CN102186727A

CN102186727A - Apparatus and process for packaging a power

Info

Publication number: CN102186727A
Application number: CN2009801406861A
Authority: CN
Inventors: 弗雷德里克.J.迪特里克
Original assignee: Fydec Holding SA
Current assignee: Fydec Holding SA
Priority date: 2008-10-14
Filing date: 2009-10-13
Publication date: 2011-09-14
Anticipated expiration: 2029-10-13
Also published as: EP2212205B1; ATE503688T1; EP2212205A1; CN102186727B; US20110258967A1; WO2010043369A1; DE602009000989D1

Abstract

The invention is directed at a process for enabling the packaging of a powder (32), in particular a pharmaceutical product powder, comprising the steps of: a) Providing a first bag (9) from a flexible packaging material, b) fixing the opening (19) of the first bag (9) to a lower outlet (11) of a DCS (drum containment system) glove box (1), c) inside the DSC glove box (1) pulling a continuous liner (14) at a closed end of the liner (14) and inserting the liner (14) into the first bag (9), thus providing a second bag (16) inside the first bag (9), d) filling the second bag (16) with the powder (32), in particular through an upper opening of the DCS glove box (1), e) closing the second bag (16) by disconnecting the continuous liner (14), f) closing the first bag (9) and removing the first and second bags (9, 16) from the DSC glove box (1). Furthermore the invention is directed at an apparatus for performing the process.

Description

The equipment and the technology of packing powder

Technical field

The present invention relates to such technology and equipment/system: can carry out technology of the package to powder (particularly API) to hold, and need not clean room around the fill area with the mode of GMP.In addition, the present invention relates to be used for the pharmacy powder and/or be used for the technology of specific pharmacy technology of the package and the use of equipment.

Summary of the invention

The objective of the invention is to show a kind of technology and equipment, utilize described technology and the equipment can be, and need not in the clean room, to set up the equipment that is proposed with powder (preferably pharmacy powder) packing near clean-room condition ground at least.

About technology, described purpose is realized by the feature of claim 1; About equipment, described purpose is realized by the feature of claim 11.Other advantageous embodiments of the present invention is showed in the dependent claims.Framework of the present invention is included in all combinations of at least two of disclosed feature in specification sheets, claim and/or the accompanying drawing.For fear of repetition, should be applicable also and can require (claimable) about equipment about the disclosed feature of technology.Be equal to ground, should be applicable also and can require (claimable) about technology about the disclosed feature of equipment.

More particularly, according to the technology that the claim of enclosing requires, can describe together with the technology of this specification sheets and read.Though appended claim has required a cover step, this does not limit the scope of the invention, but every kind of combination of two or more obvious processing steps is protected to being described by the technology of this specification sheets.

It is whole disclosures (specification sheets, claim and accompanying drawing) of the european patent application of EP 0 801 793 2.8 that this application has requires the application number of preceence, should be as the disclosed part of the application, particularly: any one feature at least of the application should be capable of being combined and claimable with any one feature of the application and/or EP 0 801 793 2.8.

Based on the design of using DCS (tympanum containment) glove box, the present invention also requires the equipment that is used to fill average particulate diameter powder in the scope between about 10 microns and about 1000 microns as a kind of.A kind of equipment is provided thus, and it has: the bottom is used to keep comprising first bag tympanum; And top, by at least one gloves (preferably by four gloves, more particularly removably leak free gloves) expert's movable contact and described top, as will be described later, to seal second bag and first bag, this first bag is surrounded second bag.Ideally; the exclusive ground of powder to be filled (exclusively) contacts with second bag; and first bag forms second protectiveness and hides; first bag and second bag is surrounded by equipment thus; so this forms the single-piece protectiveness and hides and/or barrier, preferably is in under-voltage (negative pressure) and/or overvoltage (malleation).

Described technology and device are particularly suitable for powder filler, API powder more particularly, and particle size is between 1 and 1000 micron.The density of the powder of preferably, pouring into is 0.1 and 1kg/dm ³Between.

Particularly preferably, for example as the applicant described in WO 2007/088022 A1, metering device forms the part of described equipment.Metering device preferably is adapted to: more particularly be the result of vibration, can flow in second bag that continuous liner (liner) by hose-like (hose-like) forms from the powder of described metering device in the DCS glove box.About the possible advantageous embodiments of metering device, the disclosure of WO 2007/088022 A1 should be as the disclosed theme part of the application.

