CN102372624A - Method for extracting sodium gulonate from sodium gulonate fermented liquid - Google Patents
Method for extracting sodium gulonate from sodium gulonate fermented liquid Download PDFInfo
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Abstract
The invention provides a method for extracting sodium gulonate from sodium gulonate fermented liquid, which comprises the following steps that: the sodium gulonate fermented liquid is firstly centrifugally treated at a high speed, then clear liquid after the high-speed centrifugal treatment is processed by a ultra-filtration system, and the slag liquid after the high-speed centrifugal treatment is re-filtered by a ceramic membrane system. The method adopts different membranes to process the clear liquid and the slag liquid of the sodium gulonate fermented liquid after being centrifuged at the high speed, so on the one hand the abrasion of the high-concentration liquid on the ultra-filtration membrane can be greatly reduce, and the weakness of the original production process that the service life is short by only utilizing the ultra-filtration membrane can be solved; on the other hand, a single-batch processing time of the sodium gulonate fermented liquid is reduced, and the production efficiency is improved; and the ceramic membrane is used for substituting an original flocculation-precipitation process to process the slag liquid after the centrifugal separation and to process the slag after the ultra-filtration, no medicine is added, and the separated slag can be used for processing feed or organic fertilizer, so the economic benefit can be increased, and the pollutant emission can be reduced.
Description
Technical field
The invention belongs to the Progresses of Vitamin C Productive Technology field, the process for extracting of sodium colombate in particularly a kind of sodium colombate fermented liquid.
Background technology
Vitamins C has another name called xitix, is the acid polyol with six carbon atom.Vitamins C is not only closely related with the growth of animal, and its immunizing power, disease resistance and anti allergic reaction are all had vital role.Main as the livestock and poultry animal fodder additives in Animal nutrition research.
About 90% of world's vitamins C output concentrate on China at present; The technical process of production of vitamin C mainly is divided into fermentation, extraction, conversion, refining four big steps; Production of vitamin C raw material sorbyl alcohol produces sodium colombate through fermentation using bacteria; Sodium colombate is converted into crude vitamin C again after extracting, concentrating, crude vitamin C becomes the finished product vitamins C after refining.
At present, the topmost mode of production of domestic vitamins C is a two-step fermenting.The process that the two stage fermentation synthesis method is produced the vitamins C experiment can be divided into fermentation, extracts and transform three big steps.Fermentation: the-step of two-step fermenting is with false monospore bacillus sorbyl alcohol to be changed into the L-sorbose.In addition, bacteriums such as weak oxidized acetic acid bacteria, living Black Grape saccharic acid bacillus, stench bacillus aceticus, acetic acid bacillus aceticus, plan glue bacillus also have this transformation function.Second step of fermentation is adopted composting fermentation, promptly uses bacillus megaterium and oxidizing glucose acidfast bacilli mixed culture, and the L-sorbose is converted into sodium colombate, and wherein big bacterium is a concomitance bacterium, and little bacterium is an acid-producing bacteria.In addition, find in the production practice of vitamins C experiment two-step fermenting that the concomitance bacterium that can make up as the acid-producing bacteria of oxidizing glucose acidfast bacilli also has striped pseudomonas, bacillus cereus and bacillus macerans etc.Extract: the extraction process of fermented liquid is the problem of outbalance in the vitamins C experiment production industry.Extraction is the ancient dragon acid of precursor 2-ketone group-L-(hereinafter to be referred as ancient dragon acid) that obtains the vitamins C experiment through means such as separation, IXs.Through Secondary Fermentation, the sour sodium content of fermented liquid dragon in the middle ancient times is merely 6% ~ 9%, and impurity such as residual mycelium, protein and suspended particulates, separates difficulty of purification ratio, and the ratio that the expense of aftertreatment accounts for total cost is very big.
Transform: be converted into vitamins C by the imperial acid of Gu, have acid to transform and two kinds of methods of alkali conversion.
