CN102327313A - Preparation method of Lianzhi anti-inflammation soft capsule - Google Patents
Preparation method of Lianzhi anti-inflammation soft capsule Download PDFInfo
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Abstract
The invention provides a preparation method of a Lianzhi anti-inflammation soft capsule and relates to a preparation method of a traditional Chinese medicine preparation. The preparation method comprises the following steps of: taking andrographis paniculata leaves and mountain sesame roots as raw materials; adopting the ultrasonic wave to extract; proportioning, mixing glue, pressing a soft capsule, cleaning and drying the capsule and packing; and finally obtaining the Lianzhi anti-inflammation soft capsule. The preparation method has the beneficial effects that a method for extracting drug effect ingredients by adopting the ultrasonic wave at a normal temperature has the advantages that the extraction efficiency is high and quick; the time as well as solvents are saved, and the like; active ingredients in a medicinal material cell are quick to dissolve out; the chemical structures of the active ingredients are not easy to damage; the drug effect ingredients have high extraction efficiency and stable content, the total content of andrographolide and dehydroanddrographolide in an andrographis paniculata extractive is not less than 7.5 percent; the total content of an N-butyl alcohol extract in a mountain sesame extractive is not less than 1.75 percent, so that the preparation of the soft capsule is convenient and controllable; the energy sources are saved, and the emission is reduced.
Description
Technical field
The present invention relates to a kind of method for preparing of Chinese medicine preparation, be specifically related to a kind of method for preparing of lotus sesame anti-inflammation soft capsule prepn.
Background technology
Lotus sesame anti-inflammation soft capsule is made up of Herba Andrographis, Radix Helicteris, and function is a heat-clearing and toxic substances removing, the removing heat from blood detumescence, and being used for the lung stomach has heat, the interior Sheng of fire-toxin to cause diseases such as cough and asthma, mumps, tonsillitis, sore throat pharyngalgia.
Existing lotus sesame anti-inflammatory medicine preparation method of extract generally adopts alcohol dipping method and heat reflow method to extract the effective ingredient in the medical material.Because dipping and return time are longer, to waste time and energy, heat reflow method is prone to cause efficacy component to destroy again, expends the energy and causes solvent loss easily, and the quality to extract lacks effectively control simultaneously, requires extremely incompatible with the Chinese medicine preparation technical modernization.
Summary of the invention
Said defective above the objective of the invention is to be directed against provides a kind of simple to operate, and extraction time is short, need not to heat and the method for preparing of the lotus sesame anti-inflammation soft capsule that the efficacy component extraction ratio is high.
The objective of the invention is to be achieved through following technical scheme.
A kind of method for preparing of lotus sesame anti-inflammation soft capsule; Comprise following bulk drugs material: Folium Andrographis 555-575g, Radix Helicteris root 2150-2170g; It is characterized in that method for preparing in turn includes the following steps: 1. Folium Andrographis adopts ultrasonic extraction, and solvent is a 60-70% ethanol; Extracting solution is through concentrated, the dry Herba Andrographis extract that gets, and is subsequent use; 2. the Radix Helicteris root adopts ultrasonic extraction, and solvent is the ethanol of 70-80%, and extracting solution is through concentrated, the dry Radix Helicteris extract that gets, and is subsequent use; 3. with step 1., 2. extract obtained, be the De Lianzhi anti-inflammation soft capsule through batching, impregnation, compacting soft capsule, after washing ball and drying, packing.
The 1. described Folium Andrographis of step adopts ultrasonic extraction, concentrates, drying is meant and earlier Folium Andrographis was pulverized 20 mesh sieves; In concentration is to soak 1.5-2 hour in the ethanol of 60%-70%; Then with material-liquid (ethanol) than being 1:10-12 (g/ml); Extract at 35-40kHz with the ultrasonic extraction device, filter; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 30-50min; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.85-0.95Mpa, 60-70 ℃ of relative density when being evaporated to 50 ℃ is the extractum of 1.20-1.30.Extractum is at vacuum 0.85-0.95Mpa, and 60-70 ℃ of vacuum drying to moisture gets Herba Andrographis extract less than 5%.
