CN102207995A - Quantitative analysis method for three-dimensional geometric structure of heart mitral valve device - Google Patents
Quantitative analysis method for three-dimensional geometric structure of heart mitral valve device Download PDFInfo
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- CN102207995A CN102207995A CN2011101381596A CN201110138159A CN102207995A CN 102207995 A CN102207995 A CN 102207995A CN 2011101381596 A CN2011101381596 A CN 2011101381596A CN 201110138159 A CN201110138159 A CN 201110138159A CN 102207995 A CN102207995 A CN 102207995A
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Abstract
The invention discloses a quantitative analysis method for a three-dimensional geometric structure of a heart mitral valve device in the technical field of computer application. Quantitative analysis is realized by establishing a three-dimensional simplified model of the mitral valve device and using three-dimensional geometric structure parameters of a local coordinate system of the mitral valve device as the input of a support vector machine-based classification system. According to the method, reconstruction of the mitral valve device is not affected by an imaging mode, and the simplified three-dimensional model of the mitral valve device is obtained. The local coordinate system of the mitral valve device is established on the basis of simplified expression, so that the mitral valve device is independent of the influence factors such as the position of a sampling probe, heart motion displacement and displacement of a detected main body and the like, the three-dimensional geometric structure parameters of the mitral valve device are calculated, and the structure and the function of the mitral valve device and the spatial structure relation between the components of the mitral valve device are described.
Description
Technical field
What the present invention relates to is the method in a kind of Computer Applied Technology field, specifically is a kind of quantitative analysis method of three-dimensional geometrical structure of heart bicuspid valve device.
Background technology
The real-time three-dimensional ultrasonic system is the main diagnosis imaging instrument of current diagnosis heart mitral lesion.Yet being evaluated in the clinical diagnosis of bicuspid valve three-dimensional geometrical structure and function is relatively limited.One, current widely used clinically reference value is generally all extracted in two dimensional echocardiogram; Its two, the rich space information that traditional function index (as left ventricular volume and ejection fraction etc.) does not make full use of three-dimensional data to be provided is described the anatomical structure of the complexity of bicuspid valve device; Its three, though there are some researches show that the shape of a saddle structure of mitral annulus and its motor function are closely related, be in rough form observation in the actual clinical diagnosis mostly; At last, from anatomical structure and functional integrity, the bicuspid valve device is made up of mitral annulus, lobe leaf, papillary muscle, chordae tendineae, and wherein papillary muscle and chordae tendineae are formed pulling device under the bicuspid valve lobe, therefore is necessary the bicuspid valve device is relatively comprehensively analyzed.
Find through retrieval prior art, P.Nordblom and O.Bech-Hanssen are at " Echocardiography:aJournal Of Cardiovascular Ultrasound and Allies Technology " (echocardiogram: cardiovascular ultrasonic and correlation technique) (2007, what adopt in article 24-7:665-672) " Reference Values Describing the Normal Mitral Valveand the Position ofthe Papillary Muscles " (" describing the reference value of normal bicuspid valve and papillary muscle position ") is two-dimensional ultrasonic image, its reference value of choosing all is to measure on the two-dimensional section, lost three-dimensional spatial information, therefore only be applicable to of the quantitative analysis of two-dimensional ultrasound instrument the bicuspid valve device.
Summary of the invention
The present invention is directed to the prior art above shortcomings, a kind of quantitative analysis method of three-dimensional geometrical structure of heart bicuspid valve device is provided, make the reconstruction of bicuspid valve device not be subjected to the influence of imaging mode, obtain the simplification three-dimensional model of bicuspid valve device.Set up the local coordinate system of bicuspid valve device based on this reduced representation, make its position that is independent of sampling probe, heart movement displacement and examined influence factors such as main body displacement, thereby calculate the three-dimensional geometrical structure quantization parameter of bicuspid valve device, the 26S Proteasome Structure and Function of bicuspid valve device is described, and the relation of the space structure between the component.
