CN102292120A - Drug delivery device dose setting mechanism - Google Patents
Drug delivery device dose setting mechanism Download PDFInfo
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- CN102292120A CN102292120A CN2010800051431A CN201080005143A CN102292120A CN 102292120 A CN102292120 A CN 102292120A CN 2010800051431 A CN2010800051431 A CN 2010800051431A CN 201080005143 A CN201080005143 A CN 201080005143A CN 102292120 A CN102292120 A CN 102292120A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
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- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
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- A61M5/178—Syringes
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- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
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- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/586—Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
Abstract
A method and system for proving a drug delivery device are provided. The device comprises a drug delivery device housing and a medicament contained in the drug delivery device housing. A dose dial sleeve is positioned in the housing and is rotatable to set a non- inverted dose of the medicament contained in the medical delivery device. The non- inverted dose may be increased by turning the dose dial sleeve in a direction towards a user of the drug delivery device. The dose medicament may be decreased by rotating the dose dial sleeve in a direction away from the user.
Description
U.S. Patent application has been described the dosing mechanism that is used for drug delivery device No. 11/520598, and its mode by reference is herein incorporated in full, and the reader is pointed to described application to obtain more information.
Technical field
Present patent application relates generally to the dosing mechanism that is used for drug delivery device.More specifically, present patent application relates generally to for example drug delivery device of pen type drug delivery device.Such device is provided for the administration of drugs from multiple dose cartridge case oneself, and allows user to set dosage delivered.The application can be applicable to disposable and two kinds of delivery apparatus of reusable type medicine.But content of the present invention also can be used in other situations on ground of equal value.
Background technology
The pen type drug delivery device can be used for being undertaken by the personnel that do not accept regular medical training the occasion of conventional injection.This is more and more common in suffering from the patient of diabetes, and this moment, Heal Thyself made these patients effectively to manage its disease.
Verified diabetes can cause some problem.For instance, the people who suffers from diabetes may get hypertension, kidney disease, nerve injury, heart disease or even can lose one's sight in some cases.The damage that is caused by these problems may occur among the uncontrolled for many years patient of blood glucose.Mode by effective insulin administration keeps blood glucose to be controlled being a kind of method of preventing this type of damage to take place of can helping.
In addition, the people who suffers from diabetes may enter " diabetic coma " when its blood glucose is too high.Do not obtain enough food at it, or its excessive exercise and when not adjusting insulin or food, they also can produce low blood glucose (that is hypoglycemia).If untimely treatment, diabetic coma and hypoglycemia both may be very serious, or even fatal.Closely observe blood glucose, know hypoglycemia or too high early stage sign and symptom, and treat described situation early and can prevent that these problems from becoming too serious.
With pen type drug delivery device design and be developed to the patient who helps to suffer from diabetes, to stop the generation of these problems.More than Shuo Ming situation has been given prominence to some design consideration and the standard of drug delivery device (particularly can be used to treat those devices of diabetes).For instance, a requirement is that drug delivery device must sound construction.Drug delivery device must be controlled and understand and all be easy to use aspect the operation two of equipment at drug delivery device.The diabetics own duplicate injection insulin solutions of having nothing for it but, and the volume of the insulin of injection is different because of the patient, in addition because of injection different.At least for this reason, some diabeticss may need to allow the patient to inject the insulin solutions of successive survey preset vol measured same dose or inequality exactly, and to the drug delivery device of the challenge minimum of motility.This has proposed further challenge to design, and this is because in the situation of some diabetes, user may visual impairment and/or may physical weakness and only have limited motility.
Force the patient to use the medication device of his or her weak hand further to increase the weight of patient's visual impairment and the limited problem of motility.In other words, tend to use the personnel that suffer from diabetes (that is left hand type patient) of its left hand maybe needing to thirst for more urgently considering that thus this user ' s preference no longer forces this patient to use the drug delivery device of his or her weak hand or more weak hands.
For instance, some studies show that in the adult colony about 10% for left hand type.Also be well known that these left hand type individualities sometimes owing to the in vogue of right handed instrument or device is in the inferior position position, described device is the medical medicine delivery apparatus for example.A lot of instruments and drug delivery device are designed to can cosily use with the right hand of user, and can not with the left hand of user.For instance, the right handed shears be arranged such that line to be cut be the right handed user as seen, concerning the left hand type user, but blocked.In addition, often the handle of these shears is molded as and concerning the left hand type user, is difficult to hold or holds uncomfortable.Therefore, a large amount of uses in these cases can cause different levels of efficiency and/or discomfort in various degree.As another example of the right handed essence of instrument and equipment, sometimes computer mouse is made and with respect to left hand, be more suitable for the right hand.
Therefore, about the use of medication device, many left hand type patients have particularly suffered for example patient of meropia and limited motility of specific limited, the challenge in the face of strengthening when using the right handed drug delivery device.These patients are forced to use its weak hand and control some drug delivery devices, and many these class devices have complicated dosage setting and injection operation.This leftward the type patient must use his or she non-common right hand controlling equipment setting the accurate dosage of medicine (for example insulin), and like this especially when also wanting dose of medicament subsequently.As mentioned above, the inaccurate dosage setting of the medicine that some oneselfs are used (for example insulin) or injection may cause fatal result.
Therefore, totally need in the design of drug delivery device and exploitation, consider these left hand types and right handed problem.Such drug delivery device will allow user to use his or she more habitual hands (their left hand) to set and the accurate dosage of injectable drug subsequently.
Summary of the invention
According to exemplary, drug delivery device comprises drug delivery device housing and the medicine that is contained in the described drug delivery device housing.Dosage setting cover (dose dial sleeve) is positioned at described housing, and the rotatable dosage of not putting upside down that is contained in medicine described in the described drug delivery device with setting.Can rotate described dosage setting cover towards the direction of the user of described drug delivery device by the edge and increase the described dosage of not putting upside down.When medicine is sent, can rotate the described dosage that described dosage setting cover reduces described medicine away from the direction of described user by the edge.
