CN102279236A - Chromatograph mass spectrometer - Google Patents
Chromatograph mass spectrometer Download PDFInfo
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- CN102279236A CN102279236A CN2010101940355A CN201010194035A CN102279236A CN 102279236 A CN102279236 A CN 102279236A CN 2010101940355 A CN2010101940355 A CN 2010101940355A CN 201010194035 A CN201010194035 A CN 201010194035A CN 102279236 A CN102279236 A CN 102279236A
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Abstract
The invention discloses a chromatograph mass spectrometer. The chromatograph mass spectrometer comprises a first machine body and a second machine body, wherein a radio frequency power supply and a molecular pump are arranged in the first machine body; a fluorocarbon (FC) reagent device is arranged outside the first machine body; a vacuum gauge is arranged in the second machine body and connected with a vacuum cavity; the vacuum cavity is connected with a sampling probe; a mass analyzer is arranged in the vacuum cavity and provided with a quadrupole; the length of each pole of the quadrupole is 180 to 200mm; the diameter of each pole is 6 to 10.8mm; and the radio frequency power supply is a high voltage power supply. The chromatograph mass spectrometer has two functions of high resolution and high sensitivity, is an effective tool for determining the nature and the quantity of Chinese medicines and metabolites in a biological sample, has a simple structure and is easy to disassemble and assemble.
Description
Technical field
The present invention relates to identify the quasi-instrument field, be specifically related to a kind of chromatograph-mass spectrometer.
Background technology
Mass spectrometer claims mass spectrograph again, is a kind of separation and detect different isotopic instruments, promptly according to charged particle can deflection in electromagnetic field principle, by the quasi-instrument that the mass discrepancy of material atom, molecule or molecular fragment is separated and detection material is formed.Mass spectrometer is a core with ion gun, mass analyzer and ion detector.Ion gun is to make sample molecule Ionized device under high vacuum condition.Molecule after the ionization is because of having accepted multiple fragmention and the neutral particle that too much energy can further be fragmented into less quality.They obtain the mean kinetic energy with identical energy and enter mass analyzer under the accelerating field effect.Mass analyzer is to enter the ion of different quality wherein simultaneously, by the device of mass-to-charge ratio m/z size separation.Ion after the separation enters ion detector successively, gathers and amplifies ion signal, and machine is handled as calculated, is depicted as mass spectrogram.Ion gun, mass analyzer and ion detector all respectively have polytype.Mass spectrometer is divided into isotope mass spectrometer, inorganic mass spectrometer and organic mass spectrometer by range of application; Be divided into high-resolution, middle resolution and Low Resolution Mass Spectra instrument by resolving power; Be divided into static instrument and dynamic instrument by principle of work.
Chromatograph is the device that carries out chromatographic resolution analysis usefulness.Comprise sampling system, detection system, record and data handling system, temperature control system and moving phase control system etc.Modern chromatograph has characteristics such as stability, sensitivity, versatility and automaticity height.Gas chromatograph, liquid chromatograph and gel permeation chrommatograph etc. are arranged.These chromatographs are widely used for chemical products, certain analysis on Content of macromolecular material, and gel chromatography can also be measured the molecular weight and the distribution thereof of macromolecular material.
The chromatograph joint used instrument complex structure of mass spectrum of the prior art is not easy to the dismounting maintenance, and volume ratio is bigger simultaneously, and the mass number scope of analysis is smaller, can not well analyze out for macromolecular chemical substance, as decabromodiphenyl oxide.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of chromatograph-mass spectrometer that is used for, this combined instrument has chromatographic high resolving power and mass spectrometric high sensitivity, and macromolecular chemicals mass-energy is well analyzed.
For solving the problems of the technologies described above, realize above-mentioned technique effect, the present invention adopts following technical scheme:
A kind of chromatograph-mass spectrometer, comprise the first housing and the second housing, be mounted with radio-frequency power supply and a part pump in the described first housing, described first housing outside is equipped with a FC reagent device, be mounted with a vacuum gauge in the described second housing, described vacuum gauge connects a vacuum chamber, and described vacuum chamber connects a sampling detecting head.
Further, described vacuum chamber comprises a cavity, described cavity two ends are respectively equipped with first end cap and second end cap, be disposed with an ion source device, mass analyzer and ion detector in the described cavity, be connected by a jointing between described ion source device and the described mass analyzer, described mass analyzer contains a level Four bar by a shielding cavity to be formed.
