CN102334521A - 雷公藤蚊香及其制备方法 - Google Patents
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Abstract
本发明公开一种雷公藤蚊香及其制备方法，该雷公藤蚊香由下述组分按重量份组成：雷公藤50-60份，茵陈20-25份，芫花3-6份，白芷1-3份，榆树皮15-25份，檀香1-3份，樟木35-40份，薄荷1-3份，金银花1-3份，麝香0.5-1.5份。本发明的雷公藤蚊香对蚊子具有较强的驱杀作用，并且不会对人体产生不良影响。
Description
技术领域
本发明涉及一种蚊香及其制备方法，尤其涉及一种雷公藤蚊香及其制备方法。
背景技术
蚊香是一种驱蚊物，其中的药物被点燃后所发出的烟可赶走蚊子或熏死蚊子。我国点蚊香有非常悠久的历史，传统的蚊香分线香和盘香两种。
然而大多数蚊香的有效成份是除虫菊脂杀虫剂，以及有机填料、黏合剂、染料和其他添加剂等，蚊香燃烧的烟里因此含有许多对人体有害的物质，有可能诱发哮喘等疾病。
发明内容
针对现有技术中存在的上述不足，本发明所要解决的技术问题之一提供一种雷公藤蚊香，对蚊子具有较强的驱杀作用，并且不会对人体产生不良影响。
本发明所要解决的技术问题之二提供一种雷公藤蚊香的制备方法。
本发明目的是通过如下技术方案实现的：
一种雷公藤蚊香，由下述组分按重量份组成：雷公藤50-60份，茵陈20-25份，芫花3-6份，白芷1-3份，榆树皮15-25份，檀香1-3份，樟木35-40份，薄荷1-3份，金银花1-3份，麝香0.5-1.5份。
优选的，一种雷公藤蚊香，由下述组分按重量份组成：雷公藤50-60份，茵陈20-25份，芫花3-6份，白芷1-3份，榆树皮15-25份，檀香1-3份，樟木35-40份，薄荷1-3份，金银花1-3份，麝香0.5-1.5份，藜芦2-4份，党参0.5-1.5份。
本发明的雷公藤蚊香可以采用本行业常规方法制备而成。
进一步的，本发明还提供了上述雷公藤蚊香的制备方法，由下述步骤组成：
将上述各组分分别干燥粉碎成80-120目的粉末，按照配比称取各组分，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
具体的，在本发明中：
雷公藤，为植物卫矛科雷公藤的根。产于浙江、安徽、江西、湖南、广东、广西、福建、台湾、云南等地。《湖南药物志》：“杀虫，消炎，解毒。”
茵陈，本品为菊科植物滨蒿或茵陈蒿的干燥地上部分。记载于《中华人民共和国药典》2005年版一部-166。
芫花，为瑞香科植物芫花的干燥花蕾。记载于《中华人民共和国药典》2005年版一部-109。
白芷，为伞型科植物白芷或杭白芷的干燥根。记载于《中华人民共和国药典》2005年版一部-69-70。
榆树皮，为榆科植物榆树的干燥树皮或根皮。记载于《实用中草药彩色图集》第四册，民族出版社《藏汉大辞典》1985年版。
檀香，为檀香科植物檀香树干的心材。记载于《中华人民共和国药典》2005年版一部-264。
樟木，常绿乔木，树皮黄褐色，有不规则的纵裂纹，主产长江以南及西南各地。冬季伐树劈碎或锯成块状，晒干或风干。木材块状大小不一，表面红棕色至暗棕色，横断面可见年轮。质重而硬。有强烈的樟脑香气，味清凉，有辛辣感。
薄荷，本品为唇形科植物薄荷的干燥地上部分。记载于《中华人民共和国药典》2005年版一部-261。
金银花，为忍冬科植物忍冬的干燥花蕾或带初开的花。功能与主治：清热解毒，凉散风热。记载于《中华人民共和国药典》2005年版一部-152-153。
麝香，为鹿科动物林麝、马麝或原麝成熟雄体香囊中的干燥分泌物。记载于《中华人民共和国药典》2005年版一部-266。
藜芦(学名：Veratrum nigrum L.)百合科藜芦属的植物，多年生草本。功效：清热解毒、杀虫。在《中华人民共和国药典》2005年版一部中亦多处有记载。
党参，为桔梗科植物党参、素花党参或川党参的干燥根。记载于《中华人民共和国药典》2005年版一部-199。
本发明完全由天然野生中草药制成，雷公藤、茵陈、芫花和白芷复配，在燃烧过程中散发的气味能够抑制、杀灭病毒病菌，预防呼吸道疾病，增强人体免疫功能，驱灭蚊虫；榆树皮、檀香和樟木制成的粉末使蚊香成型且兼做燃烧基质，并且檀香、樟木、薄荷、金银花和麝香在燃烧过程中，不但清新空气，并能除毒抑菌，特别能够有效驱灭蚊虫，更为关键的是长期使用本发明并不会对人体产生不良影响。
特别的，在《中华人民共和国药典》2005年版一部中特别指出：党参不宜与藜芦同用。然而经过发明人大量实验后发现，在蚊香中同时添加党参与藜芦不但能够增加驱蚊效果，而且并不会对人体产生不良影响。
实验证明，本发明对黄金色葡萄球菌、痢疾杆菌、结核杆菌、绿脓杆菌、炭疽杆菌、肝炎杆菌等多种病菌有一定的抑制、杀灭作用，特别是对于流行性传染性疾病的病毒细菌具有很强的灭杀效果，对蚊子具有较强的驱杀作用。