The present invention is achieved by the following technical solutions, the present invention includes following steps:
The first step, from the total volume three-dimensional data that the left apex of the heart is gathered, choose the unique point of bicuspid valve device, the i.e. unique point of the unique point of mitral annulus and front and back papillary muscle with interactive means;
Second step, the unique point of annulus of mitral valve sorted after, with non-homogeneous B-spline Curve match annulus of mitral valve, thus with the three-dimensional simplified of front and back papillary muscle unique point composition bicuspid valve device;
The 3rd the step, set up bicuspid valve device local coordinate system according to the point range of mitral annulus;
The 4th step, under bicuspid valve device local coordinate, calculate the three-dimensional geometrical structure parameter of bicuspid valve device, and it carried out standardization with body surface area;
The 5th step, with standardized three-dimensional geometry parameter as input, distinguish all kinds of valve device pathology groups and normal group based on the categorizing system of support vector machine, realize quantitative test.
Described man-machine interaction mode is chosen the unique point of bicuspid valve device, be meant: the arbitrary frame in a cardiac cycle, choose respectively and can clear view respectively 5 cut into slices to mitral major axis and short-axis direction, on each tangent plane, choose the unique point of 2 mitral annuluses, obtain 20 of mitral annulus unique points like this; The unique point of papillary muscle is the central point of papillary muscle to the application point of chordae tendineae root, and in 5 sections on papillary muscle summit, the papillary muscle application point asks it on average to obtain action center point, i.e. papillary muscle unique point then before and after choosing before and after observing.
Described ordering is meant:
A) calculate lobe ring unique point { P
i, i=1,2 ..., the barycenter of N
B) with { P
iAnd P
oProject on the XOY plane, obtain corresponding
With
I=1,2 ..., N;
C) calculate
About
Projection angle
I=1,2 ..., N;
D) according to projection angle
Ascending order or descending sort { P
iObtain new sequence P '
i;
So obtain three-dimensional end to end closure feature point sequence P '
i, i=1,2 ..., N, with it as data point, based on non-homogeneous cubic B-spline match mitral annulus, the cubic B-spline matched curve of structure only with 4 the obligatory point P ' in front and back
I-1, P '
i, P '
I+1, P '
I+2Relevant, the independence of maintenance edge feature.
Described bicuspid valve device local coordinate system is to try to achieve the Quadratic Optimum fit Plane according to the annulus of mitral valve of match, as the reference planes of bicuspid valve device local coordinate system, by the optimal fitting plane by minimizing:
Try to achieve, wherein: A, B, C are that (z)=coefficient of z-Ax-By-C=0, the optimum reference planes that obtain like this are the XOY plane of the local coordinate system of bicuspid valve device to plane f for x, y, are the Z axle perpendicular to the normal direction on this plane.
The three-dimensional geometrical structure parameter of described bicuspid valve device comprises: mitral annulus useful area S
A, promptly annulus of mitral valve is in the projected area of optimum reference planes; Front and back papillary muscle distance D
AL-PM, promptly before and after the three dimensions Euclidean distance of papillary muscle unique point; The distance D of papillary muscle and mitral annulus
AL-AAnd D
PM-A, promptly papillary muscle is to the three-dimensional Euclidean distance of the optimum reference planes of mitral annulus; Front and back papillary muscle angle theta
AL-C-PM, promptly before and after the three dimensions angle of papillary muscle and lobe ring central point.The invention has the beneficial effects as follows: (1) extracts unique point on the bicuspid valve device based on interactive means, is not subjected to the influence of imaging mode substantially, can be used for ultrasonic, three-dimensional datas such as CT, MRI and bring up again the complicated meticulous space characteristics information of bicuspid valve of getting; (2) consider from structure and physiologico-anatomic integrality, make full use of the spatial information of three-dimensional imaging data, set up the simplified model that comprises papillary muscle under mitral annulus and the lobe; (3) under the bicuspid valve local coordinate system, the descriptor of new bicuspid valve device three-D space structure has been proposed; (4) these architectural features are input to the support vector machine categorizing system and discern various mitral lesions, support study dies mitral lesion mechanism, clinical diagnosis and surgery planning.
