CN102205075A - Preparation method and application of external application ointment composition for treating mastopathy - Google Patents
Preparation method and application of external application ointment composition for treating mastopathy Download PDFInfo
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- CN102205075A CN102205075A CN2011101216141A CN201110121614A CN102205075A CN 102205075 A CN102205075 A CN 102205075A CN 2011101216141 A CN2011101216141 A CN 2011101216141A CN 201110121614 A CN201110121614 A CN 201110121614A CN 102205075 A CN102205075 A CN 102205075A
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Abstract
The invention discloses a preparation method of an ointment composition for treating mastopathy and relates to a Chinese medicinal external application ointment. Constituent compositions and a preparation process are provided in the invention, and the preparation method comprises the following steps of: putting a full dose of rhubarb, moutan bark, dried orange peel, green tangerine orange peel, peach kernel, cassia twig, trigone, spina gleditsiae, Chinese angelica root, rhizome of chuanxiong, raw oysteer shell, common fennel, chinaberry fruit and asarum into a low-temperature drying ozone sterilizer for drying; mixing and grinding; adding vinegar into a container for sealing; and boiling on slow fire, adding ground colophony powder and uniformly stirring to form an ointment. The preparation method belongs to a pure traditional medicine external application formula, the untoward effect of the conventional drinkable liquid medicine on a human body is avoided, the medicine can directly permeate into the focus of a disease; and the ointment composition is safe for clinical application.
Description
[technical field]
The present invention relates to a kind of Chinese medicine external-applied ointment, particularly a kind of treatment mastotic external-applied ointment preparation of compositions method and application thereof.
[background technology]
Known, cyclomastopathy is the modal cystic hyperplasia of breast of women, can betide later any age of adolescence; Sickness rate in China's cyclomastopathy rises just year by year, and the trend that becomes younger is arranged; In fact cyclomastopathy is in essence neither inflammation, neither tumor, but mammary gland normal structure structure disturbance is caused; Cyclomastopathy serves as main performance with lump in breast and mastalgia.Lump in breast is the important evidence of diagnosis cyclomastopathy, is generally multiple lump, differs in size, and quality is hard, and the lump surface is often rough, and that touches has a granular sensation, does not link to each other with skin; And most of patients has the symptom of pain, often is one-sided or bilateral distending pain of the breast or tenderness, and pain takes place or increases the weight of at premenstrua, alleviates after passing through or disappears, and has cyclophysis.
Because the cyclomastopathy course of disease is long, slower development can have performances such as nipple discharge sometimes.It is inaccurate that the menstruation time also can appear in this patient, the amount less or color light, can accompany dysmenorrhea.What symptom of somebody does not all have yet; Cyclomastopathy mainly is because of women self endocrine disturbance, and estrogen and progestogen ratio imbalance stimulate cyclomastopathy excessively to recover incomplete.
Cause the cause of disease of cyclomastopathy a lot, the common Long-term High-fat fat that has hangs down the fiber diet, often drinks; Long-term depression or be subjected to violent direct stimulation etc., also have due to Inheritance or the unknown cause; Though certainly cyclomastopathy and breast carcinoma do not have what necessary relation, cyclomastopathy cancerates and becomes the risk of cancer and often will work energetically healthy people.It seems according to traditional Chinese medical science pathology, breast and meridians in close relations, stomach channel of foot-Yang-ming row passes through the Ruzhong; Spleen meridian, network Weishang diaphragm is distributed in the breast; The liver channel of foot-Jueyin postcibal vomiting, the cloth breast side of body is gone around nipple; Kidney meridian, on pass through the liver diaphragm and join with breast.Dash wantonly two arteries and veins and arise among the born of the same parents, conception vessel follows in the abdomen, and last cv is to breast; Chong channel folder umbilicus is up, to loosing in the heart.Woman's nipple belongs to liver, and breast belongs to stomach.So cystic hyperplasia of breast and liver, stomach two warps and kidney channel, the closest towards wantonly two arteries and veins relation; Liver being bold and firm viscera, the happiness bar reaches and dislikes depression.Liver plays a part to regulate feelings will.If often excessive the or long-term depression of the long-term pressure of women will cause depression of liver-QI, mechanism of qi blocks in breast stomach network, and meridian and vessels obstruction is obstructed, stagnation of QI and blood may bring about pain, and cause mastalgia; Hepatic depression heat-transformation of a specified duration, the bright body fluid of heat is expectorant, the stagnation of QI expectorant blood coagulation stasis of blood can form lump in breast, usually can cause cyclomastopathy, even breast carcinoma takes place; Ancients think " married woman's disease, a lot of in strongly fragrant ".