The 2. said Radix Helicteris root of step adopts ultrasonic extraction, concentrates, drying is meant and earlier the Radix Helicteris root was pulverized 20 mesh sieves; In concentration is to soak 1.5-2 hour in the ethanol of 70-80%; Then with material-liquid (ethanol of 70-80%) than being 1:8-10 (g/ml); Extract at 35-40kHz with the ultrasonic extraction device, filter; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 30-50min; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.85-0.95Mpa, 60-70 ℃ of relative density when being evaporated to 50 ℃ is the extractum of 1.30-1.40.Extractum is at vacuum 0.85-0.95Mpa, and 70-80 ℃ of vacuum drying to moisture gets Radix Helicteris extract less than 5%.
Step 3. described in impregnation be meant pure water be heated to 80 ℃, add gelatin, glycerol and account for the PEG-400 of sizing material gross weight 8% amount, call in pigment, antioxidant, the ascorbic acid of conventional amount used again, boil 80 ℃ of collosol temperatures, 70 ℃ of glue bucket holding temperatures; The mass ratio of gelatin, pure water and glycerol is: 1:0.9:0.4.
Step 3. described in batching be meant Herba Andrographis extract mixed with Radix Helicteris extract; Be ground into 120 purpose fine powders; Add soybean oil, by being routinely added to hydrogenated vegetable oil, Cera Flava, Arlacel-80 mix homogeneously, wherein the quality of Herba Andrographis extract and Radix Helicteris extract fine powder be Herba Andrographis extract and Radix Helicteris extract fine powder, soybean oil, Arlacel-80 quality and 48-50%; Through colloid mill emulsifying, make it become uniform emulsion; Then emulsion is put in the pellet press, started pellet press, the compacting soft capsule.
Step is washed ball described in 3., drying is meant that the soft capsule that suppresses is added ethanol to be cleaned, and volatilization goes ethanol, soft capsule under 26-28 ℃, to be dried to moisture content below 40%; Add 75% ethanol again and clean soft capsule, soft capsule is dried to moisture content below 40% under 26-28 ℃.
The invention has the beneficial effects as follows: the present invention adopts the method for ultrasound wave extract at room temperature active ingredient, compares with heating reflux method, extraction, has extraction ratio height, fast, saves time, advantage such as solvent.Effective ingredient stripping in the crude drug cell is rapid; And the chemical constitution of survivable active ingredient; High, the efficacy component stable content of efficacy component extraction ratio, in the Herba Andrographis extract total amount of andrographolide and dehydrorographolide not＜7.5%, n-butyl alcohol extractum total amount is not＜1.75% in the Radix Helicteris extract; Make soft capsule preparation become more convenient controlled, and energy savings reduce discharging.
The specific embodiment
embodiment one.
The preparation of Herba Andrographis extract: the material Folium Andrographis 555g that gets it filled pulverized 20 mesh sieves, with soaking 1.5 hours in the ethanol of 5550ml concentration 60%, extracted at 35kHz with the ultrasonic extraction device, filtered; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 30min; Merge ethanol extraction filtrating afterwards, reclaim ethanol, at vacuum 0.85Mpa, 70 ℃ of relative densities when being evaporated to 50 ℃ are 1.20 extractum.Extractum is at vacuum 0.85Mpa; 70 ℃ of vacuum dryings get the dried cream 99.5g of Herba Andrographis ethanol extraction; The dried cream moisture of extract is 4.5%; Andrographolide and dehydrorographolide content 7.6% in the dried cream of extract, sanitary index meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The preparation of Radix Helicteris extract: getting Radix Helicteris root 2150g and pulverized 20 mesh sieves, is to soak 1.5 hours in 70% the ethanol in 17200ml concentration, extracts 30min with the ultrasonic extraction device at 35kHz, filtration; Medicinal residues in kind repeat to extract, and extract altogether 3 times; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.85Mpa, 70 ℃ of relative densities when being evaporated to 50 ℃ are 1.30 extractum.Extractum is at vacuum 0.85Mpa, and 80 ℃ of vacuum dryings get the dried cream 83.8g of Radix Helicteris ethanol extraction.The dried cream moisture 4.3% of Radix Helicteris ethanol extraction, n-butyl alcohol extractum 1.85% in the extract, sanitary index meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The moulding process of soft capsule is described below.
1. prepare burden: get the dried cream 99.5g of Herba Andrographis ethanol extraction, the dried cream 83.8g mixing of Radix Helicteris ethanol extraction; Be ground into 120 purpose fine powders; Add the 214.6g soybean oil, by being routinely added to hydrogenated vegetable oil, Cera Flava, Arlacel-80 (counting the soybean oil total amount) mix homogeneously, through colloid mill emulsifying; Process uniform emulsion 397.9g, subsequent use.
