CN102302387A - Small and medium diameter artificial blood vessel with adjustable pressure and flow - Google Patents
Small and medium diameter artificial blood vessel with adjustable pressure and flow Download PDFInfo
- Publication number
- CN102302387A CN102302387A CN201110164976A CN201110164976A CN102302387A CN 102302387 A CN102302387 A CN 102302387A CN 201110164976 A CN201110164976 A CN 201110164976A CN 201110164976 A CN201110164976 A CN 201110164976A CN 102302387 A CN102302387 A CN 102302387A
- Authority
- CN
- China
- Prior art keywords
- regulation
- control
- blood vessel
- pressure flow
- artificial blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a small and medium diameter artificial blood vessel with adjustable pressure and flow. The artificial blood vessel comprises a blood vessel wall, a blood vessel cavity is in the blood vessel wall, and a pressure and flow controller capable of adjusting the diameter of the artificial blood vessel is arranged outside the artificial blood vessel. Concave and convex grains are arranged on the blood vessel wall. The pressure and flow controller comprises a fixed shell and a control spring, wherein the fixed shell takes the shape of a cylindrical structure, and the control spring is configured to be a cylindrical structure, the control spring is arranged in the fixed shell and sleeved outside of the blood vessel wall of the artificial blood vessel, the control spring is provided with a limit spring handle for adjusting the diameter of the blood vessel, and the spring handle passes through a control frame. The fixed shell is provided with position fixing holes, and the control spring is provided with position fixing holes. The fixed shell is provided with a fastener. The pressure and flow controller comprises a mechanical pressure and flow controller, an in-vitro remote control pressure and flow controller and an in-vivo induction pressure and flow controller. The blood vessel is applicable to controlling the size of fractional flow according to an induced pressure of a hepatic portal vein after a portosystemic blood vessel is anastomosed and shunted so as to ensure the hepatic portal vein perfusion pressure required by individuals.
Description
Technical field
The invention belongs to medical instruments field, specifically, is small-caliber artificial blood vessel in the pressure flow adjustability.
Background technology
In the vascular surgery field, big medium caliber artificial blood vessel has been widely used in clinical, and it is remarkable to substitute the tremulous pulse effect.But, the small-caliber artificial blood vessel tremulous pulse (＜6mm), and be used for transplantation substitute vein person long-term effect and unsatisfactory.Need regulate and control the middle small-caliber artificial blood vessel of blood flow or substitute anastomotic vessel still to belong to shortage especially for the human body special organ, make corresponding disease can mustn't go to effective treatment or early stage containment.For example; The anastomosis of blood vessel that at present is used for the shunting of liver cirrhosis portal hypertension; No matter be biological or artificial person, owing to can't require to control the blood flow of anastomotic vessel according to the portal vein pressure controlling, thereby clinically the Surgery Treatment portal hypertension is held conservative attitude always; Be that digestive tract hemorrhage can not be controlled in principle, perhaps splenomegaly hypersplenism person is as operative indication.
According to statistics, the annual tens million of approximately Crinis Carbonisatus life chronic hepatitis property liver cirrhosis of China, portal hypertension cause digestive tract hemorrhage, hepatic encephalopathy or secondary hepatocarcinoma etc. and fatal.Discover that chronic hepatitis liver cirrhosis is early stage,,, and make the serious congestion of sinus hepaticus because central vein is narrow though lobules of liver and liver rope partly exist, the hepatocyte edema, congestion is heavily distinguished born of the same parents' inner structure and is lost.This possibly form with the part pseudolobuli, hepatic sinusoid is destroyed, and the liver blood vessel bed reduces, and it is excessive to cause alive hepatic tissue blood flow, hypertonia, and the portal hypertension that promptly forms is relevant.The hepatic congestion phenomenon also belongs to common in liver transplantation pathology.The anoxia that this type of congestion forms promptly causes in the liver inflammation reflection in various degree.This inflammatory reaction will speed up the liver cirrhosis development undoubtedly again; Increase the weight of the open and shunting naturally of portal vein side Zhi Xunhuan; And then cause with portal vein side Zhi Xunhuan in the congestion anoxia-induced apoptosis and the severe complication of relevant organ, comprising: the 1. generation repeatedly of digestive tract congestion varicosis-massive hemorrhage, and then bring out Ischaemia hepatitis; Impel the displacement of digestive tract toxin and pathogenic bacteria again and bring out toxic hepatitis; Promptly develop into viral+anoxia property+multiple factor nocuity hepatitis such as toxic, and be repeatability, laddering outbreak, quicken the liver cirrhosis process by viral hepatitis; 2. the hepatic congestion anoxia cause liver function low-hyperammonemia, bring out hepatic encephalopathy; 3. the canalis spinalis and the spinal cord congestion anoxia that cause of side Zhi Xunhuan, and bring out hepatic myelopathy etc.This shows; But the portal vein hemodynamics due to the liver cirrhosis changes the hepatic injury of secondary multiple factor except that infective virus, increases the weight of the degree of liver cirrhosis, promotes the vicious cycle of liver cirrhosis Secondary cases hepatic injury; Also have except that liver many organ injuries such as central nervous system, kidney, lung.
If the liver cirrhosis portal hypertension continues to prolong the medical treatment with conservative, until esophagus, the varices of fundus of stomach-hemorrhage operation again of breaking by the time, mortality in said patients can be increased to 30%～50%; And in case take place hemorrhagely, hemorrhage again probability is nearly 70%～80% in 2 years, hemorrhage after again the survival rate of operator then more obviously reduce.Report according to clinical research; Hepatocirrhosis symptoms often shows as abdominal distention, weak, can infer, in the pathology development and forming process of liver cirrhosis → portal hypertension → portal vein shunting; The appearance of portal hypertension such as abdominal distention promptly point out the existing congestion of organs such as digestive tract, spleen regulating liver-QI itself to take place; The existing congestion anoxia existence of organ such as spinal cord are promptly pointed out in the formation such as the esophageal varicosis of portal vein shunting.This two stages portal hypertension is not if solve; Can cause progressive dysfunction of the organ of getting involved and organic disease; Its function can show as compensatory or lose compensatory; Or organ congestion and handicapped mild are only arranged, like abdominal distention poor appetite (gastrointestinal congestion), lower limb heavy weak (spinal function is low) etc.Show that thus portal hypertension and portal vein are the anoxybiotic basic cause of disease of congestion pro-already, by the many organs due to it significantly damage after; The atypia symptom pro-of patient performance, and the classical symptom of its outbreak after.
Consider thus; To the prevention principle that causes this type of disease of multiple organ injury as the liver cirrhosis portal hypertension should be to solve portal hypertension in early days and portal vein is the congestion anoxia; With heavy weak, esophageal varicosis of patient's clinical symptoms such as abdominal distention, lower limb and splenomegaly etc. and the portal hypertension sign confirmed etc., as the indication of surgical intervention, when advocating to internal medicine Supporting Therapy; Follow up a case by regular visits to closely, adopt surgical intervention to remove basic cause of disease problem in early days.China's chronic hepatitis liver cirrhosis portal hypertension is a commonly encountered diseases; Add top hepatocarcinoma and also have portal hypertension; Some of them patient is not because of liver function or the problem of hepatocarcinoma own; But since portal hypertension former thereby get killed for these patients, can improve its quality of life effectively, prolong its valuable life through solving portal hypertension.
At present, no matter in the liver or the liver external drainage, part has obtained better effects, but still the recurrent bleeding or the excessive fatal complication such as hepatic encephalopathy HE, hepatic myelopathy HM of bringing out of shunt volume that exist part shunt volume deficiency to cause; Though liver transplantation is respond well, but still exist the liver source in short supply, or the medical ethics problems of relatives or volunteer liver donation (healthy iatrogenic wound) etc. makes operation limited, and also need solve microhepatia property portal hypertension after the liver transplantation.Therefore; Microhepatia property portal hypertension after liver cirrhosis or the liver transplantation no matter; If can divide stream treatment by early stage portal vein according to portal vein pressure enforcement controlled amounts; Alleviate liver, spleen, digestive tube etc. by secondary injury and complication due to the congestion anoxia, thereby can liver be played a protective role, the multiple organ injury who is caused by hepatopathy is played more effective preventive effect.