Usually adopt the operation method treatment for the breast disease doctor trained in Western medicine, but operation must injure human body, and equipment cost is relative with cost of labor higher, what common people were difficult to bear rises.More with good grounds each patient's of the traditional Chinese medical science concrete condition difference aspect the Chinese traditional treatment breast disease and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs has characteristics evident in efficacy, that toxic and side effects is little; Modal have tcm treatment according to syndrome differentiation, external treatment, acupuncture and moxibustion treatment, physical therapy, ear acupuncture or the like, and special advantages is all arranged.
The dosage form of present clinical conventional Chinese medicine preparation mostly is medicinal liquid, causes that assimilation effect is poor, the size of drug dose is difficult to problems such as control; Take obviously unusual trouble of medicinal liquid, and patient is required for the acceptance level and the state of an illness of Chinese medicine abnormal smells from the patient, makes patient will repeatedly take strong dose liquid, and this is to cause a lot of patients to take medicine to interrupt the principal element that falls flat; So a lot of women select external treatment.
[summary of the invention]
In order to overcome the deficiency in the background technology, the invention discloses a kind of treatment mastotic external-applied ointment preparation of compositions method and application thereof, the present invention mainly is made of Radix Et Rhizoma Rhei, Cortex Moutan, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Ramulus Cinnamomi, rhizoma sparganic, Spina Gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Concha Ostreae, Fructus Foeniculi, Fructus Toosendan, Herba Asari, belong to pure Chinese medicine external prescription, avoided existing and drunk the discomfort of medicinal liquid, can make medicine directly permeate the arrival focus human body; Clinical practice safety.
In order to realize the purpose of described invention, the present invention adopts following technical scheme:
A kind of preparation method for the treatment of mastotic ointment composition comprises to become to be grouped into and preparation technology;
Wherein composition consists of " according to weight ratio ", comprises following composition:
Ointment composition preparation method of the present invention is as follows:
A, get capacity Radix Et Rhizoma Rhei, Cortex Moutan, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Ramulus Cinnamomi, rhizoma sparganic, Spina Gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Concha Ostreae, Fructus Foeniculi, Fructus Toosendan, Herba Asari and be placed in the oven drying at low temperature ozone disinfection cabinet oven dry 40 to 80 minutes, dry drug;
B, the rapid dry drug of previous step put into ultrafine crusher mix to pulverize, smashing fineness 20～50, dry medicated powder;
C, the rapid dry medicated powder of previous step is placed in the glass container, adding vinegar and stirring makes dry medicated powder form mass, mass is advisable can trickle into line, left standstill 20 minutes, on pasty state medicated powder, add a spot of vinegar once more, make vinegar flood pasty state medicated powder fully and be advisable, then with seal of vessel, temperature is controlled between 20～30 degree and placed at least 24 hours, and is stand-by;
D, the rapid mass of previous step is poured in the stainless-steel pan, slow fire boiled 30 minutes at least then, stirred while enduring to make mass form the thickness state, and wherein temperature is controlled between 80～900 degree, added the Colophonium foam of pulverizing then and stirred, and formed ointment; The addition of wherein said Colophonium foam is 60～100 grams;
E, ointment is split on the coating while hot forms the mastotic external-applied ointment of treatment.
The preparation method of the mastotic ointment composition of described treatment, described oven drying at low temperature ozone disinfection cabinet are the diligent equipment company limited production of sky, Hebei province.
The preparation method of the mastotic ointment composition of described treatment, described ultrafine crusher are really pharmaceutical machine factory production in the Jishou City.