Preferably, metering device is based on operating on low voltage, so that by drawing powder.The filling of the dumping of powder/second bag preferably takes place by vibration, and this allows the accurate feeding of powder.Particularly preferably, dryer is provided in the upstream of metering device, and powder is transferred to the pulveriser from described dryer, more particularly online taper pulveriser (online conical mill), and described pulveriser preferably is provided in the top of PTS feeder.Powder from pulveriser is drawn in the metering device then.The core of described technology is, powder is filled in the continuous liner, first bag of second bag of being surrounded by sealing with separate remaining continuous liner and form by continuous liner.Particularly preferably, described device comprises the volatile particles filter (volatile particle filter) of at least one import and/or at least one outlet, high efficiency particulate air(filter) (HEPA particulate filter) more specifically is with the inside of avoiding equipment and/or the pollution of peripheral region.

Technology according to the present invention may further comprise the steps:

Initially, be provided with first bag that makes by flexible packages, preferably be arranged in the tympanum, more particularly by tympanum being inserted bottom at the DCS glove box.Particularly advantageously, cooresponding therewith door is set, and the bottom of DCS glove box is closed in four sides after closing described door.Perhaps, the bottom can be embodied as does not have door, and preferably the front side is open.Preferably, after opening tympanum, first bag is attached at down in the outlet, the described bottom that originates in top and put in the DCS glove box that exports down.For this reason, the operation gloves on the top of equipment have been used.

After this, the continuous liner that lower end is closed passes described control box from the top of glove box following outlet enters first bag, thereby second bag is arranged in first bag, is preferably located in the tympanum.Then, to second bag of powder filler, particularly preferably fill via the upper outlet in the top of DCS glove box.Place first bag with second bag, preferably manually carry out, but alternately can automatically carry out by starting filling process by gloves.Particularly preferably, as described described in the PCT application, be used to fill/metering device of dosing.Second bag is closed and separates with the continuous liner of remainder after filling process, and the lower end of continuous liner that preferably should remainder is sealed.Then, with first bag of sealing of surrounding second bag fully, and, preferably, first bag with second bag preferably together with tympanum from the bottom of DCS glove box preferably by a preferential side to the exit door different with access door remove before, the tympanum that is provided with alternatively in the bottom of DCS glove box is sealed.Preferably, for the ease of removing of tympanum, roller mechanism is set.

The invention still further relates to the equipment that is used to carry out above-mentioned technology, i.e. DCS (tympanum containment) glove box.Described equipment is characterised in that: top, described top comprises at least one pair of gloves, can interfere (intervention) by described at least one pair of gloves in described top, described at least one pair of gloves preferably for good and all but be connected with housing with sealing means replaceably; And the bottom, first bag can be contained in the described bottom, and preferably this first bag is provided in the tympanum.Particularly advantageously, described in the PCT application of quoting previously, equipment comprises metering device.Particularly advantageously, following connecting bridge is only connection between the upper and lower, and first bag can be attached to described down connecting bridge, and continuous liner can pass down connecting bridge from top and enters the bottom.Preferably, more particularly, connecting bridge is in the partition wall (partition wall) of isolating the upper and lower under the tubulose.

The continuous liner that forms second bag damage or the situation of fault under, the DCS glove box prevents the pollution of product and continuous liner can be replaced.The equipment that is proposed, top at least more particularly, the preferred top of DCS glove box exclusively by further exploitation of the present invention, is connected to air circulation system, and air circulation system is designed to guarantee the two-forty of air inerchange.Preferably, windstream is through the volatile particles filter, HEPA filter more particularly, and particularly preferably with 100Nm ³/ hour rate of volume flow, this is preferably corresponding to the gas exchange rate (according to the volume on top) of per minute 5 to 10 times.The two-forty of gas exchange prevents that also powder from resting in the top and contaminated in top, guaranteed extra quality supervision for arbitration thus.

Particularly advantageously, in filling process, have overvoltage a little in the top of DCS glove box at least, can prevent that air from entering system from the outside, such result makes product obtain optimum protection.

Especially, in the situation of packed height deletrious (highly toxic) product, not to produce malleation in top, but preferably implement negative pressure, eliminate thus to the pollution of peripheral region with to the harm of operating personal with respect to barometric pressure.

