CN102218110B - Four-medicine grinding soup concentrated pill and preparation method thereof - Google Patents
Four-medicine grinding soup concentrated pill and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a four-medicine grinding soup concentrated pill and a preparation method thereof. The four-medicine grinding soup concentrated pill is prepared from water extract containing radix linderae and Areca catechu, costus root and fructus aurantii. The preparation method comprises the following steps: making the water extract containing radix linderae and Areca catechu, costus root and fructus aurantii into pills, and drying to obtain the four-medicine grinding soup concentrated pill. The four-medicine grinding soup concentrated pill has the advantages of high stability, high quality and better drug effect, and is applicable to patients with poor gastrointestinal functions, stagnation of qi, indigestion, abdominal distension, bellyache, constipation and the like.
Description
Technical field
The present invention relates to a kind of Decoction of Four-Drug Juice concentrated pill and preparation method thereof.
Background technology
Decoction of Four-Drug Juice comes from recipes for Saving Lives, pleasant sending down the abnormal ascending QI, removing food stagnancy pain relieving.Decoction of Four-Drug Juice can be used for the card that stagnates in the infant breast food, and food stagnation card, disease are seen the gastral cavity abdomen, the uneasiness of crying, anorexia poor appetite, diarrhoea or constipation; Also can be used for person in middle and old age's stagnation of QI, food stagnation card, disease is seen distension and fullness in the abdomen, stomachache, constipation; And but abdominal postoperative promotes the recovery of gastrointestinal function.Modern medicine study shows that the Radix Aucklandiae can make enterokinesia amplitude and muscular tension obviously strengthen, and gastric emptying and intestinal propelling are all had facilitation, and the myenteron spasm due to acetylcholine and the histamine is had antagonism; Semen Arecae can excited M-cholinoceptor, causes that glandular secretion increases, and makes digestive juice secretion vigorous, and has excited smooth muscle effect; The Radix Linderae plays key effect in prescription, can not only strengthen the pharmacological action of other medicines in the prescription, and can make intestinal shrink enhancing by excited gastrointestinal smooth muscle.Therefore, the Simo Decoction Treatment Acute constipation often can be received good effect.
Decoction of Four-Drug Juice is comprised of the Radix Aucklandiae, Fructus Aurantii, the Radix Linderae and four kinds of medical materials of Semen Arecae, the conventional dosage form of using of present Decoction of Four-Drug Juice only has Chinese medicine oral liquid, its active ingredient in preparation process loses easily, and the oral liquid existence and stability is poor, quality is unstable, finished product transports, store, carry the limitation such as inconvenient.Therefore, Decoction of Four-Drug Juice need to substitute dosage form and is applied to clinical; Yet, if attempt dosage formulation transformation of ownership one-tenth and the diverse another kind of preparation of regular dosage form with particular types Chinese medicine, need to test through a large amount of manpower and materials, and if to realize that simultaneously novel form medicine and original dosage form have equal even better drug effect extremely difficult especially.This present situation needs to be resolved hurrily.
Summary of the invention
Technical problem to be solved by this invention is to have overcome that Decoction of Four-Drug Juice only has the Chinese medicine oral liquid dosage form single in the prior art, and there is active ingredient easily loss in preparation process in it as liquid preparation, and finished product poor stability, quality are unstable, transport, store, carry the defectives such as inconvenient, a kind of good stability, quality height are provided and have had Decoction of Four-Drug Juice concentrated pill of better drug effect and preparation method thereof.
Decoction of Four-Drug Juice concentrated pill prescription of the present invention contains the water extract of the Radix Linderae and Semen Arecae, the Radix Aucklandiae, and Fructus Aurantii.
Among the present invention, described Decoction of Four-Drug Juice is the conventional described Decoction of Four-Drug Juice in this area, and raw material generally comprises the medical material Radix Aucklandiae, Fructus Aurantii, the Radix Linderae and Semen Arecae.The described Radix Aucklandiae, Fructus Aurantii, the Radix Linderae and Semen Arecae are the conventional medical material that uses in this area.
