CN102254780B - improved ion guide and collision cell - Google Patents
improved ion guide and collision cell Download PDFInfo
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- CN102254780B CN102254780B CN201110128900.0A CN201110128900A CN102254780B CN 102254780 B CN102254780 B CN 102254780B CN 201110128900 A CN201110128900 A CN 201110128900A CN 102254780 B CN102254780 B CN 102254780B
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
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Abstract
The present invention relates to improved ion guide and collision cell. In an embodiment, ion guide (102) comprising: rod (201,202,203,301,302,303), each has first end (204,205,206) and away from described first end (204 described rod, 205,206) the second end (207,208,209); Inductor (402), described inductor is connected to contiguous excellent between (201,202,203,301,302,303); For contiguous excellent to (201,202,203,301,302,303) between, apply the device of radio frequency (RF) voltage (502), wherein said RF voltage is at described rod (201,202,203,301,302,303) region between produces multipole fields; And apply for each the length along described rod (201,202,203,301,302,303) device that direct current (DC) voltage (505) falls.
Description
The cross reference of association request
The application requires U.S. Provisional Patent Application that the people such as HarveyLoucks submit on May 11st, 2010 according to united states patent law 119 (e) money number 61/333,592, denomination of invention is the priority of " IMPROVEDIONGUIDESANDCOLLISIONCELLS ". By reference, the full content of U.S. Provisional Patent Application number 61/333,592 is comprised in this manual.
Technical field
The present invention relates to improved ion guide and collision cell.
Background technology
Mass spectrometry (MS) is a kind of analytical method of quantitative analysis and qualitative analysis for sample. Molecule in sample is ionized and is separated by mass spectrograph based on their quality separately. Then the analyte ions separating is detected and produces the mass spectrum of sample. Mass spectrum provides the quality of various analyte compounds and the information of quantity about composition sample. Particularly, mass spectrum can be used for determining the molecular fragment in molecular weight and the analyte of molecule. In addition the composition that, mass spectrum can be based in fragmentation figure discriminance analysis thing.
For can utilize any ionizing system to produce by the analyte ions of mass spectral analysis. In mass spectrometer system, can adopt such as atmospheric pressure substance assistant laser desorpted ionized (AP-MALDI), atmospheric pressure photoelectric ionization (APPI), electron spray ionisation (ESI), APCI (APCI) and inductively coupled plasma system (ICP) etc. to produce ion. A lot of systems in these systems produce ion at atmospheric pressure (760Torr) or its vicinity. Once produce the analyte ions mass spectrograph that must inject or sample. Conventionally, mass spectrometric analysis part keeps the high vacuum levels from 10-4Torr to 10-8Torr. In fact, extracting the sample of ion comprises analyte ions is transported to high vacuum mass spectrograph chamber via vacuum chambers in the middle of one or more from ion gun with the form of the ion beam of meticulous restriction. Each of middle vacuum chamber all remains on the vacuum level between the vacuum level of previous vacuum chamber and the vacuum level of a rear vacuum chamber. Therefore, ion beam is transported to mass spectrometric stress level by analyte ions from forming with ion the stress level being associated by transition progressively. In great majority application, be ion to be carried to each chamber in the various chambers in spectrometer system in the situation that there is no significant losses of ions ideally. Conventionally in MS system, use ion guide to limit moving iron in direction.
Ion guide in allowing or impelling ion axially to transmit, utilizes electromagnetic field radially to limit ion conventionally. One type of ion guide produces multipole fields by applying time dependent voltage, and it is conventionally in radio frequency (RF) frequency spectrum. The multipole ion guide of so-called RF has been widely used in transmitting the various applications of ion between the parts of MS system, and the parts of ion trap. In the time working in the situation that there is buffer gas, the ion that RF guider can be vertically and radially both direction reduces ion can (speed). Because the multiple impacts of the low energy neutral molecule of ion and buffer gas, ion can vertically and radially reduce to be known as the set of " thermalization " or " cooling " ion. Conventionally, the ion guide that is used for the set of " cooling " ion is called to collision cell. Radially the thermalization bundle of compression can be used for improvement by the ion transfer in the aperture of MS system and reduces the radiation velocity diffusion in flight time instrument. The multipole ion guide of RF generates pseudo-potential well, and it is confined to ion in ion guide. In other application, particularly, in triplequadLC-MS, collision cell is used to separate energetic ion so that the extraneous information that relates to its molecular structure to be provided.
In constant cross-section is long-pending multipole, above-mentioned pseudo-current potential, along consistent length, therefore can not produce axial force in entrance and the position outside outlet. Can utilize lens or overcome in the entrance of multipole ion guide and the above-mentioned end effect in exit by other technologies. Lens can be with respect to the RF field on ion screening electrode, and can be enough to enter or leave multipole energy to ion transport. Known multipole ion guide generally includes relatively large diameter entrance, and it is for receiving ion. But, for from going out port transmission small diameter beam, there is identical larger-diameter outlet not preferred. But known do not have the long-pending ion guide of constant cross-section and can generate the variable pseudo-potential barrier that can produce axial force along transmission axis, this can hinder even reflect ions of ion. Finally, can also can in ion guide, form ion at the buffer gas of the cooling middle use of ion delays. Can be by overcoming or reverse above-mentioned delay and ion obstruction power along the impedance rod increase DC gradient in multipole assembly. Be generally about 2V and can generate accelerating potential field to this DC gradient of about 10V size, it forces ion to move along the axis of collision cell.