Liver cirrhosis portal hypertension, hepatocarcinoma portal hypertension; Perhaps microhepatia property portal hypertension etc. after the liver transplantation; Fail in time to carry out the reason of early prevention property shunt operation, just because of can't controlling effectively to its shunt volume, to such an extent as to bring a body shunt volume not enough or excessive due to post-operative complication.
The existing manual blood vessel fails to be used for a vena systemica shunting; Just because of no matter be clinical used from body blood vessel, allosome blood vessel; Still promptly there are thromboembolism at a specified future date in synthetic material artificial blood vessel, engineering blood vessel etc., lack the performance issue of its blood flow that can suit again.And " small-caliber artificial blood vessel in the pressure flow regulatable type " of this research invention can satisfy clinical needs to this application; After being adapted to a body vascular anastomosis shunting; Can be according to the hepatic portal vein pressure that records, the size of regulation and control shunt volume is to guarantee individual needed portal vein perfusion pressure; Can avoid because of liver and digestive tract congestion anoxia due to the portal hypertension, can prevent again that shunt volume is excessive and the portal vein hypoperfusion that causes and the hepatic ischemia anoxia that causes and malnutrition etc.
Summary of the invention
The objective of the invention is to, small-caliber artificial blood vessel in a kind of pressure flow adjustability is provided, to overcome the above-mentioned shortcoming and defect of existing in prior technology.The present invention is applicable to that hepatic portal arteries and veins hyperbarism, wound, blood vessel self pathological changes, organ tumor undermine blood vessel or cause angiemphraxis etc., and small-bore artery and vein blood vessel substitutes and coincide or the bridge joint person in needing.
Another object of the present invention provides a kind of artificial blood vessel's pressure flow modulator.
The technical problem that will solve required for the present invention, can realize through following technical scheme:
First aspect of the present invention; Small-caliber artificial blood vessel in a kind of pressure flow adjustability, said artificial blood vessel comprises blood vessel wall, is lumen of vessels in the said blood vessel wall; It is characterized in that said artificial blood vessel is provided with the pressure flow modulator of scalable artificial blood vessel bore outward.
Wherein, said pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
Further, corresponding said artificial blood vessel comprises: mechanical pressure flow control type artificial blood vessel, external remote-control pressure flow control type artificial blood vessel and body internal induction pressure flow regulation and control type artificial blood vessel.
Wherein, said artificial blood vessel's shape comprises: straight-through cast, three lumen types and multi-cavity cast artificial blood vessel.
Wherein, said artificial blood vessel's bore is: 5mm, 6mm or 8mm.
Wherein, on the said blood vessel wall asperity is set.
Second aspect of the present invention, a kind of artificial blood vessel's pressure flow modulator is characterized in that, said pressure flow modulator comprises set casing and regulation and control spring,
Said set casing is set to columnar structured, and said regulation and control spring is set to columnar structured, and said regulation and control spring is arranged at set casing inside, and said regulation and control spring is enclosed within outside the artificial blood vessel;
Said regulation and control spring is provided with spacing snapholder, and said snapholder passes the regulation and control frame.
Wherein, the fixed-site hole is set on the said set casing, on the said regulation and control spring fixed-site hole is set.
Wherein, on the said set casing clasp is set.
Wherein, said pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
Said mechanical pressure flow control device comprises: set casing and regulation and control spring; The regulation and control mouth also is set on the set casing; The regulation and control spring comprises: regulation and control spring wall circle and snapholder.
Further, said snapholder comprises: two spring leafs, and said two spring leafs connect the turning part respectively, and two turning parts connect button loop portion.
Further again, spacing governing stage groove is set on the said spring leaf, the one end setting operation hole, the outside of said spring leaf, inboard one end of said spring leaf is provided with the fixed-site hole, and snapholder is connected with regulation and control spring wall circle through the fixed-site hole.
Further, said regulation and control spring wall circle comprises: the fixed-site hole that is connected with snapholder, the fixed-site hole that is connected with the artificial blood vessel, the fixed-site hole that is connected with set casing and regulation and control frame.
Further again, said regulation and control frame comprises turnover fixed arm and turnover fixed arm, and two turnover fixed arms are thought back of the body outside turnover, connected and composed the regulation and control frame, regulation and control frame mouth is set below the said regulation and control frame.
Said external remote-control pressure flow control device comprises: set casing, regulation and control spring, regulation and control axle core and external remote controller; The regulation and control mouth also is set on the said set casing; Said regulation and control spring comprises: regulation and control spring wall circle and snapholder; Said regulation and control axle core comprises: a regulation and control axle core wall circle cylindraceous; In the said regulation and control axle core wall circle is the arbor wheel chamber, and the center in arbor wheel chamber is an axis, on the regulation and control axle core wall circle regulation and control hole and minicell box is set; Hold minicell in the minicell box; Cover motor coil in the axis, the meshing wheel of motor coil both sides cover, the said meshing outside cover capping of taking turns.
Further, said snapholder comprises: two spring leafs are provided with the governing stage hole of regulating external caliber on the said spring leaf; The outside one end of said spring leaf is provided with stiff end, and inboard one end of said spring leaf is provided with the fixed-site hole, and snapholder is connected with regulation and control spring wall circle through the fixed-site hole.
Further, said regulation and control spring wall circle comprises: the fixed-site hole that is connected with snapholder, the fixed-site hole that is connected with the artificial blood vessel, the fixed-site hole that is connected with set casing and regulation and control frame.
Further again, the said meshing center of taking turns is provided with the axis hole that passes axis, and the draw-in groove of snapholder is held in the said meshing edge setting of taking turns.
Further, said external remote controller comprises: external caliber increases switch, external caliber reduces switch and external caliber regulating switch.
Said body internal induction pressure flow modulator comprises: set casing, regulation and control spring, regulation and control axle core and induction apparatus; The regulation and control mouth also is set on the said set casing; Said regulation and control spring comprises: regulation and control spring wall circle and snapholder; Said regulation and control axle core comprises: a regulation and control axle core wall circle cylindraceous; In the said regulation and control axle core wall circle is the arbor wheel chamber, and the center in arbor wheel chamber is an axis, on the regulation and control axle core wall circle regulation and control hole and minicell box is set; Hold minicell in the minicell box; Cover motor coil in the axis, the meshing wheel of motor coil both sides cover, the said meshing outside cover capping of taking turns.
Further, said induction apparatus is set to loop configuration, and said induction apparatus comprises: governing stage hole, the closed loop induction apparatus fixing hole of induction high pressure limit switch, induction low pressure limit switch, adjusting external caliber, the fixed-site hole that is connected with the artificial blood vessel.
Beneficial effect of the present invention:
" small-caliber artificial blood vessel in the pressure flow adjustability " of the present invention performance characteristics comprises:
1. blood flow Modulatory character.This is of paramount importance, after blood vessel transplantation coincide, can regulate and control the blood flow (comprising the adjusting of machinery or external remote control and body internal induction) that anastomotic vessel passes through according to the pressure needs, and suitable especially hepatic portal body shunting is selected for use.
2. good physical property.Have arterial vascular toughness, elasticity and tensile property, guarantee to be implanted in the stretching resistance and the pressure of body; Form and tube chamber are unobstructed to be kept, and through healing and reconstruction, tube chamber does not have constriction or the variation of expanding.
3. the favorable tissue compatibility.Implantable intravascular be connected from the body blood vessel and reconstruct no rejection.
