CN102347199B - Fine adjustment mechanism of extension elongation of metal capillary tube in ESI (electronic spray ionization) source mass spectrum - Google Patents
Fine adjustment mechanism of extension elongation of metal capillary tube in ESI (electronic spray ionization) source mass spectrum Download PDFInfo
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- CN102347199B CN102347199B CN201010244097.2A CN201010244097A CN102347199B CN 102347199 B CN102347199 B CN 102347199B CN 201010244097 A CN201010244097 A CN 201010244097A CN 102347199 B CN102347199 B CN 102347199B
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Abstract
The invention discloses a fine adjustment mechanism of extension elongation of a metal capillary tube in an ESI (electronic spray ionization) source mass spectrum. The fine adjustment mechanism comprises a frame and the metal capillary tube, wherein a knob seat is fixed at the other end of the frame; one side of the knob seat is provided with a second capillary tube penetration piece; an adjusting rod is installed at the other side of the knob seat; and one end of the adjusting rod is connected with a high-pressure connection piece through a pin. The mechanism disclosed by the invention is used for the fine adjustment of the extension elongation of the metal capillary tube in the ESI source mass spectrum; the knob of the adjusting rod drives a metal sleeve to move in a PEEK (polyetheretherketone) pipeline, so as to drive the metal capillary tube and the metal sleeve to move, thereby conveniently adjusting the distance between the metal capillary tube and a sub-inlet.
Description
Technical field
The present invention relates to mass spectrometer field, be specifically related to the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of a kind of ESI source.
Background technology
Mass spectrometer is a kind of high sensitivity for detection of material chemical composition, high-resolution instrument, first it become gas ion by sample changeover, then by electric field or magnetic field, ion is separated according to the size of mass-to-charge ratio (m/z), the intensity of measuring again ion forms mass spectrogram, can be qualitative or quantitative according to mass spectrogram obtain material chemical composition.
Electrospray ionization source (ESI) is the one in mass spectrometer intermediate ion source, ESI is by the capillary (spray needle) of working fluid sample, high voltage source, reverse electrode composition, cation and anion by high voltage electric field in can separation solution, for example, under positive ion mode, the relative reverse electrode of spray needle of electron spray keeps very high positive potential, negatively charged ions attracted to the other end of pin, assembling a large amount of positive charge ions at semi-moon shaped liquid surface, between them, mutually repel, and expand away from the liquid surface of needle point, liquid surface is tapered, be called Taylor cone, along with the drop at needle point place diminishes, electric field strength strengthens gradually, superfluous electric charge overcomes surface tension and forms very thin droplet, finally sputter out from the tip of Taylor cone, the solvent of droplet evaporates gradually, electrical charge rejection power is greater than surface tension and cracking occurs, through repeatedly cracking, produce ion.On electron spray process nature, it is electrophoresis process.
We know, electric field is along with external diameter capillaceous reduces and increases to some extent, reduce to some extent with the increase of the distance of the sub-porch of capillary distance.Conventional typical capillary external diameter and internal diameter are respectively 0.2mm and 0.1mm under normal circumstances, capillary is apart from the about 1-5 centimetre in ion porch, this shows, the length that capillary stretches out has directly determined the degree of liquid ions, and this just needs a mechanism to adjust at any time capillary length out.
But in prior art, additional adjusting mechanism capillaceous but simple passing through changes magnitude of voltage adjusts the effect of spraying often in ESI source, is difficult to find best ionization state like this.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of a kind of ESI source, the length that this mechanism can regulate metal capillary to stretch out easily, thus the distance of metal capillary apart from sub-porch regulated.
For solving the problems of the technologies described above, realize above-mentioned technique effect, the present invention adopts following technical scheme:
The micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of a kind of ESI source, comprise a frame and a metal capillary, described frame one end connects a PEEK pipe by a PEEK pipe connections, in described PEEK tube chamber, is provided with a metal sleeve, and described metal sleeve one end is provided with a capillary syringe needle.