A defect of the known spectrometer system that comprises collision cell is size. Along with the increase to the demand that less compacter instrument is provided, be necessary to reduce the size (" floor space ") of the assembly in mass spectrograph.
Therefore need such device, wherein guider passes through spectrometer system, and at least overcomes the defect of above-mentioned known devices.
Summary of the invention
Ion guide according to the present invention comprises: resistor rod, and each has first end and the second end away from described first end described resistor rod; Inductor, described inductor be connected to contiguous excellent between; And for contiguous excellent between apply the device of radio-frequency voltage. The region of described RF voltage between described rod produces multipole fields; For apply the device of direct current pressure drop along each length of described rod.
Brief description of the drawings
In the time utilizing accompanying drawing to read, better understand this instruction from detailed description below. Feature is not necessarily drawn by size. No matter reality how, similar label represents similar feature.
Fig. 1 shows according to the simplified block diagram of MS system 100 that represents embodiment.
Fig. 2 shows according to the top view of ion guide of collision cell that represents embodiment.
Fig. 3 A shows along the excellent sectional view of the ion guide of the line 3A-3A of Fig. 2.
Fig. 3 B shows along the excellent sectional view of the ion guide of the line 3B-3B of Fig. 2.
Fig. 4 shows according to the top view of ion cable guiding device of collision cell that represents embodiment.
Fig. 5 A shows according to the equivalent circuit of ion guide that represents embodiment.
Fig. 5 B shows according to the equivalent circuit of ion guide that represents embodiment.
Fig. 5 C shows according to the equivalent circuit of ion guide that represents embodiment.
Detailed description of the invention
Term definition
Should be appreciated that, term used herein is only used to describe specific embodiment, and is not intended to limit. The term defining is except the general technology of understanding and receive and Scientific Meaning in the technical field of this instruction.
As used in description and claims, term ' ', ' one ' and ' being somebody's turn to do ' comprise single and multiple indication things, unless context clearly instruction in addition. Therefore, for example, ' device ' comprises a device and multiple device.
As used herein, term ' collision cell ' is the device for ion and gas (" collision gas ") collision. Collision cell generally includes chamber and the ion guide in chamber, and wherein this chamber comprises the entrance of Receiving collision gas. Ion guide in the collision cell of this instruction be configured to set up four utmost points or sextupole or the ends of the earth or ten utmost points or more the electric field of the high-order utmost point to comprise and to guide ion beam.
As used in description and claims, and except their general sense, term ' basic ' or ' basic Shangdi ' mean within acceptable limit or degree. For example, ' be substantially eliminated ' and mean that those skilled in the art can think that this elimination is acceptable.
As used in description and claims, and except their general sense, term ' approx ' means to those skilled in the art within acceptable limit or amount. For example, ' approximate identical ' means that those of ordinary skill in the art can think that the project being compared is identical.
Describe in detail
In the following detailed description, for the purpose of illustration and not limitation, the representative embodiment that discloses detail is described, so that the thorough understanding to this instruction to be provided. Omit the description of known system, equipment, material, method of operating and manufacture method, to avoid the explanation of fuzzy example embodiment. But, can be according to representing that embodiment uses system, equipment, the materials and methods within one skilled in the relevant art's experience.
Fig. 1 shows according to the series connection MS system 100 that represents embodiment. MS system 100 comprises ion gun 101, multipole ion guide 102, chamber 103 (for example, vacuum chamber), mass-synchrometer 104 and ion detector 105. Ion gun 101 can be the one in the ion gun of a lot of known types. Each can be the one in multiple known quality analyzer for mass-synchrometer 102,104, and wherein known quality analyzer includes but not limited to flight time (TOF) instrument, Fourier transformation MS analyzer (FTMS), ion trap, level Four mass-synchrometer or magnetic sector mass-synchrometer, is suitable for the combination of tandem mass spectrometer. Similarly, ion detector 105 is in many known ion detectors.
Below in conjunction with representing that embodiment describes multistage ion guide 102 in more detail. Multistage ion guide 102 can be arranged in chamber 103, and it is for providing the rank of the one or more pressure conversions between ion gun 101 and mass-synchrometer 104. Because ion gun 101 is maintained near atmospheric pressure or atmospheric pressure conventionally, and mass-synchrometer 104 is retained as relatively high vacuum state conventionally. According to representing embodiment, multipole ion guide 102 can be used for changing relatively low pressure into from high pressure relatively. Ion gun 101 can be a kind of known ion gun, and can comprise extra ionic control device and vacuum insulation part, includes but not limited to separator, multipole, aperture, small diameter conduits and ion optics. In a representative embodiment, ion gun 101 comprises the mass filter of himself, and chamber 103 comprises collision cell. Below description is represented to the collision cell of embodiment.
