CN102232955A - Preparation method of oral amorphous cefuroxime axetil antibacterial composition, and composition and compound preparation prepared by same - Google Patents
Preparation method of oral amorphous cefuroxime axetil antibacterial composition, and composition and compound preparation prepared by same Download PDFInfo
- Publication number
- CN102232955A CN102232955A CN2010101609485A CN201010160948A CN102232955A CN 102232955 A CN102232955 A CN 102232955A CN 2010101609485 A CN2010101609485 A CN 2010101609485A CN 201010160948 A CN201010160948 A CN 201010160948A CN 102232955 A CN102232955 A CN 102232955A
- Authority
- CN
- China
- Prior art keywords
- cefuroxime
- oral
- antibacnterial
- preparation
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of an oral amorphous cefuroxime axetil antibacterial composition, and a composition and compound preparation prepared by the same. The preparation method comprises the steps of: dissolving crystalline cefuroxime axetil and crystalline sulbactam pivoxil in an organic solvent, decoloring, and spray drying to obtain the oral amorphous cefuroxime axetil antibacterial composition. By the preparation method disclosed by the invention, the oral amorphous cefuroxime axetil antibacterial composition with uniform spherical shapes, large specific area, good bioavailability and a smaller dose of sulbactam pivoxil can be obtained, and the compound preparation prepared by the preparation method has low cost and good antibacterial effect.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of preparation method of amorphous cefuroxime oral antibacnterial composition and amorphous cefuroxime oral antibacnterial composition, the compound preparation of preparation thereof.
Background technology
CEFUROXIME AXETIL (Cefuroxime Axetil) is a second generation cephalosporin, as a kind of broad-spectrum sterilization antibiotic, gram positive bacteria and most gram negative bacteria is all had stronger antibacterial action, and liver, nephrotoxicity are low.Along with CEFUROXIME AXETIL extensive use clinically, the original responsive bacterial strain of part has produced drug resistance to cefuroxime, and its antibacterial effect is descended.Discover that antibacterial produces chemical sproof main mechanism to cephalosporins medicine and decomposes medicine for producing specific beta-lactamase.
In order to overcome the problems referred to above, Chinese patent application CN1742735A discloses a kind of cefuroxime oral antibacnterial composition of being made up of CEFUROXIME AXETIL and (Pivaloyloxy)methyl penicillanate S,S-dioxide, wherein, CEFUROXIME AXETIL (in cefuroxime) is 1: 1 to 15: 1 with the weight ratio scope of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam), be preferably 1: 1 to 6: 1, most preferably be 2: 1.
But, in above-mentioned application, just CEFUROXIME AXETIL simply to be mixed with (Pivaloyloxy)methyl penicillanate S,S-dioxide, the mixed bioavailability of the CEFUROXIME AXETIL of crystal type and (Pivaloyloxy)methyl penicillanate S,S-dioxide is relatively poor.In addition, because the (Pivaloyloxy)methyl penicillanate S,S-dioxide price is higher, its large usage quantity makes the preparation cost higher, is unfavorable for that its sufferer by economic backward area etc. is accepted.
Summary of the invention
The technical problem to be solved in the present invention is, above-mentioned defective at prior art, a kind of preparation method of amorphous cefuroxime oral antibacnterial composition is provided, and this method can prepare bioavailability height, amorphous cefuroxime oral antibacnterial composition that cost is low.
The technical problem that the present invention further will solve is, a kind of amorphous cefuroxime oral antibacnterial composition also is provided.
The technical problem that the present invention further will solve is, a kind of amorphous cefuroxime oral antibacnterial compound preparation also is provided.
In order to reach above-mentioned purpose, according to the present invention, provide a kind of preparation method of amorphous cefuroxime oral antibacnterial composition: crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in the organic solvent decolouring, spray drying obtains amorphous cefuroxime oral antibacnterial composition.
In the preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, preferably, the mass volume ratio of described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide the two and described organic solvent is 1: 3～15.
In the preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, preferably, described organic solvent is two or more a mixture of acetone, butanone, methanol, ethanol, isopropyl alcohol, dichloromethane, chloroform, carbon tetrachloride, dichloroethanes, trichloroethane, acetonitrile, positive propyl ether, diisopropyl ether, oxolane, Ethyl formate, propyl formate, methyl acetate, ethyl acetate or they.
In the preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, preferably, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～20: 1 by the weight ratio of cefuroxime and sulbactam respectively.
In the preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, preferably, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～15: 1 by the weight ratio of cefuroxime and sulbactam respectively.
In the preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, preferably, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～10: 1 by the weight ratio of cefuroxime and sulbactam respectively.
In order to reach above-mentioned purpose, according to the present invention, also provide a kind of amorphous cefuroxime oral antibacnterial composition, adopt the preparation method of above-mentioned amorphous cefuroxime oral antibacnterial composition to prepare.
