CN102327422B

CN102327422B - Anti-inflammatory bone-healing medicine and preparation method thereof

Info

Publication number: CN102327422B
Application number: CN201110309934XA
Authority: CN
Inventors: 尹立焱; 尹旖旎
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-10-13
Filing date: 2011-10-13
Publication date: 2013-07-03
Anticipated expiration: 2031-10-13
Also published as: CN102327422A

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an anti-inflammatory bone-healing medicine and a preparation method thereof. The medicine is prepared from the following active pharmaceutical ingredients: 5-16 parts of Sappanwood, 10-22 parts of szechuan aconite, 8-16 parts of draconis sanguis, 10-22 parts of teasel root, 10-22 parts of red paeonia, 8-16 parts of dragon bone, 8-16 parts of dalbergia wood, 3-10 parts of prepared frankincense, 5-10 parts of pyrite, 3-10 parts of lumbricus, 8-16 parts of Sambucus nigra and 3-10 parts of prepared myrrh. The anti-inflammatory bone-healing medicine has good curative effect on fracture, delayed healing of fracture and acute and chronic osteomyelitis, and is simple to prepare.

Description

A kind of antiinflammatory medicine of bone and preparation method thereof of healing

Technical field

The invention belongs to motherland's medicine technology field, particularly a kind of antiinflammatory medicine of bone and preparation method thereof of healing.

Background technology

Osteomyelitis is a kind of pyogenic infection disease that is caused by a kind of microbial bacterial intrusion body of with the naked eye can't see, be not the common simple bone marrow inflammation of understanding of people, and refer to whole osseous tissue, the a series of pathological changes that comprise periosteum, cortical bone, bone marrow all to be subjected to bacterial infection and produce, therefore single title osteomyelitis is also incorrect, and should be called bone, marrow inflammation.But owing to " osteomyelitis " this title is commonly used for a long time, so still name with " osteomyelitis " clinically.Osteomyelitis is a kind of infection and destruction of bone.Caused by aerobic or anaerobe, mycobacteria, fungus.Osteomyelitis is sent out well in the foot of vertebra, diabetics or because the penetrance bone injury position that wound or operation cause.The common site of child is that blood is for good long bone (as the metaphysis of tibia or femur).Osteomyelitis belongs to " pyogenic infection of the bone " or " attached bone pernicious influence " in Chinese medicine.

Fracture refers to a kind of disease of causing sclerotin partially or completely to rupture owing to reasons such as wound or pathology.Its main clinical manifestation is: fractures has limitation pain and tenderness, local swelling and ecchymosis occurs, and limb function is partially or completely lost, and complete fracture still cacomelia and abnormal movement can occur.

For osteomyelitis and treatment of fractures, medicine needs can antiinflammatory, and the bone of healing again simultaneously so just can have better therapeutic effect.

Summary of the invention

The object of the present invention is to provide a kind of antiinflammatory medicine of bone and preparation method thereof of healing, can well treat diseases such as osteomyelitis and fracture.

The technical solution used in the present invention is as follows:

The heal medicine of bone of a kind of antiinflammatory is made by following bulk drugs: Lignum Sappan 5-16 part, Radix Aconiti 10-22 part, Sanguis Draxonis 8-16 part, Radix Dipsaci 10-22 part, Radix Paeoniae Rubra 10-22 part, Os Draconis 8-16 part, Lignum Dalbergiae Odoriferae 8-16 part, Olibanum (processed) 3-10 part, Pyritum 5-10 part, Pheretima 3-10 part, Ramulus Sambuci Williamsii 8-16 part, Myrrha (processed) 3-10 part.

Further, crude drug weight is composed as follows: 10 parts of Lignum Sappans, 15 parts of Radix Aconitis, 12 parts of Sanguis Draxonis, 15 parts of Radix Dipsacis, 15 parts of Radix Paeoniae Rubra, 12 parts of Os Draconis, 12 parts of Lignum Dalbergiae Odoriferaes, 6 parts of Olibanum (processed)s, 7 parts of Pyritums, 6 parts of Pheretimas, 12 parts of Ramulus Sambuci Williamsii, 6 parts of Myrrha (processed)s.

Described crude drug can be prepared into any acceptable forms on the pharmaceutics according to conventional method, and preferred honey refining is pill.Concrete, described crude drug ground to making pellets by mixing medical powder with honey behind the smalls get final product.Every ball is advisable about with 6g, when taking, obeys 1 ball every day, and the child can be cut down according to the circumstance in right amount.