Comprising the quality analysis instrument system device of the collision cell with multipole ion guide 102, neutral gas (being commonly called " buffer gas ") can be introduced into chamber 103 so that " cooling " ion, and promote the separation of the ion that moves through multipole ion guide 102. The above-mentioned collision cell using in multiple mass/charge analytical systems is in the industry cycle known as " triplequad " or referred to as " QQQ " system.
In alternate embodiment, collision cell is comprised in ion gun 101 and indoor (for example, the chamber 103) of multipole ion guide 102 in himself. In a preferred embodiment, collision cell and multipole ion guide 102 are the separators that are arranged in chamber 103.
In use, the ion (its notional path is illustrated by the arrow in Fig. 1) producing in ion gun 101 is filtered or is analyzed by multipole ion guide 102. Then ion is cracked to produce daughter ion in chamber 103, and daughter ion is analyzed by mass-synchrometer 104. Ion is delivered to ion detector 105 from mass-synchrometer 104, detected in ion detector 105.
Fig. 2 shows according to the top view of a part that represents the ion guide in the collision cell 200 of embodiment. In the embodiment describing now, collision cell 200 comprises 6 rods, and therefore sextupole radiofrequency field is provided. Especially, figure 2 illustrates the first leg 201, the second leg 202 and the third leg 203, remaining three rods be cannot see from the selected perspective of Fig. 2. It is emphasized that it is only illustrative selecting sextupole ion guide, and this instruction is applicable to comprise other collision cell of level Four ion guide. As explanation, collision cell 200 can comprise 4 or 8 rods, thereby can produce respectively four utmost points or ends of the earth electric field. Representing in embodiment, rod 201～203 is being arc (, bending) in shape. The radius of curvature of rod 201～203 is along they length variations separately. In certain embodiments, to have along its length (, between rod 201～203 far-ends separately) be the radius of curvature of circle to rod 201～203 substantially. But this is only illustrative, and other shapes are expected. The variation of the guide path of rod 201～203 arc permission ions along its length. For example, according to representing embodiment, the variation of the ion of traversal collision cell 200 in guide path is about 90 °. As described below, with the collision cell comparison with " directly " rod, represent that the collision cell 200 of embodiment can be along identical path guiding ion in taking the less gross area. Therefore, by using curved rod to realize the floor space reducing.
Rod 201～203 is arranged in housing (not shown in Fig. 2), and this housing has substantially the same with rod 201～203 arc illustratively. Or this housing can have other shapes such as square or rectangle. This housing is conventionally made up of conductive material and is can be used for providing electrical ground. As explanation, housing comprises metal or metal alloy, conducing composite material, conducting ceramic material or conducting polymer. In addition, excellent fixator (not shown) can be arranged on enclosure interior to keep the position of rod 201～203. Rod fixator can be used to arrange and excellent 201～203 selective electrical connection.
Rod 201～203 has respectively first end 204,205 and 206, and the second end 207,208 and 209. Conventionally, and describe more fully as follows, excellent 201～203 to have input 210 and the layout placement that converges at the output 211 of the far-end of input 210. In the representative embodiment more fully describing below, rod 201～203rd, at input 210 and output 211 to be substantially the rod of circular layout placement. As mentioned above, due to the curvature of rod 201～203, input 210 is not parallel to output 211 in direction, but is orientated the angle of non-zero with respect to output 211. As explanation, input 210 can be orientated with respect to output 211 angle of approximately 90 °. It is emphasized that selecting rod 201～203 curvature is only illustrative input 210 is arranged to substantially orthogonal with output 211, and by selecting the radius of curvature of input 210 can expect other orientations of input 210. For example, or antiparallel also out of plumb not parallel at the input 210 shown in Fig. 2 and output 211. Like this, (curved) rod 201～203 has promoted 200 the floor space reducing.
First end 204～206 is away from each the second end 207～209, be connected to the radius of the inscribed circle (the first circle) of the first end 204～206 of the rod 201～203 at input 210 places, be greater than the radius at the second end 207～209 of output 211 place's rods 201～203, the inscribed circle of pitman 201～203 (the second circle). In another embodiment, replace and arrange excellent 201-203 in circular mode at input 210 and output 211 places, can arrange excellent 201-203 by ellipse. This ellipse is arranged symmetrically with and can forms the pseudo-field that keeps of RF of limiting in a similar manner ion. Finally, excellent 201-203 is disposed in input 210 with circular, fashion, and at roughly " smooth " of output 211, makes the ion leaving form relatively long narrower bundle. In the U.S. Patent Application Publication No. 2010/0301210 that the denomination of invention that can submit people such as J.L.Bertsch is " ConvergingMultipoleIonGuideForIonBeamShaping ", recognize other details that excellent 201-203 is set in the above described manner. By reference, by the full content combination of the above-mentioned patent application of submitting on May 28th, 2009 in this manual.
