CN102220508A - Preparation method and usage of medical porous tantalum - Google Patents
Preparation method and usage of medical porous tantalum Download PDFInfo
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- CN102220508A CN102220508A CN 201110128842 CN201110128842A CN102220508A CN 102220508 A CN102220508 A CN 102220508A CN 201110128842 CN201110128842 CN 201110128842 CN 201110128842 A CN201110128842 A CN 201110128842A CN 102220508 A CN102220508 A CN 102220508A
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Abstract
Provided is a preparation method and usage of medical porous tantalum. The preparation method comprises the steps of preparation of powder, moulding by pressing, sintering and cooling of an apparatus. The medical porous tantalum prepared has a purity of 99.95%, an aperture of 0.25 to 0.3 mm and a porosity of 75%. Such porous tantalum can be directly implanted into a desired part of a human body, which enables medicament in the aperture of porous tantalum to be absorbed by the human body gradually; therefore, the medical porous tantalum prepared has a high application value.
Description
Technical field
The invention belongs to the rare metal technical field, be specifically related to a kind of Preparation method and use of medical porous tantalum.
Background technology
Tantalum is VB family the 6th period element, and ordination number is 73, and relative atomic mass is 180.95, and volume density is 16.6g/cm
3, fusing point is only second to tungsten and rhenium near 3000 ℃ (2980 ± 20 ℃), belongs to rare refractory metal.The tantalum quality is tightly hard, and hardness can reach HV120, has good ductility simultaneously.Its thermal expansivity is very little, and every rising only expands about 6/1000000ths. six for one degree centigrade.In addition, tantalum also has characteristics such as high erosion resistance, wear resistance and excellent biological compatibility.More than these characteristics make metal tantalum obtain to use widely in fields such as chemical industry, metallurgy, electronics, electric, medical science, can be used for aspects such as chemical reaction equipment, vacuum oven, electrical condenser, nuclear reactor, aerospacecraft, guided missile and surgery embedded material.The porous tantalum prior preparation method has powder sintering and vapour deposition process, and powder sintered is that the sintered compact that will make is placed in the electrolyte solution, and tantalum powder particles surface forms the layer oxide film medium, handles and makes through following process; Vapour deposition process elder generation pyrolysis polyurethane foam obtains the carbon network skeleton, again the mode of metal tantalum by chemical vapour deposition covered on the carbon skeleton, thereby obtain three-dimensional netted porous tantalum product, adopt above-mentioned two kinds of porous tantalums that method makes, porous tantalum need be made the model of human synovial earlier, and then in the implant into body, operation is loaded down with trivial details, the needed time is long, and production efficiency is low, therefore is necessary to improve.
Summary of the invention
The technical problem that the present invention solves: the Preparation method and use that a kind of medical porous tantalum is provided, the porous tantalum that adopts this method to prepare is the sponge blocky-shaped particle, its purity can reach 99.95%, hole is that 0.25～0.3mm, porosity can reach 75%, and have suitable physical strength, Young's modulus, solidity to corrosion and excellent biological compatibility, directly implant into body makes the intrapore medicine of porous tantalum slowly be absorbed by human body.
The technical solution used in the present invention: the preparation method of medical porous tantalum comprises the steps:
1) preparation tantalum particle and sodium hydrate particle, and both are mixed in proportion are composite grain;
2) composite grain is put into mixer, in mixer, the composite grain mixing was formed powdery granule in 20-24 hour;
3) powdery granule that mixes is put on the above oil press of 200T be pressed into the base bar;
4) the base bar is put into vacuum sintering furnace and carry out sintering, sintering temperature is 1500～1950 ℃, is incubated 1.5-2 hour;
5) vacuum sintering furnace is cooled to normal temperature with water cycle, then cooled base bar is taken out, the stripping and slicing packing gets final product.
Preferably, above-mentioned steps one, the granularity of described tantalum particle are 0.25～0.3mm, and sodium hydroxid particulate granularity is 0.25～0.3mm, are composite grain with tantalum particle and sodium hydroxid particle by 3: 1 mixed.
Preferably, above-mentioned steps two, the granularity of described powdery granule are 0.24～0.29mm.
Preferably, above-mentioned steps four, described sintering temperature are 1750 ℃.
The medical porous tantalum purposes of above-mentioned preparation method's preparation also is provided, and the direct implant into body desired area of described porous tantalum makes the intrapore medicine of porous tantalum slowly be absorbed by human body.
The present invention compared with prior art adds sodium hydrate particle in the tantalum powder, it is that can to reach 75% specification be the porous tantalum of 8mm * 8mm * 20mm for 0.25～0.3mm, porosity that methods such as repressed, sintering can form hole, and sodium hydroxide mixture storage is few in the porous tantalum that guarantees to prepare, can not work the mischief to human body, have higher using value.
Embodiment
A kind of embodiment of the present invention is described below.