2. impregnation: select gelatin: the consumption of distilled water: glycerol=1:0.9:0.4; Be heated to about 80 ℃ to pure water by routine, add gelatin, glycerol and account for the PEG-400 of sizing material gross weight 8%, call in (the counting the gelatin total amount) such as Photoresists, antioxidant, ascorbic acid of conventional amount used again; Boil; 80 ℃ of collosol temperatures, glue bucket remain under 70 ℃ of insulations, and be subsequent use.
3. compacting soft capsule: above-mentioned mix is put in the pellet press, started pellet press compacting soft capsule, process 1000 of soft capsules.
4. wash ball, drying: choose the good soft capsule of above-mentioned compression moulding, add an amount of ethanol and clean soft capsule, discard ethanol, soft capsule is dried to moisture content below 40% under 26～28 ℃; Add an amount of 75% ethanol again and clean soft capsule, discard ethanol, soft capsule in 26～28 ℃ of following after drying to moisture content below 40%, subsequent use.
5. packing: adopt Aluminium-coating Packer to be distributed into 12 of every plates, outsourcing gets product.
product character and quality standard.
1, character: these article are soft capsule, and content is the thick fluid of sepia to brown, bitter in the mouth.
2, differentiate:(1) get the content of 2 of these article, with 60% ethanol 10ml dissolving, filter, filtrating is put in the water-bath and is volatilized, and residue adds water 10ml makes dissolving, adds the ethyl acetate jolting and extracts 3 each 5ml, obtains ethyl acetate liquid and is concentrated into 1ml, as need testing solution.Other gets Radix Helicteris control medicinal material 1g, with 60% alcohol heating reflux 1 hour, filters, and shines medical material solution in pairs with legal system.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2010 B); Drawing each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developing solvent with toluene-ethyl acetate-glacial acetic acid (7: 1: 0.5); Launch; Take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical sapphirine fluorescence speckle.
(2) get 1 of these article, inclining content, adds ethanol 10ml and makes dissolving, filters, and filtrating is as need testing solution.Other gets the dehydrorographolide reference substance, adds ethanol and processes the solution that every 1ml contains 1mg, as reference substance solution.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica GF254 lamellae of adhesive with the sodium carboxymethyl cellulose; With chloroform-ethyl acetate-methanol (4: 3: 0.4) is developing solvent, launches, and takes out; Dry, put inspect under the ultra-violet lamp (254nm) after, in the test sample chromatograph; With the corresponding position of reference substance chromatograph on, show the speckle of same color.
3, inspection: meet the requirement of each item regulation relevant under Chinese Pharmacopoeia (an appendix I of version in 2010 L) the capsule item.
4, assay: according to the content of Chinese Pharmacopoeia (an appendix VI of version in 2010 D) high effective liquid chromatography for measuring active ingredient.
Chromatographic condition and system suitability test:Use octadecylsilane chemically bonded silica to be filler; Methanol-water (50: 50) is a mobile phase; Dehydrorographolide detects wavelength 254nm, andrographolide detection wavelength is 225nm; Number of theoretical plate calculates by dehydrorographolide peak and andrographolide all should be not less than 2000.
The preparation of reference substance solution:Precision takes by weighing dehydrorographolide and the andrographolide reference substance is an amount of, adds methanol and processes the solution that every 1ml contains 40g and 30g, promptly gets.
The preparation of need testing solution:Content under these article of getting content uniformity item, mixing is got about 0.2g, and accurate the title, decide, and puts in the 100ml tool plug triangular flask, and the accurate methanol 50ml that adds claims to decide weight, and ultrasonic (power 250w, frequency 33kHz) handled 30 minutes.Put coldly, claim again to decide weight, add the weight that methanol is supplied minimizing.Shake up, filter, promptly get with microporous filter membrane (0.45 μ m).
Algoscopy:Accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing inject chromatograph of liquid, measure, and promptly get.
Every of these article contain dehydrorographolide (C
20H
28O
4) and andrographolide (C
20H
30O
5) total amount be 7.36mg.
embodiment two.