Representing in embodiment, rod 201～203 comprises pottery or other electrically insulating material. In certain embodiments, rod 201～203 also comprises resistive outer skin (not shown). Between each first end 204～206 of resistive outer skin permission rod 201～203 and each the second end 207～209, apply DC voltage poor. Resistive outer skin also arranges to propagate and is created in the RF signal that keeps needed of ion in collision cell 200. In another embodiment, rod 201～203 can be the United States Patent (USP) 7 as owned together with Crawford etc. and exercise question is " the multipole device of mass spectrograph ", 064,322 is described, and wherein this patent open is incorporated into this and by reference particularly for all objects. In this case, rod 201～203 can have conduction internal layer (not shown) and resistive outer skin (not shown), and it is configured to rod 201～203 distribution capacity of the resistive outer skin for RF voltage delivery being delivered to rod 201～203. Inner conducting layer is delivered to resistive outer skin by RF voltage by thin dielectric layer (not shown).
Rod 201～203rd, one or more in multiple cross sectional shapes. In certain embodiments, rod 201～203 has than having larger diameter at their second ends 207～209 separately at their first ends 204～206 separately. In other embodiment, rod 201～203 is tapered along its length, is also to have than at the larger diameter of each the second end 207～209 at each first end 204～206. Tapered degree is optional and rod 201～203 can have taper shape. Comprise in the embodiment of different diameters at first end 204～206 and the second end 207～209 places at rod 201～203, diameter at each first end 204～206 places is chosen for relatively large, think that ion reception provides better configuration, and be chosen at the diameter at each the second end 207～209 places relatively large, to improve restriction. Rod some aspect of 201～203 can with the common exercise question of transferring the possession of such as the J.L.Bertsch U.S. Patent application No.12/474 that is " be shaped for ion beam converge multipole ion guide ", find in 160. The whole open of this patent application of submitting on May 28th, 2009 is incorporated into this by reference particularly.
The variation of the guide path direction of the ion of the arc permission traversal collision cell 200 of rod 201～203. This variation of the direction of the thread guide path of collision cell 200 allows ion guide 202 to be contained in to have in MS system 100 in total instrumentation package of small size in fact more. Slightly differently describe, by arc rod 201～203 is set, make the ion specific distance that leads in the less gross area. By comparing, the known collision cell with " straight " or linear steering element needs physically longer linear ion optical path, and it needs larger area to comprise whole instrument conversely. Advantageously, by the bow bar 201～203 of selected radius of curvature is set, along designated length restriction ion, generation is there is to total instrument of less " floor space ".
Realize compared with " straight " collision cell except providing, reduced outside the benefit of collision cell 200 of the instrument of floor space, also can realize reducing owing to the noise of arcuate geometries. It should be noted that RF pseudo potential ion keeps track or a route guidance ion along rod 201～203, thereby force ion to follow the bow-shaped route of ion guide 200. As should be understood that to only have ion to be led by electric field (not shown) between the input 210 of the rod 201～203 of collision cell 200 and output 211. As a result, the ion traversal path parallel with the path of rod 201～203. Under comparing directly, some of droplet, particle and the neutral molecule (being referred to as " neutral corpuscle ") producing as the part in ionization process in the ion gun 101 in Fig. 1, enter multipole ion guide 102, then enter chamber 103. These neutral corpuscles will can not led by electric field. Housing or both collisions of the major part of these neutral corpuscles one in 201～203 or collision cell 200 with rod, dissipate they energy and be reduced to less, the more low-energy neutral corpuscle that can not advance to ion detector 105. Like this, these neutral corpuscles are by the pressure differential between input 210 and the output 211 of collision cell 200, instead of incide ion detector 105 and become ambient noise. As a result, the major part of these neutral corpuscles travels through the path tangent with bow bar 201～203, and can not be directed to the output 211 of collision cell 200. In the disappearance of the buffer gas at output 211 places and at least a portion of solvent gas, cause neutral corpuscle to the minimizing of the incident on ion detector 105 and along with and the reducing of the noise that comes. As should be understood that the favourable increase that reduces to provide the minimum detectable analyte ions peak value causing due to the increase of signal to noise ratio (SNR) of this noise.
Collision cell 200 has promoted the cracked of relatively high-octane analyte ions. As should be understood that, the molecular structure of analyzed molecule is better determined in cracked permission. The cracked ion energy at incident analyte ions is increased to intermolecular linkage to be occurred while starting to rupture, produces parent ion fragment. Then, these fragment ions are analyzed mass spectrum, produces the information of informing user's molecular structure.
Fig. 3 A shows the excellent sectional view of the collision cell 200 of 3A-3A along the line. It should be noted that the sectional view of Fig. 3 A described the input 210 of the rod 201～203 of collision cell 200. As mentioned above, the rod of collision cell 200, illustratively with the configuration layout of sextupole, has therefore been arranged 6 rods. Like this, except rod 201～203, arranged at input 210 places substantially around the rod 301,302 and 303 of inscribed circle with radius r 1. Rod 301～303 is with above-mentioned excellent 201～203 basic identical. For this reason, rod 301～303 and excellent 201～203 shapes, cross section, radius of curvature, length, composition are identical with material.