In order to reach above-mentioned purpose, according to the present invention, also provide a kind of amorphous cefuroxime oral antibacnterial compound preparation, it includes above-mentioned amorphous cefuroxime oral antibacnterial composition.
In amorphous cefuroxime oral antibacnterial compound preparation of the present invention, preferably, described amorphous cefuroxime oral antibacnterial compound preparation is capsule, tablet, granule.
The preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, obtain the amorphous cefuroxime oral antibacnterial composition that sphere is even, specific surface area is big and bioavailability is good, and can reduce the consumption of (Pivaloyloxy)methyl penicillanate S,S-dioxide in the compositions, and then reduce cost.
The preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, it is not the simple mixing of CEFUROXIME AXETIL and (Pivaloyloxy)methyl penicillanate S,S-dioxide, but they are dissolved in mix homogeneously in the organic solvent, just obtain amorphous cefuroxime oral antibacnterial composition after decolouring, spray drying, its antibacterial action is stronger.
The preparation method of amorphous cefuroxime oral antibacnterial composition of the present invention, because CEFUROXIME AXETIL and (Pivaloyloxy)methyl penicillanate S,S-dioxide all do not have reactive group, the two mixing is dissolved in the organic solvent and can react to each other, and mix more even, the spray-dried amorphous cefuroxime oral antibacnterial composition that obtains is even, single, helps the production of compound preparation.
Amorphous cefuroxime oral antibacnterial composition of the present invention, because of its component all is amorphous states, the bioavailability height, and under the less situation of the higher (Pivaloyloxy)methyl penicillanate S,S-dioxide consumption of price, still can access good antibacterial effect, thereby reduce cost.
Amorphous cefuroxime oral antibacnterial compound preparation of the present invention can be made as forms such as capsule, tablet or granules by amorphous cefuroxime oral antibacnterial composition according to process well known in the art, is convenient to the oral medication of sufferer.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention is elaborated below in conjunction with specific embodiment.
The present invention prepares processes such as capsule, tablet as used herein and is technology well known in the art, and those skilled in the art can consult on the coherent reference book and learn.
In the preparation method of amorphous cefuroxime oral antibacnterial composition, organic solvent can be lower aliphatic ketone, saturated lower alcohol, C
2-C
6Lower paraffin hydrocarbon, C
2-C
6Nitrile, ethers, low-grade carboxylic acid's esters or their mixture.For example, preferably, lower aliphatic ketone is acetone, butanone or their mixture, and saturated lower alcohol is methanol, ethanol, isopropyl alcohol or their mixture, C
2-C
6Lower paraffin hydrocarbon be dichloromethane, chloroform, carbon tetrachloride, dichloroethanes, trichloroethane or their mixture, C
2-C
6Nitrile be acetonitrile, C
2-C
6Ethers be positive propyl ether, diisopropyl ether, oxolane, low-grade carboxylic acid's esters is Ethyl formate, propyl formate, methyl acetate, ethyl acetate.
In the preparation method of amorphous cefuroxime oral antibacnterial composition, crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in organic solvent, spray drying after decolouring obtains amorphous cefuroxime oral antibacnterial composition.Because organic solvent can vapor away in spray-drying process, so can not contain the organic solvent that uses in the preparation process in the product that obtains.
As used in this, term " mass volume ratio " be meant crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide the two quality (is unit with g) and the ratio between the volume of organic solvent (is unit with mL).The identical meaning of following " doubly (W/V) " expression, for example, the two quality and the ratio between the volume of organic solvent of 3 times (W/V) expression crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide is 1: 3.
Embodiment 1 amorphous cefuroxime oral antibacnterial compound capsule A
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 3 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 1: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 2 amorphous cefuroxime oral antibacnterial compound tablet B
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 5 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make tablet then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 2: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 3 amorphous cefuroxime oral antibacnterial compound granular agent C
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 7 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make granule then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 4: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 4 amorphous cefuroxime oral antibacnterial compound tablet D
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 9 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make tablet then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 7: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 5 amorphous cefuroxime oral antibacnterial compound capsule E
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 11 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 10: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 6 amorphous cefuroxime oral antibacnterial compound granular agent F
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 13 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make granule then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 13: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 7 amorphous cefuroxime oral antibacnterial compound capsule G
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 15 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 17: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 8 amorphous cefuroxime oral antibacnterial compound capsule H
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 11 times of (W/V) acetone, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, wherein, CEFUROXIME AXETIL (in cefuroxime) is 20: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 9: amorphous cefuroxime oral antibacnterial compound capsule
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 10 times of (W/V) methanol, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 3: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 10: amorphous cefuroxime oral antibacnterial compound capsule
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 14 times of (W/V) dichloromethane, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 5: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 11: amorphous cefuroxime oral antibacnterial compound capsule
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 8 times of (W/V) acetonitriles, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 8: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 12: amorphous cefuroxime oral antibacnterial compound capsule
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 11 times of (W/V) oxolanes, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 11: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Embodiment 13: amorphous cefuroxime oral antibacnterial compound capsule
Crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in 15 times of (W/V) ethyl acetate, add activated carbon decolorizing, spray-driedly obtain even spheroidal particle, it is amorphous cefuroxime oral antibacnterial composition, make capsule then, CEFUROXIME AXETIL (in cefuroxime) is 15: 1 with the weight ratio of (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam).