Preferably, the length of every bar of described level Four bar is 180-200mm.
Preferably, the diameter of every bar of described level Four bar is 6-10.8mm
Preferably, described radio-frequency power supply is a high-voltage power supply.
Further, described second end cap is provided with a pair of ceramic joint, and described ceramic joint one end is drawn second end cap, and the other end connects a copper conductor, and described copper conductor is fixed on the chute of mass analyzer and ion detector.
Preferably, the described cavity and first end cap and the second end cap junction are provided with the O RunddichtringO.
Compared with prior art, chromatograph-mass spectrometer of the present invention has high resolving power and the double function of high sensitivity, the mass number scope of analyzing is bigger, well analyze for macromolecular chemicals mass-energy, it is the effective tool of biological sample Chinese traditional medicine and metabolin qualitative, quantitative, this apparatus structure is simple, is easy to dismounting, and volume ratio is less simultaneously.
Description of drawings
Fig. 1 is the structural representation of chromatograph-mass spectrometer of the present invention.
Fig. 2 is the structural representation of the vacuum chamber of chromatograph-mass spectrometer of the present invention.
Number in the figure explanation: 1. ion source device, 2. mass analyzer, 3. ion detector, 4. connector, 5. level Four bar, 6. radome, 7.O RunddichtringO, 8. cavity, 9. first end cap, 10. ceramic joint, 11. second end caps, 12. copper conductors, 13. chute, 14. first housings, 15. second housings, 16. radio-frequency power supply, 17. molecular pumps, 18. vacuum gauges, 19. vacuum chamber, 20. sampling probes, 21.FC reagent device.
Embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
See also Fig. 1, shown in Figure 2, a kind of chromatograph-mass spectrometer, comprise the first housing 14 and the second housing 15, be mounted with radio-frequency power supply 16 and a part pump 17 in the described first housing 14, the described first housing 14 outsides are equipped with a FC reagent device 21, be mounted with a vacuum gauge 18 in the described second housing 15, described vacuum gauge 18 connects a vacuum chamber 19, and described vacuum chamber 19 connects a sampling probe 20.
Further, described vacuum chamber 19 comprises a cavity 8, described cavity 8 two ends are respectively equipped with first end cap 9 and second end cap 11, be disposed with an ion source device 1, mass analyzer 2 and ion detector 3 in the described cavity 8, be connected by a connector 4 between described ion source device 1 and the described mass analyzer 2, described mass analyzer 2 contains a level Four bar 5 by a radome 6 to be formed.
Preferably, the length of every bar of described level Four bar 5 is 180-200mm.
Preferably, the diameter of every bar of described level Four bar 5 is 6-10.8mm.
Preferably, described radio-frequency power supply 16 is a high-voltage power supply.
Further, described second end cap 11 is provided with a pair of ceramic joint 10, and described ceramic joint 10 1 ends are drawn second end cap 11, and the other end connects a copper conductor 12, and described copper conductor 12 is fixed on the chute 13 of mass analyzer 2 and ion detector 3.
Preferably, the described cavity 8 and first end cap 9 and second end cap, 11 junctions are provided with O RunddichtringO 7.
More than the chromatograph-mass spectrometer that the embodiment of the invention provided is described in detail; for one of ordinary skill in the art; thought according to the embodiment of the invention; the part that all can change in specific embodiments and applications, therefore all any changes of making according to design philosophy of the present invention are all within protection scope of the present invention.
Claims (5)
1. chromatograph-mass spectrometer, it comprises the first housing (14) and the second housing (15), be mounted with radio-frequency power supply (16) and a part pump (17) in the described first housing (14), the described first housing (14) outside is equipped with a FC reagent device (21), be mounted with a vacuum gauge (18) in the described second housing (15), described vacuum gauge (18) connects a vacuum chamber (19), described vacuum chamber (19) connects a sampling probe (20), described vacuum chamber (19) comprises a cavity (8), described cavity (8) two ends are respectively equipped with first end cap (9) and second end cap (11), be disposed with an ion source device (1) in the described cavity (8), mass analyzer (2) and ion detector (3), be connected by a connector (4) between described ion source device (1) and the described mass analyzer (2), described mass analyzer (2) contains a level Four bar (5) by a radome (6) to be formed, and it is characterized in that: the length of every bar of described level Four bar (5) is 180-200mm.
