dehydrated alcohol, make into the suspension of homodisperse until 100 milliliters.
Above-mentioned suspension is spray drying in QZ type Highspeedcentrifugingandsprayingdrier, and inlet temperature 90-150 ℃, outlet temperature 60-90 ℃, charging rate 5-15 ml/min, sprinkler pressure 0.2-0.5 kilograms per centimeter
2, after cyclone separator is collected microcapsule, cross 120 mesh sieves promptly.
Eudragit E 100 is the gastric solubility macromolecular material, is soluble in PH and is among the tart water-soluble matchmaker, and insoluble in neutrality or the alkaline water solvent.Therefore often it is used for the film coating of tablet.This macromolecular material is dissolved in most organic solvents, for example acetone, ethanol, chloroform etc.It is solvent that the present invention adopts dehydrated alcohol, and its advantage is that it is lower than other organic solvent price, and toxic and side effects is little, and medicine dissolubility in dehydrated alcohol is beneficial to the formation capsule less than the dissolubility in other organic solvent.The dehydrated alcohol evaporation latent heat is higher than acetone etc., and its evaporation rate is relatively slow, and it is little to be beneficial to complete cyst wall of formation and capsule space, helps covering the disagreeable taste of medicine.
Embodiment 1: the preparation of the tasteless microcapsule of pipemidic acid
Get acrylic resin and respectively be the 3-5 gram, place 200 ml containers, add 50 milliliters of dehydrated alcohol, be dipped to resin swelling after, heating in water bath, make its dissolving, add pipemidic acid fine powder (particle diameter≤60 micron) 3-5 gram again, make it mixing after, add 1 gram Pulvis Talci, add dehydrated alcohol to 100 milliliter, spray drying in spray dryer.Inlet temperature is 90 ℃, and outlet temperature is 60 ℃, and charging rate is 5 ml/min, and sprinkler pressure is 0.2 kilograms per centimeter
2, separate to such an extent that cross 120 mesh sieves promptly behind the microcapsule in cyclone separator.
The above-mentioned microcapsule that makes stripping quantity in distilled water all was less than 20% in 20 minutes.
Embodiment 2: the preparation of the tasteless microcapsule of nitrofurantoin
Get Eudragit E 100 3-5 gram, place 200 ml containers, add 50 milliliters of dehydrated alcohol, make its swelling.Heating in water bath make molten after, add nitrofurantoin fine powder (particle diameter≤60 micron) 3-5 gram respectively, behind the mixing, add 1 gram Pulvis Talci, add dehydrated alcohol to 100 milliliter again.Above-mentioned suspension carries out spray drying.Inlet temperature is 150 ℃, and outlet temperature is 90 ℃, and charging rate is 15 ml/min, and sprinkler pressure is 0.2 kilograms per centimeter
2, in cyclone separator, separate to such an extent that cross 120 mesh sieves promptly behind the microcapsule.
The above-mentioned microcapsule that makes is less than 15% in distilled water Chinese medicine stripping quantity in 20 minutes.
Embodiment 3: the preparation of the tasteless microcapsule of sulfadiazine (SD)
Get Eudragit E 100 3 grams, put in 200 ml containers, add 50 milliliters of dehydrated alcohol, make dissolubility after, add SD fine powder (particle diameter≤30 micron) 5 grams, add Pulvis Talci 2 grams, jolting, make mix homogeneously after, add dehydrated alcohol to 100 milliliter, after becoming suspension, in the spray dryer spray drying.90 ℃ of inlet temperatures, outlet temperature are 60 ℃, charging rate 5 ml/min, sprinkler pressure 0.5 kilograms per centimeter
2In cyclone separator, collect and obtain microcapsule, cross 120 mesh sieves promptly.
Above-mentioned prepared microcapsule was less than 20% in 20 minutes in distilled water Chinese medicine stripping quantity.
Embodiment 4: the preparation of the tasteless microcapsule of trimethoprim (TMP)
Get propanoic acid resin E100 3 gram, put in 200 ml containers, add 50 milliliters of dehydrated alcohol, make dissolving after, add TMP fine powder 5 grams (particle diameter≤30 micron), Pulvis Talci 1 gram, jolting, make mix homogeneously, add dehydrated alcohol to 100 milliliter, spray drying in spray dryer.Inlet temperature is 150 ℃, and outlet temperature is 90 ℃, and sprinkler pressure is 0.5 kilograms per centimeter
2, charging rate 15 ml/min are collected to such an extent that microcapsule is crossed 120 mesh sieves promptly in cyclone separator.
Above-mentioned microcapsule is in distilled water, and the stripping quantity of medicine was less than 20% in 20 minutes.
Claims (1)
1, a kind of drying process with atomizing for preparing tasteless micro capsule for medicine, this technology comprises that with gastric solubility macromolecular material Eudragit E 100 be the capsule material, make capsule material solution with the organic solvent dehydrated alcohol as solvent, be that fine drug powder and an amount of additives Pulvis Talci below 30 microns or 30 microns evenly is suspended in the capsule material solution then with particle diameter, spray-dried machine spray drying, make its inlet temperature be controlled at 90-150 ℃, outlet temperature is 60-90 ℃, charging rate is the 5-15 ml/min, sprinkler pressure is the 0.2-0.5 kg/cm, after cyclone separator is collected microcapsule, cross 120 mesh sieves and promptly get tasteless microcapsule goods, raw materials used component is respectively: high score ascus material Eudragit E 100 is 3%-5% (W/V) in the suspension, and fine drug powder 3%-5% (W/V), additives Pulvis Talci are 1%-2%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90105089 CN1023766C (en) | 1990-04-09 | 1990-04-09 | Spraying desiccation process for producing tasteless micro capsule for medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90105089 CN1023766C (en) | 1990-04-09 | 1990-04-09 | Spraying desiccation process for producing tasteless micro capsule for medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1055484A CN1055484A (en) | 1991-10-23 |
| CN1023766C true CN1023766C (en) | 1994-02-16 |
Family
ID=4878923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90105089 Expired - Fee Related CN1023766C (en) | 1990-04-09 | 1990-04-09 | Spraying desiccation process for producing tasteless micro capsule for medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1023766C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1878539B (en) * | 2003-12-15 | 2010-06-23 | 科学与工业研究委员会 | Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100462083C (en) * | 2006-05-12 | 2009-02-18 | 上海中医药大学 | Method for relieving bitter taste in compound Chinese medicine |
| CN100500127C (en) * | 2006-08-04 | 2009-06-17 | 苏州科牧动物药品有限公司 | Compound sulfanilamide suspension and preparation method thereof |
| CN102228440B (en) * | 2011-06-22 | 2013-05-22 | 武汉回盛生物科技有限公司 | Method for preparing hydrophilic drug microsphere through spray drying process |
-
1990
- 1990-04-09 CN CN 90105089 patent/CN1023766C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1878539B (en) * | 2003-12-15 | 2010-06-23 | 科学与工业研究委员会 | Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1055484A (en) | 1991-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 19940216 |