CN102174610A - Method and process for drying sodium hyaluronate finished product - Google Patents
Method and process for drying sodium hyaluronate finished product Download PDFInfo
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- CN102174610A CN102174610A CN201010599681XA CN201010599681A CN102174610A CN 102174610 A CN102174610 A CN 102174610A CN 201010599681X A CN201010599681X A CN 201010599681XA CN 201010599681 A CN201010599681 A CN 201010599681A CN 102174610 A CN102174610 A CN 102174610A
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- finished product
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- sodium hyaluronate
- hyaluronic acid
- sucrose
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Abstract
The invention provides a method and a process for drying a sodium hyaluronate finished product. The finished product consists of starch, sucrose, beef extract, yeast powder, potassium dihydrogen sulfate, sodium hydroxide, water and defoaming oil. The method and the process comprise the following steps of: adding 15 to 25 milliliters of defoaming oil into the raw materials prepared in a ratio to culture, performing fermentation, flocculation, centrifugal separation, dissolution, filtration, precipitation and pulverization on the cultured seeds to obtain a hyaluronic acid finished product, pouring the hyaluronic acid finished product into a drying tank, heating the drying tank to the temperature of about 34 DEG C for drying, then cooling the drying tank to the temperature of between 0 and 5 DEG C, and continuously drying till the sodium hyaluronate finished product is obtained. The sodium hyaluronate finished product has the advantages of good uniformity, high yield, attractive appearance and high molecular weight; and the product quality is greatly improved.
Description
Technical field
The present invention relates to a kind of field of inorganic nonmetallic material, be specifically related to a kind of drying means and technology of finished product hyaluronate sodium.
Background technology
At present hyaluronic acid (being called for short HA) is the mucopolysaccharide class material that the disaccharide repeating unit by N-acetylglucosamine and glucuronic acid constitutes, its sodium-salt form is referred to as hyaluronate sodium, the maximum characteristics of low molecule HA are easy Transdermal absorption, porous promotes blood microcirculation to skin corium, regulates skin metabolism, improve skin-nourishing, play crease-resistant beauty and health care, prevent skin aging, keep the function of collagen protein; Existing hyaluronic production process is generally that seed culture, fermentation, wadding are heavy, centrifugation, dissolving, filtration, precipitation powder process, vacuum-drying, but existing method is temperature to be controlled at carry out drying about 34 °, the hyaluronic acid finished product lack of homogeneity that this method makes, yield is low, molecular weight is low, greatly reduces quality product.
Summary of the invention
For solving the deficiencies in the prior art, the invention provides a kind of drying means and technology of finished product hyaluronate sodium.
The technical solution used in the present invention is: a kind of drying means of finished product hyaluronate sodium and technology, by starch, sucrose, extractum carnis, yeast powder, sulfuric acid two hydrocarbon potassium, sodium hydroxide, water, anti-crawl agentfoam oil is formed, the per-cent that constitutive material accounts for cumulative volume is starch 1%, sucrose 0.5%, extractum carnis 0.5%, yeast powder 0.5%, sulfuric acid two hydrocarbon potassium 0.02%, sodium hydroxide 0.05%, water 97.43%, cultivate adding anti-crawl agentfoam oil 15-25ml in the raw material that configures in proportion, seed after cultivating is fermented, wadding is heavy, centrifugation, dissolving, filter, precipitation powder process makes the finished product hyaluronic acid, the finished product hyaluronic acid is poured in the drying chamber, drying chamber is warming up to carries out drying about 34 °, and then be cooled to 0-5 ° and continue to be dried to last.
The invention has the beneficial effects as follows: good uniformity, the yield height, outward appearance is good, and the molecular weight height has improved quality product greatly.
Embodiment
A kind of drying means of finished product hyaluronate sodium and technology, by starch, sucrose, extractum carnis, yeast powder, sulfuric acid two hydrocarbon potassium, sodium hydroxide, water, anti-crawl agentfoam oil is formed, the per-cent that constitutive material accounts for cumulative volume is starch 1%, sucrose 0.5%, extractum carnis 0.5%, yeast powder 0.5%, sulfuric acid two hydrocarbon potassium 0.02%, sodium hydroxide 0.05%, water 97.43%, cultivate adding anti-crawl agentfoam oil 15-25ml in the raw material that configures in proportion, seed after cultivating is fermented, wadding is heavy, centrifugation, dissolving, filter, precipitation powder process makes the finished product hyaluronic acid, the finished product hyaluronic acid is poured in the drying chamber, drying chamber is warming up to carries out drying about 34 °, and then be cooled to 0-5 ° and continue to be dried to last.
Claims (1)
1. the drying means of a finished product hyaluronate sodium and technology, by starch, sucrose, extractum carnis, yeast powder, sulfuric acid two hydrocarbon potassium, sodium hydroxide, water, anti-crawl agentfoam oil is formed, the per-cent that constitutive material accounts for cumulative volume is starch 1%, sucrose 0.5%, extractum carnis 0.5%, yeast powder 0.5%, sulfuric acid two hydrocarbon potassium 0.02%, sodium hydroxide 0.05%, water 97.43%, cultivate adding anti-crawl agentfoam oil 15-25ml in the raw material that configures in proportion, seed after cultivating is fermented, wadding is heavy, centrifugation, dissolving, filter, precipitation powder process makes the finished product hyaluronic acid, it is characterized in that the finished product hyaluronic acid is poured in the drying chamber, drying chamber is warming up to carries out drying about 34 °, and then be cooled to 0-5 ° and continue to be dried to last.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010599681XA CN102174610A (en) | 2010-12-22 | 2010-12-22 | Method and process for drying sodium hyaluronate finished product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010599681XA CN102174610A (en) | 2010-12-22 | 2010-12-22 | Method and process for drying sodium hyaluronate finished product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102174610A true CN102174610A (en) | 2011-09-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010599681XA Pending CN102174610A (en) | 2010-12-22 | 2010-12-22 | Method and process for drying sodium hyaluronate finished product |
Country Status (1)
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| CN (1) | CN102174610A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1563109A (en) * | 2004-04-13 | 2005-01-12 | 阮春学 | Method for preparing hyaluronic acid |
| CN101676307A (en) * | 2008-09-19 | 2010-03-24 | 上海建华精细生物制品有限公司 | Method for purifying sodium hyaluronate |
| CN101914594A (en) * | 2010-08-13 | 2010-12-15 | 武汉嘉发胶原蛋白研究所 | Biological fermentation extracting method for hyaluronic acid |
-
2010
- 2010-12-22 CN CN201010599681XA patent/CN102174610A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1563109A (en) * | 2004-04-13 | 2005-01-12 | 阮春学 | Method for preparing hyaluronic acid |
| CN101676307A (en) * | 2008-09-19 | 2010-03-24 | 上海建华精细生物制品有限公司 | Method for purifying sodium hyaluronate |
| CN101914594A (en) * | 2010-08-13 | 2010-12-15 | 武汉嘉发胶原蛋白研究所 | Biological fermentation extracting method for hyaluronic acid |
Non-Patent Citations (1)
| Title |
|---|
| 梁天佐: "微生物发酵法产透明质酸工艺研究", 《中国优秀硕士学位论文全文数据库 工程技术I期》 * |
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Application publication date: 20110907 |