CN102302152A - Nutritious composition and preparation method thereof - Google Patents
Nutritious composition and preparation method thereof Download PDFInfo
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- CN102302152A CN102302152A CN201110205955A CN201110205955A CN102302152A CN 102302152 A CN102302152 A CN 102302152A CN 201110205955 A CN201110205955 A CN 201110205955A CN 201110205955 A CN201110205955 A CN 201110205955A CN 102302152 A CN102302152 A CN 102302152A
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Abstract
The invention relates to a nutritious composition for patients with tumors and cachexia. The nutritious composition provided by the invention is clinically significant in enteral nutrition support. The application of the nutritious composition provided by the invention at the early stage of enteral nutrition support not only effectively promotes recovery of gastrointestinal functions and improves postoperative nutritional status but also has no significant adverse effects on a human body. The nutritious composition has economic value and application value in clinic and is worthy of promotion and application.
Description
Technical field
The present invention relates to the alimentation composition that a kind of tumour and cachexia patient use.Through enforcement of the present invention, can significantly improve patient's quality of life, prolong life cycle, partner treatment.
Background technology
The reason that tumour patient generation malnutrition and body weight descend is many-sided, and main cause comprises: feed minimizing, metabolic disorder, acute inflammatory response increase etc.Because antineoplastons such as operation, chemotherapy, radiotherapy all can cause the feed of tumour patient and reduce, the alimentary canal that tumour itself causes blocks that to wait also often be one of reason of feed minimizing.Along with to the pathogenetic continuous understanding of tumour dyscrasia, it is found that the malnutrition of tumour patient often is difficult to correct through common nutritional support means and method, and regulate to the abnormal metabolism of tumour patient when it must be emphasized that nutritional support.
The nutritional support method mainly is divided in the intestines and parenteral nutrition is supported two technology.The using priciple of nutritional support is, and is good and can use safely the time, first-selected EA is supported approach when gastrointestinal function, because EA accordance with physiology, low price, easy and simple to handle, and relatively is suitable for carrying out of nutritional support in the family.But the general administered through oral of the use of EA, nasal feeding, gastrostomize and jejunum are made number of ways such as mouth.The enforcement of nutritional support and development in the family of tumour patient have also received people's attention in recent years.For the quality of life of improving tumour patient further, reduce the expense of treatment, the nutritional support technology has important function in the family
It is encouraging that some researchs in recent years prove, use the immunity nourishment material, not only do not promote the growth of tumour cell, suppressed the growth of tumour cell on the contrary, obtained the effect of certain antineoplaston.In addition, this type of nutrients can not produce the serious toxic and side effect that chemotherapeutics can cause usually when the performance antineoplastic treatment function, and this also is to excite People more and more how to pay close attention to one of major reason of the application of nutritional support in oncotherapy.
The old man of underlying diseases such as the elderly, especially apoplexy, dementia, diabetes, the absorption of its nutrition has more and more relied on outside special dietary (the interior or nutrition outside the venue of intestines).This is one of such treatment of diseases focus.
Summary of the invention
The object of the present invention is to provide a kind of alimentation composition that improves special disease crowd's nutritional status, wherein contain following composition in 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition, contain following composition in its 1000 ml of formulation:
Above-mentioned alimentation composition can also comprise a kind of and multiple in mushroom extract, Ganodenna Lucidum P.E and the Semen Coicis extract.
Above-mentioned alimentation composition can also comprise anticorrisive agent and flavor enhancement.
Another object of the present invention is to provide the preparation method of alimentation composition of the present invention; Alimentation composition of the present invention adopts following method preparation: with the cholecalciferol of recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride and lactose and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Through enforcement of the present invention, can a kind of very effective enriched nutritive source be provided for heavy patient crowd, for prolonging life, improve the sufferer life quality and play a role.
Specific embodiment
Embodiment 1
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride and lactose and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 2
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 3
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 4
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 5
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 6
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 7
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 8
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 9
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 10
Prescription feeds intake:
The preparation method is with embodiment 1.
Experimental example 11
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride; Lactose and mushroom extract and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 12
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride; Lactose and Ganodenna Lucidum P.E and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 13
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride; Lactose and Semen Coicis extract and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 14
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride; Lactose and flavoring pineapple essence and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 15
Prescription feeds intake:
Cholecalciferol with recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride; Lactose and flavoring orange essence and pure water mix; Regulate pH to 3.5 with sodium citrate; The Sodium Benzoate that adds recipe quantity; Mixing; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
Embodiment 16
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 17
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 18
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 19
Prescription feeds intake:
The preparation method is with embodiment 1.