4. suitable little permeability.Rich suitable porosity and hydrophilic can allow an amount of tissue fluid nutritional labeling to infiltrate in the tube wall, be easy to cells involved and move into and attach growth, are beneficial to the building in structural reform of artificial blood vessel, endothelialization and adaptability formation.
5. good partially anti-freezing function is courageous and upright.Can prevent that blood vessel embolism or pipeline are narrow, guarantee at the tube chamber blood flow of body unobstructed.
6. good biological stability and part degradability.Transplant its form stable in the body, part composition degraded time-histories is with reconstruct time-histories the body artificial blood vessel consistent, guarantees with to form time-histories from the body blood vessel structure identical.
7. reliable reduced immunogenicity.After transplanting in the body, do not cause part and systemic inflammatory response, do not cause phenomenons such as leukocyte infiltration or blood leukocytes rising.
8. have avirulence, transplant toxic reactions such as the no heating in back, liver, kidney, nervous system in the body.
Description of drawings
Fig. 1 is an artificial blood vessel's of the present invention partial structurtes sketch map.
Fig. 2 is the mechanical pressure flow control device structural representation of first kind of embodiment.
Fig. 3 is the structural representation of the set casing of first kind of embodiment.
Fig. 4 is the structural representation of the regulation and control spring of first kind of embodiment.
Fig. 5 is the construction drawing of the snapholder of first kind of embodiment.
Fig. 6 is the construction drawing of the regulation and control spring of first kind of embodiment.
Fig. 7 is the construction drawing of the regulation and control spring of first kind of embodiment.
Fig. 8 is the assembly drawing of first kind of embodiment.
Fig. 9 is the assembly drawing of first kind of embodiment.
Figure 10 is the assembly drawing of first kind of embodiment.
Figure 11 is the external remote-control pressure flow control device structural representation of second kind of embodiment.
Figure 12 is the structural representation of the set casing of second kind of embodiment.
Figure 13 is the structural representation of the regulation and control spring of second kind of embodiment.
Figure 14 is the structural representation of the regulation and control axle core of second kind of embodiment.
Figure 15 is the assembly drawing of second kind of embodiment.
Figure 16 A is the structural representation of the external remote controller of second kind of embodiment.
Figure 16 B is the structural representation of the external remote controller of second kind of embodiment.
Figure 17 is the construction drawing of the regulation and control axle core of second kind of embodiment.
Figure 18 is the construction drawing of the regulation and control axle core of second kind of embodiment.
Figure 19 is the construction drawing of the regulation and control axle core of second kind of embodiment.
Figure 20 is the construction drawing of the snapholder of second kind of embodiment.
Figure 21 is the construction drawing of the regulation and control spring of second kind of embodiment.
Figure 22 is the assembly drawing of second kind of embodiment.
Figure 23 is the part schematic diagram of second kind of embodiment.
Figure 24 is the part schematic diagram of second kind of embodiment.
Figure 25 is the body internal induction pressure flow modulator structural representation of the third embodiment.
Figure 26 is the structural representation of the induction apparatus 340 of the third embodiment.
Figure 27 is the part schematic diagram of the third embodiment.
Figure 28 is the part schematic diagram of the third embodiment.
Reference numeral:
Mechanical pressure flow control device: set casing 110: fixedly shell wall circle 111, set casing inner chamber 112, fixed-site hole 114, clasp 116, regulation and control mouthfuls 117.
Regulation and control spring 120: regulation and control spring wall circle 121, fixed-site hole 1212, fixed-site hole 1213, fixed-site hole 1214, blood vessel are worn body cavity 122, snapholder 123, regulation and control frame 125, turnover fixed arm 1251, turnover fixed arm 1252, regulation and control frame mouth 1253.
External remote-control pressure flow control device: set casing 210, regulation and control spring 220, a regulation and control axles core 230, external remote controller 240, fixedly shell wall circle 211, set casing inner chamber 212, fixed-site hole 214, fixed-site hole 215, clasp 216.
Regulation and control spring wall circle 221, blood vessel break-through chamber 222, snapholder 223, regulation and control frame 225; Spring leaf 2234.
A regulation and control axles core wall circle 231, arbor wheel chamber 2302, regulation and control hole 2303, meshingly take turns 2304, minicell box 2305, axis 2306, motor coil 2307, capping 2308.
Regulation and control spring wall circle 221, snapholder 223, spring leaf 2234, governing stage hole 2233, fixed-site hole 2235, stiff end 2236, fixed-site hole 2212, fixed-site hole 2213, fixed-site hole 2214, regulation and control frame 225.
External caliber increases switch 241, external caliber reduces switch 242, external caliber regulating switch 243.
Pressure transducer threshold setting and feedback unit 23071, artificial blood vessel's bore control set-up function unit 23072, display unit 23073.
Body internal pressure flow control device: set casing 310, regulation and control spring 320, regulation and control axle core 330, induction apparatus 340.
Regulation and control spring wall circle 321 snapholders 323.
Induction high pressure limit switch 341, induction low pressure limit switch 342, governing stage hole 343, closed loop induction apparatus fixing hole 344, fixed-site hole 345.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described further.Should be understood that following examples only are used to the present invention is described but not are used to limit scope of the present invention.
The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition that manufacturer provides is carried out.
Small-caliber artificial blood vessel in a kind of pressure flow adjustability, as shown in Figure 1, artificial blood vessel 400 comprises blood vessel wall 410, and asperity 430 is set on the blood vessel wall 410, blood vessel wall 410 inside are lumen of vessels 420.Artificial blood vessel's 400 outer pressure flow modulators that scalable artificial blood vessel bore is set.
The pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
According to pressure flow modulator branch, artificial blood vessel's kind comprises: mechanical pressure flow control type artificial blood vessel, external remote-control pressure flow control type artificial blood vessel and body internal induction pressure flow regulation and control type artificial blood vessel.
Above-mentioned all kinds of by artificial blood vessel and pressure flow modulator (being the blood flow modulator) composition.
The pressure flow modulator comprises set casing and regulation and control spring,
Said set casing is set to columnar structured, and said regulation and control spring is set to columnar structured, and said regulation and control spring is arranged at set casing inside, and said regulation and control spring is enclosed within outside the artificial blood vessel;
Said regulation and control spring is provided with spacing snapholder, and said snapholder passes the regulation and control frame.
Wherein, the fixed-site hole is set on the said set casing, on the said regulation and control spring fixed-site hole is set.
Wherein, on the said set casing clasp is set.
Wherein, said pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
Embodiment 1 mechanical pressure flow control type artificial blood vessel
Mechanical pressure flow control type artificial blood vessel forms (Fig. 1, Fig. 2-10) by artificial blood vessel 400 with mechanical pressure flow control device.
1, mechanical pressure flow control device
Mechanical pressure flow control device comprises: set casing 110 and regulation and control spring 120.Regulation and control mouth 117 also is set on the set casing 110; Regulation and control spring 120 comprises: regulation and control spring wall circle 121 and snapholder 123.Like Fig. 2, Fig. 3 and shown in Figure 4, fixed-site hole 114, clasp 116 are in order to the fixing regulation and control of assembling spring 120 and artificial blood vessel's 400 usefulness.
Regulation and control spring 120 (Fig. 4) by snapholder 123 and regulation and control spring wall circle 121 bipartitions, is prepared against the bore of regulating regulation and control spring wall circle 121 in using, can look at straight and regulate and the adjusting of peritoneoscope clamp.
(1) set casing 110, like Fig. 2, shown in Figure 3, but processed by the rectangle thin slice with hardness folding endurance and elastomeric material, are the fixedly shell wall circle 111 of short cylinder shape.Be set casing inner chamber 112 in the shell wall circle 111 fixedly.