Among the present invention, the water extract Raw medicine Radix Linderae of the described Radix Linderae and Semen Arecae and Semen Arecae, with the consumption of the Radix Aucklandiae and Fructus Aurantii better be mass ratio (0.2～3): (0.2～3): (0.2～3): (0.2～3), better is mass ratio 1: 1: 1: 1.
Among the present invention, the described Radix Aucklandiae and Fructus Aurantii all refer to the medicinal raw material medicine Radix Aucklandiae and Fructus Aurantii.
Among the present invention, the size of the described Radix Aucklandiae and Fructus Aurantii is that this area routine is described, and better is 100 orders～120 orders, and better is 120 orders.
Among the present invention, the water extract of the described Radix Linderae and Semen Arecae is generally by this area conventional method and obtains through water extraction, preferably, made by following method, the method comprises the steps: the raw material Radix Linderae and Semen Arecae are carried out the precipitate with ethanol remove impurity after the extracting solution of water extraction is concentrated, and reconcentration namely gets water extract afterwards.
Wherein, soak by this area is conventional before the described water extraction, better 6～15 times of water soakings with the raw material Radix Linderae and Semen Arecae quality of medicinal material, better is 8～12 times of water; What the time of described immersion was better is 1～3 hour, and better is 2 hours.
Wherein, the water consumption of described water extraction is this area conventional amount used, and better is 3～10 times of amounts of quality of medicinal material.
Wherein, the temperature of described water extraction is conventional by this area, generally is heated to boiling and extracts.
What wherein, the time of described water extraction was better is 0.3～1 hour.
Wherein, what the number of times of described water extraction was better is 1～3 time, and better is 2 times.The number of times of described water extraction merge extractive liquid, during more than 1 time.
The concentrated concentrating under reduced pressure that is preferably when wherein, carrying out the precipitate with ethanol remove impurity after described the concentrating.What described striking point was better is 1.05～1.15 clear paste for being concentrated into 60 ℃～70 ℃ relative densities.Described clear paste refers to that Chinese medicine extraction liquid is through being concentrated into and extraction medical material amount suitable Chinese medicine extraction liquid roughly.
Wherein, described precipitate with ethanol remove impurity is this area routine operation, and better is to add ethanol to containing pure percent by volume 70%～80%, and cold preservation, filtration except ethanol, add water again and stir cold preservation, filtration.
Described contain pure percent by volume better be 75%.
What the temperature of described cold preservation was better is 0 ℃～10 ℃.
What described cold preservation time was better is 10～24 hours, and better is 12 hours.
Described add water consumption that water stirs better be 3～6 times of medical material amounts.
Wherein, the described concentrated concentrating under reduced pressure that is preferably that concentrates when namely getting water extract.The better relative density when being concentrated into 60 ℃ of described striking point is 1.03～1.08 clear paste.
The invention still further relates to the preparation method of Decoction of Four-Drug Juice concentrated pill of the present invention, it comprises the steps: by described prescription, with the water extract of the Radix Linderae and Semen Arecae, and the Radix Aucklandiae, and Fructus Aurantii pill, drying namely gets the Decoction of Four-Drug Juice concentrated pill.
Among the present invention, the water extract of the Radix Linderae and Semen Arecae, the Radix Aucklandiae, Fructus Aurantii are all as previously mentioned.
Among the present invention, the method for described pill is that this area is conventional, and general better is general method for making or moulds method for making, and better is general method for making.Relate to use equipment during described pill and be this area routine.
Wherein, described general method for making is that this area routine is described, generally is with by described prescription, and the water extract of the Radix Aucklandiae, Fructus Aurantii and the Radix Linderae and Semen Arecae by alternately dusting and moistening, increases gradually pill and makes pill.
Wherein, the described method for making of moulding is that this area routine is described, and is better for by described prescription, the water extract of the Radix Aucklandiae, Fructus Aurantii and the Radix Linderae and Semen Arecae is mixed and made into the plastic ball piece of tool, ball bar after, divided dose is made pill again.