The preparation method of medical porous tantalum comprises the steps:
1) prepared sizes are that tantalum particle and the granularity of 0.25～0.3mm are the sodium hydrate particle of 0.25～0.3mm, and be composite grain by 3: 1 mixed with both, sodium hydroxide mixture storage is few in the porous tantalum that this ratio preparation can guarantee to prepare, and can not work the mischief to human body;
2) composite grain is put into mixer, in mixer the composite grain mixing being formed granularity in 20-24 hour is the powdery granule of 0.24～0.29mm;
3) be that the powdery granule of 0.24～0.29mm is put into the base bar that is pressed into 8mm * 100mm * 20mm specification on the above oil press of 200T with the granularity that mixes;
4) the base bar of 8mm * 100mm * 20mm specification is put into vacuum sintering furnace and carry out sintering, sintering temperature is 1500～1950 ℃, and preferred sintering temperature is 1750 ℃, is incubated 1.5-2 hour;
5) vacuum sintering furnace is cooled to normal temperature with water cycle, then cooled base bar is taken out, stripping and slicing is that the tantalum piece packing of 8mm * 8mm * 20mm specification gets final product.
The medical porous tantalum that adopts aforesaid method to make, purity is 99.95%, hole is that 0.25～0.3mm, porosity can reach 75%, this kind porous tantalum is the implant into body desired area directly, and the intrapore medicine of porous tantalum is slowly absorbed by human body, has higher using value.
The foregoing description is preferred embodiment of the present invention, is not to be used for limiting the scope of the present invention, so all equivalences of being done with the described content of claim of the present invention change, all should be included within the claim scope of the present invention.
Claims (5)
1. the preparation method of medical porous tantalum is characterized in that comprising the steps:
1) preparation tantalum particle and sodium hydrate particle, and both are mixed in proportion are composite grain;
2) composite grain is put into mixer, in mixer, the composite grain mixing was formed powdery granule in 20-24 hour;
3) powdery granule that mixes is put on the above oil press of 200T be pressed into the base bar;
4) the base bar is put into vacuum sintering furnace and carry out sintering, sintering temperature is 1500～1950 ℃, is incubated 1.5-2 hour;
5) vacuum sintering furnace is cooled to normal temperature with water cycle, then cooled base bar is taken out, the stripping and slicing packing gets final product.
2. the preparation method of medical porous tantalum according to claim 1, it is characterized in that: the granularity of the described tantalum particle of above-mentioned steps (1) is 0.25～0.3mm, sodium hydroxid particulate granularity is 0.25～0.3mm, is composite grain with tantalum particle and sodium hydroxid particle by 3: 1 mixed.
3. the preparation method of medical porous tantalum according to claim 1, it is characterized in that: the granularity of the described powdery granule of above-mentioned steps (2) is 0.24～0.29mm.
4. the preparation method of medical porous tantalum according to claim 1, it is characterized in that: the described sintering temperature of above-mentioned steps (4) is 1750 ℃.
5. adopt the medical porous tantalum purposes of claim 1,2,3 or 4 described preparation method's preparations, it is characterized in that: the direct implant into body desired area of described porous tantalum makes the intrapore medicine of porous tantalum slowly be absorbed by human body.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011101288421A CN102220508B (en) | 2011-05-18 | 2011-05-18 | Preparation method and usage of medical porous tantalum |
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| CN2011101288421A CN102220508B (en) | 2011-05-18 | 2011-05-18 | Preparation method and usage of medical porous tantalum |
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| CN102220508A true CN102220508A (en) | 2011-10-19 |
| CN102220508B CN102220508B (en) | 2012-11-21 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013113249A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material through selective laser sintering forming |
| WO2013113251A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material |
| WO2013113250A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing biological medical porous implant material |
| WO2013113248A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material through three-dimensional printing forming |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005072785A1 (en) * | 2004-01-30 | 2005-08-11 | Cam Implants B.V. | Highly porous 3 dimensional biocompatible implant structure |
| CN101418391A (en) * | 2008-12-15 | 2009-04-29 | 哈尔滨理工大学 | Method for preparing gradient porous material |
-
2011
- 2011-05-18 CN CN2011101288421A patent/CN102220508B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005072785A1 (en) * | 2004-01-30 | 2005-08-11 | Cam Implants B.V. | Highly porous 3 dimensional biocompatible implant structure |
| CN101418391A (en) * | 2008-12-15 | 2009-04-29 | 哈尔滨理工大学 | Method for preparing gradient porous material |
Non-Patent Citations (2)
| Title |
|---|
| 《Biomaterials》 20060605 Brett Russell Levine et al. Experimental and clinical performance of porous tantalum in orthopedic surgery 第4671-4681页 1-4 第27卷, 第27期 * |
| 《科技创新导报》 20080131 夏凤金 等 多孔钽的制备方法 第83-84页 1-4 , 第1期 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013113249A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material through selective laser sintering forming |
| WO2013113251A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material |
| WO2013113250A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing biological medical porous implant material |
| WO2013113248A1 (en) * | 2012-01-31 | 2013-08-08 | 重庆润泽医药有限公司 | Method for preparing porous tantalum medical implant material through three-dimensional printing forming |
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| CN102220508B (en) | 2012-11-21 |
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