In the crude drug of the present invention, Lignum Sappan, sweet, salty, flat; GUIXIN, liver, spleen channel; The promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.Radix Aconiti, hot, bitter, hot; Very toxic; GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Sanguis Draxonis, sweet, salty, flat; GUIXIN, Liver Channel; Removing blood stasis and relieving pain, hemostasia and promoting granulation; Be used for falling to pounce on losing ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.Radix Dipsaci, hardship, hot, tepor; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia; Be used for injury from falling down.Radix Paeoniae Rubra, hardship is slightly cold; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain; Be used for injury from falling down, too fat to move skin infection.Os Draconis, according to the Shennong's Herbal record, sweet in the mouth is flat; Main trusted subordinate's tuberculosis, the old evil spirit of smart thing, cough with dyspnea is let out sharp pus and blood, and the woman is leaked down, and the ， mass in the abdomen is hard ties children's's steam infantile convulsion.Lignum Dalbergiae Odoriferae, hot, warm; Return liver, spleen channel; Promoting flow of QI and blood ends carbuncle, hemostasis; Be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.Olibanum (processed), hardship, suffering, tepor; Promoting blood circulation and stopping pain, detumescence and promoting granulation.Pyritum, suffering, flat; Return Liver Channel; Dissipating blood stasis, synthetism, pain relieving; Be used for tumbling and swelling, the muscles and bones folding is hindered.Pheretima is salty, cold; Return liver, spleen, urinary bladder channel; Heat clearing away arresting convulsion, collateral dredging, relieving asthma, diuresis.Ramulus Sambuci Williamsii, sweet, bitter, flat; Return liver, kidney channel; Wind-expelling pain-stopping, promoting blood circulation and stopping pain, inducing diuresis to remove edema; Be used for rheumatalgia, fall and pounce on fracture, oedema due to nephritis, dysuria.Myrrha (processed), hardship, suffering, flat; GUIXIN, liver, spleen channel; The analgesic therapy of invigorating blood circulation, detumescence and promoting granulation; Cure mainly traumatic injury, incised wound, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, skin infection does not close up after bursting for a long time.More than all medicines share, can disperse blood stasis and dredge collateral, bone-setting pain stopping, anti-inflammation of bone.Treatment for miscellaneous fracture, the healing of fracture slowness and acute and chronic osteomyelitis has better curative effect.

The present invention has following advantage with respect to prior art:

The heal medicine of bone of antiinflammatory of the present invention has better curative effect for the treatment of fracture, fracture slowness healing and acute and chronic osteomyelitis, makes simple.

The specific embodiment

Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:

Embodiment 1

The heal medicine of bone of antiinflammatory is made by the following raw materials in part by weight medicine: 10 parts of Lignum Sappans, 15 parts of Radix Aconitis, 12 parts of Sanguis Draxonis, 15 parts of Radix Dipsacis, 15 parts of Radix Paeoniae Rubra, 12 parts of Os Draconis, 12 parts of Lignum Dalbergiae Odoriferaes, 6 parts of Olibanum (processed)s, 7 parts of Pyritums, 6 parts of Pheretimas, 12 parts of Ramulus Sambuci Williamsii, 6 parts of Myrrha (processed)s.

The above-mentioned raw materials medicine ground to making pellets by mixing medical powder with honey behind the smalls get final product.Every ball is advisable about with 6g, when taking, obeys 1 ball every day, and the child can be cut down according to the circumstance in right amount.

Embodiment 2

The heal medicine of bone of antiinflammatory is made by the following raw materials in part by weight medicine: 5 parts of Lignum Sappans, 10 parts of Radix Aconitis, 8 parts of Sanguis Draxonis, 10 parts of Radix Dipsacis, 10 parts of Radix Paeoniae Rubra, 8 parts of Os Draconis, 8 parts of Lignum Dalbergiae Odoriferaes, 3 parts of Olibanum (processed)s, 5 parts of Pyritums, 3 parts of Pheretimas, 8 parts of Ramulus Sambuci Williamsii, 3 parts of Myrrha (processed)s.

Preparation and the method for taking are with embodiment 1.

Embodiment 3

The heal medicine of bone of antiinflammatory, made by the following raw materials in part by weight medicine:

16 parts of Lignum Sappans, 22 parts of Radix Aconitis, 16 parts of Sanguis Draxonis, 22 parts of Radix Dipsacis, 22 parts of Radix Paeoniae Rubra, 16 parts of Os Draconis, 16 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Olibanum (processed)s, 10 parts of Pyritums, 10 parts of Pheretimas, 16 parts of Ramulus Sambuci Williamsii, 10 parts of Myrrha (processed)s.

Preparation and the method for taking are with embodiment 1.

Above-described embodiment is the preferred embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the change that other any the present invention of not deviating from does all should be the substitute mode of equivalence, is included within protection scope of the present invention.