Among the present invention, the temperature of described drying is that this area is conventional, and better is 40 ℃～60 ℃, and better is 40 ℃.What the time of described drying was better is 12～36 hours, and better is 24 hours.
Among the present invention, described Decoction of Four-Drug Juice concentrated pill size is consistent with the conventional concentrated pill in this area, is generally the heavily about 0.3g of per 10 balls.
Among the present invention, on the basis that meets this area general knowledge, each above-mentioned technical characterictic optimum condition can combination in any obtain preferred embodiments.
Agents useful for same of the present invention and raw material equal commercially available getting except specified otherwise.
Positive progressive effect of the present invention is: Decoction of Four-Drug Juice concentrated pill good stability of the present invention, quality be high, carry taking convenience, and has better drug effect than existing oral mushroom liquor, to the poor stagnation of QI of gastrointestinal function, food stagnation card, it is applicable that disease sees that the patients such as distension and fullness in the abdomen, stomachache, constipation are, simultaneously its transportation as solid preparation, store and carry also very convenient.
The specific embodiment
Mode below by embodiment further specifies the present invention, but does not therefore limit the present invention among the described scope of embodiments.
Embodiment 1
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 2 hours of 9 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.5 hour of 5 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 75%, 0 ℃ of lower cold preservation of pure percent by volume 12 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, the water that adds again 5 times of amounts of medical material stirs, cold preservation, filtration, and relative density was 1.03～1.08 clear paste (water extract of the Radix Linderae and Semen Arecae) when filtrate was concentrated into 60 ℃.Get above-mentioned Radix Aucklandiae fine powder, each 37.5g mix homogeneously of Fructus Aurantii fine powder, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 24 hours namely get Decoction of Four-Drug Juice concentrated pill 86g, the heavily about 0.3g of per 10 balls.
Embodiment 2～3
Get that the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii are ground into respectively 100 orders (embodiment 2), 80 orders (embodiment 3) fine powder is for subsequent use, and by moulding the method for making pill; Other is all with embodiment 1.
Embodiment 4～11
The water extract Raw medicine Radix Linderae of the Radix Linderae and Semen Arecae and Semen Arecae and the Radix Aucklandiae, Fructus Aurantii consumption are as shown in the table; Other is all with embodiment 1.
Embodiment 12
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 3 hours of 6 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 1 hour of 3 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 70%, 0 ℃ of lower cold preservation of pure percent by volume 12 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, the water that adds again 5 times of amounts of medical material stirs, cold preservation, filtration, and relative density was 1.03～1.08 clear paste (water extract of the Radix Linderae and Semen Arecae) when filtrate was concentrated into 60 ℃.Get above-mentioned Radix Aucklandiae fine powder, each 37.5g mix homogeneously of Fructus Aurantii fine powder, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 24 hours namely get the Decoction of Four-Drug Juice concentrated pill.
Embodiment 13
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 1 hour of 15 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.3 hour of 10 times of amounts of medical material amount; Repetitive operation once merges 3 times water extraction liquid, is evaporated to 60 ℃ of relative densities and is 1.05～1.15 clear paste; Add ethanol to containing 75%, 0 ℃ of lower cold preservation of pure percent by volume 12 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, the water that adds again 3 times of amounts of medical material stirs, cold preservation, filtration, and relative density was 1.03～1.08 clear paste (water extract of the Radix Linderae and Semen Arecae) when filtrate was concentrated into 60 ℃.Get above-mentioned Radix Aucklandiae fine powder, each 37.5g mix homogeneously of Fructus Aurantii fine powder, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 24 hours namely get the Decoction of Four-Drug Juice concentrated pill.