2. chromatograph-mass spectrometer according to claim 1 is characterized in that: the diameter of every bar of described level Four bar (5) is 6-10.8mm
3. chromatograph-mass spectrometer according to claim 1 is characterized in that: described radio-frequency power supply (16) is a high-voltage power supply.
4. chromatograph-mass spectrometer according to claim 2, it is characterized in that: described second end cap (11) is provided with a pair of ceramic joint (10), described ceramic joint (10) one ends are drawn second end cap (11), the other end connects a copper conductor (12), and described copper conductor (12) is fixed on the chute (13) of mass analyzer (2) and ion detector (3).
5. according to claim 2 or 3 described chromatograph-mass spectrometers, it is characterized in that: described cavity (8) is provided with O RunddichtringO (7) with first end cap (9) and second end cap (11) junction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101940355A CN102279236A (en) | 2010-06-08 | 2010-06-08 | Chromatograph mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101940355A CN102279236A (en) | 2010-06-08 | 2010-06-08 | Chromatograph mass spectrometer |
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| Publication Number | Publication Date |
|---|---|
| CN102279236A true CN102279236A (en) | 2011-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101940355A Pending CN102279236A (en) | 2010-06-08 | 2010-06-08 | Chromatograph mass spectrometer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104199476A (en) * | 2014-09-06 | 2014-12-10 | 郑旭 | Vacuum control device used for maintenance of mass spectrometer of gas chromatograph-mass spectrometer |
| CN104616962A (en) * | 2015-02-16 | 2015-05-13 | 江苏天瑞仪器股份有限公司 | Ion source assembly used for liquid chromatogram-mass spectrometer |
| CN107833824A (en) * | 2017-11-13 | 2018-03-23 | 江苏天瑞仪器股份有限公司 | Four-electrode quality analyzer connecting structure for electrical equipment |
| CN109298123A (en) * | 2018-04-23 | 2019-02-01 | 河北丰研翔科技发展限公司 | A kind of novel thin layer chromatogram scanner and the analysis method using the scanner |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2549462Y (en) * | 2002-07-08 | 2003-05-07 | 郭跃辉 | Helium mass spectroscopic leakage inspector with wide range |
| WO2005001421A2 (en) * | 2003-06-05 | 2005-01-06 | Oakland University | Improved piezoimmunosensor |
| US7547555B2 (en) * | 2002-10-30 | 2009-06-16 | Varian, Inc. | Use of temperature and flow profiles in gradient elution based analytical process |
| CN201773095U (en) * | 2010-06-08 | 2011-03-23 | 江苏天瑞仪器股份有限公司 | Chromatograph-mass spectrometer |
-
2010
- 2010-06-08 CN CN2010101940355A patent/CN102279236A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2549462Y (en) * | 2002-07-08 | 2003-05-07 | 郭跃辉 | Helium mass spectroscopic leakage inspector with wide range |
| US7547555B2 (en) * | 2002-10-30 | 2009-06-16 | Varian, Inc. | Use of temperature and flow profiles in gradient elution based analytical process |
| WO2005001421A2 (en) * | 2003-06-05 | 2005-01-06 | Oakland University | Improved piezoimmunosensor |
| CN201773095U (en) * | 2010-06-08 | 2011-03-23 | 江苏天瑞仪器股份有限公司 | Chromatograph-mass spectrometer |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104199476A (en) * | 2014-09-06 | 2014-12-10 | 郑旭 | Vacuum control device used for maintenance of mass spectrometer of gas chromatograph-mass spectrometer |
| CN104616962A (en) * | 2015-02-16 | 2015-05-13 | 江苏天瑞仪器股份有限公司 | Ion source assembly used for liquid chromatogram-mass spectrometer |
| CN104616962B (en) * | 2015-02-16 | 2017-03-01 | 江苏天瑞仪器股份有限公司 | Ion source component for liquid chromatography mass instrument |
| CN107833824A (en) * | 2017-11-13 | 2018-03-23 | 江苏天瑞仪器股份有限公司 | Four-electrode quality analyzer connecting structure for electrical equipment |
| CN107833824B (en) * | 2017-11-13 | 2024-04-12 | 江苏天瑞仪器股份有限公司 | Electrical connection structure of quadrupole mass analyzer |
| CN109298123A (en) * | 2018-04-23 | 2019-02-01 | 河北丰研翔科技发展限公司 | A kind of novel thin layer chromatogram scanner and the analysis method using the scanner |
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Application publication date: 20111214 |