In the production of vitamin C flow process, owing to adopt fermentation using bacteria, protein-colloid and opsonigenous substances and a difficult problem that is extraction workshop section separating of sodium colombate feed liquid in the fermented liquid.The extraction method of using in the production mainly contains thermal precipitation method, chemical coagulation method and ultrafiltration and extracts 3 kinds.Heating can make sodium colombate partly degrade influences yield; Flocculation needs in fermented liquid, to add two kinds of flocculation agents, and price is more expensive, has increased production cost, runs into serious microbiological contamination lot number, and flocculating effect is very poor, simultaneously owing to need in the flocculation process to add flocculation agent, thereby the separating material slag can't be utilized again, has increased discharge amount of pollution.Ultrafiltration extract have no phase transformation, energy-conservation, easy and simple to handle, do not cause new advantages such as environmental pollution, obtain widespread use aborning, but the ultrafiltration extraction exists diaphragm work-ing life is short, replacement charge is high, the film cleaning charge is with problems such as height at present.
At " use ultra-filtration technique and improve the Vc production technique " (author: Zhang Linmao, Gao Yongtao, Li Jing; Membrane science and technology; The 20th the 5th phase of volume) in a kind of improvement technology has been proposed; The ancient dragon acid of sodium colombate fermented liquid → pre-treatment → membrane sepn → resin desalination → condensing crystal → 2-ketone-L-, this process using ultra-filtration technique is removed protein and colloid in the fermented liquid.Ultra-filtration membrane; Be that a kind of aperture specification is consistent, specified pore diameter range is the micropore filtering film of 0.001-0.02 micron, imposes suitable pressure in a side of film; Just can sift out solute molecule less than the aperture, with the isolated molecule amount greater than 500 dalton, particle diameter particle greater than 2～20 nanometers.But since ultra-filtration membrane diaphragm work-ing life is short when using, replacement charge is high, the film cleaning charge is with high, and the filter residue behind the ultra-filtration filters also contains a certain amount of sodium colombate.At present slag liquid is generally taked the method for flocculating, relatively poor and unstable but this part slag liquid adopts flocculation to exist treatment effect, problems such as the serious and production cost height of pollutant emission.Therefore need provide that a kind of long service life, working cost are low, the process for extracting of environmental protection.
Summary of the invention
The process for extracting of sodium colombate in a kind of sodium colombate fermented liquid that the objective of the invention is to propose to the problems referred to above.This process for extracting carries out high speed centrifugation to the sodium colombate fermented liquid earlier to be separated; Take different films to separate to clear liquid and slag liquid then, solved simple employing ultra-filtration membrane work-ing life short, replacement charge is high and adopt that flocculation treatment effect is relatively poor and unstable, pollutant emission is serious and defective such as production cost height.
To achieve these goals, technical scheme of the present invention is:
The process for extracting of sodium colombate in a kind of sodium colombate fermented liquid; Earlier the sodium colombate fermented liquid being carried out high speed centrifugation handles; The clear liquid that obtains after then high speed centrifugation being handled adopts ultrafiltration system to handle, and adopts the ceramic membrane system to carry out filtration treatment once more to the slag liquid that obtains after the high speed centrifugation processing.
The ultra-filtration membrane filter residue that described clear liquid obtains after uf processing adopts the ceramic membrane system to carry out filtration treatment once more.
The technology of the filtration treatment of described employing ceramic membrane system may further comprise the steps:
(1) the slag liquid and the ultra-filtration membrane filter residue that obtain after the high speed centrifugation processing are transported to prefilter, carry out pre-filtering and handle, obtain pre-filtering liquid, incoming stock jar of described pre-filtering liquid;
(2) the pre-filtering liquid in the head tank is squeezed in the first step ceramic membrane system through charging pump; Carrying out thickening filtration handles; Obtain first step filtrating and first step liquid concentrator, first step filtrating gets into next step ion exchange treatment, and first step liquid concentrator gets in the secondary ceramic membrane system;
(3) first liquid concentrator is carried out dialysis treatment, obtain second stage filtrating, second stage filtrating gets into next step ion exchange treatment; Described dialysis treatment adds pure water through feeding line, when effective constituent in the concentrated residue during less than certain numerical value, stops to add pure water, shuts down;
(4) raffinate of emptying prefilter, head tank and ceramic membrane system is washed film and is handled, and washes and repeats above-mentioned steps after film is accomplished.