Embodiment 14
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 2 hours of 8 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.5 hour of 5 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 80%, 10 ℃ of lower cold preservation of pure percent by volume 24 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, the water that adds again 5 times of amounts of medical material stirs, cold preservation, filtration, and relative density was 1.03～1.08 clear paste (water extract of the Radix Linderae and Semen Arecae) when filtrate was concentrated into 60 ℃.Get above-mentioned Radix Aucklandiae fine powder, each 37.5g mix homogeneously of Fructus Aurantii fine powder, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 36 hours namely get the Decoction of Four-Drug Juice concentrated pill.
Embodiment 15
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 2 hours of 12 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.5 hour of 5 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 75%, 0 ℃ of lower cold preservation of pure percent by volume 10 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, the water that adds again 6 times of amounts of medical material stirs, cold preservation, filtration, and relative density was 1.03～1.08 clear paste (water extract of the Radix Linderae and Semen Arecae) when filtrate was concentrated into 60 ℃.Get above-mentioned Radix Aucklandiae fine powder, each 37.5g mix homogeneously of Fructus Aurantii fine powder, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 60 ℃ of dryings 12 hours namely get the Decoction of Four-Drug Juice concentrated pill.
Comparative Examples 1
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii, the Radix Linderae and be ground into respectively 120 order fine powders, for subsequent use; Get Semen Arecae 37.5g, relative density is 1.03～1.08 clear paste when being prepared into 60 ℃ by embodiment 1 water extraction method, adds 7% hydroxypropyl emthylcellulose aqueous solution 30ml as general ball liquid.Get the Radix Aucklandiae, Fructus Aurantii, the general method for making pill of each 37.5g mix homogeneously of Radix Linderae fine powder, drying namely gets the Decoction of Four-Drug Juice concentrated pill.
Comparative Examples 2
Get the Radix Aucklandiae, Fructus Aurantii, the Radix Linderae, four kinds of each 37.5g of medical material of Semen Arecae, add 10 times of water gagings, soaked 2 hours, extracted volatile oil 3 hours with the way of distillation, collect volatile oil, for subsequent use; The medicinal liquid of said extracted volatile oil is filtered, and medicinal liquid is for subsequent use, and medicinal residues add 6 times of water gagings of medical material amount and decoct secondary, and each 0.5 hour, filter, collecting decoction is with the medicinal liquid merging behind the extraction volatile oil; Medicinal liquid is evaporated to the clear paste that relative density is 1.10 (60～70 ℃), adding ethanol makes and contains alcohol amount and reach 75%, cold preservation 12 hours filters, and filtrate recycling ethanol is to distinguishing the flavor of without alcohol, adding 5 times of water gagings of medical material amount stirs, cold preservation 12 hours filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25～1.30 (60 ℃), add starch 30g, mixing, drying is pulverized to get extract powder, ethanol with 70% is as general ball liquid flooding method for making pill, add volatile oil, mixing is heated to 40 ℃, moistening is 24 hours in hermetic container, namely gets the Decoction of Four-Drug Juice concentrated pill.
The preparation of effect embodiment 1 Decoction of Four-Drug Juice concentrated pill is on the impact of drug effect
Get kunming mice, body weight 18～22g, 50, be divided at random 5 groups, the listed medicine of according to the form below and dosage gastric infusion, matched group is given the equal-volume normal saline, successive administration 5 days.
Fasting 24h before the last administration freely drinks water, and 30min after the last administration only gavages india ink 0.1ml/, takes off neck behind the 30min and puts to death, and opens the abdominal cavity and separates mesentery, and the clip upper end is to pylorus, and the lower end is tiled on the glass plate to the intestinal tube of ileocecus.Measure Length of intestine as " small intestinal total length "; Distance from pylorus to the prepared Chinese ink forward position is as " prepared Chinese ink is at the enteral advance distance ", and calculating prepared Chinese ink ink propulsive rate.Result such as following table:
Annotate:
*Compare P＜0.01 with matched group;
#Compare P＜0.05 with oral mushroom liquor and other reagent group.