Particularly advantageously, the bottom of DCS glove box is by three side walls enclose, and more particularly described three sidewalls are adapted to vertical mutually, door are arranged at least one sidewall, preferably in antetheca thus.Perhaps, the front side is permanent open.Particularly advantageously, the rear side of perforated plate (perforated plate) is a leak free, described perforated plate is connected to the fan that has volatile particles filter (more particularly HEPA filter), described thus fan arranges and is designed so that---at least roof of tympanum remove with first bag with process that the following connecting bridge of DCS glove box is connected in, high pressure plays dominating role.When first bag of separate/, also preferred overvoltage.Particularly preferably, air flows with maximum rate 0.5 meter per second.Perhaps, under the situation that need not to be used to provide overvoltage or under-voltage device, just can access the bottom.

Particularly preferably, described system has CIP, therefore can obtain cleaning by CIP.

The favourable exploitation of other of described method and apparatus is illustrated in the following description and accompanying drawing of preferred exemplary of embodiment.Have the accompanying drawing of the explanation of enclosing, should not only form the entity of disclosure, and the independent accompanying drawing that has an explanation of enclosing also should be as source openly independently.

Description of drawings

Fig. 1 to Figure 23: according to the processing step of the preferred form of a kind of implementation of processes example of the present invention design.

Figure 24 to Figure 43: a kind of preferable methods (technology) that is used to change and/or upgrade continuous liner.

Figure 44: a kind of modification of the embodiment of described equipment, wherein in continuous liner and in the upper and lower of DCS glove box with interior generation high pressure.

Figure 45: wherein there is high pressure in a kind of alternative embodiment variant, and has low pressure (described high pressure and described low pressure each with respect to barometric pressure) in the outside of continuous liner in top in continuous liner and in the bottom of DCS glove box.

Figure 46:, show the chart of advantage of the combination gained of any two barrier characteristics at form according to the embodiment of Figure 44.

Figure 47: a chart similar to Figure 46, at form according to the embodiment of Figure 45.

Figure 48 a to 48c: the various views and the details of the non-partly DCS glove box that intactly illustrates.

Figure 49: total system comprises the DCS glove box that is used for powder filler.

The specific embodiment

In the accompanying drawing, components identical indicates identical Reference numeral with the element with identical function.

Fig. 2 illustrates DCS glove box (equipment 1 hereinafter).The bottom 3 that this comprises top 2 and adjoins (adjoin) described top.Bottom 3 intercepts by the partition wall of general horizontal direction and with top 2 isolated (isolated)/hermetically and opens (hermetically sealed off).2 have a waste canister (waste container) 5 that schematically illustrates with interior on top.In top 3, the gloves 6 that only partly illustrate (operation gloves) put in the opening set in (project into) housing and removably are provided on the housing 7.Shown in the embodiment example in, a pair of such gloves of being made by flexible material are arranged on mutual dorsad each side of both sides.

In figure plane, be useful on two pivoted door that open and close bottom 3 in the front side of equipment, thus, be used for the lifting mechanism 10 that lifting has first bag 9 tympanum 8, the tympanum 8 that can will have first bag 9 is inserted into the bottom 3 from described front side.Perhaps, there is not door in described front side.Then preferably, described front side is permanent open.

Following outlet (connecting bridge) 11 passes partition wall can be attached to the described periphery of outlet 11 down for 4, the first bag 9.Under to export 11 are only connecting bridges between top 2 and the bottom 3.

Upper outlet (connecting bridge) 12 and the outlet 11 down segment distance of being separated by, this upper outlet 12 puts in the top 2.Powder to be filled can be via last connecting bridge 12, and preferably by unshowned metering device, more particularly the PTS feeder is supplied with.

The free end 13 of upper outlet 12 is surrounded (surround) by the continuous liner 14 of base seal.In order to seal described continuous liner 14, be provided with anchor clamps 15 or rope bundle part (cable binder).By sealing continuous liner 14, just form second bag 16 by the continuous liner in the bottom 14, upper outlet 12 puts in the described continuous liner 14.

Upper outlet 12 is surrounded by tubular support structure 17, folding continuous liner remains on the periphery of described tubular support structure 17 by holding ring (particularly elastomeric), described folding continuous liner preferably has the length between 10 to 50 meters, preferably approximately 30 meters upon deployment.