According to embodiment preferred, the term of Shi Yonging " medicine " or " medicine " all refer to and comprise at least a pharmaceutically active compound that has up to the molecular weight of 1500Da herein, or pharmaceutically active peptides, protein, DNA, RNA, antibody, enzyme, hormone or oligonucleotide, or the pharmaceutical formulation of its mixture; Preferably comprise at least a peptide, more preferably be used for for example peptide of the treatment of diabetic retinopathy of diabetes or the complication relevant with diabetes; Analog or the derivant of preferred especially insulin human, human insulin analogue or derivant, glucagon-like peptide (GLP-1) or its analog or derivant or exedin-3 or exedin-4 or exedin-3 or exedin-4.
Insulin analog exemplarily is Gly (A21), Arg (B31), Arg (B32) insulin human; Lys (B3), Glu (B29) insulin human; Lys (B28), Pro (B29) insulin human; Asp (B28) insulin human; Insulin human, wherein by the proline on Asp, Lys, Leu, Val or the Ala the position of substitution B28, and wherein position B29Lys can be replaced by Pro; Ala (B26) insulin human; Des (B28-B30) insulin human; Des (B27) human insulin and Des (B30) insulin human.
Insulin derivates exemplarily is B29-N-myristoyl-des (B30) insulin human; B29-N-palmityl-des (B30) insulin human; B29-N-myristoyl insulin human; B29-N-palmityl insulin human; B28-N-myristoyl LysB28ProB29 insulin human; B28-N-palmityl-LysB28ProB29 insulin human; B30-N-myristoyl-ThrB29LysB30 insulin human; B30-N-palmityl-ThrB29LysB30 insulin human; B29-N-(N-palmityl-Y-glutamy)-des (B30) insulin human; B29-N-(N-stone gallbladder acyl-Y-glutamy)-des (B30) insulin human; B29-N-(ω-carboxylic heptadecanoyl)-des (B30) insulin human and B29-N-(ω-carboxylic heptadecanoyl) insulin human.
Exendin-4 preferably refers to Exendin-4 (1-39), and promptly sequence is the peptide of H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Me t-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-As n-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.
The Exendin-4 derivant is exemplarily by selecting in the following compounds:
H-(Lys)4-des?Pro36，des?Pro37?Exendin-4(1-39)-NH2，
H-(Lys)5-des?Pro36，des?Pro37?Exendin-4(1-39)-NH2，
des?Pro36[Asp28]Exendin-4(1-39)，
des?Pro36[IsoAsp28]Exendin-4(1-39)，
des?Pro36[Met(O)14，Asp28]Exendin-4(1-39)，
des?Pro36[Met(O)14，IsoAsp28]Exendin-4(1-39)，
des?Pro36[Trp(O2)25，Asp28]Exendin-4(1-39)，
des?Pro36[Trp(O2)25，IsoAsp28]Exendin-4(1-39)，
des?Pro36[Met(O)14?Trp(O2)25，Asp28]Exendin-4(1-39)，
Des Pro36[Met (O) 14 Trp (O2) 25, IsoAsp28] Exendin-4 (1-39); Or
des?Pro36[Asp28]Exendin-4(1-39)，
des?Pro36[IsoAsp28]Exendin-4(1-39)，
des?Pro36[Met(O)14，Asp28]Exendin-4(1-39)，
des?Pro36[Met(O)14，IsoAsp28]Exendin-4(1-39)，
des?Pro36[Trp(O2)25，Asp28]Exendin-4(1-39)，
des?Pro36[Trp(O2)25，IsoAsp28]Exendin-4(1-39)，
des?Pro36[Met(O)14?Trp(O2)25，Asp28]Exendin-4(1-39)，
des?Pro36[Met(O)14?Trp(O2)25，IsoAsp28]Exendin-4(1-39)，
Wherein-Lys6-NH2 group can be connected the C end of Exendin-4 derivant;
Or the derivant of Exendin-4, its sequence is
H-(Lys)6-des?Pro36[Asp28]Exendin-4(1-39)-Lys6-NH2，
des?Asp28?Pro36，Pro37，Pro38Exendin-4(1-39)-NH2，
H-(Lys)6-des?Pro36，Pro38[Asp28]Exendin-4(1-39)-NH2，
H-Asn-(Glu)5des?Pro36，Pro37，Pro38[Asp28]Exendin-4(1-39)-NH2，
des?Pro36，Pro37，Pro38[Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36[Trp(O2)25，Asp28]Exendin-4(1-39)-Lys6-NH2，
H-des?Asp28?Pro36，Pro37，Pro38[Trp(O2)25]Exendin-4(1-39)-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Trp(O2)25，Asp28]Exendin-4(1-39)-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Trp(O2)25，Asp28]Exendin-4(1-39)-NH2，
des?Pro36，Pro37，Pro38[Trp(O2)25，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Trp(O2)25，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Trp(O2)25，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36[Met(O)14，Asp28]Exendin-4(1-39)-Lys6-NH2，
des?Met(O)14?Asp28?Pro36，Pro37，Pro38?Exendin-4(1-39)-NH2，
H-(Lys)6-desPro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-NH2，
des?Pro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-Asn-(Glu)5?des?Pro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-Lys6-des?Pro36[Met(O)14，Trp(O2)25，Asp28]Exendin-4(1-39)-Lys6-NH2，
H-des?Asp28?Pro36，Pro37，Pro38[Met(O)14，Trp(O2)25]Exendin-4(1-39)-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Met(O)14，Asp28]Exendin-4(1-39)-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Met(O)14，Trp(O2)25，Asp28]Exendin-4(1-39)-NH2，
des?Pro36，Pro37，Pro38[Met(O)14，Trp(O2)25，Asp28]Exendin-4(1-39)-(Lys)6-NH2，
H-(Lys)6-des?Pro36，Pro37，Pro38[Met(O)14，Trp(O2)25，Asp28]Exendin-4(S1-39)-(Lys)6-NH2，
H-Asn-(Glu)5-des?Pro36，Pro37，Pro38[Met(O)14，Trp(O2)25，Asp28]Exendin-4(1-39)-(Lys)6-NH2；
Or the pharmaceutically acceptable salt of above-described Exedin-4 derivant or solvate (solvat).