Pre-filtering liquid was concentrated into 3-5 doubly during described thickening filtration was handled.
Pre-filtering liquid was concentrated into 4 times during thickening filtration was handled.
The described film of washing is handled and to be comprised the cleaning of ceramic membrane systemic circulation side and the cleaning of ceramic membrane system per-meate side, describedly washes film to handle the device of employing be purge tank and scavenging pump.
Described ceramic membrane is an inorganic ceramic film, and described inorganic ceramic film is the microporous film layers that applies the densification of 4 ~ 6 micron thick in wide-aperture supporting body surface.
The aperture of described ultra-filtration membrane is 10 nanometers, and the aperture of described ceramic membrane is 50 nanometers.
The invention has the beneficial effects as follows:
(1) clear liquid of the sodium colombate fermented liquid of process for extracting of the present invention after to high-speed separation adopts different films to handle with slag liquid; Greatly reduce of the wearing and tearing of high density feed liquid on the one hand, solved the defective that work-ing life is short, replacement charge is high when using ultra-filtration membrane merely in original production technique ultra-filtration membrane; Reduce single batch processing time of sodium colombate fermented liquid on the other hand, improved production efficiency;
(2) slag liquid after adopting ceramic membrane to spinning and the filter residue after the ultrafiltration are handled once more, and separation accuracy is high, can increase substantially product yield, reduces loss of material;
(3) because sepn process need not to add auxiliary agent, the filter residue after therefore handling through ceramic membrane is pollution-free, can directly be used to process feed or organic fertilizer, realizes resource circulation utilization, increases income;
(4) adopt process for extracting of the present invention, wastewater discharge reduces greatly, and COD significantly reduces in the waste water, alleviates the pressure of follow-up WWT;
(5) adopt process for extracting of the present invention, equipment drops into low, and working cost is low.
Below in conjunction with accompanying drawing and embodiment the present invention is made a detailed description.
Description of drawings
Fig. 1 is the synoptic diagram of extraction process of the present invention.
Fig. 2 is the material balance figure of the embodiment of the invention 5.
Embodiment
Embodiment 1
Referring to Fig. 1; The process for extracting of sodium colombate in a kind of sodium colombate fermented liquid; Earlier the sodium colombate fermented liquid being carried out high speed centrifugation handles; Clear liquid after then high speed centrifugation being handled adopts ultrafiltration system to carry out filtration treatment, and adopts the ceramic membrane system to carry out filtration treatment once more to the slag liquid that obtains after the high speed centrifugation processing.
What the present invention proposed is the process for extracting of sodium colombate in a kind of sodium colombate fermented liquid; Earlier sodium colombate fermented liquid 1 being carried out high speed centrifugation 2 handles; Clear liquid after then high speed centrifugation being handled adopts ultra-filtration membrane 3 to carry out uf processing; Ultra-filtration membrane filtrating after the uf processing is sodium colombate solution, be collected into the ion exchange treatment usefulness of sodium colombate solution storage tank 4 in order to next step, and the residue of uf processing is the ultra-filtration membrane filter residue; Adopt ceramic membrane to carry out filtration treatment once more to the slag liquid after the high speed centrifugation processing; Ceramic membrane filtrating after the filtration treatment is sodium colombate solution, also is collected into sodium colombate solution storage tank, carries out follow-up ion exchange treatment with the sodium colombate solution merging after the uf processing; Residue after ceramic membrane filter is handled is the ceramic membrane filter residue; Because the ceramic membrane filter residue contains a large amount of protein, and does not have any chemical substance of interpolation in the filtration treatment, can directly be used to process feed or fertilizer.