In order to fill first bag 9, initially tympanum 8 is inserted bottom 3 from the front side, described bottom 3 is defined by three sidewalls, substrate and partition wall 4.The lid 18 of initial osed top tympanum 8 is opened in bottom 3, as shown in Figure 1, and parks (parked) in cooresponding retainer, and this retainer is not shown.

After this, as shown in Figure 3, first bag 9 opening 19 is attached to down outlet 11 by O shape ring 21, promptly be in position 20 (referring to Fig. 3), thereby first bag 9 is attached to circumferential groove 22.Under export on 11, last position 20 is above upper/lower positions 23, the remainder 24 of first bag of osed top is attached to described upper/lower positions 23 by the O shape ring 25 in the circumferential groove 26 down again.Therefore, new first bag 9 is also surrounded previous first bag remainder 24.

First bag of 9 new periphery that is attached to the following outlet 11 of tubulose---in last position 20, more specifically is being arranged in circumferential groove 22 by O shape ring 21---afterwards particularly, just realization situation as shown in Figure 4.

In the next step of described technology, tympanum 8 and first bag 9 move up by lifting mechanism 10 direction along partition wall in figure plane, up to the downside of the last circumferential edge of tympanum 8 27 contact partition walls 4.Foregoing technology is united in Fig. 5 and Fig. 6 and is illustrated.Preferably, unshowned Qianmen is only closed at this moment, makes bottom 3 be shielded from external environment condition.Perhaps, the bottom is not provided with Qianmen and/or side door.

Fig. 7 and Fig. 8 unite and illustrate, pass down outlet 11 by means of gloves remove previous first bag 9 remainder 24 and upwards enter top 2, and transfer to waste canister 5, make at this moment between top 2 is with first bag 9 to exist directly to be connected via bottom 11.

As shown in Figure 9, in the bottom, be pressed against supporting structure 17 from the outside with continuous liner 14 by inflatable gasket 28.By the O V-shaped ring upper end 29 of folding continuous liner 14 is pressed against supporting structure 17.In processing step according to Fig. 9 and Figure 10, gas, air more particularly, disengage from inflatable gasket 28, thereby the gloves by top in 2 can be with continuous liner 14 downward tractives as shown in arrow 31, and are inserted in first bag 9 by the following outlet 11 of axially aligning with last connecting bridge 12.Therefore, second bag 16 is arranged within first bag 9, as from the direct finding of Figure 12.After transferring in first bag 9 with second bag 16, inflatable gasket reexpands, inflatable gasket 28 is pressed against supporting structure 17 from the outside with continuous liner 14 once more thus, and such result is to prevent the pollution in the zone above inflatable packing ring 28 reliably.

In the next step of technology, as shown in figure 13, first bag 9 is filled with powder 32.Scale (scale) 33 is arranged below lifting mechanism 10, and this scale is connected with the control unit of metering device 34, make dosing unit 34 by last connecting bridge 12 feeding powder up to reaching needed weight.Metering device 34 is connected to the low-voltage tube 35 that is used for by suction (suction) absorption (attract) powder.Via filter cell 36, thereby prevented the pollution of low-voltage tube 35.Preferably, can be by fluctuating pressure (surge pressure) cleaning and filtering element 36.Metering device 34 comprises and appears (emerge) pump chamber 37 in tipping tube 28 that vibrator 39 is provided on the described tipping tube 28 so that can be exactly to powder dosing 32.Metering device 34 also comprises the closing means 40 that preferably is designed to sliding part (slide), is used for preferably regulating loading and/or stopping fill process according to the measured filling weight of described scale.

Preferably in filling process, exist with respect to atmospheric overvoltage in the bottom of tympanum 8, the outside at continuous liner 14 in top 2 exists alternatively with respect to atmospheric low pressure or high pressure.Preferably, in filling process, in continuous liner 14, exist equally with respect to atmospheric certain high pressure.

Roller mechanism 41 as seen from Figure 13, this roller mechanism 41 be provided in bottom 3 with interior and in the bottom 3 sides, the roller of this roller mechanism 41 can be by motor-driven.Roller mechanism 41 is used for first bag of 9/ tympanum 83 unloaded from the bottom.Figure 13 also illustrates, and equipment 1 has two

operating positions

42,43 at opposite side.The renewal that two

operating positions

42,43 help continuous liner 14 is set, and this will be explained below.Preferably, sliding door 44 was arranged before roller mechanism 41.