Hormone is pituitary hormone or hypothalamic hormone or modulability bioactive peptide and the antagonist listed in the 50th chapter of the Rote Liste of version in 2008 thereof preferably.Hormone be exemplified as promoting sexual gland hormone (follitropin (Follitropin), lutropin (Lutropin), chorionic-gonadotropin hormone (Chorion gonadotropin), follicle stimulating hormone (Menotropin)), growth hormone (Somatropine) (growth hormone (Somatropin)), Desmopressin (Desmopressin), terlipressin (Terlipressin), gonadorelin (Gonadorelin), triptorelin (Triptorelin), leuprorelin (Leuprorelin), buserelin (Buserelin), nafarelin (Nafarelin), goserelin (Goserelin).
Pharmaceutically acceptable salt exemplarily is acid-addition salts and basic salt.Acid-addition salts exemplarily is HCl or HBr salt.Basic salt shows exemplarily for having the cationic salt that is selected from alkali or alkaline matter, described cation is Na+ or K+ or Ca2+ for example, or ammonium ion N+ (R1) (R2) (R3) (R4), wherein R1 to R4 refers to independently of one another: hydrogen, the optional C1-C6-alkyl group that replaces, the optional C2-C6-alkenyl group that replaces, the optional C6-C10-aromatic yl group that replaces or the optional C6-C10-heteroaryl groups that replaces.In 1985 by being positioned at Easton, Pa., other examples of pharmaceutically-acceptable salts have been described in the Mark Publishing Company of U.S.A. " Remington ' s Pharmaceutical Sciences " that publish, that be compiled as Alfonso R.Gennaro the 17th edition and the drug technique encyclopedia (Encyclopedia of Pharmaceutical Technology).
Pharmaceutically-acceptable salts exemplarily is a hydroxide.
In another kind configuration (arrangement), the pen type drug delivery device comprises the drug delivery device housing.Described housing has the near-end that is used to that the far-end of needle assembly is installed and comprises the dosage setting handle.Cartridge case is contained in the described housing, and described cartridge case contains medicine.Described dosage setting handle is rotatably installed and operationally be coupled to the dosage setting cover.Can set dosage along rotate this dosage setting handle towards the direction of user.When the described dosage setting handle of rotation, described dosage setting handle and described dosage setting overlap both and deviate from the described near-end translation that described medicine is sent housing.The visible scale of not putting upside down has been represented described dosage in the window portion of described housing.In this drug delivery device, can be by increasing described dosage along rotating described dosage setting handle towards the direction of user.
Those of ordinary skills are by reading following detailed description, and suitably with reference to the accompanying drawings, will understand described and other advantages of the various aspects of the drug delivery device that the applicant proposes.
The accompanying drawing summary
With reference to the accompanying drawings exemplary is described at this, wherein:
First embodiment that Fig. 1 shows drug delivery device according to described device be in first, the profile of the configuration of full cartridge case position;
Fig. 2 shows the profile that is in second, has set the drug delivery device among Fig. 1 of position of maximum first dosage;
Fig. 3 show be in the 3rd, the profile of the drug delivery device among Fig. 1 of the position after the dispensing of maximum first dosage;
Fig. 4 shows the profile that is in the 4th, has set the drug delivery device among Fig. 1 of position of final dose;
Fig. 5 show be in the 5th, the profile of the drug delivery device among Fig. 1 of the position after the final dose dispensing;
Fig. 6 shows the cutaway view of first details of the drug delivery device among Fig. 1;
Fig. 7 shows the partial sectional view of second details of the drug delivery device among Fig. 1;
Fig. 8 shows the partial sectional view of the 3rd details of the drug delivery device among Fig. 1;
Fig. 9 shows first relative motion of the part of the drug delivery device shown in Fig. 1 when raising dosage;
The relative motion of the part of the drug delivery device shown in Fig. 9 when Figure 10 shows downward modulation dosage;
The relative motion of the part of the drug delivery device when Figure 11 shows delivered dose shown in Fig. 9;
Figure 12 shows the partial sectional view that is in second, has set the drug delivery device among Fig. 1 of position of maximum first dosage;
Figure 13 shows the partial sectional view that is in the 4th, has set the drug delivery device among Fig. 1 of position of final dose;
Figure 14 shows the partial sectional view of the drug delivery device among the Fig. 1 that is in one of the first, the 3rd or the 5th position;
Figure 15 shows the right handed user and can how to use the drug delivery device among Fig. 1 to set dosage;
Figure 16 shows the left hand type user and can how to use the drug delivery device among Fig. 1 to set dosage;
Figure 17 shows the scale configuration that the drug delivery device that can be used among Fig. 1 is set dosage;
Figure 18 shows along the scale configuration among Figure 17 of the outer surface setting of dosage setting cover;
How Figure 19 can use the drug delivery device injected dose shown in Fig. 1 if showing the right handed user;
Figure 20 shows the right handed user and can how to use the drug delivery device among Fig. 1 to set dosage;
How Figure 21 can use optionally (alternative) drug delivery device setting dosage if showing the left hand type user;
Figure 22 shows the optional scale configuration of the optional drug delivery device that can be used among Figure 20; And
Figure 23 shows along the optional scale configuration among Figure 22 of the outer surface setting of dosage setting cover.
Detailed Description Of The Invention
At first, wherein show: be used for dosage setting and be used for dosage using or injecting according to the drug delivery device 1 that is in a kind of configuration of a plurality of operating positions referring to Fig. 1 to 5.Drug delivery device 1 comprises housing and second main (outside) housing parts 4 with first cartridge case retaining part 2.By keeping feature 6 that first end of cartridge case holding device 2 and second end of main casing 4 are fixed together.In the configuration shown in this, cartridge case holding device 2 is fixed in second end of main casing 4.
To be arranged in the cartridge case retaining part 2 by the cartridge case 8 of a plurality of drug doses of wherein can providing and delivering out.Preferably, cartridge case contains a kind of medicine that must often use, for example once a day or repeatedly.A kind of such medicine is an insulin.Piston 10 is remained in first end of cartridge case.Removable medicated cap 12 is remained on releasedly on second end of cartridge case retaining part 2.
The dosing mechanism of the drug delivery device shown in Fig. 1-5 can be used as disposable or reusable drug delivery device.When drug delivery device comprises the disposable drug delivery apparatus, can not under the situation of not damaging this device, cartridge case be removed.Perhaps, when drug delivery device comprised reusable drug delivery device, cartridge case was removable, and can under the situation of not damaging this device it be removed from device.In the drug delivery device shown in Fig. 1-5 1, this drug delivery device is depicted as the disposable drug delivery apparatus.Yet, one skilled in the art would recognize that also and this dosing mechanism can be used on reusable drug delivery device.