The sodium colombate fermented liquid is after the high speed centrifugation art breading, and clear liquid is comparatively transparent, and contained solid content is lower, adopts ultra-filtration membrane to handle; And the lower floor's slag liquid solid content after the high speed centrifugation processing is higher, if adopt ultra-filtration membrane to filter, ultra-filtration membrane is easy to result in blockage, and can increase the wash number of ultra-filtration membrane, therefore causes the PT to increase, ultra-filtration membrane shortening in work-ing life; And ceramic membrane is high temperature resistant, chemicalstability is good, the antimicrobial degraded of ability; For organic solvent, etchant gas and microbial attack performance satisfactory stability property; Physical strength is high, high pressure resistant, and good wear-resisting, abrasion resistance ability are arranged; Pore size distribution is narrow, and separation performance is good, and infiltration capacity is big, repeatedly cleaning and regeneration.But the cost of ceramic membrane is higher, so the present invention adopts ultra-filtration membrane and ceramic membrane bonded process for extracting, adopts ultra-filtration membrane that clear liquid is handled, and adopts ceramic membrane that slag liquid is handled, and can collect the effective constituent in the filter residue to greatest extent, improves the yield of product.The sodium colombate solution clear that obtains through extraction process of the present invention reaches more than 99% the rejection of thalline, and can directly be used to process feed or organic fertilizer through the filter residue behind the ceramic membrane filter; The extraction yield that sodium colombate in the sodium fermented liquid liquid is dissolved in imperial acid to Gu simultaneously is higher than the technology that only adopts ultrafiltration membrance filter up to 99%.
The filter residue of traditional sodium colombate fermented liquid is handled and is generally taked the method for flocculating, and flocculation needs in fermented liquid, to add two kinds of flocculation agents, and price is more expensive; Increased production cost; Run into serious microbiological contamination lot number, flocculating effect is very poor, simultaneously owing to need to add flocculation agent in the flocculation process; Thereby the separating material slag can't be utilized again, increased discharge amount of pollution.
Adopt that impurity such as albumen, starch, polysaccharide reduces with respect to traditional technology content in the sodium colombate fermented liquid that process for extracting of the present invention obtains; Greatly reduce the pollution burden of follow-up ion exchange resin, vaporizer; The protein emulsifying phenomenon that produces in the time of can reducing simultaneously the solvent extraction; Improve quality product, shortened the PT.
The comparing result that table 1 adopts different process to handle for sodium colombate fermentation melt cinder liquid:
| Technology | Yield % | Transmittance % |
| Flocculation | 72.2 | 48 |
| Ceramic membrane | 94.56 | 70 |
The technology that adopts ceramic membrane to handle slag liquid is compared with former flocculation process, and yield improves 23.64%, and transmittance improves 31.5%.Yield in the table 1 is the yield that sodium colombate contained in the slag liquid is extracted.On behalf of high speed centrifugation slag liquid, the transmittance in the table 1 handle the transmittance of the sodium colombate solution that is reclaimed the back, and transmittance is high more, represents filter effect good more, and the protein contnt in the solution is low more.
The comparing result that table 2 adopts different process to handle for the sodium colombate fermented liquid:
| Technology | Yield % | Transmittance % |
| Ultrafiltration+flocculation | 92.34 | 51 |
| Ultra-filtration membrane | 90 | 73 |
| Ceramic membrane | 97.21 | 63 |
| Ultrafiltration+ceramic membrane | 98.42 | 72 |
Table 2 adopts the comparative result of the resulting sodium colombate solution of different processes for the sodium colombate fermented liquid.Yield in the table 2 is the yield that sodium colombate contained in the sodium colombate fermented liquid is extracted.On behalf of slag liquid, the transmittance in the table 2 handle the transmittance of the sodium colombate solution that is reclaimed the back, and transmittance is high more, represents filter effect good more, and the protein contnt in the solution is low more.The yield of analyzing the treatment process can obtain adopting ultrafiltration+ceramic membrane through table 2 is higher than the yield of the recovery technology of employing ultrafiltration+flocculation, and treatment effect is superior to adopting merely the treatment process (according to transmittance) of ceramic membrane.