As seen from the above table, the Decoction of Four-Drug Juice concentrated pill of the Decoction of Four-Drug Juice concentrated pill of embodiments of the invention 1 and oral mushroom liquor and Comparative Examples 1 and Comparative Examples 2 advances the facilitation that highly significant is all arranged to small intestinal peristalsis, but (all be equivalent to Decoction of Four-Drug Juice medical material amount 0.75g) under the same dose, Decoction of Four-Drug Juice concentrated pill of the present invention will significantly be better than oral mushroom liquor and other two kinds of Decoction of Four-Drug Juice concentrated pills to the small intestinal peristalsis progradation.
Effect embodiment 2 Radix Aucklandiae, two kinds of pulverizing medicinal materials degree of Fructus Aurantii are on the impact of drug effect
The medical material Radix Aucklandiae, Fructus Aurantii are ground into respectively the Decoction of Four-Drug Juice concentrated pill that 80 orders (embodiment 3), 100 orders (embodiment 2), 120 orders (embodiment 1) are made, i.e. the concentrated pill of embodiment 1～3 experiment.
Get kunming mice, body weight 18～22g, 40, be divided at random 4 groups, the listed medicine of according to the form below and dosage gastric infusion, matched group is given the equal-volume normal saline, successive administration 5 days.
Fasting 24h before the last administration freely drinks water, and 30min after the last administration only gavages india ink 0.1ml/, takes off neck behind the 30min and puts to death, and opens the abdominal cavity and separates mesentery, and the clip upper end is to pylorus, and the lower end is tiled on the glass plate to the intestinal tube of ileocecus.Measure Length of intestine as " small intestinal total length "; Distance from pylorus to the prepared Chinese ink forward position is as " prepared Chinese ink is at the enteral advance distance ", and calculating prepared Chinese ink ink propulsive rate.Result such as following table:
Annotate:
*Compare P＜0.01 with matched group;
#Compare P＜0.05 with the Decoction of Four-Drug Juice concentrated pill of 80 order medical material powder
The result shows, Decoction of Four-Drug Juice concentrated pill effect of the present invention is much better than matched group, wherein, the Radix Aucklandiae, two kinds of pulverizing medicinal materials of Fructus Aurantii become the Decoction of Four-Drug Juice concentrated pill of 120 orders, 100 purpose powder preparations will significantly be better than the Decoction of Four-Drug Juice concentrated pill that is ground into 80 order powder preparations to the small intestinal peristalsis progradation.
Effect embodiment 3 concentrated pill baking temperatures are on the impact of effective ingredient
Prepare to pill by embodiment 1 method, under 30 ℃, 40 ℃, 50 ℃, 60 ℃ temperature dry 24 hours respectively, get the Decoction of Four-Drug Juice concentrated pill for preparing under four kinds of different drying conditions.
Get above-mentioned four kinds of Decoction of Four-Drug Juice concentrated pills, respectively get 30 ball pulverizes, measure immediately water content, and each precision takes by weighing 3 parts in the concentrated pill powder that is equivalent to 0.15g Decoction of Four-Drug Juice raw medicinal herbs amount, add respectively water 10ml dissolving or be ground into suspension, place D
101Type macroporous adsorptive resins (the about 2cm of internal diameter, packed height 10cm) on, with the flow velocity of per minute 2.5ml, water 200ml eluting, discard water liquid, continue with 70% ethanol 150ml eluting, collect eluent, put and fling to part ethanol in the water-bath, be transferred in the 50ml measuring bottle, add water to scale, shake up, as the Decoction of Four-Drug Juice concentrated pill need testing solution of four kinds of different drying conditions.It is an amount of that other precision takes by weighing the naringin reference substance, adds methanol and make the solution that every 1ml contains 0.15mg, is prepared into the naringin reference substance solution.Under following chromatographic condition, (be filler with octadecylsilane chemically bonded silica; Methanol-1% acetic acid (38: 62) is mobile phase; The detection wavelength is 283nm), precision is drawn above-mentioned reference substance solution and each 5 μ l of need testing solution respectively, and the injection liquid chromatography is measured, and calculates the content of each sample naringin by external standard method.The results are shown in following table:
| Decoction of Four-Drug Juice concentrated pill drying condition | Water content (n=3) | Naringin content (n=3) |
| 30 ℃ 24 hours | 8.2％ | 6.28mg |
| 40 ℃ 24 hours | 4.01％ | 6.15mg |
| 50 ℃ 24 hours | 3.86％ | 4.86mg |
| 60 ℃ 24 hours | 3.67％ | 3.11mg |
The result shows, 40 ℃, 50 ℃, 60 ℃ lower dry 24 hours prepared Decoction of Four-Drug Juice concentrated pill water content meet the requirements (being lower than 5%), and 30 ℃ of lower dry 24 hours prepared Decoction of Four-Drug Juice concentrated pill water content are undesirable, and 40 ℃ of lower dry 24 hours prepared Decoction of Four-Drug Juice concentrated pills are little on the impact of effective ingredient, are better drying condition.