In use, can use suitable needle unit (not shown) to replace removable medicated cap 12 by user.This needle unit can be screwed on the far-end of housing, perhaps with its hasp (snap) on this far-end.Interchangeable medicated cap 14 is used for covering by main casing 4 extended cartridge case retaining parts 2.Preferably, the external dimensions of interchangeable medicated cap 14 is similar or identical with the external dimensions of main casing 4, so that the impression of a unified integral body to be provided when the interchangeable medicated cap 14 covering cartridge case retaining part 2 on the throne.In the configuration that illustrates, insert 16 is arranged on first end of main casing 4.This insert 16 is fixing, it can not be rotated or lengthwise movement.Insert 16 is provided with screw thread annular opening 18.Alternatively, can be with this insert and main casing global formation, its form is the flange that radially inwardly leads with internal whorl.
First spiral grooves 19 begins to extend from first end of piston rod 20.In a kind of configuration, the cross section of piston rod 20 is roughly annular, but also can use other configuration.The threaded openings 18 that first end of piston rod 20 (far-end of piston rod 20) passes in the insert 16 is extended.Pressure foot 22 is positioned at the far-end or first end of piston rod 20.This pressure foot 22 is set to the second end adjacency with cartridge piston 10.Second spiral grooves 24 begins to extend from second end (near-end of piston rod 20) of piston rod 20.In the configuration that illustrates, second spiral grooves 24 begins to extend from the near-end or second end of piston rod 20.
In the configuration that illustrates, second spiral grooves 24 comprises a series of part spiral grooves, rather than a complete spiral grooves.An advantage of this configuration that illustrates is that it is easy to make generally, and helps to have reduced user activate the required overall strength of described device from drug delivery device 1 when medicine is provided and delivered out.
First spiral grooves 19 and second spiral grooves 24 are oppositely arranged, that is, the chirality of groove is opposite.Second end of piston rod 20 (that is the near-end of piston rod 20) is provided with and holds recess 26.Drive sleeve 30 is extended around piston rod 20.Drive sleeve 30 is roughly cylindrical.For drive sleeve 30 is provided with first radially extending flange 32 at its first end.Second radially extending flange 34 is set to along drive sleeve 30 and first flange 32 from a distance.Intermediate conveyor screw groove 36 is arranged on the Outboard Sections of actuating sleeve 30, it extends between first flange 32 and second flange 34.Spiral grooves 38 is extended along the inner surface of drive sleeve 38.Second spiral grooves 24 of piston rod 20 is set to be suitable for operation in spiral grooves 38.
First end of first flange 32 is adapted to second side of insert 16 conforms to.Partial nut (part nut) 40 and is arranged on it between first flange 32 and second flange 34 between drive sleeve 30 and main casing 2.In the configuration that illustrates, this partial nut 40 comprises half-nut.Partial nut 40 has the internal helicoid groove that the intermediate conveyor screw groove 38 with drive sleeve 30 is complementary.In a preferred configuration, mode by spline 42 locks together (simultaneously referring to Figure 10,11,15 and 16) with the outer surface of partial nut 40 and the inner surface of main casing 5, to stop the relative rotation between partial nut 40 and the main casing 4, but allow between these two members relative to moving longitudinally.
Shoulder 37 is formed second end (near-end of drive sleeve 30) in drive sleeve 30 and be arranged between the extension 38 (far-end of drive sleeve 30) of second end of drive sleeve 30.This extension 38 is compared with the remainder of drive sleeve 30 has the inside and outside diameter that reduces.Second end of extension 38 is provided with the flange 39 of guiding radially outward.To carry out most description to it hereinafter, will ring sheet device (clicker) 50 and shaft coupling 60 be arranged in drive sleeve 30 near, between drive sleeve 30 and dosage setting cover 70.
Ringing sheet device 50 is positioned near second flange 34 of drive sleeve 30.Sound sheet device 50 is roughly cylindrical, and at its first end pliability spiral extension arm 52 (referring to for example Fig. 6) is set.The free end of arm 52 is provided with the dentation parts 54 of radially-directed.Second end that rings sheet device 50 is provided with a series of sawtooth 56 (Fig. 7) along the circumference guiding.Each sawtooth all comprises longitudinally guiding surface and inclined surface.
In optionally disposing, ring the sheet device and also comprise at least one spring members.This at least one spring members aids in the medicine replacement of shaft coupling 60 afterwards of the previous set amount of dispensing.Shaft coupling 60 is positioned near second end of drive sleeve 30.This shaft coupling 60 is roughly cylindrical, and is provided with a series of sawtooth 66 (referring to for example Fig. 7) along the circumference guiding at its first end (far-end).Each sawtooth all comprises longitudinally guiding surface and inclined surface.Second end 64 (near-end) towards shaft coupling 60 is furnished with radially the inwardly flange 62 of guiding.The flange 62 of shaft coupling 60 is arranged between the shoulder 37 of drive sleeve 30 and the flange 39 that extension 38 radially outward leads.
Second end of shaft coupling 60 is provided with a plurality of claw type teeth (dog teeth) 65 (referring to Fig. 8).Mode (not shown) by spline is sealed to drive sleeve 30 with shaft coupling 60, to stop the relative rotation between shaft coupling 60 and the drive sleeve 30.In a preferred flat configuration, ring the only about half of length that sheet device 50 and shaft coupling 60 extend drive sleeve 30 separately.But those of ordinary skills will appreciate that other configurations about the relative length of these parts also are possible.For example, will ring sheet device 50 and shaft coupling 60 engages shown in Fig. 6 and 7.
Main casing 4 also is provided with spiral ribs 46, and it is set to be suitable for to be contained in the spiral grooves 74 on the outer surface of dosage setting cover 70.In a preferred configuration, spiral ribs 46 is extended the inner surface (the helical rib 46 extends for a single sweep of the inner surface of the main housing 4) of the inswept described main casing 4 of single.First retainer is arranged between spline 42 and the spiral ribs.Form second retainer that becomes 180 degree angles with first retainer by the framework around window portion 44 in the main casing 4.