Description of drawings
Fig. 1 is the three-dimensional data that the left apex of the heart is gathered.
Fig. 2 is a unique point of extracting the bicuspid valve device at three-dimensional tangent plane.
Fig. 3 is the reconstruction and the three-dimensional geometry parameter synoptic diagram of bicuspid valve device.
Fig. 4 is the optimum reference planes synoptic diagram of bicuspid valve device local coordinate system.
Fig. 5 is the dynamic change of bicuspid valve device in the cardiac cycle.
Fig. 6 is that the bicuspid valve device of end-systole (red circle) and diastasis (blue circle) changes for how much.
Embodiment
Below embodiments of the invention are elaborated, present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
The environment of following exemplary application is a Philips Sonos7500 type real-time three-dimensional diasonograph and an IntelPentium IV 2.4GHz, the desktop computer of 2G internal memory, condition are that three-dimensional matrice (matrix) probe is positioned at the difference that left apex of the heart collection Full-volume data can be known resolution bicuspid valve device and background.Do further detailed narration with the total volume data instance that arbitrary moving whole-heartedly cycle gathers:
(1) size of data of Philips Sonos7500 real-time three-dimensional Ultrasound Instrument collection is 144 * 160 * 208, and Fig. 1 is the thtee dimensional echocardiography synoptic diagram that the left apex of the heart is gathered.Arbitrary frame in a cardiac cycle is chosen the unique point of bicuspid valve device with interactive means, i.e. the unique point of the unique point of mitral annulus and front and back papillary muscle, as shown in Figure 2.
(2) unique point of annulus of mitral valve is sorted after, with non-homogeneous B-spline Curve match annulus of mitral valve, thereby form the three-dimensional simplified of bicuspid valve device, as shown in Figure 3 with front and back papillary muscle unique point.
(3) set up bicuspid valve device local coordinate system according to the point range of mitral annulus.Bicuspid valve device local coordinate system is tried to achieve the Quadratic Optimum fit Plane according to the annulus of mitral valve of match, as the reference planes of bicuspid valve device local coordinate system, as shown in Figure 4.The optimum reference planes that obtain like this are the XOY plane of the local coordinate system of bicuspid valve device, are the Z axle perpendicular to the normal direction on this plane.
(4) under bicuspid valve device local coordinate, calculate the three-dimensional geometrical structure parameter of new bicuspid valve device, and it is carried out standardization with body surface area.The three-dimensional geometrical structure parameter of bicuspid valve device as shown in Figure 3, comprising: mitral annulus useful area S
A, promptly annulus of mitral valve is in the projected area of optimum reference planes; Front and back papillary muscle distance D
AL-PM, promptly before and after the three dimensions Euclidean distance of papillary muscle unique point; The distance D of papillary muscle and mitral annulus
AL-AAnd D
PM-A, promptly papillary muscle is to the three-dimensional Euclidean distance of the optimum reference planes of mitral annulus; Front and back papillary muscle angle theta
AL-C-PM, promptly before and after the three dimensions angle of papillary muscle and lobe ring central point.Then these parameters are all carried out standardization divided by body surface area, thereby reduce individual difference, be i.e. height, body weight, age, sex, condition etc.
Implementation result is as follows:
What Fig. 5 showed is the bicuspid valve device of one cardiac cycle of reconstruct.Fig. 6 has compared the geometry of end-systole and ED bicuspid valve device.Result such as following table that the children that severe in 20 examples (11 men, 11 woman, 5.96 ± 3.12 years old mean age) normal child and 20 examples (9 men, 11 woman, 5.59 ± 3.30 years old mean age) bicuspid valve is instead flowed experimentize:
Presentation of results in the table, normal group and mitral regurgitation group significant difference on the geometrical structure parameter of bicuspid valve device has embodied the descriptive power of this method to the geometry of bicuspid valve device, and clinical diagnosis and research are had certain reference and enlightenment.