Fig. 3 B shows the excellent sectional view of the collision cell 200 of 3B-3B along the line. It should be noted that the sectional view of Fig. 3 B described the output 211 of the rod 201～303 of collision cell 200. As shown in the figure, rod 201～303 is arranged as substantially around the inscribed circle with radius r 2 at output 211 places. As mentioned above, because rod is arranged as the form of convergence between input 210 and output 211, therefore radius r 1 is greater than radius r 2. Radius r 1 is chosen for enough large so that the ion beam that enters collision cell 200 is passed through. Representing in embodiment, the radius r 1 shown in Fig. 3 A, 3B to the ratio (r1: r2) of radius r 2 at approximately 1: 1 and approximately between 4: 1. Conventionally avoid being greater than the ratio of 4: 1, because such ion that can cause is at high proportion delayed at output 211 places.
Choose radius r 1 and enter into collision cell 200 to catch the ion of greater number. Like this, the face size of optimization input 210 is to guarantee sampling ion applicable from ion gun 101. On the contrary, select radius r 2 to relay " cooling " ion to ion detector 105 with limitation. Larger size of input 210 is hunted down by the greater part that makes ion, promotes the improvement of signal to noise ratio (SNR).
The collision cell 200 that comprises rod 201～303 that represents embodiment provides a lot of advantages and benefit. But the use of resistor rod can produce Joule effect heat. Resistance (joule) heat is to be produced by the AC voltage along rod 201～303 length and DC voltage. As should be understood that, due to overheated may the running counter to desire in the collision cell 200 of its any assembly. Particularly, the function of collision cell 200 is to reduce the kinetic energy of ion before impinging upon on mass-synchrometer 104 and ion detector 105. The heat producing in collision cell 200 can increase the kinetic energy of ion, is unfavorable for thus the realization of the function of collision cell 200. And, the mechanical failure of the overheated final structures that can cause collision cell being produced by rod 201～303, and finally can deleteriously affect the reliability of collision cell. Like this, preferably substantially prevent the heating in collision cell 200 or be relieved to possible degree.
A kind of mode that alleviates the impact of the heating being caused by the electric current of edge rod 201～303 is to disperse heat. But, for example, in the relatively low pressure of collision cell 200 (, vacuum and approach vacuum) environment, remove heats from rod 201～203 unsatisfactory. And, the heat conduction that the dispersing of heat is subject between optimization rod 201～203 conventionally and the impact of supporting construction (not shown in detail). Heat conduction and their supporting construction between rod 201～303, the restriction of the conflict of interest of the size (" floor space ") that is subject to rod 201～303 physical sizes and the minimum thermal conduction surface producing and reduces collision cell 200.
Fig. 4 shows according to the schematic top view of ion guide of collision cell 400 that represents embodiment. Collision cell 400 comprises a lot of features common with above-mentioned collision cell 200 about Fig. 2-3B. For avoiding the explanation of fuzzy the present embodiment, no longer repeat a lot of features in these common traits.
Collision cell 400 comprises as shown in Figure 4 rod 201～203, and in Fig. 4 unshowned excellent 301～303. Rod 201～203 is arranged in the arc essentially identical arc housing (not shown) having with rod. As mentioned above, shell is not necessarily substantially similar to rod 201～203 in shape. And, it is emphasized that collision cell 400 arc be only illustrative and other shapes of collision cell 400 are expected. Note, collision cell 400 can comprise roughly " straight " rod, and it arranges with polymerized form, for example, described in the referenced patent application of submitting as people such as J.L.Bertsch.
Inductor 402 be connected to rod 201～203 (and rod 301～303, but not shown in Fig. 4) the place of intermediate length substantially. As mentioned above, rod 201～303 is electrically connected to produce hexapole field in alternate mode. Inductor 402 is connected to not in addition between two rods of electrical connection. For instance, suppose rod 201,301 and 303 electrical connections; And rod 202,302 and 203 is electrically connected to produce hexapole field. In this example, inductor 402 can be connected between rod 201 and rod 203, to be created in the inductance coupling high between the each group of rod 201,301,303 connecting and rod 202,302,303. As described more fully below, inductor 402 is set up L-C circuit in parallel with the stray capacitance of rod 201～303. The impact of electrical loss is to be caused by the series resistance of each rod 201～303 and the reactive current that caused by stray capacitance. Suppose that reactance (Xc) is much larger than excellent resistance (Xc > > R), the approximate I=Vpp/Xc of reactive current in the absence of inductor. Rod 201～303 can be approximate by a series of lamped element resistors and capacitor.