Return Fig. 1-5, dosage setting handle 76 is arranged near the outer surface of second end of dosage setting cover 70.The outer dia of dosage setting handle 76 is preferably corresponding to the outer dia of main casing 4.Dosage setting handle 76 is fixed to dosage setting cover 70, to stop the relative motion between these two members.Dosage setting handle 76 is provided with central opening 78.The annular notch 80 that is positioned at second end of dosage setting handle 76 extends near opening 78.Second end of device will totally be arranged on for the button of T section.The bar portion 84 of button 85 can pass opening 78 and extends in dosage setting handle 76, pass drive sleeve 30 extension 38 inside diameter and enter the holding in the recess 26 of proximal end of piston rod 20.Bar portion 84 is fixing, make it can only axially-movable limitedly in drive sleeve 30, and can not rotate with respect to drive sleeve.The head 85 of button 82 is roughly annular.Skirt section 86 85 periphery from the head extends out.Skirt section 86 is set to be suitable for it is contained in annular 10 recesses 80 of dosage setting handle 76.
To the operation according to the preferred right handed drug delivery device that is provided be described.In Fig. 9,10 and 11, button 82, dosage setting handle 76, dosage setting cover 70, drive sleeve 30, shaft coupling 60, sound sheet device 50 and partial nut 40 motion separately in arrow A, B, C, D, E, F and a kind of configuration of G representative.
In order to set dosage in the configuration shown in Figure 9, user is held in main casing 4 in the his or her left hand, and uses the right hand along direction (arrow B) the rotation dosage setting handle 76 away from this user.Also show this situation in Figure 15, wherein user uses the his or her right hand to rotate dosage setting handle 76 along the direction of arrow 120: along the direction away from user.Along with ringing sheet device 50 and shaft coupling 60 engages, drive sleeve 30, ring sheet device 50, shaft coupling 60 and dosage setting cover 70 and rotate towards user with dosage setting handle 76.Provide audition and tactile feedback by ringing sheet device 50 and shaft coupling 60 to setting dosage.Transmit moment of torsion by the sawtooth 56,66 that rings between sheet device 50 and the shaft coupling 60.Flexible arm 52 makes 54 distortion of dentation parts, and it is pulled through spline 42 to produce click sound.Preferably, spline 42 is arranged so that each click sound correspondence conventional unit dose, or its analog.
The visible mark of the dosage that can set can be arranged on the outer surface 72 of dosage setting cover 70, described sign exemplarily can be reference number or scale (for example, referring to Figure 12 and 14).Exemplarily, Figure 17 shows first scale configuration 122 that can be arranged on the dosage setting cover outer surface 72.In the scale configuration 122 shown in Figure 17, this configuration 122 comprises 5 column of figures: first row 124, secondary series 126, the 3rd row 128, the 4th row 130 and the 5th row 132.In every row, along these row upwards, the numeral in the row reduces 2 successively.Exemplarily, with reference number " 80 " beginning, and each other numerals that provide in these row reduce 2 (that is, 80 units, 78 units subsequently, 76 units etc. subsequently) successively at first row, 124, the first row 124 that are arranged in configuration 122 left-hand side.
The amount of the dosage that first scale configuration 122 can be set according to user provides the particular visual sign by drug delivery device window portion 44 to user.As dispose from this first scale that provides Figure 17 122 visible, maximum scale reference number " 80 " 134 is arranged on the bottom of first row 124, and minimum scale reference number " 0 " 136 is arranged on the top of the 5th row 132.Use this scale configuration 122, the maximal dose that can be set by drug delivery device 1 be " 80 " individual unit 134, and I setting dosage is " 0 " unit 136.Respectively between maximum reference number 134 and minimum reference number 136, the increment with 2 marks other dosage (for example, 2,4,6,8 etc.).Also can set single unit dose and odd number unit dose, and provide by the mode that is arranged on a plurality of scale marks between the even number reference number.For instance, set between dosage " 0 " unit 136 and 2 units in I half scale mark (" 1 " individual unit) 138 is set at the top of row 132.
As also can seeing from this first scale configuration 122, reference number increases to the left side of scale 122 (towards the first scale configuring arrange 124) from the right-hand side or the 5th scale configuring arrange 132 of scale 122.Figure 18 shows the scale configuration among Figure 17, and its outer surface 72 along dosage setting cover 70 is provided with.As can be seen from Fig. 18, scale configuration 122 has the I setting dose value " 0 " that the maximum that is arranged on far-end 73 can be set dose value " 80 " and be arranged on the near-end 74 of dosage setting cover 70.Also provide middle scale numeral " 60 " individual unit 172, " 40 " individual unit 176 and " 20 " individual unit 178.
Therefore, if scale configuration 122 is arranged on the dosage setting cover 70 shown in Fig. 1-5, when user overlaps 70 by dosage setting handle 76 along the direction rotation dosage setting away from this user, when setting dosage with the right hand that uses this user as shown in Fig. 9 to 15, dosage setting cover 70 can stretch out outside the housing.For instance, in Figure 15, user uses the his or her right hand to set the dosage of 30 units.As shown in figure 15, when user along away from the direction (this direction being shown) of this user rotation dosage setting handle 76 and when therefore rotating dosage setting and overlapping 70 by arrow 120, the scale configuration 122 among Figure 17 is provided with and can read on upright orientation by window portion 44 thus along the outside drum type portions of dosage setting cover 70.
Therefore, when user uses the his or her right hand to rotate this dosage setting cover, user can be accepted the correct visual confirmation at least two material particulars: (1) amount and (2) drug delivery device supplier by window portion 44 observable dosage may be included in other signs (from label 112) on the housing.For instance, label 112 can comprise: to effect duration of the description of the medicine that provides in the drug delivery device, medicine, certain color of the type of providing medicine is specified or certain color of the type of providing drug delivery device is specified.Only as an example, drug delivery device label 112 can provide the colour code of the insulin type that provides in the drug delivery device (for example, protamine zine insulin or short-acting insulin) and/or can show that this drug delivery device intention is used for right handed or left hand type diabetics.That is tend to those diabeticss that its left hand of preference is set dosage and/or injected dose.
