CN102258590B - 甘石青黛膏及其制备方法 - Google Patents
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Abstract
一种治疗皮炎湿疹的甘石青黛膏，由如下重量份的原料制成：青黛3重量份、滑石8重量份、苦参8重量份、煅石膏3重量份、冰片1重量份、枯矾2重量份、煅龙骨6重量份、炉甘石9重量份、威灵仙5重量份、紫草5重量份、凡士林50重量份。其制备方法是分别将药物原料碎成细粉；然后将除冰片之外的药物细粉混合搅匀，并加热至50-60℃保温；在所述细粉混合物中加入凡士林，待搅拌均匀后冷却，然后加入冰片细粉搅匀，之后冷却成膏状；最后分装入药盒、塑封并进行紫外线灭菌。本发明提供的治疗皮炎湿疹的甘石青黛膏，具有清热燥湿、凉血止痒的作用，可用于神经性皮炎、湿疹等出现皮疹色红、瘙痒、甚至苔藓化等症状的治疗。
Description
技术领域
本发明涉及一种治疗皮炎湿疹的药物及其制备方法，具体来说涉及一种甘石青黛膏及其制备方法。
背景技术
神经性皮炎和湿疹为常见多发性皮肤病，其中神经性皮炎是以阵发性皮肤瘙痒和皮肤苔藓化为特征的慢性皮肤病；而湿疹是一种常见的由多种内外因素引起的表皮及真皮浅层的炎症性皮肤病，其临床表现具有渗出性、瘙痒性和复发性等特点。
目前适用于难治型皮肤病如神经性皮炎、湿疹的外用药膏偏少，而激素类外用药膏应用普遍，因此为避免激素类药物带来副作用的风险，降低患者医疗风险，需要开发疗效可靠的中药外用制剂。
发明内容
本发明要解决的技术问题是提供一种甘石青黛膏及其制备方法，以减少或避免前面所提到的问题。
具体来说，本发明提供了一种甘石青黛膏，其可用于治疗皮炎湿疹，所述甘石青黛膏由如下重量份的原料制成：青黛3重量份、滑石8重量份、苦参8重量份、煅石膏3重量份、冰片1重量份、枯矾2重量份、煅龙骨6重量份、炉甘石9重量份、威灵仙5重量份、紫草5重量份、凡士林50重量份。
另外，本发明还提供了一种治疗皮炎湿疹的甘石青黛膏的制备方法，包括如下步骤：
(1)分别将青黛、滑石、苦参、煅石膏、冰片、枯矾、煅龙骨、炉甘石、威灵仙和紫草粉碎成细粉，过200目筛备用；
(2)分别取步骤1中备用的细粉：青黛3重量份、滑石8重量份、苦参8重量份、煅石膏3重量份、枯矾2重量份、煅龙骨6重量份、炉甘石9重量份、威灵仙5重量份、紫草5重量份混合搅匀，并加热至50-60℃保温；
(3)在步骤2中的所述细粉混合物中加入50重量份的凡士林，利用所述细粉混合物的温度使凡士林加热熔化，同时搅拌，待搅拌均匀后冷却至30-35℃，然后加入步骤1中备用的冰片细粉1重量份搅匀，之后在4-6℃下冷却成膏状；
(4)将步骤3中制得的药膏分装入药盒、塑封并进行紫外线灭菌。
本发明提供的治疗皮炎湿疹的甘石青黛膏，具有清热燥湿、凉血止痒的作用，可用于神经性皮炎、湿疹等出现皮疹色红、瘙痒、甚至苔藓化等症状的治疗。
其中，紫草具有凉血、活血、解毒透疹的功效，对炎症急性渗出期的血管通透性亢进、渗出和水肿及增殖期炎症均有拮抗作用；威灵仙祛风除湿，通经络；炉甘石，燥湿止痒敛疮，解毒，具有保护皮肤治疗炎症或表面创伤的作用；煅龙骨生肌敛疮，具有促进皮损愈合的作用；青黛具有清热解毒、凉血消斑，其主要成分靛玉红可以调节细胞免疫功能到正常水平；凡士林作为一种填充剂，具有护肤、湿的作用，此外还有无刺激性，安定不易变质，也不易造成人体敏感的优点。
并且，本发明所提供的治疗皮炎湿疹的甘石青黛膏的制备方法，利用药物细粉的温度加热融化凡士林，使得各药物的有效成分得以充分释放并混合均匀；然后为了避免冰片挥发而冷却至30-35℃后方才加入；最后将药物在4-6℃下冷却成，相较于室温冷却速度更快，这样可以尽可能减少药物细粉在凡士林中沉淀，从而使得分装之前药粉分布更加均匀。