In described frame, be provided with a high pressure connector near described PEEK pipe connections end, the other end of described high pressure connector one end and described metal sleeve interconnects, described high pressure connector and the mutual UNICOM of described metal sleeve, the described high pressure connector other end is provided with the first capillary penetrating member.
The described frame other end is fixed with a knob base, and described knob base one side is provided with the second capillary penetrating member, and described knob base opposite side is provided with an adjusting rod, and described adjusting rod one end connects described high pressure connector by a pin.
Described metal capillary passes described metal sleeve and capillary cartridge by described the second capillary penetrating member, the first capillary penetrating member and high pressure connector.
Further, the described adjusting rod other end is provided with an adjusting rod knob.
Preferably, described adjusting rod knob is insulating material.
Object of the present invention realizes by the following course of work:
Drive metal sleeve to move in PEEK pipeline by the knob of described adjusting rod, thereby drive the movement of metal capillary and metal sleeve, thereby can regulate easily the distance of the sub-porch of metal capillary distance.
Tool of the present invention has the following advantages:
Mechanism of the present invention makes simple and convenient, with low cost, convenient operation, can be good at regulating the distance of metal capillary apart from sub-porch, thereby solved the drawback that cannot regulate metal capillary extension elongation in prior art, mechanism of the present invention can promote the use of.
Accompanying drawing explanation
Fig. 1 is the structural representation of one embodiment of the invention.
Fig. 2 is the cutaway view of one embodiment of the invention part-structure.
Number in the figure explanation: 1. adjusting knob, 2. adjusting rod, 3. frame, 4. pin, 5. high pressure connector, 6.PEEK pipe, 7. metal sleeve, 8. capillary syringe needle, 9.PEEK connector, 10. the first capillary penetrating member, 11. knob bases, 12. second capillary penetrating members, 13. metal capillaries.
Embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
Refer to shown in Fig. 1 and Fig. 2, the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of a kind of ESI source, comprise a frame 3 and a metal capillary 13, described frame 3 one end connect a PEEK pipe 6 by a PEEK pipe connections 9, described PEEK manages in 6 cavitys and is provided with a metal sleeve 7, and described metal sleeve 7 one end are provided with a capillary syringe needle 8;
In described frame 3, be provided with a high pressure connector 5 near described PEEK pipe connections 9 ends, the other end of described high pressure connector 5 one end and described metal sleeve 7 interconnects, described high pressure connector 5 and the mutual UNICOM of described metal sleeve 7, described high pressure connector 5 other ends are provided with the first capillary penetrating member 10;
Described frame 3 other ends are fixed with a knob base 11, and described knob base 11 1 sides are provided with the second capillary penetrating member 12, and described knob base 11 opposite sides are provided with an adjusting rod 2, and described adjusting rod 2 one end connect described high pressure connector 5 by a pin 4;
Described metal capillary 13 passes described metal sleeve 7 and capillary cartridge 8 by described the second capillary penetrating member 12, the first capillary penetrating member 10 and high pressure connector 5.
Further, described adjusting rod 2 other ends are provided with an adjusting rod knob 1.
Preferably, described adjusting rod knob 1 is insulating material.
In the ESI source the mass spectrum above embodiment of the present invention being provided, the micro-adjusting mechanism of metal capillary extension elongation is described in detail; for one of ordinary skill in the art; according to the thought of the embodiment of the present invention; all will change in specific embodiments and applications, therefore all any changes of making according to design philosophy of the present invention are all within protection scope of the present invention.