The preparation of Herba Andrographis extract: the material Folium Andrographis 565g that gets it filled pulverized 20 mesh sieves, with soaking 2 hours in the ethanol of 6215ml concentration 65%, extracted at 35kHz with the ultrasonic extraction device, filtered; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 40min; Merge ethanol extraction filtrating afterwards, reclaim ethanol, at vacuum 0.90Mpa, 65 ℃ of relative densities when being evaporated to 50 ℃ are 1.25 extractum.Extractum is at vacuum 0.90Mpa, and 65 ℃ of vacuum dryings get the dried cream 98.7g of Herba Andrographis ethanol extraction.The dried cream moisture 4.8% of extract, andrographolide and dehydrorographolide content 7.7%, sanitary index should meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The preparation of Radix Helicteris extract: getting Radix Helicteris root 2160g and pulverized 20 mesh sieves, is to soak 2 hours in 75% the ethanol in 19440ml concentration, extracts 40min with the ultrasonic extraction device at 35kHz, filtration; Medicinal residues in kind repeat to extract, and extract altogether 3 times; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.90Mpa, 70 ℃ of relative densities when being evaporated to 50 ℃ are 1.35 extractum.Extractum is at vacuum 0.90Mpa, and 75 ℃ of vacuum dryings get the dried cream 84.3g of Radix Helicteris ethanol extraction.The dried cream moisture 4.6% of Radix Helicteris ethanol extraction, n-butyl alcohol extractum 1.80% in the extract, sanitary index meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The moulding process of soft capsule is described below.
1. prepare burden: get the dried cream 98.7g of Herba Andrographis ethanol extraction, the dried cream 84.3g mixing of Radix Helicteris ethanol extraction; Be ground into 120 purpose fine powders; Add the 217.0g soybean oil, by being routinely added to hydrogenated vegetable oil, Cera Flava, Arlacel-80 (counting the soybean oil total amount) mix homogeneously, through colloid mill emulsifying; Process uniform emulsion 397.9g, subsequent use.
2. impregnation: select gelatin: the consumption of distilled water: glycerol=1:0.9:0.4, be heated to about 80 ℃ to pure water by routine, add gelatin, glycerol and account for the PEG-400 of sizing material gross weight 8%; Call in the Photoresist, antioxidant, ascorbic acid etc. (counting the gelatin total amount) of conventional amount used again, boil dissolving, 80 ℃ of collosol temperatures, glue bucket holding temperature is 70 ℃, and is subsequent use.
3. compacting soft capsule: above-mentioned mix is put in the pellet press, started pellet press compacting soft capsule, process 1000 of soft capsules.
4. wash ball, drying: choose the good soft capsule of above-mentioned compression moulding, add an amount of ethanol and clean soft capsule, discard ethanol, soft capsule is dried to moisture content below 40% under 26～28 ℃; Add an amount of 75% ethanol again and clean soft capsule, discard ethanol, soft capsule in 26～28 ℃ of following after drying to moisture content below 40%, subsequent use.
5. packing: adopt Aluminium-coating Packer to be distributed into 12 of every plates, outsourcing gets product.
product character and quality standard.
1, character: these article are soft capsule, and content is the thick fluid of sepia to brown, bitter in the mouth.
2, differentiate:(1) with embodiment one.In the test sample chromatograph, with the corresponding position of Radix Helicteris control medicinal material control medicinal material chromatograph on, show identical sapphirine fluorescence speckle.
(2) with embodiment one.In the test sample chromatograph, with the corresponding position of dehydrorographolide reference substance chromatograph on, show the speckle of same color.
3, inspection: meet the requirement of each item regulation relevant under Chinese Pharmacopoeia (an appendix I of version in 2010 L) the capsule item.
4, assay: according to the content of Chinese Pharmacopoeia (an appendix VI of version in 2010 D) high effective liquid chromatography for measuring active ingredient.Method is with embodiment one.
Every of these article contain dehydrorographolide (C
20H
28O
4) and andrographolide (C
20H
30O
5) total amount be 7.40mg.
embodiment three.