In case reached required filling weight, just utilize anchor clamps 15 that the every bit place of continuous liner 14 at two

points

45,46 of the segment distance of being separated by sealed, as by Figure 14 and Figure 15 as seen, then, the zone between

point

45,46 cuts off.Therefore, obtain second bag 16 of osed top in first bag 9, this second bag 16 is provided in the tympanum 8 in turn.

In the next step of described technology, the result of this step as seen from Figure 17, tympanum 8 turns back to its initial position downwards by lifting mechanism as shown in figure 16.Then with first bag 9 in the sealing of two some places of the segment distance of being separated by, preferably anchor clamps are arranged and between described two points, cut off at described each some place.Obtain second bag 16 of osed top in first bag 9 of osed top like this.

Figure 18 and Figure 19 illustrate, by cut off make for first bag 9 remainder 24 following connecting bridge 11 places from position 20 move to upper/lower positions 23, thereby be first bag of slot milling of the next one of next filling process.

In the next step shown in Figure 20 and Figure 21, tympanum 8 is sealed by the lid of being put 18.

After this, as Figure 22 and shown in Figure 23, have first and

second bag

9,16 tympanum 8 laterally via roller mechanism 41 and the sliding door 44 opened and remove.

Below, by means of Figure 24 to Figure 42, the preferable methods of upgrading continuous liner 14 is described.

For this reason, (new) continuous liner 14 in first bag 9 moves to the bottom 3 of equipment 1 by the Qianmen, also holds O V-shaped ring 30 in described first bag 9.As shown in Figure 24, be closed for first bag 9 and institute's contents are aseptic.

As Figure 26 and Figure 27 as seen, after previous first bag remainder 24 had moved to upper/lower positions 23, first bag 9 was fixed on position 20 by O shape ring 21.

Use gloves that remainder 24 is placed waste canister 5 then, make between top 2 is with first bag 9, to produce to be connected, and make O V-shaped ring 30 and new continuous liner 13 to remove and/or to move in the top 2 by following connecting bridge 11.As seen from Figure 30, in the additional external packing 47 in continuous liner 14 is contained in first bag 9, so this outer packaging is opened at this moment.Continuous liner 14 produces under clean-room condition and is packed.

Then, as Figure 32 and shown in Figure 33, gas disengages from inflatable gasket 28, and the carrier structure 48 of supporting inflatable gasket 28 removes (referring to Figure 32) together with inflatable gasket 28 from tubular support structure 17.Before this, new continuous liner 14 rests on connecting bridge 12 sides in top 2.

In next step, as shown in figure 34, after the upper end of the remainder 49 of the continuous liner that has used had moved to upper/lower positions, the upper end 29 of new continuous liner 14 was attached to supporting structure 17 by O shape ring 30.In inside, the lower end 50 of continuous liner is passed down through the carrier structure 48 through inflatable gasket 28.Preferably, above control step respectively uses a pair of gloves to implement by two people of the opposite side that is positioned at equipment 1, and preferably equally in next step, the inflatable gasket of band carrier structure 48 moves up and carrier structure 48 is attached in the bottom of tubular support structure 17.

In Figure 36 and later step shown in Figure 37, new continuous liner 14 makes that by anchor clamps 15 sealings therefore remainder 49 forms new second bag in new continuous liner.

In Figure 38 and next step shown in Figure 39, the remainder 49 of previous continuous liner removes and transfers to from supporting structure 17 together with the O shape of previous continuous liner ring and enters second bag 16 that is formed by continuous liner 14 fully, therefore, as Figure 40 and shown in Figure 41, continuous liner utilizes anchor clamps 15 to be enclosed in to be separated by two some places of a segment distance, and second bag of 16 location between described two points separated with this continuous liner 14.Second bag 16 in conjunction with described remainder 49 can fall into first bag 9 now fully, therefore as shown in figure 42, first bag of 9 sealing, the contents of previous thus waste canister 5, promptly previous first bag remainder 24 is transferred to first bag from waste canister 5.Then, can only remove first bag 9, this first bag 9 is equipped with refuse and second bag.So equipment 1 is got ready for further filling process.

Figure 44 illustrates the transparent view of the device 1 of band dosing unit 34.As seen from the figure, in filling process, in continuous liner 14 positive air pressure, be positive air pressure in top 2 and be positive air pressure in bottom 3.This structure provides optimum quality supervision for arbitration.The table of Figure 46 has been summed up the interaction result of various barriers.