Claims (2)
1. Decoction of Four-Drug Juice concentrated pill is characterized in that:
Made by following methods:
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 2 hours of 9 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.5 hour of 5 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 75%, 0 ℃ of lower cold preservation of pure percent by volume 12 hours, filter, Recycled ethanol adds the water stirring of 5 times of amounts of medical material, cold preservation, filtration again to without the alcohol flavor, relative density was 1.03～1.08 clear paste when filtrate was concentrated into 60 ℃, i.e. the water extract of the Radix Linderae and Semen Arecae; Get above-mentioned Radix Aucklandiae fine powder, each 37.5g of Fructus Aurantii fine powder, mix homogeneously, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 24 hours, and get final product.
2. the preparation method of a Decoction of Four-Drug Juice concentrated pill, it is characterized in that: its preparation method is:
Get the Decoction of Four-Drug Juice Chinese crude drug Radix Aucklandiae, Fructus Aurantii is ground into respectively 120 order fine powders, and is for subsequent use; Get each 37.5g of the Radix Linderae and Semen Arecae, add the water soaking 2 hours of 9 times of amounts of medical material amount, being heated to boils extracted 1 hour, filtered, and medicinal residues add the water extraction 0.5 hour of 5 times of amounts of medical material amount; Merge water extraction liquid twice, be evaporated to 60 ℃ of relative densities and be 1.05～1.15 clear paste; Add ethanol to containing 75%, 0 ℃ of lower cold preservation of pure percent by volume 12 hours, filter, Recycled ethanol adds the water stirring of 5 times of amounts of medical material, cold preservation, filtration again to without the alcohol flavor, relative density was 1.03～1.08 clear paste when filtrate was concentrated into 60 ℃, i.e. the water extract of the Radix Linderae and Semen Arecae; Get above-mentioned Radix Aucklandiae fine powder, each 37.5g of Fructus Aurantii fine powder, mix homogeneously, with the general method for making pill of the water extract of the Radix Linderae and Semen Arecae, 40 ℃ of dryings 24 hours, and get final product.
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| CN105866279A (en) * | 2016-04-20 | 2016-08-17 | 广西壮族自治区梧州食品药品检验所 | Method for determining content of naringin in Qinghouliyan granules by high performance liquid chromatography (HPLC) |
| CN108542990A (en) * | 2018-07-16 | 2018-09-18 | 资兴市泰坤农林生态产业有限公司 | It is a kind of that there is the composition and preparation method thereof for adjusting livestock functions of intestines and stomach |
| CN111450185B (en) * | 2020-05-14 | 2021-07-20 | 湖南汉森制药股份有限公司 | Simotang soft capsule and preparation method thereof |
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| 四磨汤治疗功能性消化不良30例疗效观察;黄恒青等;《福建中医药》;20030830;第34卷(第04期);5 * |
| 陈佩文等.四磨汤口服液治疗老年性便秘疗效观察.《江西医药》.2008,第43卷(第01期),33-34. |
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