Comparative Examples CEFUROXIME AXETIL capsule I
The CEFUROXIME AXETIL capsule, Shenzhen pharmaceutical factory produces, specification: 0.125g/ grain.
Contrast test:
Test method: adopt the full dose broth dilution method that embodiment 1～8 and Comparative Examples are measured;
Test strain: clinical isolating staphylococcus aureus, escherichia coli, each two strain of Klebsiella Pneumoniae;
Comparative test result sees Table 1 and table 2, and every kind of each row is all represented the result of the test to a strain bacterial strain.
Table 1: testing sample is to the MIC result (μ g/mL) of test strain
Table 2:MIC outcome record is single
By table 1 and table 2 as can be seen, when the weight ratio scope of CEFUROXIME AXETIL (in cefuroxime) and (Pivaloyloxy)methyl penicillanate S,S-dioxide (in sulbactam) is 1～20: in the time of 1, the amorphous cefuroxime oral antibacnterial compound preparation of embodiment of the invention preparation is all less, antibiotic to the MIC of staphylococcus aureus, escherichia coli and Klebsiella Pneumoniae, fungistatic effect is all better.
The above only is representative embodiment of the present invention, does not limit the present invention in any way, and all any modifications of being done within the spirit and principles in the present invention, is equal to and replaces or improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. the preparation method of an amorphous cefuroxime oral antibacnterial composition is characterized in that, crystal type CEFUROXIME AXETIL and crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are dissolved in the organic solvent, and decolouring, spray drying obtains amorphous cefuroxime oral antibacnterial composition.
2. the preparation method of amorphous cefuroxime oral antibacnterial composition according to claim 1 is characterized in that, the mass volume ratio of described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide the two and described organic solvent is 1: 3～15.
3. the preparation method of amorphous cefuroxime oral antibacnterial composition according to claim 1 and 2, it is characterized in that described organic solvent is two or more a mixture of acetone, butanone, methanol, ethanol, isopropyl alcohol, dichloromethane, chloroform, carbon tetrachloride, dichloroethanes, trichloroethane, acetonitrile, positive propyl ether, diisopropyl ether, oxolane, Ethyl formate, propyl formate, methyl acetate, ethyl acetate or they.
4. the preparation method of amorphous cefuroxime oral antibacnterial composition according to claim 3 is characterized in that, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～20: 1 by the weight ratio of cefuroxime and sulbactam respectively.
5. the preparation method of amorphous cefuroxime oral antibacnterial composition according to claim 4 is characterized in that, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～15: 1 by the weight ratio of cefuroxime and sulbactam respectively.
6. the preparation method of amorphous cefuroxime oral antibacnterial composition according to claim 4 is characterized in that, described crystal type CEFUROXIME AXETIL and described crystal type (Pivaloyloxy)methyl penicillanate S,S-dioxide are 1～10: 1 by the weight ratio of cefuroxime and sulbactam respectively.
7. an amorphous cefuroxime oral antibacnterial composition is characterized in that, adopts the preparation method of each described amorphous cefuroxime oral antibacnterial composition of claim 1～6 to prepare.
8. an amorphous cefuroxime oral antibacnterial compound preparation is characterized in that, includes the described amorphous cefuroxime oral antibacnterial composition of claim 7.