The preparation of Herba Andrographis extract: the material Folium Andrographis 575g that gets it filled pulverized 20 mesh sieves, with soaking 2 hours in the ethanol of 6900ml concentration 70%, extracted at 40kHz with the ultrasonic extraction device, filtered; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 50min; Merge ethanol extraction filtrating afterwards, reclaim ethanol, at vacuum 0.90Mpa, 65 ℃ of relative densities when being evaporated to 50 ℃ are 1.30 extractum.Extractum is at vacuum 0.95Mpa, and 60 ℃ of vacuum dryings get the dried cream 99.2g of Herba Andrographis ethanol extraction.The dried cream moisture 4.7% of extract, andrographolide and dehydrorographolide content 7.7%, sanitary index should meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The preparation of Radix Helicteris extract: getting Radix Helicteris root 2170g and pulverized 20 mesh sieves, is to soak 2 hours in 80% the ethanol in 21700ml concentration, extracts 50min with the ultrasonic extraction device at 40kHz, filtration; Medicinal residues in kind repeat to extract, and extract altogether 3 times; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.95Mpa, 65 ℃ of relative densities when being evaporated to 50 ℃ are 1.40 extractum.Extractum is at vacuum 0.95Mpa, and 65 ℃ of vacuum dryings get the dried cream 85.2g of Radix Helicteris ethanol extraction.The dried cream moisture 4.8% of Radix Helicteris ethanol extraction, n-butyl alcohol extractum 1.76% in the extract, sanitary index meet the WM2-2001 " medicinal plants and preparation are imported and exported green industry standard " that State Ministry of Foreign Trade and Economic Cooperation issues.
The moulding process of soft capsule is described below.
1. prepare burden: get the dried cream 99.2g of Herba Andrographis ethanol extraction, the dried cream 85.2g mixing of Radix Helicteris ethanol extraction; Be ground into 120 purpose fine powders; Add the 215.6g soybean oil, by being routinely added to hydrogenated vegetable oil, Cera Flava, Arlacel-80 (counting the soybean oil total amount) mix homogeneously, through colloid mill emulsifying; Process uniform emulsion 397.9g, subsequent use.
2. impregnation: select gelatin: the consumption of distilled water: glycerol=1:0.9:0.4, be heated to about 80 ℃ to pure water by routine, add gelatin, glycerol and account for the PEG-400 of sizing material gross weight 8%; Call in the Photoresist, antioxidant, ascorbic acid etc. (counting the gelatin total amount) of conventional amount used again, boil, 80 ℃ of collosol temperatures, 70 ℃ of glue bucket holding temperatures, subsequent use.
3. suppress soft capsule: above-mentioned mix is put in the pellet press, started pellet press compacting soft capsule, process 1000 of soft capsules.
4. wash ball, drying: choose the good soft capsule of above-mentioned compression moulding, add an amount of ethanol and clean soft capsule, discard ethanol, soft capsule is dried to moisture content below 40% under 26～28 ℃; Add an amount of 75% ethanol again and clean soft capsule, discard ethanol, soft capsule in 26～28 ℃ of following after drying to moisture content below 40%, subsequent use.
5. packing: adopt Aluminium-coating Packer to be distributed into 12 of every plates, outsourcing gets product.
product character and quality standard.
1, character: these article are soft capsule, and content is the thick fluid of sepia to brown, bitter in the mouth.
2, differentiate:(1) with embodiment one.In the test sample chromatograph, with the corresponding position of Radix Helicteris control medicinal material control medicinal material chromatograph on, show identical sapphirine fluorescence speckle.
(2) with embodiment one.In the test sample chromatograph, with the corresponding position of dehydrorographolide reference substance chromatograph on, show the speckle of same color.
3, inspection: meet the requirement of each item regulation relevant under Chinese Pharmacopoeia (an appendix I of version in 2010 L) the capsule item.
4, assay: according to the content of Chinese Pharmacopoeia (an appendix VI of version in 2010 D) high effective liquid chromatography for measuring active ingredient.Method is with embodiment one.
Every of these article contain dehydrorographolide (C
20H
28O
4) and andrographolide (C
20H
30O
5) total amount be 7.10mg.
Claims (6)
1. the method for preparing of a lotus sesame anti-inflammation soft capsule; Comprise following bulk drugs material: Folium Andrographis 555-575g, Radix Helicteris root 2150-2170g; It is characterized in that method for preparing in turn includes the following steps: 1. Folium Andrographis adopts ultrasonic extraction, and solvent is a 60-70% ethanol; Extracting solution is through concentrated, the dry Herba Andrographis extract that gets, and is subsequent use; 2. the Radix Helicteris root adopts ultrasonic extraction, and solvent is the ethanol of 70-80%, and extracting solution is through concentrated, the dry Radix Helicteris extract that gets, and is subsequent use; 3. with step 1., 2. extract obtained, be the De Lianzhi anti-inflammation soft capsule through batching, impregnation, compacting soft capsule, after washing ball and drying, packing.