According to representing embodiment, produce resonant condition at the bosom point of rod 201～303, improve in power consumption, energy loss and the excessively improvement of Joule heat. But, in the time of On current during operation, rod 201～303 dispersing characteristics due to the stray capacitance extra energy that dissipates between their ends separately and center. In another embodiment, between the intermediate point of rod each end of 201～303 and rod 201～303, (, 1/4 of excellent length, 3/4 interval of 1/2 and excellent length of excellent length) arranges extra inductor (not shown). The layout of these extra capacitors will further reduce reactive current, and provide than the structure of the inductor 402 of the intermediate point that is only included in rod 201～303 (excellent length 1/4), further reduce the improvement of power consumption approximately 50%. Because extra inductor is disposed in the intermediate point between existing inductor and/or stick end, therefore power consumption will trend towards being gradually to 0.
According to representing embodiment, inductor 402 is cylindrical substantially, and comprises the conducting circular cylinder core that it has arranged conductive coil around. For example, inductor 402 can comprise dust core, and this dust core is with the conductor wire coil around press-powder iron, core cylindrical arrangement. Or inductor 402 can comprise the air core inductor with conductive coil, or with ferrite core or the non-ferrite core of conductive coil. In addition, inductor 402 can comprise ring-type configuration, bar-shaped configuration and the configuration of electronics core. Ferrite core is useful, the applicable path that it provides relatively high quality factor (Q), rational Q and conducts/be dissipated to peripheral conductor (for example, metal) for heat.
The size of the inductance of quality factor (Q) and inductor 402 is for the RF frequency optimization of collision cell 400. Conventionally, the quality factor of inductor 402 (Q) should be at least 102Or on the larger order of magnitude. The inductor that obtains the highest as far as possible quality factor (Q) is favourable. As should be understood that, represent that the electrical power consumed in the collision cell of embodiment is that the electric current I=Vpp/Rp being produced by the effective parallel resistance from coil (Rp) and stray capacitance resonance circuit causes. Q is increased to degree as much as possible and will reduce electrical power consumed. Certainly, the selection of inductance size is taking the value of rod 201～303 stray capacitance and resonant frequency as basis.
Fig. 5 A shows the equivalent circuit 501 of the collision cell (for example, collision cell 200) representing in embodiment. Rod 201～303 nonmetallic substance with resistive coating normally described above, and arrange (six rods, arranging around inscribed circle) around axis with symmetric form. Rod 201～303 distributed resistance that are equal to 506,507,508 and 509 that are approximately in 501. Rod 201～303 utilizes ACRF voltage (for example,, from AC source 502 and transformer 503～504) to drive. ACRF voltage is applied to excellent two ends with identical amplitude and phase place conventionally. Ideally, DC voltage (for example, 505) is also applied between the first end 204～206 and the second end 207～209 of rod 201～203 simultaneously, remains on different DC gesture with each end that makes rod. In certain embodiments, be subject to the impact of the resistance (being equal to by resistance 506～509) that provides relatively high in rod 201～303 along DC biasing (difference) voltage of rod 201～303 length. Except the distributed resistance of rod 201～303, set up the distributed stray capacitance (C between rodstray) 510. As shown in the figure, distributed resistance 506,507,508 and 509 and stray capacitance (Cstray) 510 electricity series connection. Distributed stray capacitance (Cstray) 510 can produce relatively high reactive current with the resistance 506～509 of flowing through, produce along the AC voltage drop of rod 201～303. This AC voltage drop not only causes the distortion of the AC field of rod heating and expectation, and needs higher electric current demand with drive circuit.
Fig. 5 B shows according to the equivalent circuit 511 of collision cell 400 that represents embodiment. Collision cell 400 comprises and the stray capacitance (C producing from rod 201～303stray) 510 inductors 402 that are electrically connected in parallel. Inductor 402 is chosen at RF frequency and stray capacitance (Cstray) 510 resonance, and be added to the tie point that is positioned at excellent center. Therefore, the size of inductor 402 is by 1/ ωo 2CstrayCalculate, wherein and ωo＝2πfoFoResonant frequency. In the time of resonance, by stray capacitance (Cstray) 510 reactive currents that cause are offset substantially by the inductor in parallel with it 402. As a result, consequent drive current depends primarily on inductor 402, stray capacitance (Cstray) parallel resistance of 510 L-C combination, and the series resistance (being formed by resistance 506～509) of rod 201～303.
In the time of resonance, homophase resistive element (Rp) is provided by Rp=Q ω L. L is by 1/ ω2CstrayCalculate wherein ω=2 π f. Suppose the R of Xc > > rod, in the situation that there is no inductor, reactive current is that (wherein reactance is by Xc=1/ ω C for Vpp/Xc generallystrayProvide). Having the electric current in the situation of inductor is Vpp/Rp; Rp is much larger than Xc.
Although distributed capacitor can not be offset with intermediate point inductor, supply current and overall power requirement have subsequently reduced approximately 50%. The degree that power is saved will depend on the ratio of the impedance of drive circuit and the parallel impedance of inductor 402 and stray capacitance 510.
