CN102351688A - Preparation method of high soluble crystal calcium citrate - Google Patents
Preparation method of high soluble crystal calcium citrate Download PDFInfo
- Publication number
- CN102351688A CN102351688A CN2011102336494A CN201110233649A CN102351688A CN 102351688 A CN102351688 A CN 102351688A CN 2011102336494 A CN2011102336494 A CN 2011102336494A CN 201110233649 A CN201110233649 A CN 201110233649A CN 102351688 A CN102351688 A CN 102351688A
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- China
- Prior art keywords
- calcium citrate
- calcium
- high soluble
- soluble crystal
- citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention relates to a preparation method of high soluble crystal calcium citrate in the fields of biochemical engineering, medicine and food. The technical scheme of the method comprises the following steps: (1) mixing citric acid, calcium carbonate and water, serving as raw materials, in a ratio of 3.84:3:1; (2) placing the mixture in a reaction tank at 20-50 DEG C after mixing, starting a machine to perform a chemical reaction for 50-60 minutes; (3) stopping the machine for 25-35 minutes to perform a chemical reaction for maturing; (4) starting the machine for 25-35 minutes to discharge high soluble crystal calcium citrate under the crystallization temperature; and (5) filtering, drying and packaging to obtain the finished product. The invention has the following beneficial effects: the molecular formula of the synthesized high soluble crystal calcium citrate is Ca3H3 (C6H5O7)2(HCO3)3, the solubility is 98%, the high solution type calcium citrate is soluble calcium and can be used to supplement calcium and cure osteoporosis and osteomalacia, human and animals can absorb the high soluble crystal calcium citrate easily; and the calcium citrate injection and calcium citrate oral liquid can also be used, and the use of the high soluble crystal calcium citrate is not limited by insoluble calcium citrate.
Description
Technical field
The present invention relates to the preparation method of a kind of high molten crystal formation citrate of lime in biochemical industry medicine food field.
Background technology
On the current biochemical industry medicine food market both at home and abroad, mostly the medicinal component of replenishing the calcium, control osteoporosis, richets commonly used is four water citric acid calcium, English name: Calcium citrate tetrahydrate, molecular formula: C12H10Ca3O144H
2The O molecular weight: 570.52, calcium content 21.08% because of it is insoluble in water, has only the meltage of 0.095g/100ml under 25 ℃, and humans and animals is difficult for absorbing, and use is restricted.
Summary of the invention
The object of the invention is exactly the deficiency that exists to prior art, and the height that provides a kind of solubleness height and humans and animals to be prone to absorb dissolves the preparation method of crystal formation citrate of lime.
Technical scheme:Form by following steps:
(1) raw material and proportioning: Hydrocerol A, lime carbonate and water 3.84:3:1 ratio mixing:
(2) behind the mixing, put into the reaction kettle that temperature is the 20-50 degree, start chemical reaction 50-60 minute:
(3) shut down 25-35 minute, chemical reaction is ripe;
(4) start is 25-35 minute, and the height of emitting under the Tc dissolves the crystal formation citrate of lime;
(5) filter, dry the back packaging final prod.
Beneficial effect:High crystal formation citrate of lime, the molecular formula: Ca of dissolving of synthetic
3H
3(C
6H
5O
7)
2(HCO
3)
3Molecular weight: 684.52 white crystalline powder, contain Hydrocerol A 68.46%, contain crystal water 9.77%,
Calcium contents 17.5%,Solubleness 98%; Hydrochloric acid insoluble substance 0.1%, weight loss on drying 3.0%, plumbous 0.0005%; Heavy metal 0.002%; Arsenic 0.0003%, fluorochemical 0.003% is a soluble calcium; Replenish the calcium and control the osteoporosis richets; Humans and animals is prone to absorb, and available citrate of lime injection and citrate of lime oral liquid, uses and does not receive the restriction of indissoluble citrate of lime.
Embodiment
Embodiment:
WillHydrocerol A, lime carbonate and water are in 3.84:3:1 ratio mixing; Behind the mixing, putting into temperature is the reaction kettle of 30 degree, start chemical reaction 55 minutes; Shut down 30 minutes, chemical reaction is ripe; Started shooting 30 minutes, the height of emitting under the Tc dissolves the crystal formation citrate of lime; Filter, dry the back packaging final prod.
Its chemical equation: 3CaCO
3+ 2C
6H
8O
7→ Ca
3H
3(C
6H
5O
7) 2 (HCO
3)
3
In conjunction with national standard and company standard, detected result is through detection department of this enterprise:
Claims (1)
1. the high preparation method that dissolves the crystal formation citrate of lime is characterized in that: be made up of following steps:
(1) raw material and proportioning: Hydrocerol A, lime carbonate and water are in the ratio mixing of 3.84:3:1:
(2) behind the mixing, put into the reaction kettle that temperature is the 20-50 degree, start chemical reaction 50-60 minute:
(3) shut down 25-35 minute, chemical reaction is ripe;
(4) start is 25-35 minute, and the height of emitting under the Tc dissolves the crystal formation citrate of lime;
(5) filter, dry the back packaging final prod.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102336494A CN102351688A (en) | 2011-08-16 | 2011-08-16 | Preparation method of high soluble crystal calcium citrate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102336494A CN102351688A (en) | 2011-08-16 | 2011-08-16 | Preparation method of high soluble crystal calcium citrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102351688A true CN102351688A (en) | 2012-02-15 |
Family
ID=45575363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102336494A Pending CN102351688A (en) | 2011-08-16 | 2011-08-16 | Preparation method of high soluble crystal calcium citrate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102351688A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110437057A (en) * | 2019-08-20 | 2019-11-12 | 长江大学 | A kind of synthetic method of caprylic acid calcium |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1680258A (en) * | 2004-02-18 | 2005-10-12 | 卡夫食品集团公司 | Amorphous water-soluble calcium citrate salts and method of making and using same |
| CN101348431A (en) * | 2007-07-20 | 2009-01-21 | 南通市飞宇精细化学品有限公司 | Method for producing low lead light density granular calcium citrate |
-
2011
- 2011-08-16 CN CN2011102336494A patent/CN102351688A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1680258A (en) * | 2004-02-18 | 2005-10-12 | 卡夫食品集团公司 | Amorphous water-soluble calcium citrate salts and method of making and using same |
| CN101348431A (en) * | 2007-07-20 | 2009-01-21 | 南通市飞宇精细化学品有限公司 | Method for producing low lead light density granular calcium citrate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110437057A (en) * | 2019-08-20 | 2019-11-12 | 长江大学 | A kind of synthetic method of caprylic acid calcium |
| CN110437057B (en) * | 2019-08-20 | 2022-04-05 | 长江大学 | Synthesis method of calcium n-octoate |
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Legal Events
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120215 |
|
| WD01 | Invention patent application deemed withdrawn after publication |