CN102188437A - Glycerol fructose injection and preparation method thereof - Google Patents
Glycerol fructose injection and preparation method thereof Download PDFInfo
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- CN102188437A CN102188437A CN2010101219198A CN201010121919A CN102188437A CN 102188437 A CN102188437 A CN 102188437A CN 2010101219198 A CN2010101219198 A CN 2010101219198A CN 201010121919 A CN201010121919 A CN 201010121919A CN 102188437 A CN102188437 A CN 102188437A
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- injection
- fructose
- glycerol
- sodium chloride
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Abstract
The invention relates to a compound medicinal preparation of two compounds, namely glycerol fructose injection and a preparation method thereof. The injection is sterilization solution prepared from glycerol, fructose, sodium chloride and proper additives and injected to the human body. The using amount of the glycerol and the using amount of the fructose are 10 percent and 5 percent of the water for injection respectively, and the using amount of the sodium chloride is 0.9 percent of the water for injection. The preparation method comprises the following steps of: (1) adding a formula amount of sodium chloride and a proper amount of active carbon into injection water in an amount which is about two thirds of the total amount, performing rough filtration; (2) adding a formula amount of glycerol and fructose, a proper amount of active carbon and the water for injection till the total amount, and performing filtration; (3) regulating the pH value by using hydrochloric acid or sodium hydroxide, filtering, and filling the filtrate into a transfusion bottle of 50 to 500 milliliters after the filtrate is qualified in intermediate inspection; and (4) sealing the transfusion bottle, performing high-temperature moist heat sterilization for 30 minutes at the temperature of 115 DEG C, and packing the injection after the injection is qualified in lamp inspection. The formula of the injection is reasonable, and the injection is mainly used for cerebrovascular diseases, cerebral trauma, brain tumor, intracranial inflammation, acute and chronic increased intracranial pressure caused by other reasons, cerebral edema and the like.
Description
Technical field
The present invention relates to the compound medicinal formulation of two kinds of chemical compounds, i.e. glycerin and fructose injection and preparation method thereof.
Background technology
Glycerin and fructose injection oozes injection as a kind of novel height, is used for the treatment of cerebral edema, and obviously be better than mannitol to improving hemorheological effect, and act on more lasting stability, no rebound phenomenon, and can be the brain metabolism energy source is provided.What studies confirm that cerebral edema in recent years in early days should not be with high sugared injection, but the cell of ischemia is badly in need of energy again and supplies with, and has just produced the contradiction II in the treatment, and glycerin and fructose injection solves the good medicine of this contradiction just.Product attribute: steadily reduce intracranial pressure, the persistent period is longer; Improve cerebral blood flow and brain metabolism; When reducing intracranial pressure, but energize; Be difficult for crystallization, easy to use.
Summary of the invention
Bulk capacity injection product of a kind of reasonable recipe that the purpose of this invention is to provide, the Glycerin Fructose that can satisfy clinical practice and preparation method thereof.
Technical solution of the present invention is: glycerol and fructose and sodium chloride are added injection water and additives make and can inject the intravital sterile solution of people.
The consumption of glycerol and fructose is respectively 10% and 5% of water for injection among the present invention, and amount of sodium chloride is 0.9% of a water for injection.
As additives of the present invention antioxidant, metal chelating agent, PH regulator, active carbon (adsorbent) etc. are arranged.
PH regulator among the present invention includes but not limited to lactic acid, hydrochloric acid, sodium hydroxide, sodium bicarbonate, phosphate, acetic acid and salt thereof, citric acid and salt thereof, aminoacid and salt thereof etc.
The preparation method of above-mentioned glycerol and fructose sodium chloride injection is:
(1) above-mentioned recipe quantity sodium chloride, proper amount of active carbon are added in the water for injection of full dose about 2/3rds coarse filtration;
(2) add recipe quantity glycerol and fructose, proper amount of active carbon again, water for injection adds to full dose, returns filter;
(3) regulate pH value with hydrochloric acid or sodium hydroxide, filter, intermediate is filled in the infusion bottle of 50ml-500ml after the assay was approved;
(4) infusion bottle seals, and through 115 ℃ of 30min high-temperature heat sterilizations, the qualified back of lamp inspection packing promptly.