Set casing 110 1 sides are provided with regulation and control mouth 117, prepare against the visual and operation of the snapholder 123 of regulation and control spring 120.The side, two ends of set casing 110 is respectively equipped with fixed-site hole 114; The purposes in fixed-site hole 114 has many places; Coincide with artificial blood vessel 400 after this sutured like set casing 110, prevent displacement and the transposition of modulator and influence the vascular patency function, or external peritoneoscope control manipulation; Fixed-site hole 114 makes set casing 110 corresponding stable with the position relation of regulation and control spring 120 each structure with the orientation of fixing regulation and control spring 120.
Set casing 110 corresponding regulation and control spring wall circle 121 1 sides are left the regulation and control mouth 117 that is shaped on regulation and control snapholder 123, pass in order to the snapholder 123 of regulating and control spring 120 to expose and control manipulation.
The transverse section at the two ends of set casing 110 is provided with clasp 116, and clasp 116 is to cut out the part of removing and reserving by fixing shell wall circle 111 through discontinuity, and the base portion of clasp 116 is wide slightly; Strengthen its steadiness, free-end is narrow slightly, is easy to roll over to the inner ring hook; So that collude the regulation and control spring wall circle 121 of card regulation and control spring 120; Regulation and control spring wall circle 121 positions that guarantee regulation and control spring 120 are constant relatively, and to protect or to prevent to involve blood vessel, the regulation and control spring wall circle 121 of conveniently regulating and controlling spring 120 is gone up the slip that changes the ring size in position again.
(2) regulation and control spring 120 like Fig. 4-shown in Figure 10, comprising: regulation and control spring wall circle 121 and snapholder 123.
Regulation and control spring 120, as shown in Figure 4, by snapholder 123 and regulation and control spring wall circle 121 bipartitions, prepare against the bore of regulating regulation and control spring wall circle 121 in using, can look at straight and regulate and the adjusting of peritoneoscope clamp.
Regulation and control spring wall circle 121 is made up of whippy rectangle sheeting; One end of this thin slice is made as back of the body outside regulation and control frame 125 ends; Respectively cut the back of the body arm of reserving 1 certain width in both sides and make it to be folded to dorsal part, to the back of the body frame of synthetic deltiod, the spring leaf 1234 of preparing against snapholder 123 passes.
Regulation and control spring wall circle 121, as shown in Figure 6, comprising: the fixed-site hole 1212 that is connected with snapholder 223, the fixed-site hole 1213 that is connected with the artificial blood vessel, the fixed-site hole 1214 that is connected with set casing 110 and regulation and control frame 125.
Regulation and control frame 125, as shown in Figure 7, comprising: 1252, two turnovers of turnover fixed arm 1251 and turnover fixed arm fixed arm is thought the turnover of back of the body outside, is connected and composed regulation and control frame 125, regulation and control frame mouth 1253 is set below the said regulation and control frame 125.
As shown in Figure 5, Fig. 5 is the front view of snapholder, vertical view, front view and the construction drawing of turning back from top to bottom.Snapholder 123 comprises: 1234, two spring leafs 1234 of two spring leafs connect 1232, two turning parts, turning part 1232 respectively and connect button loop portion 1231.
Spacing governing stage groove 1233 is set on the spring leaf 1234, the one end setting operation hole 1236, the outside of spring leaf 1234, inboard one end of spring leaf 1234 is provided with fixed-site hole 1235, and snapholder 123 is connected with regulation and control spring wall circle 121 through fixed-site hole 1235.
(3) assembling of regulation and control spring 120 (Fig. 5-Figure 10); Fixed-site hole 1235 correspondences of spring leaf 1234 are regulated and control the fixed-site hole 1212 of spring wall circles 121; Adopt miniature pin formula rivet alive through good above-mentioned two holes (Fig. 8, Fig. 9) of correspondence, compacting is fixing, guarantees can rotate through this pin hinge of living when fixed-site hole 1212 pushes away in external pressure; But pop into position after the removal external force; So as to the governing stage groove 1233 of regulating spring sheet 1234, change the size of regulation and control spring wall circle 121, reach through the blood flow of regulating shunt vessel and control by the purpose of shunt vessel system pressure.Regulation and control spring wall circle 121 is connected with the artificial blood vessel through fixed-site hole 1213.
Shown in figure 10; After transferring snapholder 123 and regulation and control spring wall circle 121 to assemble; Two end ring folding is surrounded blood vessel wear body cavity 122; Two handles that make spring leaf 1234 are taken advantage of a situation through regulation and control frame 125 ports of regulation and control spring wall circle 121 and are passed its regulation and control frame mouth 1253, let governing stage groove 1233 be stuck in two edge of regulation and control frame 125, and through the flexibility ratio of the snapholder 123 examination key control springs 120 that open and close two ends.
(4) assembling of regulation and control spring 120 and set casing 110; To regulate and control spring 120 and transfer to the bore minimum; Place in the set casing 110; Make snapholder 123--regulation and control spring wall circle 121 regulation and control frame 125--set casing 110 regulation and control mouth 117 correspondences, spring leaf 1234 is exposed to regulation and control mouthfuls 117, the clasp 116 at folding press fit shell 110 two ends.Fixed-site hole 1214 on the regulation and control spring 120 is corresponding with the fixed-site hole 114 on the set casing 110, fixing with the connection of fine needle line, the suitable adjustment of elasticity.Regulation and control spring 120 degrees of regulation and the flexibility ratio after the assembling transferred in examination, guarantees it and reliably is advisable.
2, artificial blood vessel
Material selection polyurethane (Polyurethane, PU)+fibroin albumen (Silk fibroin, SF)+the nano inorganic material mixed type, and through necessary Chinese medicine and cells involved matrix treatments, part makes it endothelialization through external cell culture method.
Small-caliber artificial blood vessel during present embodiment adopts, artificial blood vessel's bore is made as: 5mm, 6mm, 8mm.
Artificial blood vessel's kind comprises: straight-through cast, three lumen types and multi-cavity cast artificial blood vessel can supply the organ of different shape or local vascular multiple-limb to need alternative.
3, operation principle
With mechanical pressure flow control type artificial blood vessel's two ends, can distinguish the mode of underwent operative fine needle suturing with thread management, be fit to the shunt vessel that needs connection, be fixed in suitable position through the fixed-site hole 114 on the set casing 110 of pressure flow modulator.
After treating that anastomotic vessel is communicated with, can regulate the regulation and control spring 120 of pressure flow modulator according to the height of being pressed, with the shunt volume and the pylic pressure (capacity) of regulation and control anastomotic vessel by shunt vessel (portal vein).
If portal vein pressure is higher than the upper limit of prescribed limit, then in snapholder 123, contract, push away regulation and control frame 125 inboards of snapholder 123 to regulation and control spring 120; Dwindle the card level of spring leaf 1234 rise assistant warden grooves 1233, regulation and control spring wall circle 121 is increased, this moment, the artificial blood vessel 400 by its regulation and control managed outer the expansion because of the pipe internal pressure is higher than; The tube chamber bore increases; The blood shunt amount strengthens thereupon, and then the blood vessel portal vein capacity of being shunted is reduced, and pressure reduces.
Otherwise,, then in the snapholder 123 of regulation and control spring 120, contract if portal vein pressure is lower than the lower limit of prescribed limit; Stiff spring handle 123 increases the card level that spring leaf 1234 raises assistant warden groove 1233 to regulation and control frame 125 outsides of regulation and control spring 120, and regulation and control spring wall circle 121 is dwindled; This moment, the artificial blood vessel 400 by its regulation and control contracted carefully, and lumen of vessels 420 internal diameters reduce, and the blood shunt amount also reduces thus; The result increases the blood vessel portal vein capacity of being shunted, and pressure raises.