For existing research object, the average accuracy of the classification of support vector machine reaches 85.0%, illustrate that this method can utilize the three-dimensional geometrical structure of bicuspid valve device, capable auxiliary diagnosis bicuspid valve device pathology, guidance is repaiied lobe or is changed the surgery planning of lobe, preoperative and postoperative is carried out the evaluation of quantitative and qualitative.
Ejection fraction is that heart function commonly used is clinically described index.Following table will have the EF value conduct of research object and the comparison of this experiment now.EF＞55 expression heart functions are normal, and EF＜55 expression heart functions descend.Wherein have only routine reflux disease people EF＜55, the result shows that EF can not consistently reflect that mitral valve function is unusual.
Claims (5)
1. the quantitative analysis method of the three-dimensional geometrical structure of a heart bicuspid valve device is characterized in that, may further comprise the steps:
The first step, from the total volume three-dimensional data that the left apex of the heart is gathered, choose the unique point of bicuspid valve device, the i.e. unique point of the unique point of mitral annulus and front and back papillary muscle with interactive means;
Second step, the unique point of annulus of mitral valve sorted after, with non-homogeneous B-spline Curve match annulus of mitral valve, thus with the three-dimensional simplified of front and back papillary muscle unique point composition bicuspid valve device;
The 3rd the step, set up bicuspid valve device local coordinate system according to the point range of mitral annulus;
The 4th step, under bicuspid valve device local coordinate, calculate the three-dimensional geometrical structure parameter of bicuspid valve device, and it carried out standardization with body surface area;
The 5th step, with standardized three-dimensional geometry parameter as input, distinguish all kinds of valve device pathology groups and normal group based on the categorizing system of support vector machine, realize quantitative test.
2. the quantitative analysis method of the three-dimensional geometrical structure of heart bicuspid valve device according to claim 1, it is characterized in that, described man-machine interaction mode is chosen the unique point of bicuspid valve device, be meant: the arbitrary frame in a cardiac cycle, choose respectively and can clear view respectively 5 cut into slices to mitral major axis and short-axis direction, on each tangent plane, choose the unique point of 2 mitral annuluses, obtain 20 of mitral annulus unique points like this; The unique point of papillary muscle is the central point of papillary muscle to the application point of chordae tendineae root, and in 5 sections on papillary muscle summit, the papillary muscle application point asks it on average to obtain action center point, i.e. papillary muscle unique point then before and after choosing before and after observing.
3. the quantitative analysis method of the three-dimensional geometrical structure of heart bicuspid valve device according to claim 1 is characterized in that, described ordering is meant:
A) calculate lobe ring unique point { P
i, i=1,2 ..., the barycenter of N
B) with { P
iAnd P
oProject on the XOY plane, obtain corresponding
With
I=1,2 ..., N;
C) calculate
About
Projection angle
I=1,2 ..., N;
D) according to projection angle
Ascending order or descending sort { P
iObtain new sequence P '
i;
So obtain three-dimensional end to end closure feature point sequence P '
i, i=1,2 ..., N, with it as data point, based on non-homogeneous cubic B-spline match mitral annulus, the cubic B-spline matched curve of structure only with 4 the obligatory point P ' in front and back
I-1, P '
i, P '
I+1, P '
I+2Relevant, the independence of maintenance edge feature.
4. the quantitative analysis method of the three-dimensional geometrical structure of heart bicuspid valve device according to claim 1, it is characterized in that, described bicuspid valve device local coordinate system is to try to achieve the Quadratic Optimum fit Plane according to the annulus of mitral valve of match, as the reference planes of bicuspid valve device local coordinate system, by the optimal fitting plane by minimizing:
Try to achieve, wherein: A, B, C are that (z)=coefficient of z-Ax-By-C=0, the optimum reference planes that obtain like this are the XOY plane of the local coordinate system of bicuspid valve device to plane f for x, y, are the Z axle perpendicular to the normal direction on this plane.