9. amorphous cefuroxime oral antibacnterial compound preparation according to claim 8 is characterized in that, described amorphous cefuroxime oral antibacnterial compound preparation is capsule, tablet or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010160948.5A CN102232955B (en) | 2010-04-30 | 2010-04-30 | The preparation method of amorphous cefuroxin axetil Perorally administrable antimicrobial composition and the compositions of preparation, compound preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010160948.5A CN102232955B (en) | 2010-04-30 | 2010-04-30 | The preparation method of amorphous cefuroxin axetil Perorally administrable antimicrobial composition and the compositions of preparation, compound preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102232955A true CN102232955A (en) | 2011-11-09 |
| CN102232955B CN102232955B (en) | 2016-04-06 |
Family
ID=44884379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010160948.5A Active CN102232955B (en) | 2010-04-30 | 2010-04-30 | The preparation method of amorphous cefuroxin axetil Perorally administrable antimicrobial composition and the compositions of preparation, compound preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102232955B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251467A (en) * | 2019-06-26 | 2019-09-20 | 北京济美堂医药研究有限公司 | A kind of preparation method of amorphous state Cefditoren pivoxil Cephalosporins composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634931A (en) * | 2004-11-15 | 2005-07-06 | 中山大学 | Cefuroxime axetil diastereoisomer separating method |
| CN1637001A (en) * | 2003-12-26 | 2005-07-13 | 上海华联制药有限公司 | Process of preparing amorphous cefuroxin axetil |
| CN1742735A (en) * | 2005-10-10 | 2006-03-08 | 夏中宁 | Cefuroxime oral antibacnterial composition |
| CN101284839A (en) * | 2008-06-02 | 2008-10-15 | 河北科技大学 | Method and device for preparing superfine amorphousn cefuroxime axetil |
-
2010
- 2010-04-30 CN CN201010160948.5A patent/CN102232955B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1637001A (en) * | 2003-12-26 | 2005-07-13 | 上海华联制药有限公司 | Process of preparing amorphous cefuroxin axetil |
| CN1634931A (en) * | 2004-11-15 | 2005-07-06 | 中山大学 | Cefuroxime axetil diastereoisomer separating method |
| CN1742735A (en) * | 2005-10-10 | 2006-03-08 | 夏中宁 | Cefuroxime oral antibacnterial composition |
| CN101284839A (en) * | 2008-06-02 | 2008-10-15 | 河北科技大学 | Method and device for preparing superfine amorphousn cefuroxime axetil |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251467A (en) * | 2019-06-26 | 2019-09-20 | 北京济美堂医药研究有限公司 | A kind of preparation method of amorphous state Cefditoren pivoxil Cephalosporins composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102232955B (en) | 2016-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101816635B (en) | Cephalosporin suspension granule and preparation method thereof | |
| CN101780085B (en) | Cefprozil medicinal composition | |
| CN103417512B (en) | A kind of Biomox and preparation method thereof | |
| CN102671210B (en) | Clathrate compound of beta-cyclodextrin or derivatives of beta-cyclodextrin for Nifuroxazide and preparation method for preparation of clathrate compound | |
| CN103524532B (en) | Ceftizoxime sodium compound crystal form, and preparing method and pharmaceutical preparation thereof | |
| CN101502511A (en) | Amoxicillin/clavulanate potassium tablet and preparation method thereof | |
| CN103193798A (en) | Cefixime compound and pharmaceutical composition thereof | |
| CN103012434A (en) | Cefathiamidine compound crystal and preparation method as well as pharmaceutical composition thereof | |
| CN101890006A (en) | Amoxicillin sustained-release preparation composition and preparation method thereof | |
| CN103524533A (en) | Cefprozil compound, and dispersible tablets, dry suspension and preparation method thereof | |
| CN103330685A (en) | Cefaclor granule and preparation method thereof | |
| CN103446075A (en) | Cefaclor capsule and preparation method thereof | |
| CN102232955B (en) | The preparation method of amorphous cefuroxin axetil Perorally administrable antimicrobial composition and the compositions of preparation, compound preparation | |
| CN102697736A (en) | Cefixime granule and preparation method thereof | |
| CN103073562B (en) | Method for refining cefamandole nafate, cefamandole nafate and application thereof | |
| CN101502496B (en) | Method for preparing norfloxacin capsule | |
| CN103145736A (en) | Medicine composite containing cefamandole nafate compound | |
| CN103520120B (en) | A kind of L-084 composition granule | |
| CN102258521A (en) | Cefodizime sodium composition and preparation method thereof | |
| CN103497204B (en) | A kind of Cefdinir compound, its dispersible tablet and preparation method | |
| CN102344458B (en) | Cefprozil compound crystal and medicinal composition thereof | |
| CN103304580B (en) | Cefepime dihydrochloride compound as well as preparation method and medicine composition thereof | |
| CN112007010A (en) | Stable cefuroxime axetil pharmaceutical preparation composition and preparation method thereof | |
| CN103374019B (en) | A kind of preparation method of Cefuroxime Sodium | |
| CN102716075A (en) | Ceftizoxime sodium-containing pharmaceutical composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221124 Address after: No. 8, Transit Road, Lantang Town, Zijin County, Heyuan, Guangdong 517447 Patentee after: GUANGDONG LIGUO PHARMACY Co.,Ltd. Address before: 518000 Tianxiang Building 6A, Tianan Digital City, Futian District, Shenzhen, Guangdong Patentee before: Shenzhen City Liguo Medicine Research Co.,Ltd. |
|
| TR01 | Transfer of patent right |