具体实施方式
下面结合具体实施例对本发明的治疗皮炎湿疹的甘石青黛膏及其制备方法进行详细说明。
实施例1
本实施例提供了一种治疗皮炎湿疹的甘石青黛膏，由如下原料制成：青黛30g、滑石80g、苦参80g、煅石膏30g、冰片10g、枯矾20g、煅龙骨60g、炉甘石90g、威灵仙50g、白鲜皮50g，辅料：凡士林500g。
上述甘石青黛膏的制备方法，包括如下步骤：
(1)分别将青黛、滑石、苦参、煅石膏、冰片、枯矾、煅龙骨、炉甘石、威灵仙和紫草粉碎成细粉，过200目筛备用；
(2)分别取步骤1中备用的细粉：青黛30g、滑石80g、苦参80g、煅石膏30g、枯矾20g、煅龙骨60g、炉甘石90g、威灵仙50g、白鲜皮50g混合搅匀，并加热至50-60℃保温；
(3)在步骤2中的所述细粉混合物中加入500g的凡士林，利用所述细粉混合物的温度使凡士林加热熔化，同时搅拌，待搅拌均匀后冷却至30-35℃，然后加入步骤1中备用的冰片细粉10g搅匀，之后在4-6℃下冷却成膏状；
(4)将步骤3中制得的药膏每10g分装入药盒、塑封，并在并在紫外线灯下照射30分钟灭菌。
实施例2
临床实验
采用阳性药物双盲双模拟随机对照研究方法，将334例皮炎湿疹患者随机分为治疗组(127例)和照组(127例)。其中，治疗组外涂本发明的上述治疗皮炎湿疹的甘石青黛膏，对照组外用丁酸氢化可的松乳膏。
结果：治疗组治愈率为79.7％，对照组治愈率为44.6％；治疗组止痒有效率为80.1％，对照组止痒有效率为65.3％；治疗组复发率为30.5％，对照组复发率为50.2％。
结论：本发明的治疗皮炎湿疹的甘石青黛膏对于治疗神经性皮炎和湿疹临床疗效确切，复发率低。
以上所述仅为本发明示意性的具体实施方式，并非用以限定本发明的范围。任何本领域的技术人员，在不脱离本发明的构思和原则的前提下所作的等同变化、修改与结合，均应属于本发明保护的范围。
Claims (2)
1.一种甘石青黛膏的制备方法，所述甘石青黛膏可用于治疗皮炎湿疹，所述制备方法包括如下步骤：
（1）分别将青黛、滑石、苦参、煅石膏、冰片、枯矾、煅龙骨、炉甘石、威灵仙和紫草粉碎成细粉，过200目筛备用；
（2）分别取步骤1中备用的细粉：青黛3重量份、滑石8重量份、苦参8重量份、煅石膏3重量份、枯矾2重量份、煅龙骨6重量份、炉甘石9重量份、威灵仙5重量份、紫草5重量份混合搅匀,并加热至50-60℃保温；
（3）在步骤2中的所述细粉混合物中加入50重量份的凡士林，利用所述细粉混合物的温度使凡士林加热熔化，同时搅拌，待搅拌均匀后冷却至35-40℃，然后加入步骤1中备用的冰片细粉1重量份搅匀，之后在4-6℃下冷却成膏状；
（4）将步骤3中制得的药膏分装入药盒、塑封并进行紫外线灭菌。
2.一种甘石青黛膏，其由权利要求1所述的方法制备而成，所述甘石青黛膏由如下重量份的原料制成：青黛3重量份、滑石8重量份、苦参8重量份、煅石膏3重量份、冰片1重量份、枯矾2重量份、煅龙骨6重量份、炉甘石9重量份、威灵仙5重量份、紫草5重量份、凡士林50重量份。
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| CN100425259C (zh) * | 2006-08-10 | 2008-10-15 | 邵宏 | 一种治疗烧烫伤药物的制备方法 |
| CN101530462B (zh) * | 2009-04-27 | 2011-11-02 | 郭青云 | 一种治疗湿疹的组合物及其制备方法 |
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