Embodiment 20-alimentation composition of the present invention is in the postoperative application of lung cancer
Summary: purpose is inquired into the effect to the capable EA intensive treatment of the present invention of lung cancer patients after surgery.The postoperative patient of 12 routine lung cancer is divided into EA reinforcement support group (experimental group, embodiment 1) of the present invention to method and conventional EA treatment group (control group) is carried out clinical comparative analysis.Compared and assessed before nutrition condition, hepatic and renal function, Blood Lipid and the art to two groups of patients in the 8th day with postoperative in the 1st day after surgery respectively.Postoperative is the 8th day as a result; EA of the present invention is strengthened support group (experimental group) and is compared with conventional EA treatment group (control group); Nutritive indexs such as body weight, skinfold, constitutional index, hemoglobin, total serum protein, total protein all have and increase, and difference has conspicuousness (P＞0.05).Conclusion lung cancer operation back is bestowed EA of the present invention to the patient and is strengthened support, and accordance with physiology helps improving patient's nutrition condition, reduces the incidence of postoperative complications, and is economical and practical and safe and effective.
1. data and method
1.1 clinical data and grouping
Patient's totally 12 examples are observed in screening, male 7 examples, and women 5 examples, age 41-75 (average 59.3 years old), experimental group patient is totally 6 examples, and control group is the patient who carries out conventional therapy, totally 6 examples, two groups of patients' the cause of disease and age composition do not have significant difference.
1.2 EA intensifying method of the present invention
The experimental group postoperative began to observe in 6 hours has absent bowel sounds to recover; To absent bowel sounds or gurgling sound utmost point weak person; Do not get started nutritional support of the present invention (embodiment 1) after having uncomfortable situation; Consumption 500-1000 milliliter does not wait, postoperative began to take food in the 6th～8 day semiliquid diet and carry out the transition to low fat and be prone to the general food of digestion.The conventional therapy group low fat that all began to take food in 4～6 days after surgery is prone to the general food of digestion, adopts the parenteral nutrition support before.
1.3 observation index and method
Nutritive index comprises the perioperative measurement index of patient: body weight, bicipital muscle of arm skinfold and constitutional index BMI, total serum protein and hemoglobin etc.
1.4 statistical analysis adopts the SPSS10.0 of statistical software to analyze, the result representes with x ± s, adopts paired t-test.With P＜0.05 is significant difference, and P＜0.01 is a utmost point significant difference.
2. result
2.1 after nutritional support effect experimental group used EA of the present invention to strengthen support, body weight, skinfold, constitutional index, hemoglobin and total protein had been compared significant difference with control group, all are better than control group.See table 1.
Table 1: the observation of curative effect of nutritive index
With control group ratio, * P＜0.05, * * P＜0.01
3. discuss
EA is the first-selected approach of surgical clinical nutritional support; Compare with the parenteral nutrition support, EA has cheap, easy and simple to handle, clinical effectively, meet characteristics such as Human Physiology needs; Along with the research of EA clinical application, tube feed technology and pharmaceutical formulation are constantly perfect; EA is not only the critical treatment measure of common surgical procedures, intestinal fistula, short bowel syndrome, inflammatory bowel disease etc., also is the indispensable main treatment measure of severe pancreatitis, organ transplant, coma patient, tumour and urgent patient.
Use EA of the present invention to strengthen and support to have clinical meaning preferably.Realize the early stage utilization that EA of the present invention is strengthened, not only effectively promote the recovery of gastrointestinal function and improve the postoperative nutrition condition, and body is not had tangible ill-effect.Economic worth and applying value are arranged clinically, be worthy of popularization.
Claims (13)
1. alimentation composition is characterized in that containing in 1000 ml of formulation following composition:
2. alimentation composition according to claim 1 is characterized in that containing in 1000 ml of formulation following composition:
3. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
4. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
5. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
6. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
7. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
8. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
9. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
10. alimentation composition according to claim 1 and 2 is characterized in that containing in 1000 ml of formulation following composition:
11., it is characterized in that said composition can also comprise anticorrisive agent and flavor enhancement according to each described composition of claim 1-10.
12., it is characterized in that said composition can also comprise a kind of and multiple in mushroom extract, Ganodenna Lucidum P.E and the Semen Coicis extract according to each described composition of claim 1-10.