Figure 45 illustrates the identical equipment as Figure 44, but the wind circulation in top 2 make low pressure occupy (predominate) in top 2 in continuous liner 14 outsides.In bottom 3 and in continuous liner 14, there is high pressure a little.The interactive effect of two different barriers is illustrated in the table of Figure 47.

The view of Figure 48 a to 48c illustrates the possible embodiment variant of the equipment 1 of band dosing unit 34.Outer wall is not shown.Lateral openings in the housing on top 2 51 as seen from the figure, described lateral openings 51 can be used for operating equipment 1 via integrated system's gloves, and described gloves are attached at the outside of opening 51 with the detouchable sealing means.Tympanum 8 as seen from the figure, and described tympanum 8 can move between upper/lower positions and last position by lifting mechanism 10 in top 3.Lifting mechanism 10 stands on the independent Weighing mechanism 52, and described Weighing mechanism 52 is connected to the control system of dosing unit 34 in the mode of signal conduction.

Figure 48 b illustrates the part of dosing unit 34, and described dosing unit 34 has powder feeding pipe 53, pump chamber 37, low pressure connecting bridge 35, filter cell 36, tipping tube 38, vibrator 39 and closing means 40 and/or valve.

Figure 48 c illustrates the layout of roller mechanism 41 that is used to help to remove tympanum 8 of preferred setting.

Figure 48 c illustrates the position of two volatile particles filters, and promptly intake air volatile particles filter 54 and outlet air volatile particles filter 55 preferably all are the HEPA filters, produces the wind circulation in the top 2 of equipment 1 by described filter.

Figure 49 illustrates the equipment 1 (DCS glove box) that has top 2 and bottom 3 in the total system.Metering device shown in the figure 35, powder supplies to described metering device 35 from pulveriser 56, and pulveriser 56 is correspondingly supplied with powder by dryer 57.There is sample to pipette device 58 at side, in filling process, can pipettes device 58 or utilize described sample to pipette device 58 and automatically extract specification manual from described sample.

Reference numerals list

1. equipment

2. top

3. bottom

4. partition wall

5. waste canister

6. gloves

7. housing

8. tympanum

9. first bag

10. lifting mechanism

11. following outlet

12. upper outlet

13. end

14. continuous liner

15. anchor clamps

16. second bag

17. supporting structure

18. lid

19. opening

20. last position

21.O shape ring

22. go up circumferential groove

23. upper/lower positions

24. previous first bag remainder

25.O shape ring

26. circumferential recess

27. circumferential edge

28. inflatable gasket

29. end

30.O V-shaped ring

31. arrow

32. powder

33. scale

34. metering device

35. low pressure connecting bridge/low-voltage tube

36. filter cell

37. pump chamber

38. tipping tube

39. vibrator

40. closing means

41. roller mechanism

42. operating position

43. operating position

44. sliding door

45. the point

46. the point

47. outer packaging

48. carrier structure/carrying structure

49. the remainder of previous continuous liner

50. end

51. shell nozzle

52. Weighing mechanism

53. powder feeding pipe

54. intake air volatile particles filter

55. outlet air volatile particles filter

56. pulveriser

57. dryer

58. sample pipettes device/sampling setup

Claims

One kind can be to powder (32), particularly pharmaceutical products powder, the technology of packing may further comprise the steps:

A) first bag (9) of being made by flexible packages are set,

B) opening (19) of first bag (9) is fixed to the following outlet (11) of tympanum containment glove box (1),

C) insert in first bag (9) at closed end place (14) the tractive continuous liner (14) of lining and with lining (14) in tympanum containment glove box (1) inside, thus second bag (16) be arranged on first bag of (9) inside,

D) fill second bag (16) with powder (32), particularly fill by the upper shed of tympanum containment glove box (1),

E) seal second bag (16) by disconnecting described continuous liner (14),

F) sealing first bag (9) and first bag and second bag (9,16) are moved apart tympanum containment glove box (1).
2. technology according to claim 1, be included in tympanum containment glove box (1) inside, more particularly, provide low pressure or hyperbaric environment in described continuous liner (14) outside on the top (2) of the tympanum containment glove box (1) that has gloves (6).
3. technology according to claim 1 and 2, be included in the inside of described continuous liner (14) and/or the outside of first bag (9), more particularly the outside of the described continuous liner (14) in the bottom (3) that is designed for the tympanum containment glove box (1) that keeps tympanum (8) provides overpressure conditions.
4. according to each described technology of aforementioned claim,