A kind ofly treat the application of mastotic external-applied ointment compositions in breast disease.
The application of the mastotic external-applied ointment compositions of described treatment in breast disease, women's menstruation began on the 13rd day that ointment was examined heat and be affixed on the affected part to 60 degree, kept three days.
The application of the mastotic external-applied ointment compositions of described treatment in breast disease, menstruation come to begin in 5 days before that ointment is examined heat and paste three days in the affected part to 60 degree.
Beneficial effect of the present invention is:
Radix Et Rhizoma Rhei, Cortex Moutan, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Ramulus Cinnamomi, rhizoma sparganic, Spina Gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Concha Ostreae, Fructus Foeniculi, Fructus Toosendan, Herba Asari are passed through oven drying at low temperature, can guarantee in the pulverizing of post-treatment step and can not destroy drug effect, through the hybrid medicine of pulverizing, can prevent that effective ingredient decomposes in vinegar in vinegar soaks, and make medicine merge mutually compatibility and for toxic disappear mutually to.
Compatibility of the present invention is according to being:
Radix Et Rhizoma Rhei: hardship, cold; Effect is a purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Cortex Moutan " has another name called Cortex Moutan ": have heat clearing away, removing heat from blood, and blood, the effect of repercussive regulating menstruation; Control into blood system, frightened pain is told, is defeated in battle, is had blood in stool, hectic fever due to YIN-deficiency consumptive disease heat, and amenorrhea, carbuncle and ulcer is pounced on damage.
Pericarpium Citri Reticulatae: preventing phlegm from forming and stopping coughing, digestant effect are arranged; To dyspepsia stop amassing, dyspepsia has good therapeutic effect.
Pericarpium Citri Reticulatae Viride: bitter, hot, warm.Soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.
Semen Persicae: the core youngster in the Semen Persicae.The Semen Persicae promoting the circulation of blood can be gone into Chinese medicine.
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.
Rhizoma sparganic: bitter in the mouth, property is flat.Removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving.
Spina Gleditsiae: hot, temperature, nontoxic; System carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature.Return liver, the heart, spleen channel.
Rhizoma Chuanxiong: nature and flavor: suffering, temperature.Gui Jing: go into liver, gallbladder meridian.Blood-activating and qi-promoting, wind-expelling pain-stopping.
Concha Ostreae: salty, be slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.The Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.Be used for spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Fructus Foeniculi: dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.Invigorate blood circulation, promoting the circulation of QI, pain relieving.
Fructus Toosendan: " herbal classic " another name; Fructus Toosendan, chinaberry, chinaberry are in fact.Medicinal part: mature fruit.Function: promoting the circulation of QI to relieve pain, heat clearing away parasite killing.
Herba Asari: hot, temperature, nontoxic.Li Shizhen (1518-1593 A.D.) is said: hot, temperature can be loose, thus various wind and cold, rheumatism, headache, phlegm retention, in the heart be with gas, disease such as shy, available this product is treated.
Ointment composition of the present invention is based on pathogenetic research and the Therapeutic Principle of medical science to the breast disease disease, simultaneously according to the pharmaceutical research achievement, through repeated screening, nameless gall for female breast, lump in breast, the natural drug of curing mammary gland hyperplasia according to reasonably combined composition of theory of Chinese medical science and consumption, is equipped with prepared to control through strictness and forms.
Main feature of the present invention:
1, ointment composition of the present invention is applicable to external.
2, the direct baking of the every obedient plaster of the present invention is heated, treat that plaster is affixed on disease sites after softening, push with hands can cement in 20 seconds that drug effect can reach about 20 days, intermediate demand is changed and is pasted the position, ointment is taken off, and baking is heated, and treats that being affixed on another disease sites after plaster softens just can, the present invention 3 days was a course of treatment, because direct corresponding focus so the present invention has made full use of the effective ingredient of medical material, improves the utilization rate of medical material.
3. the invention belongs to pure Chinese medicine preparation, avoid residual; Clinical practice safety.