Fig. 5 C shows according to the equivalent circuit 512 of collision cell 400 that represents embodiment. Equivalent circuit 512 comprises transformer 513, and it has and is connected to as shown in the figure the winding 516,517 and 518 that is illustrated as the excellent 201-203 that is uniformly distributed resistance 514,515. Winding 517 and 518 illustratively is bifilar winding and thinks that each end of excellent 201-203 provides the RF voltage with roughly the same phase place and amplitude. Winding 516 (inductor) is used to RF voltage to be coupled into winding 517 and 518. Apply DC voltage by the centre cap that floating voltage source Vbias519 is connected to winding 517 and 518 to excellent 201-203. Also DC is connected to 520 centre caps that are supplied to winding 518 so that the voltage bias of collision cell 400 with respect to ground to be provided. Can utilize the known circuit of realizing by transistor or integrated circuit to generate to be supplied to the time luffing degree RF voltage of winding 517. By transformer 513 or by other known voltage isolation technologies, by the variation voltage by floating voltage source Vbias supply and the isolation of other circuit grounds electricity.
In view of the disclosure, note, can be consistent with this instruction come implementation method and device. In addition, various elements, material, structure and parameter have been comprised to illustrate with the mode of example and meaning without any restrictions. In view of the disclosure, as long as comprise within the scope of the appended claims, can in other application and element, material, structure and the confirmable equipment that need to implement these application, implement this instruction.
Claims (14)
1. an ion guide (102), comprising:
Rod (201,202,203,301,302,303), each has first end described rod(204,205,206) and away from the second end of described first end (204,205,206)(207，208，209)；
Single inductor (402), described inductor be connected to contiguous paired rod (201,202,203,301,302,303) between;
For penetrating contiguous excellent applying between to (201,202,203,301,302,303)Frequently the device of (RF) voltage (502), wherein said RF voltage described rod (201,202,203,301,302,303) region between produces multipole fields; And
Apply for each the length along described rod (201,202,203,301,302,303)The device that direct current (DC) voltage (505) falls.
2. ion guide as claimed in claim 1 (102), wherein said inductor (402)Be connected to paired excellent intermediate point separately described in each.
3. ion guide as claimed in claim 1 or 2 (102), wherein said rod (201,202,203,301,302,303) each have along first end separately (204,205,206) the curved part of the length between and the second end (207,208,209).
4. ion guide as claimed in claim 1 or 2 (102), wherein said rod (201,202,203,301,302,303) each is along the length between first end and the second end separatelySubstantially be straight.
5. ion guide as claimed in claim 3 (102), wherein said rod (201,202,203,301,302,303) described first end (204,205,206) is together around greatlyTo the region that is enough to ion beam is passed through.
6. ion guide as claimed in claim 1 or 2 (102), wherein said rod (201,202,203,301,302,303) each is similar to round arc.
7. ion guide as claimed in claim 1 or 2 (102), wherein said first end(204,205,206) are arranged to around having the first radius (r1) first circle and described secondEnd (207,208,209) is arranged to around having the second radius (r2) second circle, and described inThe first radius is greater than described the second radius.
8. ion guide as claimed in claim 1 or 2 (102), wherein said rod (201,202,203,301,302,303) there is resistance.
9. ion guide as claimed in claim 1 or 2 (102), wherein said rod (201,202,203,301,302,303) non-conductive.
10. ion guide as claimed in claim 1 or 2 (102), wherein said sensing apparatusHave selected with the irritability at RF frequency and stray capacitance formation resonance circuit.
11. ion guides as claimed in claim 1 or 2 (102), wherein said RF voltageLuffing degree while having.
12. 1 kinds of collision cell (200,400), comprise in claim 1 to 11 described in any oneIon guide (102).
13. 1 kinds of spectrometer systems (100), comprise in claim 1 to 11 described in any oneIon guide.