After the shunting that coincide was regulated, regular follow-up also can be taken the circumstances into consideration to treat according to the variation of patient's portal vein pressure.If its portal vein pressure belongs to normal range, need not special handling; If its portal vein pressure raises, surpass the upper limit, can regulate the pressure flow modulator through peritoneoscope, increase shunt volume, reduce portal vein pressure; If its portal vein pressure descends and is lower than lower limit, then can regulate the pressure flow modulator through peritoneoscope, reduce shunt volume, with rising portal vein pressure.
Because the individual variation of human body, hepatoportal bore is different, and blood flow also is not quite similar; The blood flow that then need shunt is also variant, thereby the work done in the manner of a certain author vascular shunt coincide and can select the artificial blood vessel 400 (5mm of different bores; 6mm 8mm), guarantees better unobstructed and more effective adjusting of blood flow.
Embodiment 2 external remote-control pressure flow control type artificial blood vessels
External remote-control pressure flow control type artificial blood vessel comprises: artificial blood vessel 400 and external remote-control pressure flow control device.
1, external remote-control pressure flow control device
External remote-control pressure flow control device (Figure 11-Figure 24), comprising: set casing 210, regulation and control spring 220, regulation and control axle core 230 and external remote controller 240.Set casing (Figure 11, Figure 12) is provided with fixed-site hole 214, fixed-site hole 215 and clasp 216, in order to fixing in the body position after the fixing regulation and control of assembling spring 220 and the vascular anastomosis.
(1) set casing 210, like Figure 11, shown in Figure 12, but processed by the rectangle thin slice with hardness folding endurance and elastomeric material, are the fixedly shell wall circle 211 of short cylinder shape.Be set casing inner chamber 212 in the shell wall circle 211 fixedly.
Present embodiment adopts automatic remote control to regulate, and set casing 210 can be provided with outer regulation and control mouth.The side, two ends of set casing 210 is respectively equipped with and regulates and control the fixed-site hole 214 that spring 220 is connected; And the fixed-site hole 215 that is connected with artificial blood vessel 400; Coincide back, sutured in the position that is fit to artificial blood vessel 400, prevent displacement and the transposition of modulator and influence the vascular patency function.
The transverse section at set casing 210 two ends is provided with the clasp 216 of fixing regulation and control spring wall circle 221; Clasp 216 is to cut out the part of removing and reserving by fixing shell wall circle 211 through discontinuity, and the base portion of clasp 216 is wide slightly, strengthens its steadiness; Free-end is narrow slightly; Be easy to inner ring hook folding,, guarantee that regulation and control spring wall circle 221 positions of regulation and control spring 220 are constant relatively so that collude the regulation and control spring wall circle 221 of card regulation and control spring; To protect or to prevent to involve blood vessel, the regulation and control spring wall circle 221 of conveniently regulating and controlling spring 220 is gone up the slip that changes the ring size in position again.
(2) regulation and control spring 220, like Figure 11, Figure 13, shown in Figure 15, regulation and control spring 220 comprises: regulation and control spring wall circle 221 and snapholder 223.
Regulation and control spring wall circle 221 like Figure 21, shown in Figure 22, is made up of whippy rectangle sheeting, and an end of this thin slice is made as back of the body outside regulation and control frame 225 ends; Respectively cut the back of the body arm of reserving 1 certain width in both sides and make it to be folded to dorsal part, to the back of the body frame of synthetic deltiod, in order to pass (Figure 20) of the spring leaf 2234 of snapholder 223.
On the regulation and control spring wall circle 221 the fixed-site hole 2212 that is connected with snapholder 223, the fixed-site hole 2213 that is connected with the artificial blood vessel, the fixed-site hole 2214 that is connected with set casing 210 are set also.
The outside one end of spring leaf 2234 is provided with free stiff end 2236, and stiff end 2236 snaps in when assembling and is fixed in meshing 2304 (Figure 15) that take turns that axis 2306 drives.Inboard one end of spring leaf 2234 is provided with fixed-site hole 2235, and snapholder 223 is connected with regulation and control spring wall circle 221 through fixed-site hole 2235.
(3) a regulation and control axles core 230, like Figure 14, Figure 15, Figure 17, Figure 18, shown in Figure 19, auto-control axle core 230: take turns 2304 and 1 adjustable electric coils 2307 and constitute (Figure 18, Figure 19) by 2306,2 of 1 axis are meshing.
One regulation and control axle core wall circle 231 cylindraceous is arbor wheel chamber 2302 in the regulation and control axle core wall circle 231, and the center in arbor wheel chamber 2302 is an axis 2306, on the regulation and control axle core wall circle 231 regulation and control hole 2303 and minicell box 2305 is set.
Regulation and control hole 2303 supplies snapholder 223 to pass, and is connected (referring to Figure 17) with regulation and control spring 220.
Hold minicell in the minicell box 2305, cover motor coils 2307 in the axis 2306, motor coil 2307 both sides cover is meshing takes turns 2304, meshingly takes turns 2304 outside cover capping 2308 (referring to Figure 17, Figure 18 and Figure 19).Figure 18 is the construction drawing of front view, vertical view, side view and the regulation and control axle core 230 of axis 2306 from top to bottom.Capping 2308 central authorities are provided with turning cylinder support hole.
Further again, said meshing 2304 centers of taking turns are provided with the axis hole pass axis 2306, the said meshing draw-in groove (referring to shown in Figure 180) that snapholder 223 is held in 2304 edge setting of taking turns.
(4) assembling of regulation and control axles core 230 and-regulation and control spring 220-set casing 210 is referring to Figure 17, Figure 18 and Figure 19.
(5) external remote controller shown in Figure 16 A, Figure 16 B, is made up of shell protective cover and induced inside device.External remote controller 240 comprises: external caliber increases switch 241, external caliber reduces switch 242 and external caliber regulating switch 243.According to the vascular pressure size of required shunting, the bore of scalable shunt vessel and blood flow, the numeral of modulator is the external caliber (unit: mm) that is adjusted to.
2, artificial blood vessel
Material selection polyurethane (Polyurethane, PU)+fibroin albumen (Silk fibroin, SF)+the nano inorganic material mixed type, and through necessary Chinese medicine and cells involved matrix treatments, part makes it endothelialization through external cell culture method.
Small-caliber artificial blood vessel during present embodiment adopts, artificial blood vessel's bore is made as: 5mm, 6mm, 8mm.
Artificial blood vessel's kind comprises: straight-through cast, three lumen types and multi-cavity cast artificial blood vessel can supply the organ of different shape or local vascular multiple-limb to need alternative.
3, operation principle
Blood vessel portion two ends with external remote-control pressure flow control type artificial blood vessel; Can distinguish the mode of underwent operative fine needle suturing with thread management; Be fit to the shunt vessel that needs connection, be fixed in suitable position through the fixed-site hole 215 on the set casing 210 of pressure flow modulator.
The height that the blood vessel of being shunted according to Clinical detection evaluation patient (portal vein) is pressed adopts external remote-control pressure flow control device, to increase or to dwindle the mode of shunting anastomotic vessel caliber size, regulates and control its shunt volume and by the pylic pressure of shunt vessel (capacity).
If portal vein pressure is higher than the upper limit of prescribed limit; Blood vessel regulation and control spring wall circle 221 is increased; This moment, the artificial blood vessel by its regulation and control was higher than the outer passive expansion of pipe because of the pipe internal pressure, and the tube chamber bore increases, and the blood shunt amount strengthens thereupon; And then the blood vessel portal vein capacity of being shunted is reduced, pressure reduces.
Otherwise,, then regulation and control spring wall circle 221 is dwindled through regulation and control if portal vein pressure is lower than the lower limit of prescribed limit; This moment, the artificial blood vessel by its regulation and control contracted carefully, and lumen diameter reduces, and the blood shunt amount also reduces thereupon; The result increases the blood vessel portal vein capacity of being shunted, and pressure raises.
After vascular anastomosis shunting adjusting, regular follow-up also can be taken the circumstances into consideration to continue to observe, perhaps row adjusting again according to the variation of patient's portal vein pressure.