Embodiment 2
Present embodiment is the improvement of on the basis of embodiment 1, carrying out; The part identical in the present embodiment with embodiment 1; Please understand with reference to disclosed content among the embodiment 1, embodiment 1 disclosed content should not be repeated in this description as the content of present embodiment here yet.
Referring to Fig. 1, the process for extracting of embodiment 1 comprises that also the ultra-filtration membrane filter residue that clear liquid is obtained adopts the ceramic membrane system to carry out filtration treatment once more after uf processing.Because the aperture of ultra-filtration membrane is generally the 1-20 nanometer; Therefore the filter residue behind ultrafiltration membrance filter possibly contain a spot of sodium colombate; The present invention also adopts the ceramic membrane system to carry out filtration treatment once more with the slag liquid of centrifugal treating this part ultra-filtration membrane filter residue; Can reclaim sodium colombate contained in the ultra-filtration membrane filter residue, further improve yield, and need not increase any equipment.The filter residue that just obtains after the uf processing adopts the ceramic membrane system to carry out once more that the yield of sodium colombate can reach more than 99.3% after the filtration treatment, has further improved yield, and need not increase any facility investment.
Embodiment 3
Present embodiment is the improvement of on the basis of embodiment 1, carrying out; The part identical in the present embodiment with embodiment 1; Please understand with reference to disclosed content among the embodiment 1, embodiment 1 disclosed content should not be repeated in this description as the content of present embodiment here yet.
Referring to Fig. 1, the technology of the filtration treatment of the employing ceramic membrane system described in the embodiment 1 may further comprise the steps:
(1) the slag liquid and the ultra-filtration membrane filter residue that obtain after the high speed centrifugation processing are transported to prefilter 5, carry out pre-filtering and handle, remove particulate state contained in the slag liquid, fibrous impurity etc., obtain pre-filtering liquid, incoming stock jar 6 of described pre-filtering liquid;
(2) the pre-filtering liquid in the head tank is squeezed in the first step ceramic membrane system 7 through charging pump; Carrying out thickening filtration handles; Obtain first step filtrating and first step liquid concentrator; First step filtrating gets into next step ion exchange treatment, is collected into sodium colombate solution storage tank, and first step liquid concentrator gets in the secondary ceramic membrane system 8;
(3) first step liquid concentrator is carried out dialysis treatment, obtain second stage filtrating and ceramic membrane residue, second stage filtrating gets into next step ion exchange treatment, is collected into sodium colombate solution storage tank; The ceramic membrane residue can reclaim as feed or organic fertilizer; Described dialysis treatment adds pure water through feeding line, when effective constituent in the concentrated residue during less than certain numerical value, stops to add pure water, shuts down; Described filtrating is sodium colombate solution;
(4) raffinate of emptying prefilter, head tank and ceramic membrane system is washed film and is handled, and washes and repeats above-mentioned steps after film is accomplished.
The concrete parameter of ceramic membrane for example ceramic membrane area etc. is confirmed according to concrete processing condition.
With 120 cubic metres of every days of treatment capacity be example, 60 liters every square metre of design average filtration flux per hour, about 150 square metres of the required membrane area of ceramic membrane system.The ceramic membrane system adopts commercially available ceramic membrane in the present embodiment.
Embodiment 4
Present embodiment is the improvement of on the basis of embodiment 3, carrying out; The part identical in the present embodiment with embodiment 3; Please understand with reference to disclosed content among the embodiment 3, embodiment 3 disclosed contents should not be repeated in this description as the content of present embodiment here yet.