14. 1 kinds of spectrometer systems (100), comprise collision cell described in claim 12 (200,400)。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33359210P | 2010-05-11 | 2010-05-11 | |
| US61/333,592 | 2010-05-11 |
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| CN102254780A CN102254780A (en) | 2011-11-23 |
| CN102254780B true CN102254780B (en) | 2016-05-11 |
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| CN201110128900.0A Active CN102254780B (en) | 2010-05-11 | 2011-05-11 | improved ion guide and collision cell |
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|---|---|
| US (1) | US8455814B2 (en) |
| EP (1) | EP2387064B1 (en) |
| JP (1) | JP5808143B2 (en) |
| CN (1) | CN102254780B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9442887B2 (en) * | 2007-08-31 | 2016-09-13 | Dh Technologies Development Pte. Ltd. | Systems and methods for processing fragment ion spectra to determine mechanism of fragmentation and structure of molecule |
| EP2502258B1 (en) * | 2009-11-16 | 2021-09-01 | DH Technologies Development Pte. Ltd. | Apparatus and method for coupling rf and ac signals to provide power to a multipole in a mass spectrometer |
| GB2506362B (en) | 2012-09-26 | 2015-09-23 | Thermo Fisher Scient Bremen | Improved ion guide |
| US9583321B2 (en) | 2013-12-23 | 2017-02-28 | Thermo Finnigan Llc | Method for mass spectrometer with enhanced sensitivity to product ions |
| US9558925B2 (en) * | 2014-04-18 | 2017-01-31 | Battelle Memorial Institute | Device for separating non-ions from ions |
| DE112015002415B4 (en) | 2014-06-25 | 2020-01-02 | Hitachi High-Technologies Corporation | mass spectrometry |
| US9524860B1 (en) * | 2015-09-25 | 2016-12-20 | Thermo Finnigan Llc | Systems and methods for multipole operation |
| US9899181B1 (en) * | 2017-01-12 | 2018-02-20 | Fei Company | Collision ionization ion source |
| CN109216150B (en) | 2017-06-29 | 2020-12-15 | 株式会社岛津制作所 | Ion guiding device and guiding method |
| GB2571772B (en) | 2018-03-09 | 2023-02-15 | Micromass Ltd | Ion confinement device |
| DE102022100728B4 (en) * | 2022-01-13 | 2023-08-24 | Bruker Optics Gmbh & Co. Kg | Desorber for a spectrometer |
| US11908675B2 (en) | 2022-02-15 | 2024-02-20 | Perkinelmer Scientific Canada Ulc | Curved ion guides and related systems and methods |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1755890A (en) * | 2004-10-01 | 2006-04-05 | 安捷伦科技有限公司 | Multipole device for a mass spectrometer |
| CN101002296A (en) * | 2004-06-21 | 2007-07-18 | 萨默费尼根有限公司 | RF power supply for a mass spectrometer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6075244A (en) * | 1995-07-03 | 2000-06-13 | Hitachi, Ltd. | Mass spectrometer |
| US5559327A (en) | 1995-07-27 | 1996-09-24 | Bear Instruments, Inc. | Ion filter and mass spectrometer using arcuate hyperbolic quadrapoles |
| AU6653296A (en) * | 1995-08-11 | 1997-03-12 | Mds Health Group Limited | Spectrometer with axial field |
| CH691839A5 (en) | 1996-07-10 | 2001-10-31 | Hansjoerg Cueni | A process for producing a quadrupole electrode assembly. |
| JP2002033072A (en) * | 2000-07-18 | 2002-01-31 | Japan Atom Energy Res Inst | Quadrupole electrode application voltage generation circuit for quadrupole mass spectrometer |
| US6576897B1 (en) | 2000-09-13 | 2003-06-10 | Varian, Inc. | Lens-free ion collision cell |
| US6844547B2 (en) * | 2002-02-04 | 2005-01-18 | Thermo Finnigan Llc | Circuit for applying supplementary voltages to RF multipole devices |
| DE102004014584B4 (en) * | 2004-03-25 | 2009-06-10 | Bruker Daltonik Gmbh | High frequency quadrupole systems with potential gradients |
| US6998622B1 (en) | 2004-11-17 | 2006-02-14 | Agilent Technologies, Inc. | On-axis electron impact ion source |
| US7569811B2 (en) * | 2006-01-13 | 2009-08-04 | Ionics Mass Spectrometry Group Inc. | Concentrating mass spectrometer ion guide, spectrometer and method |
| DE102006011037B4 (en) | 2006-03-08 | 2008-03-06 | Chromtech Gesellschaft für analytische Meßtechnik mbH | Collision chamber of a mass spectrometer for the mass analysis of ions |
| WO2009036569A1 (en) | 2007-09-19 | 2009-03-26 | Mds Analytical Technologies, A Business Unit Of Mds Inc. Doing Business Through Its Sciex Division | Collision cell for mass spectrometer |
| US7973277B2 (en) * | 2008-05-27 | 2011-07-05 | 1St Detect Corporation | Driving a mass spectrometer ion trap or mass filter |
| US9236235B2 (en) * | 2008-05-30 | 2016-01-12 | Agilent Technologies, Inc. | Curved ion guide and related methods |
| JP5709742B2 (en) * | 2008-06-09 | 2015-04-30 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | Multipolar ion induction providing an axial electric field that increases in intensity with radial position |
| US8193489B2 (en) | 2009-05-28 | 2012-06-05 | Agilent Technologies, Inc. | Converging multipole ion guide for ion beam shaping |
-
2011
- 2011-04-15 US US13/087,748 patent/US8455814B2/en active Active
- 2011-05-03 EP EP11164605.5A patent/EP2387064B1/en active Active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002296A (en) * | 2004-06-21 | 2007-07-18 | 萨默费尼根有限公司 | RF power supply for a mass spectrometer |
| CN1755890A (en) * | 2004-10-01 | 2006-04-05 | 安捷伦科技有限公司 | Multipole device for a mass spectrometer |
Also Published As
| Publication number | Publication date |
|---|---|
| US8455814B2 (en) | 2013-06-04 |
| EP2387064B1 (en) | 2020-03-25 |
| EP2387064A2 (en) | 2011-11-16 |
| CN102254780A (en) | 2011-11-23 |
| EP2387064A3 (en) | 2017-06-14 |
| JP2011238616A (en) | 2011-11-24 |
| JP5808143B2 (en) | 2015-11-10 |
| US20110278450A1 (en) | 2011-11-17 |
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