具体实施方式
实施例1：
称取：雷公藤50公斤，茵陈25公斤，芫花3公斤，白芷3公斤，榆树皮15公斤，檀香3公斤，樟木35公斤，薄荷3公斤，金银花3公斤，麝香0.5公斤。
将上述各组分分别干燥粉碎成80-120目的粉末，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
实施例2：
称取：雷公藤60公斤，茵陈20公斤，芫花6公斤，白芷1公斤，榆树皮25公斤，檀香1公斤，樟木40公斤，薄荷1公斤，金银花1公斤，麝香1.5公斤。
将上述各组分分别干燥粉碎成80-120目的粉末，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
实施例3：
称取：雷公藤55公斤，茵陈23公斤，芫花5公斤，白芷2公斤，榆树皮20公斤，檀香2公斤，樟木38公斤，薄荷2公斤，金银花2公斤，麝香1公斤，藜芦3公斤，党参1公斤。
将上述各组分分别干燥粉碎成80-120目的粉末，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
实施例4：
称取：雷公藤55公斤，茵陈23公斤，芫花5公斤，白芷2公斤，榆树皮20公斤，檀香2公斤，樟木38公斤，薄荷2公斤，金银花2公斤，麝香1公斤。
将上述各组分分别干燥粉碎成80-120目的粉末，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
测试例1：室内药效
采用GB/T 13917.4-2009规定的蚊香室内药效测定方法及评价标准，进行测试。具体方法如下：
1、供试材料
采用实验室饲养的敏感品系标准试虫。
淡色库蚊(Culex pipiens pallens)，羽化后第3天～第5天为吸血的雌性成虫。
2、仪器设备
圆筒装置
无色透明圆筒架于支架上，圆筒上下各有一块无色透明园板。上圆板中央有一圆孔，用胶塞塞住；下圆板中央有一圆孔，用胶塞塞住，胶塞上架有蚊香架，供放置被测试蚊香用；圆筒与上、下圆板相接处分别用橡胶垫圈垫衬以防烟雾泄露。
吸蚊管、秒表、计数器
3、试验方法
实验条件：温度：(26±1)℃；相对湿度：60％±10％
4、实验步骤
采用圆筒装置。吸取试蚊30只，自筒下方圆板的中央圆孔处放入，塞紧胶塞。待试虫恢复正常活动后，随机取待测蚊香一段，水平状架在蚊香架上，在另处预先点燃5min后，移至圆筒内薰烟1min，立即将蚊香移去，塞上胶塞，并计时，每隔一定时间记录被击倒的试虫数。观察时限为20min。测试应设三次及以上重复，且重复试验用蚊香应在不同盘蚊香随机采取。每次试验结束后，应清洗试验装置。
5、计算
将重复测试数据按线性加权回归法计算KT50值及毒力回归方程。
6、评价指标
根据KT50进行药效评价。
药效结果分为A、B两级，达不到B级标准者属不合格产品。
A级：KT50≤4.0分钟；B级：KT50≤8.0分钟。
表1：蚊香室内药效表
| 实施例1 | 实施例2 | 实施例3 | 实施例4 | |
| KT50值 | 2分46秒 | 2分38秒 | 2分07秒 | 2分51秒 |
测试例2：毒性测试
参照国家卫生部《职业性急性化学物中毒性血液系统疾病诊断标准》及《中药、天然药物免疫毒性研究的技术指导原则》标准，制定本发明测试例。
1.实验材料：实施例3的蚊香
2.实验种类：两只幼龄小白鼠。
3.实验方法：
(1)实验条件：实验室温度(27±2)℃
(2)实验装置：在两个25平方米相同温度的实验室内，各放置一个大小相同规格的80×80×80cm细密透气的网状笼罩。
(3)实验步骤：将两只幼龄小白鼠分开各放于两个实验室的网状笼罩内，并分成对照组和薰本发明蚊香组，分别给予不薰本发明蚊香和薰本发明蚊香，测量幼龄小白鼠体重，观察血液学生化学指标、组织病理学变化及停止薰本发明蚊香后的恢复情况等。放置本发明蚊香时要安装在网状笼罩内离底30厘米处。给药剂量：笼罩内早晚点一盘蚊香，保持24小时蚊香常燃。时间：连续使用一个月，观察对照组和薰本发明蚊香组的幼龄小白鼠，长期使用本发明蚊香对幼龄小白鼠的毒性及副作用。清洁：笼罩内两天清洁一次。
表2：幼龄小白鼠蚊香毒性实验统计表
以上幼龄小白鼠蚊香毒性实验统计表，取自一个月内每日统计的五天有明显状况记录的抽样组合表，共试验了30天，加上停用观察的一星期，共37天。两只幼龄小白鼠抽血化验后，各项生化指标均为正常，表明本发明蚊香对幼龄小白鼠无毒副作用，只有超过24小时室内蚊香烟雾太浓时，需开窗换气10-15分钟，抽血前8小时未给两幼龄小白鼠进食。
结果：各主要脏器心、肝、脾、肺、肾、肾上腺、脑等解剖后，肉眼均未发现异常变化。薰本发明蚊香组脏器系数与未薰本发明蚊香组比较均无显著性差异，脏器组织病理学检查未见萎缩、变性、坏死等明显的病理改变，与未薰本发明蚊香组比较无显著性差异。