In the embodiment 3 described treatment steps (2), pre-filtering liquid was concentrated into 3-5 doubly during thickening filtration was handled.
Embodiment 5
Present embodiment is the improvement of on the basis of embodiment 4, carrying out; The part identical in the present embodiment with embodiment 4; Please understand with reference to disclosed content among the embodiment 4, embodiment 4 disclosed contents should not be repeated in this description as the content of present embodiment here yet.
In the embodiment 3 described treatment steps (2), pre-filtering liquid was concentrated into 4 times during thickening filtration was handled.
When pre-filtering liquid is concentrated into 3 times; The extraction yield of sodium colombate fermentation melt cinder liquid is low, and when being concentrated into 5 times, the PT is long; And cycles of concentration be 4 o'clock extraction yield up to 99%, the economic worth of considering remaining sodium colombate from the angle of economy is compared with working cost does not have the meaning extracted.
With pre-filtering liquid 120 m
3/ d (cubic meter/sky) is an example, and the material balance figure of the technology of the filtration treatment of described employing ceramic membrane is referring to Fig. 2.
Pre-filtering liquid in the head tank is 120 m
3/ d squeezes in the first step ceramic membrane system through charging pump, carries out thickening filtration and handles, and concentrates 4 times, obtains the first step 90 m that filtrate
3/ d and first step liquid concentrator 30 m
3/ d, first step filtrating gets into next step ion exchange treatment, and first step liquid concentrator gets in the secondary ceramic membrane system; First step liquid concentrator is carried out dialysis treatment, add pure water 90 m
3/ d obtains the second stage 90 m that filtrate
3/ d and ceramic membrane residue 30 m
3/ d, second stage filtrating gets into next step ion exchange treatment; The total liquid that obtains at last is 180 m
3/ d.
Therefore the required membrane area of ceramic membrane system is approximately: 180 ÷, 20 ÷ 0.06=150.0 (square metre).
Embodiment 6
Present embodiment is the improvement of on the basis of embodiment 3, carrying out; The part identical in the present embodiment with embodiment 3; Please understand with reference to disclosed content among the embodiment 3, embodiment 3 disclosed contents should not be repeated in this description as the content of present embodiment here yet.
The described film of washing is handled and to be comprised the cleaning of ceramic membrane systemic circulation side and the cleaning of ceramic membrane system per-meate side, describedly washes film to handle the device of employing be purge tank and scavenging pump.The clean-out system that adopts is conventional ceramic membrane cleaning agent.Film in the present embodiment cleans and adopts automatic control system to control.
Ceramic membrane has excellent chemicalstability and high physical strength, so the ceramic membrane cleaning can be adopted any chemical reagent.In the present embodiment, adopting mass concentration is that 1 ~ 2% common acid alkaline cleaner gets final product, and so can save cleaning charge and use.
Embodiment 6
Present embodiment is the improvement of on the basis of embodiment 1, carrying out; The part identical in the present embodiment with embodiment 1; Please understand with reference to disclosed content among the embodiment 1, embodiment 1 disclosed content should not be repeated in this description as the content of present embodiment here yet.
Described ceramic membrane is an inorganic ceramic film, and described inorganic ceramic film is the microporous film layers that applies the densification of 4 ~ 6 micron thick in wide-aperture supporting body surface.
Embodiment 7
Present embodiment is the improvement of on the basis of embodiment 1, carrying out; The part identical in the present embodiment with embodiment 1; Please understand with reference to disclosed content among the embodiment 1, embodiment 1 disclosed content should not be repeated in this description as the content of present embodiment here yet.
In the present embodiment, the aperture of described ultra-filtration membrane is 10 nanometers, can molecular weight cut-off greater than 100,000 solute molecule, the aperture of described ceramic membrane is 50 nanometers, can molecular weight cut-off greater than 500,000 solute molecule.