[specific embodiment]
Can explain the present invention in more detail by the following examples, the present invention is not limited to the following examples; Disclose purpose of the present invention and be intended to protect all changes and improvements in the scope of the invention;
A kind of preparation method for the treatment of mastotic ointment composition comprises to become to be grouped into and preparation technology;
Wherein composition consists of " according to weight ratio ", comprises following composition:
Ointment composition preparation method of the present invention is as follows:
A, get capacity Radix Et Rhizoma Rhei, Cortex Moutan, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Ramulus Cinnamomi, rhizoma sparganic, Spina Gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Concha Ostreae, Fructus Foeniculi, Fructus Toosendan, Herba Asari and be placed in the oven drying at low temperature ozone disinfection cabinet that the diligent equipment company limited in sky, Hebei province produces oven dry 40 to 80 minutes, dry drug;
B, with the rapid dry drug of previous step put into Jishou City really the ultrafine crusher produced of pharmaceutical machine factory mix and pulverize, smashing fineness 20～50, dry medicated powder;
C, the rapid dry medicated powder of previous step is placed in the glass container, adding vinegar and stirring makes dry medicated powder form mass, mass is advisable can trickle into line, left standstill 20 minutes, on pasty state medicated powder, add a spot of vinegar once more, make vinegar flood pasty state medicated powder fully and be advisable, then with seal of vessel, temperature is controlled between 20～30 degree and placed at least 24 hours, and is stand-by;
D, the rapid mass of previous step is poured in the stainless-steel pan, slow fire boiled 30 minutes at least then, stirred while enduring to make mass form the thickness state, and wherein temperature is controlled between 80～900 degree, added the Colophonium foam of pulverizing then and stirred, and formed ointment; The addition of wherein said Colophonium foam is 60～100 grams;
E, ointment is split on the coating while hot forms the mastotic external-applied ointment of treatment;
Wherein coating is 10 to 20 centimeters of diameters and is circular configuration.
The finished product ointment is placed on the following preservation of 20 degree.
A kind ofly treat the application of mastotic external-applied ointment compositions in breast disease.
The application of the mastotic external-applied ointment compositions of described treatment in breast disease, women's menstruation began on the 13rd day that ointment was examined heat and be affixed on the affected part to 60 degree, kept three days.
The application of the mastotic external-applied ointment compositions of described treatment in breast disease, menstruation come to begin in 5 days before that ointment is examined heat and paste three days in the affected part to 60 degree.
The present invention is for six times a course of treatment, can increase according to actual effect.
Anemia of pregnant woman's forbidding of the present invention.
Clinical trial statistical table of the present invention is as follows;
| Classification | Case | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage |
| Nameless gall | 163 | 146 | 3 | 2 | 12 | 93.6％ |
| Lump in breast | 19 | 15 | 2 | 1 | 1 | 94.8％ |
| Cyclomastopathy | 215 | 98 | 77 | 23 | 17 | 92.1％ |
Wherein going up the table criterion of therapeutical effect is judged to be: treat after three to six courses of treatment to recur in 1 year and confirm as recovery from illness; Treat after three to six courses of treatment that recurrence is produce effects in 1 year; Treating after three to six courses of treatment the state of an illness alleviates to effectively; Treat do not have after three to six courses of treatment obviously be improved as invalid.
After 397 breast disease sufferers were treated three to six courses of treatment through external application medical ointment of the present invention, it was invalid to have 30 people, and total effective rate reaches 92.5%.
Wherein comparatively typical three cases further specify curative effect of the present invention after using the present invention.
Sufferer: Wang Tingting, woman, 26 years old, peasant.One side breast began nameless gall before half a year, each menstruation is arrived a few days ago more so, found it is that mammary gland has streak lump in the breast through health check-up; Use the present invention fully recovered after six courses of treatment.
Sick loyal two: Zang Min, woman, 47 years old, certain mill hand.The both sides lump in breast finds it is mastofibroma through health check-up; Use the present invention's rear udder attachment fiber six courses of treatment lump obviously to dwindle.
Sufferer three: noble and unsullied, woman, 32 years old, workman.The bilateral lump in breast is diagnosed as cyclomastopathy through B ultrasonic; Use the present invention fully recovered after six courses of treatment.