Get back to the drug delivery device 1 shown in Fig. 1-5, when arriving final dose delivery location (in addition referring to Fig. 4,5 and 13), radial stop device 108 adjacency on the first surface of the radial stop device that forms on the second surface of partial nut 40 106 and second flange 34 of drive sleeve 30, both continue rotation to stop nut 40 and drive sleeve 30.In optional configuration, the first surface of partial nut 40 can be provided with the radial stop device, for the second surface that is arranged on first flange 32 on radial stop device adjacency.This helps nut 40 location in full cartridge case position in the assembling process of drug delivery device.
If user is cursorily set the dosage that has surpassed needs, the drug delivery device among Fig. 9 allows this dosage is reduced and the medicine (referring to for example Figure 10) of can not providing and delivering out from cartridge case.For instance, as shown in Figure 15, user has been set the dosage of 30 units.Yet user may wish to reduce this dosage now, and the dosage of 30 units of setting before this of not providing and delivering.In this configuration, in order to allow user reduce this dosage, with dosage setting cover 70 along direction rotation, and with 76 reverse rotations of dosage setting handle (referring to, the arrow B among Figure 10 for example) towards user.This will cause, and system is reverse to work.Flexible arm 52 stops sound sheet device 50 to rotate.The moment of torsion that transmits by shaft coupling 60 makes sawtooth 56,66 slip over each other, to produce the click sound corresponding to the dosage reduction of setting.Preferably, sawtooth 56,66 is arranged so that each sawtooth distance along the circumferential direction is corresponding to unit dose.
When having set the dosage that needs, user can be subsequently by pressing button 82 this dosage of dispensing (referring to, for example, Figure 11).When user is pushed button 82 as shown in Figure 11 and Figure 18, this will make shaft coupling 60 overlap 70 axial displacements with respect to dosage setting, cause the separation of claw type tooth 65.But shaft coupling 60 keeps the spin locking with drive sleeve 30.Dosage setting cover 80 can rotate freely (being led by the spiral ribs 46 that is arranged in spiral grooves 74) now with relevant dosage setting handle 76.
Axially-movable makes flexible arm 52 distortion that ring sheet device 50, to guarantee that sawtooth 56,66 can be by hyper-traction (overhauled) in dispensing.This stops the rotation of drive sleeve 30 with respect to main casing 4, but it still can freely move axially with respect to described housing 4.Subsequently this distortion is used for promoting to ring sheet device 50 and shaft coupling 60 backward, to overlap connection between 70 from button 82 removes pressure after, recovering shaft coupling 60 and dosage setting along drive sleeve 30.The opening 18 that vertical axially-movable of drive sleeve 30 makes piston rod 20 pass in the insert 16 rotates 5, and piston 18 is stretched in the cartridge case 8.
As seen from Figure 19, when user used the his or her right hand 130 pressing buttons 82, user can monitor the dosage of providing and delivering by scale configuration 122 via window portion 44.In addition, when user uses his or her right hand pressing button 82 when using this dosage, other labels 124 that are provided with along housing (referring to, for example, may also be visible Figure 15).
But it should be understood that then these incidents can not take place if left hand type user (that is, the left hand type diabetics) is attempted to use his or her left hand at first to set dosage and used this previous dosage of setting subsequently.For instance, Figure 16 shows the situation that can take place when the left hand type user attempts to set the dosage of the drug delivery device shown in Fig. 1-5.At first, the left hand type user can use the his or her right hand to hold drug delivery device housing 4, uses the left hand of this user to rotate dosage setting handle 76 subsequently.With this orientation, dosage setting handle 76 must be rotated with setting dosage towards user, rather than as in the right handed drug delivery device, rotating away from user ground.In Figure 16, represent this situation by arrow 110.In such incident, scale configuration 122 and label 112 boths that are arranged on the dosage setting cover 70 can be put upside down: they can turn upside down, rather than face up (right side up), as shown in Figure 16.Therefore, concerning the left hand user of drug delivery device, must will be arranged on the scale and label 112 transformations of the way that dosage setting puts, think that these left hand user provide scale that can read and the label that can read.
Figure 21 shows optional drug delivery device 140, and wherein the left hand user is selected dosage by the direction rotation dosage setting handle 144 along arrow 142: promptly, and towards user rotation dosage setting handle 144.In this configuration, user holds housing 146 with its right hand.Subsequently, user can use his or her left hand to set dosage via dosage setting handle 142.When user is set dosage, another optional scale configuration 152 must be provided, so that user can be observed the scale configuration 152 of the orientation that faces up by drug delivery device window portion 150, rather than use the scale of putting upside down 122 shown in the device 1 among Figure 16.To can read and the unturned scale of observing in order in this structure, providing, must to provide by the scale after the scale transformation of the way that provides among Figure 17.
Figure 22 shows a kind of configuration of optional scale configuration 152, can be with its outer surface setting along dosage setting cover in the drug delivery device 140 of Figure 21.But the total structure of the arrangement of this drug delivery device 140 and the dosing mechanism that provides in Figure 21 thereof are all substantially the same with the total structure and the operation of the drug delivery device 1 shown in Fig. 1-5.Yet optionally scale configuration 152 and optional label 148 boths are changed a social system by the scale configuration 122 and the label 112 of the device shown in Figure 20 1.In this optional structure, when the left hand user is set metering, orientation that can be correct observe scale 152 and label 148 both: wherein scale and label all face up, and are not reversed.
Figure 22 shows a kind of configuration of the scale 152 after such transformation of the way.By this optional scale configuration as seen, still provide five row referential datas: first row 160, secondary series 162, the 3rd row 164, the 4th row 166 and the 5th row 168.Dispose 122 as seen by first scale shown in Figure 17, the orientation of five row is changed by the scale configuration that provides among Figure 17 in the optional scale configuration 152.
Yet, dispose 122 different with scale among Figure 17, in optional scale configuration 152, to comprise that maximum can set the referential data of the individual unit of dosage " 80 " and be listed as along the right-hand side setting of this scale configuration, and be arranged on minimum dose " 0 " unit in the 5th scale configuring arrange 168 of this configuration left-hand side this moment.Another scale that is not both after the transformation of the way of scale configuration 152 after the transformation of the way and the scale configuration 122 among Figure 17 disposes in 152, and dosage setting numerical value increases to the top of row from the bottom of row.For instance, in first row 160 of scale configuration 152, dosage can be increased to 2,4 from minimum " 0 ", by that analogy.Therefore, if the configuration of the scale after will changing a social system 152 dosage settings that drug delivery device shown in Figure 22 140 is set put, higher dose value 154 can distribute along the far-end of dosage setting cover, and lower dose value can be overlapped 70 near-end distribution along dosage setting.Therefore, when user uses the left hand of user to overlap along the direction rotation dosage setting towards user by dosage setting handle 76, dosage setting cover 70 can stretch out outside the housing, and can in visual window portion 44, read scale configuration 152, and the configuration of described scale can not put upside down equally as shown in Figure 16 more from heads scale.