Effect data:

1. diagnostic criteria:

The diagnostic criteria of A, fracture:

Clinical manifestation

Whole body performance: hemorrhage and shock, hemorrhage more for a long time may be with fervescence;

Topical manifestations: 1) deformity; 2) unusual movable; 3) bony crepitus or bone are wiped sense; 4) pain; 5) swelling and congestion; 6) dysfunction.

Judge in conjunction with the X-ray image according to above clinical manifestation.

The criterion of B, acute and chronic osteomyelitis

A) the X line sign of acute osteomyelitis: 1) subcutaneous layer of fat increase in density, thick network structure is arranged, the fuzzy or disappearance of spatium intermusculare, the partial density at abscess place increases; 2) morbidity is after 10 days, and bone marrow occur to change, and shows as metaphysis and the limitation sclerotin occurs and " loosen ", and namely bone trabecula dissolved destruction district appears in osteoclasia then in early days, can extend to the backbone, finally involves the backbone.Periosteal reaction appears at around the cortical bone, and the area of new bone that is one deck intermediate density is parallel with cortical bone, and the course of disease more long bone film reaction is more obvious, and consistent with the focus scope, and sequestrum forms, present the strip sequestrum with demarcate on every side clear.

B) the X line sign of chronic osteomyelitis: 1) local soft tissue swelling, the reparation phase can form soft mass, and clear-cut margin can be with symptom well then dwindle; 2) bone destruction, it is low to show as bone density, edge blurry.After sequestrum forms, the density height, it is clearer to destroy the edge.3) hyperostosis osteosclerosis is that chronic osteomyelitis is repaired must reacting of phase, is the ossified shadow of even high density, and medullary cavity disappears, but still can see little vomica, and sequestrum fades away.4) it is varied that periosteal reaction and bony shell, the periosteal reaction of chronic osteomyelitis show as stratiform, Herba Alii fistulosi skin shape, wire and lacery etc.

2. criterion of therapeutical effect:

The standard of A fracture:

Cure: 1) the local no tenderness of fracture, there is not vertical percussion pain; 2) the local no abnormal activity of fracture; 3) X line plain film shows that fracture line is fuzzy, has the seriality callus to pass through fracture end; 4) the outer fixing future trouble limb of removing can satisfy following requirement, and upper limb continues 1 minute to 1 kilogram of weight of front raise; Lower limb do not have to be helped and can be no less than for 30 steps level land continuous walking 3 minutes; 5) observed continuously for 2 weeks, fracture is indeformable.

Effectively: sx but the fracture as yet the healing;

Invalid: symptom does not have improvement or increases the weight of.

The myelitic standard of B

Cure: X sign is normal

Effectively: sx or sign are improved;

Invalid: sign does not have improvement or increases the weight of.

3. case situation: patient's 305 examples, wherein 150 examples are fracture, and 100 examples are acute osteomyelitis, and 55 examples are chronic osteomyelitis.Adopt the embodiment of the invention 1 medicine to treat.

Effect data: 301 examples of fully recovering, effective 4 examples, total effective rate 100%.

Claims

1. the antiinflammatory medicine of bone of healing, it is characterized in that, made by the following raw materials in part by weight medicine: Lignum Sappan 5-16 part, Radix Aconiti 10-22 part, Sanguis Draxonis 8-16 part, Radix Dipsaci 10-22 part, Radix Paeoniae Rubra 10-22 part, Os Draconis 8-16 part, Lignum Dalbergiae Odoriferae 8-16 part, Olibanum (processed) 3-10 part, Pyritum 5-10 part, Pheretima 3-10 part, Ramulus Sambuci Williamsii 8-16 part, Myrrha (processed) 3-10 part.

2. the antiinflammatory as claimed in claim 1 medicine of bone of healing, it is characterized in that crude drug weight is composed as follows: 10 parts of Lignum Sappans, 15 parts of Radix Aconitis, 12 parts of Sanguis Draxonis, 15 parts of Radix Dipsacis, 15 parts of Radix Paeoniae Rubra, 12 parts of Os Draconis, 12 parts of Lignum Dalbergiae Odoriferaes, 6 parts of Olibanum (processed)s, 7 parts of Pyritums, 6 parts of Pheretimas, 12 parts of Ramulus Sambuci Williamsii, 6 parts of Myrrha (processed)s.

3. the antiinflammatory as claimed in claim 1 or 2 medicine of bone of healing is characterized in that, the refining of described crude drug honey is pill.

4. claim 1 or the 2 described antiinflammatories preparation method of medicine of bone that heals is characterized in that described medicine is honeyed pill, described crude drug is ground be making pellets by mixing medical powder with honey behind the smalls.