This kind of blood vessel is also according to the individual variation of human body, and hepatoportal bore is different, and the work done in the manner of a certain author vascular shunt coincide, and (5mm, the 6mm's blood vessel that can select different bores 8mm) coincide and shunting.
The principle of external remote-control pressure flow control device
Present embodiment has adopted external setting and remote control artificial blood vessel pressure flow control system, like Figure 23 and Figure 24.This system design can be used for the multifunction chip of green medical treatment, tele-medicine, is that a kind of external setting and remote control supply clinician's control monitoring to use.
Shown in figure 23, minicell 2305 is connected with functional chip control unit 2306, functional chip control unit 2306 is reported to the police respectively at the RF of 13.56MhZ is connected with extraneous communication unit 2307, MEMS pressure transducer 2308, external caliber control execution unit 2309.External caliber control execution unit 2309 connects MEMS pressure transducer 2308, and MEMS pressure transducer 2308 reacts on external caliber control execution unit 2309.MEMS pressure transducer 2308 and (RF reports to the police with extraneous) communication unit 2307.
Shown in figure 24, (RF reports to the police with extraneous) communication unit 2307 is connected with feedback unit 23071, artificial blood vessel's bore control set-up function unit 23072, display unit (pressure, state, flow velocity etc.) 23073 with the pressure transducer threshold setting respectively; Pressure transducer threshold setting and feedback unit 23071 feed back to (RF reports to the police with extraneous) communication unit 2307.
Functional chip control unit 2306 in the above Organization Chart is separated from integrated system, and independent of external remote controller 240.This pattern is easy to clinical manipulation and doctor's dynamic monitoring control, and reduces system cost, power consumption, raising reliability.The functional chip control unit comprises following function:
Wherein RF report to the police with extraneous communication unit 2307 as interface, according to Clinical detection with judge the vascular pressure height regulated and control, regulate the size of vascular shunt lumen of vessels, come the shunt volume of modulating vascular.In case built-in MEMS pressure transducer 2308 sends the set-up function signal; And demonstration pressure anomaly; Need artificial interventional procedure this moment, start blood vessel aperture control unit and set, increase or reduce external caliber to regulate blood flow and pressure until MEMS pressure transducer 2308 all clears.Also can increase digitized in artificial blood vessel's bore control set-up function unit and set, the control blood vessel is diameters within the specific limits.Through this control unit, both can realize that artificial blood vessel's diameter changed continuously, can realize the fixed value input again.
Body internal induction pressure flow regulation and control type the artificial blood vessel comprise: artificial blood vessel 400 and the regulation and control of body internal induction pressure flow.
1, body internal induction pressure flow regulation and control
(Figure 25 Figure 26), comprising the regulation and control of body internal induction pressure flow: set casing 310, regulation and control spring 320, regulation and control axle core 330 and induction apparatus 340.The body internal induction pressure flow regulation and control of present embodiment are similar with the external remote-control pressure flow control device of embodiment 2, and difference is that present embodiment is equipped with body interoceptor 340.
(1) set casing 310, regulation and control spring 320, regulation and control axle core 330, shown in figure 25, the side, two ends of set casing 310 is respectively equipped with and regulates and control the fixed-site hole 314 that spring 320 is connected; Set casing 310 can be provided with outer regulation and control mouth; All the other logical embodiment 2.
(2) regulation and control spring 320 is with embodiment 2.Regulation and control spring 320 comprises: regulation and control spring wall circle 321 and snapholder 323; Referring to the related content of embodiment 2, (like Figure 25, shown in Figure 26).
(3) regulation and control axle core 330; Referring to the related content of embodiment 2, regulation and control axle core 330 comprises: a regulation and control axle core wall circle 231 cylindraceous is arbor wheel chamber 2302 in the regulation and control axle core wall circle 231; The center in arbor wheel chamber 2302 is an axis 2306; On the regulation and control axle core wall circle 231 regulation and control hole 2303 and minicell box 2305 are set, hold minicell in the minicell box 2305, cover motor coil 2307 in the axis 2306; Motor coil 2307 both sides covers is meshing takes turns 2304, meshingly takes turns 2304 outside cover capping 2308 (concrete structure is referring to Figure 18 and Figure 19).
(4) induction apparatus 340; Like Figure 25, shown in Figure 26; Induction apparatus 340 is set to loop configuration; Comprise: governing stage hole 343, the closed loop induction apparatus fixing hole 344 of induction high pressure limit switch 341, induction low pressure limit switch 342, adjusting external caliber, the fixed-site hole 345 that is connected with the artificial blood vessel.
But the sheeting that adopts folding endurance is made induction wall circle; Design closed loop induction apparatus fixing hole 344 on the induction wall circle; That receive shunt vessel and governing stage hole 343 fixed-site hole 345 and alternative ring bore; So that be fixed in the blood vessel of being shunted, and can be adapted to the size of this individuality external caliber.
The design and installation of artificial blood vessel's face receives shunt vessel pressure limit induction installation (start button is stressed), when artificial blood vessel's pressure is elevated to the qualification degree, starts induction high pressure limit switch 341; Inspire and start decompression key "-"; Open greatly with the bore of remote control shunt vessel, increase and divide blood flow, reduce to receive the capacity of shunt vessel; Reduce the pressure that receives shunt vessel and affiliated system thereof, alleviate the congestion degree of this system's vascularity organ.When vascular pressure is reduced to the qualification degree; Start induction low pressure limit switch 342, inspire and start pressurization key "+", contract with the bore of remote control shunt vessel; Reduce its minute blood flow; Increase the capacity that receives shunt vessel, raising receives the pressure of shunt vessel and affiliated system thereof, guarantees the blood perfusion amount of this system's blood vessel to organ.
2, artificial blood vessel
Material selection polyurethane (Polyurethane, PU)+fibroin albumen (Silk fibroin, SF)+the nano inorganic material mixed type, and through necessary Chinese medicine and cells involved matrix treatments, part makes it endothelialization through external cell culture method.
Small-caliber artificial blood vessel during present embodiment adopts, artificial blood vessel's bore is made as: 5mm, 6mm, 8mm.
Artificial blood vessel's kind comprises: straight-through cast, three lumen types and multi-cavity cast artificial blood vessel can supply the organ of different shape or local vascular multiple-limb to need alternative.
3, operation principle
With body internal induction pressure flow regulation and control type artificial blood vessel's two ends, the mode of underwent operative fine needle suturing with thread management is fit to the shunt vessel that needs connection respectively, is fixed in suitable position through the fixed-site hole 345 on the pressure flow modulator set casing 310; Body internal induction pressure flow modulator is installed on by shunt vessel, and this induction apparatus 340 is set with the pressure sensitive sensing scope.
When induced blood vessel (portal vein) press and to be higher than or when being lower than the normal range of setting; Promptly open sensing function automatically; Body internal induction pressure flow modulator to the shunting anastomotic vessel sends its regulation and control instruction; With the caliber size of the shunting anastomotic vessel of the regulation and control spring wall circle that changes body internal induction pressure flow modulator and regulation and control thereof, regulate the blood flow of shunting anastomotic vessel.The shunt volume size of regulation and control anastomotic vessel is opposite relation.
When pylic pressure raises (capacity increase) congestion; As long as portal vein pressure is higher than the range limit of setting, its induction apparatus 340 promptly spreads out of adjusting information to the functional chip control unit 3306 of shunt vessel, makes it to start self regulating system; To increase the shunt vessel bore; Strengthen the blood flow of shunt vessel, reduce by the pylic blood flow of shunt vessel, portal pressure decreases.
Otherwise; Be lower than when portal vein pressure under the scope of setting in limited time, it transfers induction apparatus 340 promptly to spread out of down adjusting information to the functional chip control unit 3306 of shunt vessel, makes it to start self regulating system; To dwindle the shunt vessel bore; Reduce the blood flow of shunt vessel, reduce by the pylic blood flow of shunt vessel, portal pressure increases.