Figure 23 shows along the scale configuration of Figure 18 of outer surface 72 settings of dosage setting cover 70.As seen from Figure 18, the maximums of scale configuration 122 with the far-end 73 that is arranged on dosage setting cover 70 can be set dose value " 80 " and be arranged on the I setting variable " 0 " of the near-end 74 of dosage setting cover 70.The individual unit 186 of scale numerical value " 60 " in the middle of also being provided with, " 40 " individual unit 184 and " 20 " individual unit 182, but as comparing with Figure 18, its relative position along the outer surface 72 of dosage setting cover is changed.
Another change that can carry out the drug delivery device 1 shown in the 140 relative Figure 20 of the drug delivery device among Figure 21 is the orientation that changes label 148.Now, use the drug delivery device 140 among Figure 21, when user used its right hand to hold apparatus casing 4 and use its left hand to set dosage by rotate the dosage setting handle along the direction of arrow 142, the left hand type user can be observed label in heads mode this moment.That is, label 148 is no longer put upside down.
Exemplary to this drug delivery device is described.But it will be understood by those skilled in the art that under the situation of true scope that does not deviate from the drug delivery device that proposes that is defined by the claims herein and spirit, can change and revise these embodiments.
Claims (30)
1. drug delivery device, described equipment comprises:
The drug delivery device housing;
Be contained in the medicine in the described drug delivery device housing; With
Be arranged in the dosage setting cover of described housing,
The rotatable dosage of not putting upside down that is contained in the described medicine in the described drug delivery device with setting of described dosage setting cover;
Wherein can rotate described dosage setting cover towards the direction of the user of described drug delivery device and increase the described dosage of not putting upside down by the edge.
2. invention as claimed in claim 1 wherein can be rotated the described dosage that described dosage setting cover reduces described medicine away from the direction of described user by the edge.
3. invention as claimed in claim 1 or 2, wherein said housing also comprises label, described label representative is contained in the described medicine in the described drug delivery device, and described label comprises the text of not putting upside down and can be read by described user when described user is set the described dosage of medicine.
4. as any described invention in the claim 1 to 3, wherein said housing also comprises observation window, so that in described dosage setting operating process, can observe the scale of the described dosage of representative by described observation window.
5. as any described invention in the claim 1 to 4, wherein said dosage setting cover comprises the scale configuration, so that when described user is set described dosage by rotate described dosage setting cover towards described user, the orientation that can not put upside down is observed described scale configuration.
6. as any described invention in the claim 1 to 5, wherein said drug delivery device is the disposable drug delivery apparatus.
7. as any described invention in the claim 1 to 6, wherein said drug delivery device is reusable drug delivery device.
8. as any described invention in the claim 1 to 7, wherein when described user is injected described dosage, described dosage setting element rotates back in the described housing and along the direction away from described user.
9. as any described invention in the claim 1 to 8, the described medicine that wherein is contained in the described drug delivery device is an insulin.
10. invention as claimed in claim 9, wherein said insulin comprises protamine zine insulin.
11. as any described invention in the claim 1 to 10, wherein said medicine is contained in the described drug delivery device, the described medicine that wherein is contained in the described drug delivery device is contained in the cartridge case.
12. invention as claimed in claim 11, wherein said cartridge case are removable cartridge case.
13. as any described invention in the claim 1 to 12, it also comprises coloured part, and described coloured part shows that described user rotates the described dosage that described dosage setting cover is set the medicine in the described drug delivery device by the edge towards the direction of described user.
14. invention as claimed in claim 13 wherein is arranged on described coloured part on the label.
15. invention as claimed in claim 13, wherein with described coloured part equipment on described housing.
16. a pen type drug delivery device, wherein said device comprises:
Drug delivery device housing, described housing have the near-end that is used to that the far-end of needle assembly is installed and comprises the dosage setting handle;
Be included in the cartridge case in the described housing, described cartridge case contains medicine;
Medicine is set cover, and it is rotatably installed in the described drug delivery device housing and operationally is coupled to described dosage setting handle,
So that can be along rotating the dosage that described dosage setting handle is set described medicine towards the direction of the user of described pen type drug delivery device, so that when the described dosage setting handle of rotation, described dosage setting handle and described dosage setting overlap both deviate from described near-end translation that described medicine sends housing and
The scale of not putting upside down that can in the window portion of described housing, observe, the described dosage that described scale representative of not putting upside down is set by described user.
17. invention as claimed in claim 16, wherein said dosage can be by increasing along rotating described dosage setting handle towards the direction of described user.
18. as any described invention in claim 16 or 17, wherein said dosage can be by reducing along rotating described dosage setting handle away from the direction of described user.
19. as any described invention in the claim 16 to 18, wherein in the injection process of described setting dosage, described dosage setting cover rotates back in the described near-end of described delivery apparatus and along the direction rotation away from described user.
20., wherein in the described injection process of described setting dosage, can in the window portion of described housing, observe the described scale of not putting upside down as any described invention in the claim 16 to 19.
21. as any described invention in the claim 16 to 20, wherein said housing also comprises label, described label is included in the text that described user can be observed with the orientation of not putting upside down by described user when setting the described dosage of medicine.
22. the method for drug delivery device setting dosage, the step that described method comprises has
Described drug delivery device is held in the right hand of user,
Use the left hand of described user to set dosage along rotating the dosage setting parts towards the direction of described user; And
On described dosage setting parts, provide the scale of not putting upside down of the described setting dosage of representative to represent described setting dosage.
23. invention as claimed in claim 22, it also is included in and observes the described graduated step of not putting upside down when described user uses the described left hand of described user to set described dosage.
24. as any described invention in claim 22 or 23, it also is included in and observes the described graduated step of not putting upside down when described user is injected described dosage.