5. the quantitative analysis method of the three-dimensional geometrical structure of heart bicuspid valve device according to claim 1 is characterized in that, the three-dimensional geometrical structure parameter of described bicuspid valve device comprises: mitral annulus useful area S
A, promptly annulus of mitral valve is in the projected area of optimum reference planes; Front and back papillary muscle distance D
AL-PM, promptly before and after the three dimensions Euclidean distance of papillary muscle unique point; The distance D of papillary muscle and mitral annulus
AL-AAnd D
PM-A, promptly papillary muscle is to the three-dimensional Euclidean distance of the optimum reference planes of mitral annulus; Front and back papillary muscle angle theta
AL-C-PM, promptly before and after the three dimensions angle of papillary muscle and lobe ring central point.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284758A (en) * | 2013-05-20 | 2013-09-11 | 上海交通大学 | Automatic cardiac mitral valve annulus detecting method |
| CN106096245A (en) * | 2016-06-01 | 2016-11-09 | 浙江华电器材检测研究所 | A kind of quick-installation scaffold structure analysis method based on cubic spline function |
| CN110636817A (en) * | 2017-03-07 | 2019-12-31 | 希迪医疗有限责任公司 | Method for generating a mitral valve repair ring and mitral valve repair ring |
| CN111227868A (en) * | 2020-02-03 | 2020-06-05 | 中国医学科学院阜外医院 | Grading standard for secondary tricuspid regurgitation |
| CN112991548A (en) * | 2021-03-30 | 2021-06-18 | 华南理工大学 | Personalized mitral valve finite element modeling and simulation method, system and equipment |
| CN113057677A (en) * | 2021-03-30 | 2021-07-02 | 华南理工大学 | Heart image modeling method, system and equipment for fusing ultrasonic image and CT image |
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2011
- 2011-05-26 CN CN2011101381596A patent/CN102207995A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284758A (en) * | 2013-05-20 | 2013-09-11 | 上海交通大学 | Automatic cardiac mitral valve annulus detecting method |
| CN106096245A (en) * | 2016-06-01 | 2016-11-09 | 浙江华电器材检测研究所 | A kind of quick-installation scaffold structure analysis method based on cubic spline function |
| CN106096245B (en) * | 2016-06-01 | 2019-01-01 | 浙江华电器材检测研究所有限公司 | A kind of quick-installation scaffold structure analysis method based on cubic spline function |
| CN110636817A (en) * | 2017-03-07 | 2019-12-31 | 希迪医疗有限责任公司 | Method for generating a mitral valve repair ring and mitral valve repair ring |
| JP2020512056A (en) * | 2017-03-07 | 2020-04-23 | シーディー メッド エス．アール．エル． | Method of making a mitral annuloplasty ring, and mitral annuloplasty ring |
| CN110636817B (en) * | 2017-03-07 | 2022-02-11 | 希迪医疗有限责任公司 | Method for generating a mitral valve repair ring and mitral valve repair ring |
| CN111227868A (en) * | 2020-02-03 | 2020-06-05 | 中国医学科学院阜外医院 | Grading standard for secondary tricuspid regurgitation |
| CN112991548A (en) * | 2021-03-30 | 2021-06-18 | 华南理工大学 | Personalized mitral valve finite element modeling and simulation method, system and equipment |
| CN113057677A (en) * | 2021-03-30 | 2021-07-02 | 华南理工大学 | Heart image modeling method, system and equipment for fusing ultrasonic image and CT image |
| CN112991548B (en) * | 2021-03-30 | 2023-11-24 | 华南理工大学 | Personalized mitral valve finite element modeling and simulation method, system and equipment |
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Application publication date: 20111005 |