13. each described preparation of compositions method of claim 1-11; It is characterized in that adopting following method preparation: with the cholecalciferol of recipe quantity; Biotin; Folic acid; Vitamin B1; Vitamin B2; Vitamin B6; Cobalamin; Niacinamide; Calcium pantothenate; Vitamin C; Sucrose; Sodium fluoride; Maltodextrin; Glucose; Casein sodium; Whey protein concentrate; Inulin; Soybean polyoses; Potassium citrate; Magnesia; Calcium phosphate; Lactose; Sodium selenite; KI; Chromium chloride; Sodium molybdate; Calcium carbonate; Magnesium chloride; Potassium chloride; Sodium chloride; Ferric pyrophosphate; Zinc sulfate; Manganese chloride; Copper sulphate; Choline Chloride and lactose and pure water mix; Form the suspendible water; Again with safflower seed oil; Linseed oil; Sunflower oil; Median chain triglyceride oil; Fish oil; Soybean lecithin; Single; Bi-tristearin; Retinol Palmitate; Vitamin K1 and vitamin E fully are mixed into oil phase; Oil phase is mixed with water; Stir after liquid preparation is processed in the high pressure homogenize; Packing, sterilization promptly gets.
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Cited By (7)
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|---|---|---|---|---|
| CN103734582A (en) * | 2014-01-23 | 2014-04-23 | 甘南倍益特生物科技有限公司 | Yak lactoprotein polypeptide nutrition powder applicable to middle-aged and aged people and preparation method of powder |
| CN104305197A (en) * | 2014-10-30 | 2015-01-28 | 四川力量科技有限公司 | Composition for increasing high-density lipoprotein |
| GB2522627A (en) * | 2014-01-29 | 2015-08-05 | Greencoat Ltd | Composition |
| CN105077253A (en) * | 2015-09-11 | 2015-11-25 | 浙江海力生生物科技股份有限公司 | Full-nutritional formula food for senile hyperlipidemia patients and preparation method thereof |
| CN105410943A (en) * | 2015-11-30 | 2016-03-23 | 广州市富诺生物科技有限公司 | Compound vitamin tablets and preparation method thereof |
| CN106473149A (en) * | 2015-08-25 | 2017-03-08 | 广州硕维食品技术有限公司 | A kind of Multi-vitamin and multi-mineral compositionss |
| CN112335797A (en) * | 2020-07-22 | 2021-02-09 | 南京普恩瑞生物科技有限公司 | Preparation method of nutritional agent for improving survival rate of immune reconstructed model mice |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734582A (en) * | 2014-01-23 | 2014-04-23 | 甘南倍益特生物科技有限公司 | Yak lactoprotein polypeptide nutrition powder applicable to middle-aged and aged people and preparation method of powder |
| CN103734582B (en) * | 2014-01-23 | 2015-08-26 | 甘南倍益特生物科技有限公司 | A kind of yak milk polypeptide nutrient powder being applicable to mid-aged population and preparation method thereof |
| GB2522627A (en) * | 2014-01-29 | 2015-08-05 | Greencoat Ltd | Composition |
| CN104305197A (en) * | 2014-10-30 | 2015-01-28 | 四川力量科技有限公司 | Composition for increasing high-density lipoprotein |
| CN106473149A (en) * | 2015-08-25 | 2017-03-08 | 广州硕维食品技术有限公司 | A kind of Multi-vitamin and multi-mineral compositionss |
| CN105077253A (en) * | 2015-09-11 | 2015-11-25 | 浙江海力生生物科技股份有限公司 | Full-nutritional formula food for senile hyperlipidemia patients and preparation method thereof |
| CN105077253B (en) * | 2015-09-11 | 2017-07-04 | 浙江海力生生物科技股份有限公司 | A kind of old hyperlipemia full nutrition formula food and preparation method thereof |
| CN105410943A (en) * | 2015-11-30 | 2016-03-23 | 广州市富诺生物科技有限公司 | Compound vitamin tablets and preparation method thereof |
| CN105410943B (en) * | 2015-11-30 | 2018-05-15 | 广州富诺健康科技股份有限公司 | A kind of multivitamin tablet and preparation method thereof |
| CN112335797A (en) * | 2020-07-22 | 2021-02-09 | 南京普恩瑞生物科技有限公司 | Preparation method of nutritional agent for improving survival rate of immune reconstructed model mice |
| CN112335797B (en) * | 2020-07-22 | 2023-08-11 | 南京普恩瑞生物科技有限公司 | Preparation method of nutritional agent for improving survival rate of immune reconstruction model mice |
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Application publication date: 20120104 |