25. as any described method in the claim 22 to 24, its step that also comprises has
Provide label on described housing, described label comprises the text do not put upside down and can be read by described user when described dosage setting cover is set the described dosage of medicine along rotating towards the direction of described user at the described left hand of described user by using described user.
26. the graduated method that provides is provided the dosage setting at drug delivery device, the step that described method comprises has:
Determine the maximal dose of described drug delivery device;
Determine the minimum dose of described drug delivery device;
Determine to extend to the scale configuration of described minimum dose from described maximal dose;
Put at described dosage setting the configuration of described scale is set;
Along rotating described dosage setting cover towards the direction of described user; And
Observe described scale configuration with the orientation of not putting upside down.
27. invention as claimed in claim 26, it also comprises the step that described minimum dose is set along the left-hand side of described scale configuration.
28. as any described method in claim 26 or 27, it also comprises the step that described maximal dose is set along the right-hand side of described scale configuration.
29. as any described method in the claim 26 to 28, it also comprises the step that described scale configuration is set along the surface of described dosage setting cover.
30. as any described method in the claim 26 to 29, its step that also comprises has
On described drug delivery device, label is set so that when described user by along when the direction of described user is rotated described dosage setting cover and is set dosage, described label keeps the orientation do not put upside down.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/357,899 US9205197B2 (en) | 2003-03-03 | 2009-01-22 | Drug delivery device dose setting mechanism |
| EP09000895.4 | 2009-01-22 | ||
| EP09000895A EP2210634A1 (en) | 2009-01-22 | 2009-01-22 | Drug delivery device dose setting mechanism |
| US12/357,899 | 2009-01-22 | ||
| PCT/EP2010/050709 WO2010084164A1 (en) | 2009-01-22 | 2010-01-22 | Drug delivery device dose setting mechanism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102292120A true CN102292120A (en) | 2011-12-21 |
| CN102292120B CN102292120B (en) | 2016-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080005143.1A Expired - Fee Related CN102292120B (en) | 2009-01-22 | 2010-01-22 | Drug delivery device dose setting mechanism |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9205197B2 (en) |
| EP (2) | EP2210634A1 (en) |
| JP (1) | JP5890180B2 (en) |
| CN (1) | CN102292120B (en) |
| AU (1) | AU2010207716B2 (en) |
| BR (1) | BRPI1007174A2 (en) |
| CA (1) | CA2748958A1 (en) |
| HK (1) | HK1161150A1 (en) |
| IL (1) | IL214157A (en) |
| WO (1) | WO2010084164A1 (en) |
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2009
- 2009-01-22 EP EP09000895A patent/EP2210634A1/en not_active Withdrawn
- 2009-01-22 US US12/357,899 patent/US9205197B2/en active Active
-
2010
- 2010-01-22 CN CN201080005143.1A patent/CN102292120B/en not_active Expired - Fee Related
- 2010-01-22 JP JP2011546793A patent/JP5890180B2/en not_active Expired - Fee Related
- 2010-01-22 BR BRPI1007174A patent/BRPI1007174A2/en not_active IP Right Cessation
- 2010-01-22 CA CA2748958A patent/CA2748958A1/en not_active Abandoned
- 2010-01-22 WO PCT/EP2010/050709 patent/WO2010084164A1/en active Application Filing
- 2010-01-22 EP EP10702080A patent/EP2389211A1/en not_active Withdrawn
- 2010-01-22 AU AU2010207716A patent/AU2010207716B2/en not_active Ceased
-
2011
- 2011-07-18 IL IL214157A patent/IL214157A/en not_active IP Right Cessation
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2012
- 2012-02-21 HK HK12101679.2A patent/HK1161150A1/en not_active IP Right Cessation
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9901685B2 (en) | 2012-01-27 | 2018-02-27 | Novo Nordisk A/S | Injection device with a sliding scale |
| CN104271185A (en) * | 2012-01-27 | 2015-01-07 | 诺和诺德A/S（股份有限公司） | Injection device with a sliding scale |
| CN104203313A (en) * | 2012-04-05 | 2014-12-10 | 赛诺菲-安万特德国有限公司 | Pen-type injector with window element |
| CN104203313B (en) * | 2012-04-05 | 2017-06-09 | 赛诺菲-安万特德国有限公司 | Pen-type injector with window element |
| CN107029320B (en) * | 2012-05-16 | 2020-03-17 | 特克法马许可公司 | Dosing device, method of assembling a dosing device for an injection device |
| CN107029320A (en) * | 2012-05-16 | 2017-08-11 | 特克法马许可公司 | For feeding the device of product, the improvement device with limiting mechanism, for adjusting dosage |
| CN105102039B (en) * | 2013-04-10 | 2019-06-28 | 赛诺菲 | Injection device |
| CN105102036B (en) * | 2013-04-10 | 2019-02-15 | 赛诺菲 | Injection device |
| CN105102039A (en) * | 2013-04-10 | 2015-11-25 | 赛诺菲 | Injection device |
| CN105102036A (en) * | 2013-04-10 | 2015-11-25 | 赛诺菲 | Injection device |
| CN107206184A (en) * | 2015-02-10 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | Drive mechanism for injection device |
| US10576210B2 (en) | 2015-02-10 | 2020-03-03 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for an injection device |
| CN107206184B (en) * | 2015-02-10 | 2021-03-09 | 赛诺菲-安万特德国有限公司 | Drive mechanism for an injection device |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5890180B2 (en) | 2016-03-22 |
| US20090264828A1 (en) | 2009-10-22 |
| CN102292120B (en) | 2016-03-09 |
| IL214157A (en) | 2015-02-26 |
| WO2010084164A1 (en) | 2010-07-29 |
| EP2210634A1 (en) | 2010-07-28 |
| AU2010207716A1 (en) | 2011-08-11 |
| CA2748958A1 (en) | 2010-07-29 |
| AU2010207716B2 (en) | 2015-11-26 |
| IL214157A0 (en) | 2011-08-31 |
| JP2012515587A (en) | 2012-07-12 |
| HK1161150A1 (en) | 2012-08-24 |
| BRPI1007174A2 (en) | 2017-05-30 |
| US9205197B2 (en) | 2015-12-08 |
| EP2389211A1 (en) | 2011-11-30 |
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