It is characterized in that:

First bag (9) encircle initial fixation in last position (20) by O shape, more particularly in the upper groove (22) of described outlet (11) down, and sealing described first bag (9) afterwards the remainder (24) of remaining described first bag (9) move in the upper/lower positions (23), more particularly arrive in the low groove (26), so that go out the described position (20) of going up clearly for attached next bag (9).
5. according to each described technology of aforementioned claim,

It is characterized in that:

The sealing of second bag (16) manually realizes by the gloves (6) of tympanum containment glove box (1).
6. according to each described technology of aforementioned claim,

It is characterized in that:

In order to seal second bag (16), two points (45 at the segment distance of being separated by, 46) locate to seal described continuous liner (13), preferably by closing of fettering, and, via the gloves (6) of tympanum containment glove box (1), more particularly by scissors or cutter, zone between this 2 point (45,46) manually cuts off described continuous liner (14).
7. according to each described technology of aforementioned claim,

It is characterized in that:

In order to seal first bag (9),, for example, seal described first bag (9), and the zone between these 2 manually cuts off described first bag (9) by constraint at two some places of the segment distance of being separated by.
8. according to each described technology of aforementioned claim,

It is characterized in that:

Filling before second bag (16), the tympanum (8) that has first bag (9) moves to position (20) from upper/lower positions (23), place, position (20) is stated tympanum (8) and described top (2) and is contacted with partition wall (4) between described bottom (3) on described, more particularly sealing contact.
9. according to each described technology of aforementioned claim,

It is characterized in that:

In order to insert new continuous liner (14), the continuous liner that this is new---preferably with the O shape ring that is used for fastening this continuous liner (14)---is introduced first bag (9) of the described bottom (3) of tympanum containment glove box (1), first bag (9) are connected to described outlet (11) down, described continuous liner (14) is attached to upper outlet (12) within the described top (2), and, the described remainder (49) of last continuous liner (14) manually is placed on by transferring in first bag (9) in the described new continuous liner (14) formed second bag (16) and with this second bag.
10. according to each described technology of aforementioned claim,

It is characterized in that:

Described powder (32) is supplied with via the dosing unit (34) that has low pressure connecting bridge (35) and high pressure connecting bridge, the vibration that at least a portion amount that preferably adopts described powder (32) is produced via vibrator (39) and transmission manner is supplied with.
11. equipment, be used for and be configured to carry out each described technology according to claim 1 to 10, comprise tympanum containment glove box (1), this glove box (1) has top (2) that is provided with gloves (6) and the bottom (3) that is used to keep first bag (9), and this first bag is provided in the tympanum (8) especially.
12. equipment according to claim 11 is characterized in that:

Upper outlet (12) is open into described top (2) from powder metering device (34), and following outlet (11) is open into described bottom (3) from described top (2), and described continuous liner (14) that thus can be attached in described top (2) can pass described outlet (11) down.
13. according to claim 11 or 12 described equipment,

It is characterized in that:

Be provided with and be used for producing overvoltage and/or under-voltage device in described top (2), and/or be used for producing high-voltage device, and/or be used for producing overvoltage and/or under-voltage device in the outside of described continuous liner (14) in described bottom (3) at described continuous liner (14).
14. according to each described equipment of claim 11 to 13,

It is characterized in that:

Lifting mechanism (10) is set in described bottom (3) tympanum (8) is moved between upper/lower positions (23) and last position (20), contact partition wall (4) between described top (2) and described bottom (3) at the described tympanum in last position (8).
15. according to each described equipment of claim 11 to 14,

It is characterized in that:

Set at least one gloves (6) on each side in described top (2) two sides different, preferred opposition, preferably removably fixing gloves preferably set two gloves (6).
16. according to each described equipment of claim 11 to 15,

It is characterized in that:

At least one volatile particles filter (54,55) is set, and highefficiencyparticlefilter more particularly flows to the air of described equipment and/or flows out the air of described equipment with filtration.
17. according to the described equipment of in the claim 11 to 16 each as the application that is used for carrying out according to the packaging machine of each described technology of claim 1 to 11.