Claims (4)
1. the micro-adjusting mechanism of metal capillary extension elongation in an ESI source mass spectrum, comprise a frame (3) and a metal capillary (13), described frame (3) one end connects a PEEK pipe (6) by a PEEK pipe connections (9), in described PEEK pipe (6) cavity, be provided with a metal sleeve (7), described metal sleeve (7) one end is provided with a capillary syringe needle (8); Described frame (3) is upper is provided with a high pressure connector (5) near described PEEK pipe connections (9) end, the other end of described high pressure connector (5) one end and described metal sleeve (7) interconnects, described high pressure connector (5) and described metal sleeve (7) UNICOM mutually, described high pressure connector (5) other end is provided with the first capillary penetrating member (10); It is characterized in that: described frame (3) other end is fixed with a knob base (11), described knob base (11) one sides are provided with the second capillary penetrating member (12), described knob base (11) opposite side is provided with an adjusting rod (2), described adjusting rod (2) one end connects described high pressure connector (5), and described metal capillary (13) passes described metal sleeve (7) and capillary cartridge (8) by described the second capillary penetrating member (12), the first capillary penetrating member (10) and high pressure connector (5).
2. the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of ESI according to claim 1 source, is characterized in that: further, described adjusting rod (2) other end is provided with an adjusting rod knob (1).
3. the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of ESI according to claim 2 source, is characterized in that: described adjusting rod knob (1) is insulating material.
4. the micro-adjusting mechanism of metal capillary extension elongation in the mass spectrum of ESI according to claim 1 source, is characterized in that: described adjusting rod (2) one end is connected with described high pressure connector (5) by a pin (4).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010244097.2A CN102347199B (en) | 2010-08-04 | 2010-08-04 | Fine adjustment mechanism of extension elongation of metal capillary tube in ESI (electronic spray ionization) source mass spectrum |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010244097.2A CN102347199B (en) | 2010-08-04 | 2010-08-04 | Fine adjustment mechanism of extension elongation of metal capillary tube in ESI (electronic spray ionization) source mass spectrum |
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| CN102347199A CN102347199A (en) | 2012-02-08 |
| CN102347199B true CN102347199B (en) | 2014-07-02 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE112013002413B4 (en) * | 2012-05-09 | 2018-09-20 | Proxeon Biosystems A/S | Integrated system for liquid separation and electrospray ionization |
| CN106067413B8 (en) * | 2016-05-25 | 2017-12-26 | 哈尔滨工业大学 | For adjusting the control device and control method of electrode and electrochemical in-situ mass spectrum injection port distance |
| CN113205998B (en) * | 2021-05-06 | 2024-06-21 | 占春泓 | Capillary fine tuning device for mass spectrometer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9218956U1 (en) * | 1992-12-14 | 1996-08-14 | Bautsch, Markus, 12167 Berlin | Device for generating a beam of accelerated ions and / or atoms |
| WO1998011595A1 (en) * | 1996-09-10 | 1998-03-19 | Analytica Of Branford, Inc. | Improvements to atmospheric pressure ion sources |
| WO2006086273A2 (en) * | 2005-02-09 | 2006-08-17 | Waters Investments Limited | Apparatus and method for positioning a discharge tube with respect to an orifice |
| CN201788938U (en) * | 2010-08-04 | 2011-04-06 | 江苏天瑞仪器股份有限公司 | ESI source mass spectrum metal capillary extending length fine-adjusting mechanism |
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2010
- 2010-08-04 CN CN201010244097.2A patent/CN102347199B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9218956U1 (en) * | 1992-12-14 | 1996-08-14 | Bautsch, Markus, 12167 Berlin | Device for generating a beam of accelerated ions and / or atoms |
| WO1998011595A1 (en) * | 1996-09-10 | 1998-03-19 | Analytica Of Branford, Inc. | Improvements to atmospheric pressure ion sources |
| WO2006086273A2 (en) * | 2005-02-09 | 2006-08-17 | Waters Investments Limited | Apparatus and method for positioning a discharge tube with respect to an orifice |
| CN201788938U (en) * | 2010-08-04 | 2011-04-06 | 江苏天瑞仪器股份有限公司 | ESI source mass spectrum metal capillary extending length fine-adjusting mechanism |
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