Claims (8)
1. the process for extracting of sodium colombate in the sodium colombate fermented liquid; It is characterized in that: earlier the sodium colombate fermented liquid is carried out high speed centrifugation and handle; The clear liquid that obtains after then high speed centrifugation being handled adopts ultrafiltration system to handle, and adopts the ceramic membrane system to carry out filtration treatment once more to the slag liquid that obtains after the high speed centrifugation processing.
2. process for extracting according to claim 1 is characterized in that the ultra-filtration membrane filter residue that described clear liquid obtains adopts the ceramic membrane system to carry out filtration treatment once more after uf processing.
3. process for extracting according to claim 1 and 2 is characterized in that: the technology of the filtration treatment of described employing ceramic membrane system may further comprise the steps:
(1) the slag liquid and the ultra-filtration membrane filter residue that obtain after the high speed centrifugation processing are transported to prefilter, carry out pre-filtering and handle, obtain pre-filtering liquid, incoming stock jar of described pre-filtering liquid;
(2) the pre-filtering liquid in the head tank is squeezed in the first step ceramic membrane system through charging pump; Carrying out thickening filtration handles; Obtain first step filtrating and first step liquid concentrator, first step filtrating gets into next step ion exchange treatment, and first step liquid concentrator gets in the secondary ceramic membrane system;
(3) first step liquid concentrator is carried out dialysis treatment, obtain second stage filtrating, second stage filtrating gets into next step ion exchange treatment; Described dialysis treatment adds pure water through feeding line, when effective constituent in the concentrated residue during less than certain numerical value, stops to add pure water, shuts down;
(4) raffinate of emptying prefilter, head tank and ceramic membrane system is washed film and is handled, and washes and repeats above-mentioned steps after film is accomplished.
4. process for extracting according to claim 3 is characterized in that: pre-filtering liquid was concentrated into 3-5 doubly during described thickening filtration was handled.
5. process for extracting according to claim 4 is characterized in that: pre-filtering liquid was concentrated into 4 times during thickening filtration was handled.
6. process for extracting according to claim 3 is characterized in that: the described film of washing is handled and to be comprised the cleaning of ceramic membrane systemic circulation side and the cleaning of ceramic membrane system per-meate side, describedly washes film to handle the device of employing be purge tank and scavenging pump.
7. process for extracting according to claim 1 is characterized in that described ceramic membrane is an inorganic ceramic film, and described inorganic ceramic film is the microporous film layers that applies the densification of 4 ~ 6 micron thick in wide-aperture supporting body surface.
8. process for extracting according to claim 1, the aperture that it is characterized in that described ultra-filtration membrane is 10 nanometers, the aperture of described ceramic membrane is 50 nanometers.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383813A (en) * | 2014-11-04 | 2015-03-04 | 江苏江山制药有限公司 | Comprehensive treatment method for gulonic acid fermentation broth |
| CN109851491A (en) * | 2019-04-16 | 2019-06-07 | 同舟纵横（厦门）流体技术有限公司 | A kind of method and device of gulonate feed liquid decoloration removal of impurities |
| CN114262267A (en) * | 2021-12-29 | 2022-04-01 | 上海科琅膜科技有限公司 | Method for treating gulonic acid mash |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383813A (en) * | 2014-11-04 | 2015-03-04 | 江苏江山制药有限公司 | Comprehensive treatment method for gulonic acid fermentation broth |
| WO2016070775A1 (en) * | 2014-11-04 | 2016-05-12 | Dsm Jiangshan Pharmaceutical (Jiangsu) Co., Ltd. | A comprehensive treatment method for gulonic acid fermentation broth |
| CN109851491A (en) * | 2019-04-16 | 2019-06-07 | 同舟纵横（厦门）流体技术有限公司 | A kind of method and device of gulonate feed liquid decoloration removal of impurities |
| CN114262267A (en) * | 2021-12-29 | 2022-04-01 | 上海科琅膜科技有限公司 | Method for treating gulonic acid mash |
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