The specific embodiment:
Embodiment 1: Glycerin Fructose (sodium chloride) injection, and the 50ml/ bottle, every bottle contains glycerol 5g and fructose 2.5g, sodium chloride 0.45g.
Embodiment 2: Glycerin Fructose (sodium chloride) injection, and the 100ml/ bottle, every bottle contains glycerol 10g and fructose 5g, sodium chloride 0.9g.
Embodiment 3: Glycerin Fructose (sodium chloride) injection, and the 250ml/ bottle, every bottle contains glycerol 25g and fructose 12.5g, sodium chloride 2.25g.
Embodiment 4: Glycerin Fructose (sodium chloride) injection, and the 500ml/ bottle, every bottle contains glycerol 50g and fructose 25g, sodium chloride 4.5g.
Claims (4)
1. compound injection product that comprises glycerol and fructose is characterized in that: glycerol and fructose and sodium chloride are added injection water and additives make and can inject the intravital sterile solution of people.
2. according to described Glycerin Fructose sodium chloride injection of claim 1 and preparation technology thereof, it is characterized in that: glycerol, fructose single dose are respectively 10% and 5% of water for injection.
3. according to described Glycerin Fructose sodium chloride injection of claim 1 and preparation technology thereof, it is characterized in that: as isoosmotic adjusting agent, consumption is 0.9% of a water for injection total amount with sodium chloride.
4. according to the described glycerol of claim 1 and fructose sodium chloride injection and preparation technology thereof, it is characterized in that:
(1) above-mentioned recipe quantity sodium chloride, proper amount of active carbon are added in the water for injection of full dose about 2/3rds coarse filtration;
(2) add recipe quantity glycerol and fructose, proper amount of active carbon again, water for injection adds to full dose, returns filter;
(3) regulate pH value with hydrochloric acid or sodium hydroxide, filter, intermediate is filled in the infusion bottle of 50ml-500ml after the assay was approved;
(4) infusion bottle seals, and through 115 ℃ of 30min high-temperature heat sterilizations, the qualified back of lamp inspection packing promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101219198A CN102188437A (en) | 2010-03-11 | 2010-03-11 | Glycerol fructose injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101219198A CN102188437A (en) | 2010-03-11 | 2010-03-11 | Glycerol fructose injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102188437A true CN102188437A (en) | 2011-09-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101219198A Pending CN102188437A (en) | 2010-03-11 | 2010-03-11 | Glycerol fructose injection and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN102188437A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147724A (en) * | 2015-08-20 | 2015-12-16 | 南京正大天晴制药有限公司 | Glycerol, fructose and sodium chloride injection and preparation method thereof |
| CN112755040A (en) * | 2021-01-04 | 2021-05-07 | 北京航空航天大学 | Application of fructose in preparation of medicine for treating ischemic injury |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698625A (en) * | 2005-06-09 | 2005-11-23 | 刘晓曼 | Proportioning and preparing method of glycerose fructose composite raw material medicine |
| CN1864693A (en) * | 2005-05-18 | 2006-11-22 | 曾列丹 | A glycerin and fructose injection and preparation method thereof |
| CN101642430A (en) * | 2009-08-06 | 2010-02-10 | 蚌埠丰原医药科技发展有限公司 | Preparation method of glycerin and fructose injection |
-
2010
- 2010-03-11 CN CN2010101219198A patent/CN102188437A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864693A (en) * | 2005-05-18 | 2006-11-22 | 曾列丹 | A glycerin and fructose injection and preparation method thereof |
| CN1698625A (en) * | 2005-06-09 | 2005-11-23 | 刘晓曼 | Proportioning and preparing method of glycerose fructose composite raw material medicine |
| CN101642430A (en) * | 2009-08-06 | 2010-02-10 | 蚌埠丰原医药科技发展有限公司 | Preparation method of glycerin and fructose injection |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147724A (en) * | 2015-08-20 | 2015-12-16 | 南京正大天晴制药有限公司 | Glycerol, fructose and sodium chloride injection and preparation method thereof |
| CN105147724B (en) * | 2015-08-20 | 2018-01-16 | 南京正大天晴制药有限公司 | A kind of Mannitol sodium chloride injection and preparation method thereof |
| CN112755040A (en) * | 2021-01-04 | 2021-05-07 | 北京航空航天大学 | Application of fructose in preparation of medicine for treating ischemic injury |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110921 |