The embodiment that selects for use in this article in order to disclose purpose of the present invention currently thinks to suit, but will be appreciated that, the present invention is intended to comprise that all belong to all changes and the improvement of the interior embodiment of this design and the scope of the invention.
Claims (6)
1. the preparation method of the mastotic ointment composition of treatment comprises to become to be grouped into and preparation technology, and it is characterized in that: described composition " according to weight ratio " comprises following composition:
Ointment composition preparation method of the present invention is as follows:
A, get capacity Radix Et Rhizoma Rhei, Cortex Moutan, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Ramulus Cinnamomi, rhizoma sparganic, Spina Gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Concha Ostreae, Fructus Foeniculi, Fructus Toosendan, Herba Asari and be placed in the oven drying at low temperature ozone disinfection cabinet oven dry 40 to 80 minutes, dry drug;
B, the rapid dry drug of previous step put into ultrafine crusher mix to pulverize, smashing fineness 20～50, dry medicated powder;
C, the rapid dry medicated powder of previous step is placed in the glass container, adding vinegar and stirring makes dry medicated powder form mass, mass is advisable can trickle into line, left standstill 20 minutes, on pasty state medicated powder, add a spot of vinegar once more, make vinegar flood pasty state medicated powder fully and be advisable, then with seal of vessel, temperature is controlled between 20～30 degree and placed at least 24 hours, and is stand-by;
D, the rapid mass of previous step is poured in the stainless-steel pan, slow fire boiled 30 minutes at least then, stirred while enduring to make mass form the thickness state, and wherein temperature is controlled between 80～900 degree, added the Colophonium foam of pulverizing then and stirred, and formed ointment; The addition of wherein said Colophonium foam is 60～100 grams;
E, ointment is split on the coating while hot forms the mastotic external-applied ointment of treatment.
2. the preparation method of the mastotic ointment composition of treatment according to claim 1 is characterized in that: described oven drying at low temperature ozone disinfection cabinet is the diligent equipment company limited production of sky, Hebei province.
3. the preparation method of the mastotic ointment composition of treatment according to claim 1 is characterized in that: described ultrafine crusher is really pharmaceutical machine factory production in the Jishou City.
4. according to the application of the claim 1 mastotic external-applied ointment compositions of treatment in breast disease.
5. according to the application of the mastotic external-applied ointment compositions of the described treatment of claim 4 in breast disease, it is characterized in that: women's menstruation began on the 13rd day that ointment was examined heat and be affixed on the affected part to 60 degree, kept three days.
6. according to the application of the mastotic external-applied ointment compositions of the described treatment of claim 4 in breast disease, it is characterized in that: menstruation comes to begin in 5 days before that ointment is examined heat and paste three days in the affected part to 60 degree.
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| CN2011101216141A CN102205075B (en) | 2011-05-12 | 2011-05-12 | Preparation method and application of external application ointment composition for treating mastopathy |
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| CN2011101216141A CN102205075B (en) | 2011-05-12 | 2011-05-12 | Preparation method and application of external application ointment composition for treating mastopathy |
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| CN102205075A true CN102205075A (en) | 2011-10-05 |
| CN102205075B CN102205075B (en) | 2013-05-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030884A (en) * | 2017-12-26 | 2018-05-15 | 支誉英 | A kind of Chinese medicine for treating mastosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089501A (en) * | 1993-08-31 | 1994-07-20 | 乌鹏喜 | Moschus Hippocampus panchrest plaster and preparation method thereof |
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2011
- 2011-05-12 CN CN2011101216141A patent/CN102205075B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089501A (en) * | 1993-08-31 | 1994-07-20 | 乌鹏喜 | Moschus Hippocampus panchrest plaster and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中国药业》 20080120 徐列波 乳腺病中医治法与用药分析 58-59 1-6 第17卷, 第02期 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030884A (en) * | 2017-12-26 | 2018-05-15 | 支誉英 | A kind of Chinese medicine for treating mastosis and preparation method thereof |
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| CN102205075B (en) | 2013-05-01 |
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