2. the method for preparing of a kind of lotus sesame anti-inflammation soft capsule according to claim 1; It is characterized in that: the 1. described Folium Andrographis of step adopts ultrasonic extraction, concentrates, drying is meant and earlier Folium Andrographis was pulverized 20 mesh sieves; In concentration is to soak 1.5-2 hour in the ethanol of 60%-70%; Then with material-liquid (ethanol) than being 1:10-12 (g/ml), extract at 35-40kHz with the ultrasonic extraction device, filter; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 30-50min; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.85-0.95Mpa; 60-70 ℃ of relative density when being evaporated to 50 ℃ is the extractum of 1.20-1.30; Extractum is at vacuum 0.85-0.95Mpa, and 60-70 ℃ of vacuum drying to moisture gets Herba Andrographis extract less than 5%.
3. the method for preparing of a kind of lotus sesame anti-inflammation soft capsule according to claim 1; It is characterized in that: the 2. said Radix Helicteris root of step adopts ultrasonic extraction, concentrates, drying is meant and earlier the Radix Helicteris root was pulverized 20 mesh sieves; In concentration is to soak 1.5-2 hour in the ethanol of 70-80%; Then with material-liquid (ethanol of 70-80%) than being 1:8-10 (g/ml), extract at 35-40kHz with the ultrasonic extraction device, filter; Medicinal residues in kind repeat to extract, and extract altogether 3 times, each 30-50min; Merge ethanol extract afterwards, reclaim ethanol, at vacuum 0.85-0.95Mpa; 60-70 ℃ of relative density when being evaporated to 50 ℃ is the extractum of 1.30-1.40; Extractum is at vacuum 0.85-0.95Mpa, and 70-80 ℃ of vacuum drying to moisture gets Radix Helicteris extract less than 5%.
4. the method for preparing of a kind of lotus sesame anti-inflammation soft capsule according to claim 1; It is characterized in that: step 3. described in impregnation be meant pure water be heated to 80 ℃; Add gelatin, glycerol and account for the PEG-400 that sizing material gross weight 8% is measured, call in pigment, antioxidant, the ascorbic acid of conventional amount used again, boil; 80 ℃ of collosol temperatures, 70 ℃ of glue bucket holding temperatures; The mass ratio of gelatin, pure water and glycerol is: 1:0.9:0.4.
5. the method for preparing of a kind of lotus sesame anti-inflammation soft capsule according to claim 1; It is characterized in that: step 3. described in batching be meant Herba Andrographis extract mixed with Radix Helicteris extract; Be ground into 120 purpose fine powders; Add soybean oil, by being routinely added to hydrogenated vegetable oil, Cera Flava, Arlacel-80 mix homogeneously, wherein the quality of Herba Andrographis extract and Radix Helicteris extract fine powder be Herba Andrographis extract and Radix Helicteris extract fine powder, soybean oil, Arlacel-80 quality and 48-50%; Through colloid mill emulsifying, make it become uniform emulsion; Then emulsion is put in the pellet press, started pellet press, the compacting soft capsule.
6. the method for preparing of a kind of lotus sesame anti-inflammation soft capsule according to claim 1; It is characterized in that: step is washed ball described in 3., drying is meant that the soft capsule that suppresses is added ethanol to be cleaned; Volatilization goes ethanol, soft capsule under 26-28 ℃, to be dried to moisture content below 40%; Add 75% ethanol again and clean soft capsule, soft capsule is dried to moisture content below 40% under 26-28 ℃.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106501440A (en) * | 2016-10-24 | 2017-03-15 | 中悦民安（北京）科技发展有限公司 | The discrimination method of field pennycress in Chinese medicine compound prescription |
| CN107823152A (en) * | 2017-11-09 | 2018-03-23 | 重庆科瑞南海制药有限责任公司 | A kind of preparation method of lotus sesame sulfathiazole |
| CN107823152B (en) * | 2017-11-09 | 2020-02-11 | 重庆科瑞南海制药有限责任公司 | Preparation method of lotus seed and ganoderma lucidum anti-inflammation tablets |
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Application publication date: 20120125 |