Can long-range regular follow-up after this type of shunting that coincide is regulated.This kind of blood vessel also can be selected the shunting anastomosis of blood vessel 5mm of different bores as one sees fit, 6mm, the 8mm shunting that coincide.
The principle of body internal induction pressure flow modulator
The system design of present embodiment can be used for the multifunction chip of green medical treatment, tele-medicine, is the complete built-in chip of a kind of autonomous intelligence system, like Figure 27 and Figure 28.Be set with the complete intelligent independent property chip system that suits the requirements simultaneously.This system can need not under the situation of artificial interventional procedure; Automatically independently modulate the external caliber of shunting according to the vascular pressure that is ensured, state and flow; This chip is regulated optimum pressure and external caliber through learning model after by implant into body, and spare interface in case of emergency transfers manually-operated to simultaneously.This pattern is easy to use, and need not clinical observation at any time, can long-range information and state be reached server terminal confession doctor judgement." subsequent use control or the alarm unit " reserved increases safety coefficient in case be used in the human body control module and break down and can start dual control, improves reliability greatly.
Shown in figure 27, the functional chip control unit is carried out following function:
Shown in figure 28, RF reports to the police and extraneous communication unit 3307 is controlled set-up function unit 33072, sensing unit (pressure, state, flow velocity etc.) 33073 with pressure transducer threshold setting and feedback unit 33071, artificial blood vessel's bore respectively; Pressure transducer threshold setting and feedback unit 33071 feed back to RF and report to the police and extraneous communication unit 2307.
Artificial blood vessel's applying examples of the present invention
Practical situation according to the patient; The optional majority kind shunt operation of various artificial blood vessel (mechanical pressure flow control type artificial blood vessel, external remote-control pressure flow control type artificial blood vessel and body internal induction pressure flow regulation and control type artificial blood vessel) comprises spleen kidney, door chamber, superior mesenteric vein-postcava etc.
Body internal induction pressure flow regulation and control type artificial blood vessel selects spleen kidney, superior mesenteric vein-postcava bypass, to leave and take hepatic portal vein hepatic portal vein pressure sensitive pick off is installed, and guarantees the sensing of shunt vessel pressure flow modulator is regulated.
Small-caliber artificial blood vessel can satisfy clinical needs to this application in the pressure flow regulatable type of the present invention; After being adapted to a body vascular anastomosis shunting; Can be according to the hepatic portal vein pressure that records, the size of regulation and control shunt volume is to guarantee individual needed portal vein perfusion pressure; Can avoid because of liver and digestive tract congestion anoxia due to the portal hypertension, can prevent again that shunt volume is excessive and the portal vein hypoperfusion that causes and the hepatic ischemia anoxia that causes and malnutrition etc.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the description just explains principle of the present invention; The present invention also has various changes and modifications under the prerequisite that does not break away from spirit and scope of the invention, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (22)
1. small-caliber artificial blood vessel in the pressure flow adjustability; Said artificial blood vessel (400) comprises blood vessel wall (410); In the said blood vessel wall (410) is lumen of vessels (420), it is characterized in that the outer pressure flow modulator that scalable artificial blood vessel bore is set of said artificial blood vessel (400).
2. artificial blood vessel according to claim 1 is characterized in that, said pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
3. artificial blood vessel according to claim 1 is characterized in that, said artificial blood vessel comprises: mechanical pressure flow control type artificial blood vessel, external remote-control pressure flow control type artificial blood vessel and body internal induction pressure flow regulation and control type artificial blood vessel.
4. artificial blood vessel according to claim 1 is characterized in that, said artificial blood vessel's shape comprises: straight-through cast, three lumen types and multi-cavity cast artificial blood vessel.
5. artificial blood vessel according to claim 1 is characterized in that, said artificial blood vessel's bore is: 5mm, 6mm or 8mm.
6. artificial blood vessel according to claim 1 is characterized in that, asperity (430) is set on the said blood vessel wall.
7. an artificial blood vessel pressure flow modulator is characterized in that, said pressure flow modulator comprises set casing and regulation and control spring,
Said set casing is set to columnar structured, and said regulation and control spring is set to columnar structured, and said regulation and control spring is arranged at set casing inside, and said regulation and control spring is enclosed within outside the artificial blood vessel;
Said regulation and control spring is provided with spacing snapholder, and said snapholder passes the regulation and control frame.
8. pressure flow modulator according to claim 7 is characterized in that, the fixed-site hole is set on the said set casing, on the said regulation and control spring fixed-site hole is set.
9. pressure flow modulator according to claim 7 is characterized in that, on the said set casing clasp is set.
10. pressure flow modulator according to claim 7 is characterized in that, said pressure flow modulator comprises: mechanical pressure flow control device, external remote-control pressure flow control device and body internal induction pressure flow modulator.
11. pressure flow modulator according to claim 10 is characterized in that, said mechanical pressure flow control device comprises: set casing (110) and regulation and control spring (120);
Regulation and control mouthful (113) also are set on the said set casing (110);
Said regulation and control spring (120) comprising: regulation and control spring wall circle (121) and snapholder (123).
12. pressure flow modulator according to claim 11; It is characterized in that; Said snapholder (123) comprising: two spring leafs (1234), and said two spring leafs (1234) connect turning part (1232) respectively, and two turning parts (1232) connect button loop portion (1231).
13. pressure flow modulator according to claim 12; It is characterized in that; Spacing governing stage groove (1233) is set on the said spring leaf (1234); The one end setting operation hole (1236), the outside of said spring leaf (1234), inboard one end of said spring leaf (1234) is provided with fixed-site hole (1235), and snapholder (123) is connected with regulation and control spring wall circles (121) through fixed-site hole (1235).
14. pressure flow modulator according to claim 11; It is characterized in that; Said regulation and control spring wall circle (121) comprising: the fixed-site hole (1212) that is connected with snapholder (123); The fixed-site hole (1213) that is connected with the artificial blood vessel, the fixed-site hole (1214) that is connected with set casing (110) and regulation and control frame (125).
15. pressure flow modulator according to claim 14; It is characterized in that; Said regulation and control frame (125) comprises turnover fixed arm (1251) and turnover fixed arm (1252); Article two, the turnover fixed arm is thought back of the body outside turnover, is connected and composed regulation and control frame (125), regulation and control frame mouth (1253) is set below the said regulation and control frame (125).
16. pressure flow modulator according to claim 10 is characterized in that, said external remote-control pressure flow control device comprises: set casing (210), regulation and control spring (220), regulation and control axle core (230) and external remote controller (240); Regulation and control 213 also are set on the said set casing 210; Said regulation and control spring (220) comprising: regulation and control spring wall circle (221) and snapholder (223);
Said regulation and control axle cores (230) comprising: a regulation and control axle core wall circle (231) cylindraceous; In the said regulation and control axle core wall circles (231) is arbor wheel chamber (2302); The center in arbor wheel chamber (2302) is axis (2306); Regulation and control hole (2303) and minicell box (2305) are set on the regulation and control axle core wall circles (231), and the minicell box holds minicell in (2305), cover motor coil (2307) in the axis (2306); Motor coil (2307) both sides cover meshing wheel the (2304), the outside cover capping (2308) of said meshing wheel the (2304).
17. pressure flow modulator according to claim 16 is characterized in that, said snapholder (223) comprising: two spring leafs (2234) are provided with the governing stage hole (2233) of regulating external caliber on the said spring leaf (2234); The outside one end of said spring leaf (2234) is provided with stiff end (2236), and inboard one end of said spring leaf (2234) is provided with fixed-site hole (2235), and snapholder (223) is connected with regulation and control spring wall circle 221 through fixed-site hole (2235).