结论：长期使用本发明蚊香对幼龄小白鼠无任何毒性。
测试例3：急性经口毒性试验
实验材料：实施例3的蚊香。染毒后5分钟大鼠活动增加，持续2分钟左右，活动转为正常，饮食正常，观察期无死亡，LD50大于5000毫克/公斤，属于实际无毒。
测试例4：急性吸入毒性试验
实验材料：实施例3的蚊香。染毒后大鼠饮食活动未见异常，观察期无死亡，LD50大于10克/立方米，属于实际无毒。
测试例5：皮肤斑贴试验
实验材料：实施例3的蚊香。实验组皮肤红斑与水肿形成评分之和为0，说明对皮肤无刺激作用。
测试例6：眼刺激试验
实验组急性眼刺激积分支数为0，说明对粘膜无刺激作用。
测试例7：治疗足癣试验
特别的，发明人意外地发现本发明的蚊香燃烧后的残余物，即蚊香灰还具有治疗足癣的作用。对20例足癣患者进行测试，采用中国发明专利授权公告号CN100448443C所公开的测试方法，将本发明实施例3的蚊香燃烧后的残余物加入米醋中，所用米醋的量为蚊香燃烧后的残余物重量的10倍，搅拌混合均匀，涂覆在患有足癣的皮肤上，早晚各用药一次，14天为一疗程。治疗有效率达88％。
Claims (3)
1.一种雷公藤蚊香，其特征在于，由下述组分按重量份组成：雷公藤50-60份，茵陈20-25份，芫花3-6份，白芷1-3份，榆树皮15-25份，檀香1-3份，樟木35-40份，薄荷1-3份，金银花1-3份，麝香0.5-1.5份。
2.如权利要求1所述的雷公藤蚊香，其特征在于，由下述组分按重量份组成：雷公藤50-60份，茵陈20-25份，芫花3-6份，白芷1-3份，榆树皮15-25份，檀香1-3份，樟木35-40份，薄荷1-3份，金银花1-3份，麝香0.5-1.5份，藜芦2-4份，党参0.5-1.5份。
3.如权利要求1或2所述雷公藤蚊香的制备方法，其特征在于，由下述步骤组成：将上述各组分分别干燥粉碎成80-120目的粉末，按照配比称取各组分，加水充分混合均匀成泥浆，将泥浆放入制香机挤出成型后烘干，即可制得本发明的雷公藤蚊香。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103355361A (zh) * | 2013-08-06 | 2013-10-23 | 谢安军 | 蚊香 |
| CN103355364A (zh) * | 2013-08-06 | 2013-10-23 | 谢安军 | 中药蚊香 |
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|---|---|---|---|---|
| CN1114223A (zh) * | 1994-05-31 | 1996-01-03 | 陈志良 | 药香 |
| CN1209273A (zh) * | 1997-08-21 | 1999-03-03 | 李德安 | 一种无公害植物杀蚊蝇剂 |
| CN1356033A (zh) * | 2001-12-14 | 2002-07-03 | 宋建祥 | 中草药蚊香 |
| CN101015303A (zh) * | 2006-12-25 | 2007-08-15 | 洪云飞 | 植物灭蚊蝇剂 |
| CN101755854A (zh) * | 2008-10-27 | 2010-06-30 | 菅晓波 | 室内中药杀虫剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114223A (zh) * | 1994-05-31 | 1996-01-03 | 陈志良 | 药香 |
| CN1209273A (zh) * | 1997-08-21 | 1999-03-03 | 李德安 | 一种无公害植物杀蚊蝇剂 |
| CN1356033A (zh) * | 2001-12-14 | 2002-07-03 | 宋建祥 | 中草药蚊香 |
| CN101015303A (zh) * | 2006-12-25 | 2007-08-15 | 洪云飞 | 植物灭蚊蝇剂 |
| CN101755854A (zh) * | 2008-10-27 | 2010-06-30 | 菅晓波 | 室内中药杀虫剂 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103355361A (zh) * | 2013-08-06 | 2013-10-23 | 谢安军 | 蚊香 |
| CN103355364A (zh) * | 2013-08-06 | 2013-10-23 | 谢安军 | 中药蚊香 |
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