18. pressure flow modulator according to claim 10; It is characterized in that; Said regulation and control spring wall circle (221) comprising: the fixed-site hole (2212) that is connected with snapholder (223); The fixed-site hole (2213) that is connected with the artificial blood vessel, the fixed-site hole (2214) that is connected with set casing (210) and regulation and control frame (225).
19. pressure flow modulator according to claim 10 is characterized in that, said meshing wheel the (2304) center is provided with the axis hole that passes axis (2306), and the draw-in groove of snapholder (223) is held in the edge setting of said meshing wheel the (2304).
20. pressure flow modulator according to claim 10 is characterized in that, said external remote controller (240) comprising: external caliber increases switch (241), external caliber reduces switch (242) and external caliber regulating switch (243).
21. pressure flow modulator according to claim 10 is characterized in that, said body internal induction pressure flow modulator comprises: set casing (310), regulation and control spring (320), regulation and control axle core (330) and induction apparatus (340); The regulation and control mouth also is set on the said set casing (310);
Said regulation and control spring (220) comprising: regulation and control spring wall circle (221) and snapholder (223);
Said regulation and control axle cores (330) comprising: a regulation and control axle core wall circle cylindraceous; In the said regulation and control axle core wall circle is the arbor wheel chamber, and the center in arbor wheel chamber is an axis, on the regulation and control axle core wall circle regulation and control hole and minicell box is set; Hold minicell in the minicell box; Cover motor coil in the axis, the meshing wheel of motor coil both sides cover, the said meshing outside cover capping of taking turns.
22. pressure flow modulator according to claim 21; It is characterized in that; Said induction apparatus (340) is set to loop configuration; Said induction apparatus (340) comprising: governing stage hole (343), the closed loop induction apparatus fixing hole (344) of induction high pressure limit switch (341), induction low pressure limit switch (342), adjusting external caliber, the fixed-site hole (345) that is connected with the artificial blood vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110164976.9A CN102302387B (en) | 2011-06-17 | 2011-06-17 | Small and medium diameter artificial blood vessel with adjustable pressure and flow |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110164976.9A CN102302387B (en) | 2011-06-17 | 2011-06-17 | Small and medium diameter artificial blood vessel with adjustable pressure and flow |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102302387A true CN102302387A (en) | 2012-01-04 |
| CN102302387B CN102302387B (en) | 2014-05-28 |
Family
ID=45376381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110164976.9A Expired - Fee Related CN102302387B (en) | 2011-06-17 | 2011-06-17 | Small and medium diameter artificial blood vessel with adjustable pressure and flow |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102302387B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127267A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Intravascular stent capable of being stretched and bifurcated |
| CN106510899A (en) * | 2016-11-28 | 2017-03-22 | 浙江大学 | Artificial blood vessel flow adjustment device and artificial blood vessel |
| CN109602518A (en) * | 2017-09-30 | 2019-04-12 | 厦门大学 | A kind of fluidic gating artificial blood vessel |
| CN110811915A (en) * | 2013-03-15 | 2020-02-21 | 伊姆普兰蒂卡专利有限公司 | Restraint device |
| CN110891522A (en) * | 2017-06-02 | 2020-03-17 | 内弗罗尼公司 | Flow regulation in body cavities |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4660802A (en) * | 1985-11-08 | 1987-04-28 | Rao Medical Devices, Inc. | Liquid flow control device |
| CN1374877A (en) * | 1999-07-19 | 2002-10-16 | 恩多阿特股份有限公司 | Flow control method and device |
| US20060229548A1 (en) * | 2003-06-06 | 2006-10-12 | Creativasc Medical Lld | Arteriovenous access valve system and process |
| CN1943519A (en) * | 2006-09-03 | 2007-04-11 | 戴克发 | Self regulating and control device for space human brain blood flow |
| WO2009086548A1 (en) * | 2007-12-31 | 2009-07-09 | C.R. Bard, Inc. | Vascular graft prosthesis with selective flow reduction |
| CN101687076A (en) * | 2006-12-22 | 2010-03-31 | 世界科技有限公司 | Flow controller |
-
2011
- 2011-06-17 CN CN201110164976.9A patent/CN102302387B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4660802A (en) * | 1985-11-08 | 1987-04-28 | Rao Medical Devices, Inc. | Liquid flow control device |
| CN1374877A (en) * | 1999-07-19 | 2002-10-16 | 恩多阿特股份有限公司 | Flow control method and device |
| US20060229548A1 (en) * | 2003-06-06 | 2006-10-12 | Creativasc Medical Lld | Arteriovenous access valve system and process |
| CN1943519A (en) * | 2006-09-03 | 2007-04-11 | 戴克发 | Self regulating and control device for space human brain blood flow |
| CN101687076A (en) * | 2006-12-22 | 2010-03-31 | 世界科技有限公司 | Flow controller |
| WO2009086548A1 (en) * | 2007-12-31 | 2009-07-09 | C.R. Bard, Inc. | Vascular graft prosthesis with selective flow reduction |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110811915A (en) * | 2013-03-15 | 2020-02-21 | 伊姆普兰蒂卡专利有限公司 | Restraint device |
| CN104127267A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Intravascular stent capable of being stretched and bifurcated |
| CN106510899A (en) * | 2016-11-28 | 2017-03-22 | 浙江大学 | Artificial blood vessel flow adjustment device and artificial blood vessel |
| CN110891522A (en) * | 2017-06-02 | 2020-03-17 | 内弗罗尼公司 | Flow regulation in body cavities |
| CN110891522B (en) * | 2017-06-02 | 2021-12-14 | 内弗罗尼公司 | Flow regulation in body cavities |
| CN109602518A (en) * | 2017-09-30 | 2019-04-12 | 厦门大学 | A kind of fluidic gating artificial blood vessel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102302387B (en) | 2014-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11896754B2 (en) | Wound dressing with vacuum reservoir | |
| JP6330014B2 (en) | Apparatus and method for treating excess intraocular fluid | |
| CN102302387B (en) | Small and medium diameter artificial blood vessel with adjustable pressure and flow | |
| US8900116B2 (en) | Inflatable stomal implant | |
| US6186149B1 (en) | Occluder device and method of making | |
| US5108430A (en) | Implantable reservoir adapted to receive and store structural devices therein | |
| US20120265030A1 (en) | Devices, systems, kits and methods for treatment of obesity | |
| US20160374682A1 (en) | Surgical procedure and devices for use therein | |
| ITUB20155928A1 (en) | PROSTHESIS FOR ENTEROSTOMIZED | |
| US20120101594A1 (en) | Endoscopic implantable device and method for the apposition of the stomach walls for reducing the stomach internal volume in a weight loss surgery procedure | |
| CN202128565U (en) | Mechanical pressure flow regulation and control device for artificial vascular graft and artificial vascular graft | |
| JPS58500793A (en) | Hydraulically operated cardiac prosthesis | |
| CN217138162U (en) | Radial artery intervention puncture site compression hemostat | |
| CN100544683C (en) | Gastrointestinal device | |
| CN212547790U (en) | Portable drainage tube monitoring device | |
| CN203802515U (en) | Multifunctional chest surgery operation drag hook | |
| US20240123203A1 (en) | Surgical device for cerebral herniation | |
| CN111603622A (en) | Portable drainage tube monitoring device | |
| CN207575185U (en) | A kind of flap exercise equipment | |
| CN110301994B (en) | Manual blind flap device | |
| Akeshov et al. | CHARACTER AND FREQUENCY OF COMPLICATIONS IN EMERGENCY ABDOMINAL SURGERY | |
| Rossman | Fishbone Perforation of a Meckel'S Diverticulum | |
| Dormann | Endoscopic Feeding Techniques | |
| CN201664436U (en) | Adsorption head and mechanical leech device therewith | |
| CN107625580A (en) | Sinus promoting healing device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140528 Termination date: 20160617 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |